Uncharacterized protein

Quick info Annotations Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4IB60_LEIIN

TriTrypDb:

LINF_350020900

Length:

578

Annotations

Annotations by Jardim et al.

Uncharacterized Protein, Uncharacterized

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	9
GO:0110165	cellular anatomical entity	1	9

Expansion

Sequence features

A4IB60

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4IB60

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	190	194	PF00656	0.493
CLV_NRD_NRD_1	123	125	PF00675	0.706
CLV_NRD_NRD_1	431	433	PF00675	0.716
CLV_NRD_NRD_1	459	461	PF00675	0.647
CLV_PCSK_KEX2_1	110	112	PF00082	0.710
CLV_PCSK_KEX2_1	122	124	PF00082	0.644
CLV_PCSK_KEX2_1	143	145	PF00082	0.640
CLV_PCSK_KEX2_1	459	461	PF00082	0.642
CLV_PCSK_PC1ET2_1	110	112	PF00082	0.710
CLV_PCSK_PC1ET2_1	143	145	PF00082	0.680
CLV_PCSK_SKI1_1	10	14	PF00082	0.559
CLV_PCSK_SKI1_1	408	412	PF00082	0.534
CLV_PCSK_SKI1_1	513	517	PF00082	0.608
CLV_PCSK_SKI1_1	557	561	PF00082	0.581
CLV_PCSK_SKI1_1	59	63	PF00082	0.710
DEG_APCC_DBOX_1	496	504	PF00400	0.423
DEG_APCC_DBOX_1	9	17	PF00400	0.676
DEG_Nend_UBRbox_1	1	4	PF02207	0.706
DOC_CYCLIN_RxL_1	510	521	PF00134	0.398
DOC_MAPK_DCC_7	10	18	PF00069	0.702
DOC_MAPK_gen_1	143	151	PF00069	0.474
DOC_MAPK_gen_1	155	164	PF00069	0.499
DOC_MAPK_gen_1	330	337	PF00069	0.334
DOC_MAPK_gen_1	4	13	PF00069	0.659
DOC_MAPK_gen_1	407	413	PF00069	0.382
DOC_MAPK_MEF2A_6	144	153	PF00069	0.462
DOC_MAPK_MEF2A_6	158	166	PF00069	0.420
DOC_MAPK_MEF2A_6	460	469	PF00069	0.371
DOC_PP2B_LxvP_1	515	518	PF13499	0.411
DOC_SPAK_OSR1_1	347	351	PF12202	0.431
DOC_USP7_MATH_1	128	132	PF00917	0.395
DOC_USP7_MATH_1	276	280	PF00917	0.362
DOC_USP7_MATH_1	381	385	PF00917	0.348
DOC_USP7_MATH_1	388	392	PF00917	0.354
DOC_USP7_MATH_1	5	9	PF00917	0.719
DOC_USP7_MATH_1	53	57	PF00917	0.455
DOC_WW_Pin1_4	182	187	PF00397	0.489
DOC_WW_Pin1_4	340	345	PF00397	0.300
DOC_WW_Pin1_4	386	391	PF00397	0.428
DOC_WW_Pin1_4	461	466	PF00397	0.341
DOC_WW_Pin1_4	526	531	PF00397	0.421
DOC_WW_Pin1_4	547	552	PF00397	0.278
LIG_14-3-3_CanoR_1	173	178	PF00244	0.420
LIG_14-3-3_CanoR_1	230	239	PF00244	0.573
LIG_14-3-3_CanoR_1	284	292	PF00244	0.415
LIG_14-3-3_CanoR_1	38	46	PF00244	0.488
LIG_14-3-3_CanoR_1	478	484	PF00244	0.393
LIG_14-3-3_CanoR_1	497	501	PF00244	0.447
LIG_14-3-3_CanoR_1	543	551	PF00244	0.387
LIG_14-3-3_CanoR_1	557	565	PF00244	0.385
LIG_14-3-3_CanoR_1	6	13	PF00244	0.702
LIG_14-3-3_CanoR_1	63	73	PF00244	0.477
LIG_Actin_WH2_2	44	61	PF00022	0.510
LIG_BRCT_BRCA1_1	481	485	PF00533	0.313
LIG_Clathr_ClatBox_1	134	138	PF01394	0.524
LIG_Clathr_ClatBox_1	535	539	PF01394	0.390
LIG_deltaCOP1_diTrp_1	573	578	PF00928	0.372
LIG_FHA_1	113	119	PF00498	0.444
LIG_FHA_1	234	240	PF00498	0.532
LIG_FHA_1	531	537	PF00498	0.378
LIG_FHA_1	543	549	PF00498	0.294
LIG_FHA_1	67	73	PF00498	0.507
LIG_FHA_2	155	161	PF00498	0.439
LIG_FHA_2	190	196	PF00498	0.462
LIG_FHA_2	202	208	PF00498	0.510
LIG_FHA_2	242	248	PF00498	0.492
LIG_FHA_2	251	257	PF00498	0.478
LIG_FHA_2	285	291	PF00498	0.383
LIG_FHA_2	519	525	PF00498	0.463
LIG_HCF-1_HBM_1	486	489	PF13415	0.417
LIG_LIR_Apic_2	264	269	PF02991	0.395
LIG_LIR_Gen_1	286	297	PF02991	0.389
LIG_LIR_Gen_1	482	493	PF02991	0.319
LIG_LIR_Gen_1	529	540	PF02991	0.390
LIG_LIR_Nem_3	101	107	PF02991	0.446
LIG_LIR_Nem_3	228	232	PF02991	0.560
LIG_LIR_Nem_3	286	292	PF02991	0.378
LIG_LIR_Nem_3	311	316	PF02991	0.332
LIG_LIR_Nem_3	394	400	PF02991	0.413
LIG_LIR_Nem_3	482	488	PF02991	0.310
LIG_LIR_Nem_3	529	535	PF02991	0.399
LIG_LYPXL_yS_3	445	448	PF13949	0.480
LIG_MYND_1	514	518	PF01753	0.442
LIG_NRBOX	499	505	PF00104	0.453
LIG_PCNA_yPIPBox_3	77	87	PF02747	0.511
LIG_Pex14_1	357	361	PF04695	0.433
LIG_Pex14_2	177	181	PF04695	0.420
LIG_Pex14_2	309	313	PF04695	0.347
LIG_PTB_Apo_2	223	230	PF02174	0.500
LIG_PTB_Apo_2	301	308	PF02174	0.405
LIG_REV1ctd_RIR_1	258	267	PF16727	0.409
LIG_SH2_CRK	266	270	PF00017	0.344
LIG_SH2_CRK	438	442	PF00017	0.438
LIG_SH2_GRB2like	178	181	PF00017	0.418
LIG_SH2_GRB2like	520	523	PF00017	0.441
LIG_SH2_NCK_1	520	524	PF00017	0.445
LIG_SH2_STAT5	178	181	PF00017	0.463
LIG_SH2_STAT5	315	318	PF00017	0.396
LIG_SH2_STAT5	336	339	PF00017	0.427
LIG_SH2_STAT5	440	443	PF00017	0.369
LIG_SH2_STAT5	473	476	PF00017	0.403
LIG_SH2_STAT5	483	486	PF00017	0.322
LIG_SH2_STAT5	489	492	PF00017	0.311
LIG_SH2_STAT5	520	523	PF00017	0.464
LIG_SH2_STAT5	558	561	PF00017	0.312
LIG_SH3_3	237	243	PF00018	0.504
LIG_SH3_3	338	344	PF00018	0.317
LIG_SUMO_SIM_anti_2	130	136	PF11976	0.467
LIG_SUMO_SIM_par_1	163	168	PF11976	0.438
LIG_SUMO_SIM_par_1	501	508	PF11976	0.420
LIG_SUMO_SIM_par_1	533	539	PF11976	0.329
LIG_TRAF2_1	321	324	PF00917	0.472
LIG_TRAF2_1	95	98	PF00917	0.432
LIG_TYR_ITIM	436	441	PF00017	0.429
LIG_WRC_WIRS_1	174	179	PF05994	0.418
MOD_CDK_SPxxK_3	340	347	PF00069	0.409
MOD_CDK_SPxxK_3	386	393	PF00069	0.370
MOD_CK1_1	176	182	PF00069	0.448
MOD_CK1_1	233	239	PF00069	0.432
MOD_CK1_1	502	508	PF00069	0.420
MOD_CK2_1	154	160	PF00069	0.439
MOD_CK2_1	189	195	PF00069	0.484
MOD_CK2_1	201	207	PF00069	0.394
MOD_CK2_1	241	247	PF00069	0.467
MOD_CK2_1	250	256	PF00069	0.471
MOD_CK2_1	284	290	PF00069	0.360
MOD_CK2_1	388	394	PF00069	0.348
MOD_CK2_1	488	494	PF00069	0.398
MOD_CK2_1	495	501	PF00069	0.384
MOD_CK2_1	518	524	PF00069	0.439
MOD_GlcNHglycan	232	235	PF01048	0.751
MOD_GlcNHglycan	353	356	PF01048	0.620
MOD_GSK3_1	176	183	PF00069	0.420
MOD_GSK3_1	230	237	PF00069	0.521
MOD_GSK3_1	369	376	PF00069	0.428
MOD_GSK3_1	495	502	PF00069	0.418
MOD_GSK3_1	526	533	PF00069	0.453
MOD_GSK3_1	547	554	PF00069	0.333
MOD_N-GLC_1	112	117	PF02516	0.708
MOD_N-GLC_1	128	133	PF02516	0.558
MOD_N-GLC_1	201	206	PF02516	0.662
MOD_N-GLC_1	225	230	PF02516	0.750
MOD_N-GLC_1	261	266	PF02516	0.637
MOD_N-GLC_1	305	310	PF02516	0.548
MOD_N-GLC_1	446	451	PF02516	0.650
MOD_N-GLC_2	180	182	PF02516	0.617
MOD_NEK2_1	149	154	PF00069	0.415
MOD_NEK2_1	261	266	PF00069	0.344
MOD_NEK2_1	283	288	PF00069	0.396
MOD_NEK2_1	316	321	PF00069	0.432
MOD_NEK2_1	552	557	PF00069	0.327
MOD_NEK2_2	225	230	PF00069	0.423
MOD_PIKK_1	165	171	PF00454	0.463
MOD_PIKK_1	507	513	PF00454	0.445
MOD_PIKK_1	66	72	PF00454	0.531
MOD_PKA_2	283	289	PF00069	0.373
MOD_PKA_2	290	296	PF00069	0.374
MOD_PKA_2	37	43	PF00069	0.514
MOD_PKA_2	496	502	PF00069	0.448
MOD_PKA_2	5	11	PF00069	0.706
MOD_PKA_2	542	548	PF00069	0.356
MOD_PKB_1	367	375	PF00069	0.433
MOD_Plk_1	128	134	PF00069	0.527
MOD_Plk_1	225	231	PF00069	0.564
MOD_Plk_1	261	267	PF00069	0.438
MOD_Plk_1	305	311	PF00069	0.344
MOD_Plk_1	507	513	PF00069	0.464
MOD_Plk_2-3	96	102	PF00069	0.497
MOD_Plk_4	128	134	PF00069	0.481
MOD_Plk_4	17	23	PF00069	0.330
MOD_Plk_4	276	282	PF00069	0.411
MOD_Plk_4	479	485	PF00069	0.394
MOD_Plk_4	499	505	PF00069	0.432
MOD_ProDKin_1	182	188	PF00069	0.488
MOD_ProDKin_1	340	346	PF00069	0.300
MOD_ProDKin_1	386	392	PF00069	0.424
MOD_ProDKin_1	461	467	PF00069	0.339
MOD_ProDKin_1	526	532	PF00069	0.418
MOD_ProDKin_1	547	553	PF00069	0.279
MOD_SUMO_for_1	109	112	PF00179	0.511
MOD_SUMO_rev_2	311	316	PF00179	0.386
MOD_SUMO_rev_2	55	61	PF00179	0.512
TRG_DiLeu_BaEn_1	130	135	PF01217	0.526
TRG_DiLeu_BaEn_1	68	73	PF01217	0.534
TRG_DiLeu_BaEn_4	247	253	PF01217	0.525
TRG_DiLeu_BaLyEn_6	341	346	PF01217	0.353
TRG_DiLeu_BaLyEn_6	511	516	PF01217	0.451
TRG_ENDOCYTIC_2	104	107	PF00928	0.496
TRG_ENDOCYTIC_2	438	441	PF00928	0.401
TRG_ENDOCYTIC_2	445	448	PF00928	0.429
TRG_ENDOCYTIC_2	489	492	PF00928	0.316
TRG_ER_diArg_1	121	124	PF00400	0.478
TRG_NES_CRM1_1	140	154	PF08389	0.472
TRG_Pf-PMV_PEXEL_1	230	235	PF00026	0.712
TRG_Pf-PMV_PEXEL_1	263	267	PF00026	0.617
TRG_Pf-PMV_PEXEL_1	314	318	PF00026	0.574
TRG_Pf-PMV_PEXEL_1	383	387	PF00026	0.619
TRG_Pf-PMV_PEXEL_1	52	57	PF00026	0.665

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IJZ6	Leptomonas seymouri	43%	100%
A0A0S4J8J1	Bodo saltans	24%	100%
A0A1X0P5Y1	Trypanosomatidae	29%	100%
A0A3R7KJC8	Trypanosoma rangeli	29%	100%
A0A3S7X958	Leishmania donovani	99%	100%
A4HMI0	Leishmania braziliensis	72%	99%
E9AEY1	Leishmania major	90%	100%
E9B637	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	100%
V5BJE1	Trypanosoma cruzi	29%	100%