LeishMANIAdb
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Nuclear pore complex protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
Nuclear pore complex protein
Gene product:
hypothetical protein - conserved
Species:
Leishmania infantum
UniProt:
A4IB61_LEIIN
TriTrypDb:
LINF_350021000
Length:
780

Annotations

Annotations by Jardim et al.

Uncharacterized Protein, Uncharacterized

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 10
NetGPI no yes: 0, no: 10
Cellular components
Term Name Level Count
GO:0005643 nuclear pore 3 1
GO:0031080 nuclear pore outer ring 3 1
GO:0032991 protein-containing complex 1 1
GO:0140513 nuclear protein-containing complex 2 1

Expansion

Sequence features

A4IB61
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4IB61

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 125 129 PF00656 0.591
CLV_C14_Caspase3-7 174 178 PF00656 0.391
CLV_C14_Caspase3-7 226 230 PF00656 0.451
CLV_C14_Caspase3-7 243 247 PF00656 0.603
CLV_C14_Caspase3-7 327 331 PF00656 0.509
CLV_C14_Caspase3-7 550 554 PF00656 0.351
CLV_C14_Caspase3-7 643 647 PF00656 0.399
CLV_C14_Caspase3-7 81 85 PF00656 0.515
CLV_C14_Caspase3-7 9 13 PF00656 0.449
CLV_NRD_NRD_1 184 186 PF00675 0.482
CLV_NRD_NRD_1 414 416 PF00675 0.389
CLV_NRD_NRD_1 589 591 PF00675 0.474
CLV_NRD_NRD_1 667 669 PF00675 0.470
CLV_PCSK_KEX2_1 184 186 PF00082 0.482
CLV_PCSK_KEX2_1 203 205 PF00082 0.482
CLV_PCSK_KEX2_1 282 284 PF00082 0.517
CLV_PCSK_KEX2_1 414 416 PF00082 0.389
CLV_PCSK_KEX2_1 589 591 PF00082 0.474
CLV_PCSK_PC1ET2_1 203 205 PF00082 0.427
CLV_PCSK_PC1ET2_1 282 284 PF00082 0.517
CLV_PCSK_SKI1_1 203 207 PF00082 0.370
CLV_PCSK_SKI1_1 23 27 PF00082 0.479
CLV_PCSK_SKI1_1 279 283 PF00082 0.431
CLV_PCSK_SKI1_1 293 297 PF00082 0.246
CLV_PCSK_SKI1_1 415 419 PF00082 0.395
CLV_PCSK_SKI1_1 505 509 PF00082 0.466
CLV_PCSK_SKI1_1 590 594 PF00082 0.509
CLV_PCSK_SKI1_1 595 599 PF00082 0.515
DEG_APCC_DBOX_1 39 47 PF00400 0.455
DEG_APCC_DBOX_1 414 422 PF00400 0.355
DEG_Nend_UBRbox_3 1 3 PF02207 0.693
DEG_SPOP_SBC_1 371 375 PF00917 0.487
DEG_SPOP_SBC_1 433 437 PF00917 0.307
DOC_CYCLIN_yCln2_LP_2 428 434 PF00134 0.443
DOC_CYCLIN_yCln2_LP_2 477 483 PF00134 0.379
DOC_MAPK_gen_1 203 210 PF00069 0.435
DOC_MAPK_MEF2A_6 203 210 PF00069 0.435
DOC_PP2B_LxvP_1 428 431 PF13499 0.389
DOC_PP4_FxxP_1 210 213 PF00568 0.458
DOC_USP7_MATH_1 171 175 PF00917 0.391
DOC_USP7_MATH_1 370 374 PF00917 0.670
DOC_USP7_MATH_1 432 436 PF00917 0.454
DOC_USP7_MATH_1 645 649 PF00917 0.422
DOC_USP7_MATH_1 687 691 PF00917 0.414
DOC_USP7_MATH_1 733 737 PF00917 0.568
DOC_USP7_MATH_1 762 766 PF00917 0.539
DOC_WW_Pin1_4 472 477 PF00397 0.321
DOC_WW_Pin1_4 662 667 PF00397 0.560
LIG_14-3-3_CanoR_1 204 209 PF00244 0.456
LIG_14-3-3_CanoR_1 231 235 PF00244 0.437
LIG_14-3-3_CanoR_1 293 302 PF00244 0.383
LIG_14-3-3_CanoR_1 314 319 PF00244 0.523
LIG_14-3-3_CanoR_1 415 425 PF00244 0.294
LIG_14-3-3_CanoR_1 639 649 PF00244 0.455
LIG_Actin_WH2_2 86 101 PF00022 0.332
LIG_BIR_III_4 596 600 PF00653 0.310
LIG_BRCT_BRCA1_1 21 25 PF00533 0.402
LIG_BRCT_BRCA1_1 666 670 PF00533 0.482
LIG_BRCT_BRCA1_1 700 704 PF00533 0.465
LIG_deltaCOP1_diTrp_1 117 122 PF00928 0.404
LIG_EH1_1 355 363 PF00400 0.271
LIG_FHA_1 190 196 PF00498 0.534
LIG_FHA_1 294 300 PF00498 0.432
LIG_FHA_1 393 399 PF00498 0.651
LIG_FHA_1 420 426 PF00498 0.421
LIG_FHA_1 462 468 PF00498 0.423
LIG_FHA_1 50 56 PF00498 0.644
LIG_FHA_1 579 585 PF00498 0.428
LIG_FHA_1 709 715 PF00498 0.407
LIG_FHA_2 207 213 PF00498 0.547
LIG_FHA_2 220 226 PF00498 0.247
LIG_FHA_2 255 261 PF00498 0.595
LIG_FHA_2 292 298 PF00498 0.473
LIG_FHA_2 373 379 PF00498 0.492
LIG_FHA_2 512 518 PF00498 0.432
LIG_FHA_2 641 647 PF00498 0.479
LIG_FHA_2 703 709 PF00498 0.463
LIG_LIR_Apic_2 207 213 PF02991 0.461
LIG_LIR_Gen_1 42 50 PF02991 0.700
LIG_LIR_Gen_1 452 462 PF02991 0.419
LIG_LIR_Gen_1 570 580 PF02991 0.322
LIG_LIR_Gen_1 69 79 PF02991 0.369
LIG_LIR_Gen_1 701 708 PF02991 0.413
LIG_LIR_Nem_3 22 28 PF02991 0.344
LIG_LIR_Nem_3 307 312 PF02991 0.447
LIG_LIR_Nem_3 317 322 PF02991 0.465
LIG_LIR_Nem_3 42 48 PF02991 0.703
LIG_LIR_Nem_3 452 457 PF02991 0.417
LIG_LIR_Nem_3 498 504 PF02991 0.356
LIG_LIR_Nem_3 570 576 PF02991 0.313
LIG_LIR_Nem_3 69 74 PF02991 0.368
LIG_LIR_Nem_3 701 707 PF02991 0.411
LIG_LIR_Nem_3 89 94 PF02991 0.340
LIG_NRBOX 270 276 PF00104 0.328
LIG_PCNA_yPIPBox_3 577 590 PF02747 0.302
LIG_PDZ_Class_1 775 780 PF00595 0.500
LIG_Pex14_1 118 122 PF04695 0.425
LIG_Pex14_1 71 75 PF04695 0.409
LIG_Pex14_2 508 512 PF04695 0.478
LIG_RPA_C_Fungi 761 773 PF08784 0.476
LIG_SH2_CRK 309 313 PF00017 0.378
LIG_SH2_CRK 454 458 PF00017 0.350
LIG_SH2_CRK 474 478 PF00017 0.190
LIG_SH2_CRK 501 505 PF00017 0.365
LIG_SH2_NCK_1 747 751 PF00017 0.445
LIG_SH2_STAP1 316 320 PF00017 0.356
LIG_SH2_STAP1 33 37 PF00017 0.471
LIG_SH2_STAP1 336 340 PF00017 0.515
LIG_SH2_STAP1 454 458 PF00017 0.435
LIG_SH2_STAP1 547 551 PF00017 0.407
LIG_SH2_STAT3 546 549 PF00017 0.278
LIG_SH2_STAT5 182 185 PF00017 0.375
LIG_SH2_STAT5 322 325 PF00017 0.504
LIG_SH2_STAT5 604 607 PF00017 0.429
LIG_SH2_STAT5 628 631 PF00017 0.458
LIG_SH3_4 23 30 PF00018 0.377
LIG_SUMO_SIM_anti_2 229 236 PF11976 0.427
LIG_SUMO_SIM_anti_2 270 275 PF11976 0.317
LIG_SUMO_SIM_par_1 204 209 PF11976 0.440
LIG_SUMO_SIM_par_1 272 278 PF11976 0.330
LIG_SUMO_SIM_par_1 393 399 PF11976 0.649
LIG_SUMO_SIM_par_1 740 746 PF11976 0.481
LIG_UBA3_1 273 282 PF00899 0.459
MOD_CDC14_SPxK_1 665 668 PF00782 0.423
MOD_CDK_SPxK_1 662 668 PF00069 0.449
MOD_CDK_SPxxK_3 662 669 PF00069 0.440
MOD_CK1_1 230 236 PF00069 0.561
MOD_CK1_1 238 244 PF00069 0.474
MOD_CK1_1 249 255 PF00069 0.725
MOD_CK1_1 291 297 PF00069 0.465
MOD_CK1_1 374 380 PF00069 0.625
MOD_CK1_1 409 415 PF00069 0.528
MOD_CK1_1 513 519 PF00069 0.504
MOD_CK1_1 69 75 PF00069 0.384
MOD_CK1_1 729 735 PF00069 0.531
MOD_CK2_1 538 544 PF00069 0.484
MOD_CK2_1 687 693 PF00069 0.551
MOD_CK2_1 702 708 PF00069 0.349
MOD_CMANNOS 118 121 PF00535 0.369
MOD_GlcNHglycan 111 114 PF01048 0.347
MOD_GlcNHglycan 187 190 PF01048 0.438
MOD_GlcNHglycan 242 245 PF01048 0.713
MOD_GlcNHglycan 248 251 PF01048 0.741
MOD_GlcNHglycan 408 411 PF01048 0.569
MOD_GlcNHglycan 436 439 PF01048 0.600
MOD_GlcNHglycan 540 543 PF01048 0.454
MOD_GlcNHglycan 564 567 PF01048 0.444
MOD_GlcNHglycan 569 572 PF01048 0.364
MOD_GlcNHglycan 607 610 PF01048 0.518
MOD_GlcNHglycan 635 638 PF01048 0.378
MOD_GlcNHglycan 68 71 PF01048 0.464
MOD_GlcNHglycan 685 688 PF01048 0.278
MOD_GlcNHglycan 731 734 PF01048 0.598
MOD_GSK3_1 185 192 PF00069 0.490
MOD_GSK3_1 2 9 PF00069 0.590
MOD_GSK3_1 370 377 PF00069 0.582
MOD_GSK3_1 390 397 PF00069 0.628
MOD_GSK3_1 406 413 PF00069 0.619
MOD_GSK3_1 496 503 PF00069 0.397
MOD_GSK3_1 507 514 PF00069 0.356
MOD_GSK3_1 558 565 PF00069 0.472
MOD_GSK3_1 656 663 PF00069 0.678
MOD_GSK3_1 676 683 PF00069 0.418
MOD_GSK3_1 698 705 PF00069 0.473
MOD_GSK3_1 709 716 PF00069 0.472
MOD_GSK3_1 723 730 PF00069 0.574
MOD_N-GLC_1 109 114 PF02516 0.407
MOD_N-GLC_1 246 251 PF02516 0.657
MOD_NEK2_1 1 6 PF00069 0.604
MOD_NEK2_1 206 211 PF00069 0.448
MOD_NEK2_1 227 232 PF00069 0.523
MOD_NEK2_1 235 240 PF00069 0.563
MOD_NEK2_1 416 421 PF00069 0.353
MOD_NEK2_1 507 512 PF00069 0.354
MOD_NEK2_1 61 66 PF00069 0.562
MOD_NEK2_1 713 718 PF00069 0.490
MOD_NEK2_1 74 79 PF00069 0.286
MOD_NEK2_2 496 501 PF00069 0.367
MOD_PIKK_1 238 244 PF00454 0.527
MOD_PIKK_1 545 551 PF00454 0.314
MOD_PIKK_1 558 564 PF00454 0.367
MOD_PIKK_1 575 581 PF00454 0.430
MOD_PKA_2 230 236 PF00069 0.446
MOD_PKA_2 238 244 PF00069 0.564
MOD_Plk_1 496 502 PF00069 0.424
MOD_Plk_1 61 67 PF00069 0.608
MOD_Plk_1 645 651 PF00069 0.456
MOD_Plk_2-3 117 123 PF00069 0.377
MOD_Plk_2-3 394 400 PF00069 0.584
MOD_Plk_4 117 123 PF00069 0.470
MOD_Plk_4 171 177 PF00069 0.352
MOD_Plk_4 254 260 PF00069 0.613
MOD_Plk_4 314 320 PF00069 0.511
MOD_Plk_4 344 350 PF00069 0.286
MOD_Plk_4 44 50 PF00069 0.673
MOD_Plk_4 496 502 PF00069 0.383
MOD_Plk_4 687 693 PF00069 0.405
MOD_Plk_4 699 705 PF00069 0.333
MOD_Plk_4 709 715 PF00069 0.348
MOD_Plk_4 92 98 PF00069 0.280
MOD_ProDKin_1 472 478 PF00069 0.321
MOD_ProDKin_1 662 668 PF00069 0.555
MOD_SUMO_for_1 524 527 PF00179 0.466
MOD_SUMO_rev_2 81 90 PF00179 0.306
TRG_DiLeu_BaEn_1 89 94 PF01217 0.370
TRG_DiLeu_BaLyEn_6 201 206 PF01217 0.411
TRG_DiLeu_BaLyEn_6 738 743 PF01217 0.402
TRG_ENDOCYTIC_2 309 312 PF00928 0.356
TRG_ENDOCYTIC_2 316 319 PF00928 0.369
TRG_ENDOCYTIC_2 336 339 PF00928 0.330
TRG_ENDOCYTIC_2 454 457 PF00928 0.426
TRG_ENDOCYTIC_2 474 477 PF00928 0.189
TRG_ENDOCYTIC_2 501 504 PF00928 0.346
TRG_ER_diArg_1 183 185 PF00400 0.386
TRG_ER_diArg_1 414 416 PF00400 0.393
TRG_ER_diArg_1 588 590 PF00400 0.459
TRG_NES_CRM1_1 350 364 PF08389 0.273
TRG_NES_CRM1_1 89 102 PF08389 0.439
TRG_Pf-PMV_PEXEL_1 134 139 PF00026 0.417
TRG_Pf-PMV_PEXEL_1 766 770 PF00026 0.484

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N0P593 Leptomonas seymouri 51% 98%
A0A0S4J4X2 Bodo saltans 25% 100%
A0A3S7X934 Leishmania donovani 100% 100%
A0A422NQA4 Trypanosoma rangeli 30% 100%
A4HMI1 Leishmania braziliensis 79% 100%
C9ZZH0 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 28% 100%
E9AEY2 Leishmania major 94% 100%
E9B638 Leishmania mexicana (strain MHOM/GT/2001/U1103) 92% 99%
V5B3W9 Trypanosoma cruzi 29% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS