EF-hand domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4IB64_LEIIN

TriTrypDb:

LINF_350021300

Length:

478

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	yes	yes: 3
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4IB64

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4IB64

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	130	134	PF00656	0.629
CLV_C14_Caspase3-7	175	179	PF00656	0.508
CLV_C14_Caspase3-7	19	23	PF00656	0.576
CLV_NRD_NRD_1	259	261	PF00675	0.718
CLV_NRD_NRD_1	265	267	PF00675	0.647
CLV_NRD_NRD_1	356	358	PF00675	0.711
CLV_NRD_NRD_1	418	420	PF00675	0.659
CLV_PCSK_KEX2_1	258	260	PF00082	0.749
CLV_PCSK_KEX2_1	264	266	PF00082	0.677
CLV_PCSK_KEX2_1	355	357	PF00082	0.772
CLV_PCSK_KEX2_1	418	420	PF00082	0.659
CLV_PCSK_PC7_1	260	266	PF00082	0.755
CLV_PCSK_SKI1_1	118	122	PF00082	0.441
CLV_PCSK_SKI1_1	259	263	PF00082	0.728
CLV_PCSK_SKI1_1	442	446	PF00082	0.688
DOC_CKS1_1	56	61	PF01111	0.613
DOC_MAPK_MEF2A_6	37	45	PF00069	0.605
DOC_MAPK_RevD_3	343	358	PF00069	0.702
DOC_PP2B_LxvP_1	376	379	PF13499	0.575
DOC_USP7_MATH_1	109	113	PF00917	0.425
DOC_USP7_MATH_1	145	149	PF00917	0.595
DOC_USP7_MATH_1	170	174	PF00917	0.705
DOC_USP7_MATH_1	199	203	PF00917	0.761
DOC_USP7_MATH_1	205	209	PF00917	0.710
DOC_USP7_MATH_1	295	299	PF00917	0.711
DOC_USP7_MATH_1	365	369	PF00917	0.696
DOC_USP7_MATH_1	397	401	PF00917	0.750
DOC_USP7_MATH_1	405	409	PF00917	0.639
DOC_USP7_MATH_1	413	417	PF00917	0.583
DOC_USP7_MATH_1	95	99	PF00917	0.631
DOC_USP7_UBL2_3	252	256	PF12436	0.751
DOC_WW_Pin1_4	219	224	PF00397	0.774
DOC_WW_Pin1_4	269	274	PF00397	0.791
DOC_WW_Pin1_4	314	319	PF00397	0.550
DOC_WW_Pin1_4	343	348	PF00397	0.669
DOC_WW_Pin1_4	447	452	PF00397	0.696
DOC_WW_Pin1_4	55	60	PF00397	0.608
LIG_14-3-3_CanoR_1	152	160	PF00244	0.522
LIG_14-3-3_CanoR_1	320	324	PF00244	0.613
LIG_14-3-3_CanoR_1	361	370	PF00244	0.722
LIG_14-3-3_CanoR_1	8	13	PF00244	0.594
LIG_BIR_II_1	1	5	PF00653	0.568
LIG_BIR_III_4	412	416	PF00653	0.780
LIG_BIR_III_4	438	442	PF00653	0.703
LIG_Clathr_ClatBox_1	15	19	PF01394	0.542
LIG_FHA_1	211	217	PF00498	0.739
LIG_FHA_1	336	342	PF00498	0.689
LIG_FHA_1	349	355	PF00498	0.741
LIG_FHA_1	64	70	PF00498	0.572
LIG_FHA_2	128	134	PF00498	0.674
LIG_FHA_2	195	201	PF00498	0.721
LIG_FHA_2	276	282	PF00498	0.759
LIG_LIR_Gen_1	11	21	PF02991	0.521
LIG_LIR_Gen_1	119	129	PF02991	0.531
LIG_LIR_Gen_1	455	465	PF02991	0.689
LIG_LIR_Nem_3	11	16	PF02991	0.510
LIG_LIR_Nem_3	119	124	PF02991	0.508
LIG_LIR_Nem_3	38	43	PF02991	0.567
LIG_LIR_Nem_3	455	461	PF02991	0.671
LIG_LIR_Nem_3	78	82	PF02991	0.429
LIG_Pex14_2	359	363	PF04695	0.600
LIG_SH2_PTP2	40	43	PF00017	0.576
LIG_SH2_SRC	40	43	PF00017	0.475
LIG_SH2_STAT5	40	43	PF00017	0.475
LIG_SH3_1	267	273	PF00018	0.821
LIG_SH3_3	267	273	PF00018	0.821
LIG_SH3_3	344	350	PF00018	0.714
LIG_SH3_3	36	42	PF00018	0.605
LIG_TRAF2_1	246	249	PF00917	0.628
LIG_TRAF2_2	245	250	PF00917	0.753
LIG_UBA3_1	460	468	PF00899	0.673
LIG_WRC_WIRS_1	76	81	PF05994	0.370
LIG_WW_3	377	381	PF00397	0.712
MOD_CDC14_SPxK_1	317	320	PF00782	0.574
MOD_CDK_SPxK_1	314	320	PF00069	0.581
MOD_CK1_1	173	179	PF00069	0.632
MOD_CK1_1	467	473	PF00069	0.585
MOD_CK2_1	129	135	PF00069	0.567
MOD_CK2_1	151	157	PF00069	0.517
MOD_CK2_1	194	200	PF00069	0.724
MOD_CK2_1	275	281	PF00069	0.761
MOD_CK2_1	308	314	PF00069	0.721
MOD_CK2_1	389	395	PF00069	0.652
MOD_CK2_1	449	455	PF00069	0.673
MOD_GlcNHglycan	108	112	PF01048	0.609
MOD_GlcNHglycan	125	128	PF01048	0.414
MOD_GlcNHglycan	147	150	PF01048	0.581
MOD_GlcNHglycan	240	243	PF01048	0.839
MOD_GlcNHglycan	363	366	PF01048	0.681
MOD_GlcNHglycan	383	386	PF01048	0.669
MOD_GlcNHglycan	409	412	PF01048	0.825
MOD_GlcNHglycan	415	418	PF01048	0.733
MOD_GlcNHglycan	432	435	PF01048	0.640
MOD_GlcNHglycan	442	445	PF01048	0.626
MOD_GlcNHglycan	451	454	PF01048	0.538
MOD_GlcNHglycan	469	472	PF01048	0.483
MOD_GSK3_1	103	110	PF00069	0.638
MOD_GSK3_1	123	130	PF00069	0.367
MOD_GSK3_1	168	175	PF00069	0.606
MOD_GSK3_1	189	196	PF00069	0.628
MOD_GSK3_1	205	212	PF00069	0.710
MOD_GSK3_1	295	302	PF00069	0.729
MOD_GSK3_1	326	333	PF00069	0.653
MOD_GSK3_1	361	368	PF00069	0.720
MOD_GSK3_1	430	437	PF00069	0.755
MOD_GSK3_1	460	467	PF00069	0.667
MOD_N-GLC_1	361	366	PF02516	0.735
MOD_N-GLC_1	413	418	PF02516	0.622
MOD_NEK2_1	122	127	PF00069	0.552
MOD_NEK2_1	330	335	PF00069	0.664
MOD_NEK2_1	363	368	PF00069	0.676
MOD_NEK2_1	460	465	PF00069	0.730
MOD_NEK2_1	65	70	PF00069	0.533
MOD_PIKK_1	282	288	PF00454	0.683
MOD_PIKK_1	330	336	PF00454	0.816
MOD_PK_1	8	14	PF00069	0.487
MOD_PKA_2	151	157	PF00069	0.507
MOD_PKA_2	173	179	PF00069	0.645
MOD_PKA_2	319	325	PF00069	0.581
MOD_PKA_2	424	430	PF00069	0.689
MOD_PKB_1	166	174	PF00069	0.616
MOD_Plk_1	300	306	PF00069	0.626
MOD_Plk_4	189	195	PF00069	0.591
MOD_Plk_4	8	14	PF00069	0.487
MOD_ProDKin_1	219	225	PF00069	0.773
MOD_ProDKin_1	269	275	PF00069	0.793
MOD_ProDKin_1	314	320	PF00069	0.554
MOD_ProDKin_1	343	349	PF00069	0.669
MOD_ProDKin_1	447	453	PF00069	0.693
MOD_ProDKin_1	55	61	PF00069	0.606
TRG_ENDOCYTIC_2	40	43	PF00928	0.576
TRG_ER_diArg_1	166	169	PF00400	0.476
TRG_ER_diArg_1	257	260	PF00400	0.665
TRG_ER_diArg_1	264	266	PF00400	0.637
TRG_ER_diArg_1	354	357	PF00400	0.775
TRG_ER_diArg_1	375	378	PF00400	0.582

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P595	Leptomonas seymouri	39%	95%
A0A3S7X927	Leishmania donovani	99%	100%
A4HMI4	Leishmania braziliensis	49%	88%
E9AEY5	Leishmania major	81%	96%
E9B641	Leishmania mexicana (strain MHOM/GT/2001/U1103)	73%	91%