Protein kinase domain-containing protein

Quick info Annotations Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4IB54_LEIIN

TriTrypDb:

LINF_350020300

Length:

501

Annotations

LeishMANIAdb annotations

No conserved TM segments are present in this protein.

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

A4IB54

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4IB54

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	156	160	PF00656	0.611
CLV_MEL_PAP_1	314	320	PF00089	0.499
CLV_NRD_NRD_1	135	137	PF00675	0.487
CLV_NRD_NRD_1	277	279	PF00675	0.462
CLV_NRD_NRD_1	293	295	PF00675	0.560
CLV_NRD_NRD_1	498	500	PF00675	0.517
CLV_PCSK_KEX2_1	133	135	PF00082	0.618
CLV_PCSK_KEX2_1	277	279	PF00082	0.462
CLV_PCSK_KEX2_1	293	295	PF00082	0.560
CLV_PCSK_PC1ET2_1	133	135	PF00082	0.618
CLV_PCSK_SKI1_1	113	117	PF00082	0.531
CLV_PCSK_SKI1_1	28	32	PF00082	0.382
CLV_PCSK_SKI1_1	465	469	PF00082	0.580
DEG_Nend_UBRbox_1	1	4	PF02207	0.484
DEG_SCF_TRCP1_1	274	280	PF00400	0.488
DEG_SPOP_SBC_1	196	200	PF00917	0.630
DEG_SPOP_SBC_1	201	205	PF00917	0.602
DEG_SPOP_SBC_1	341	345	PF00917	0.616
DEG_SPOP_SBC_1	5	9	PF00917	0.448
DOC_ANK_TNKS_1	378	385	PF00023	0.526
DOC_MAPK_gen_1	183	192	PF00069	0.637
DOC_MAPK_gen_1	400	408	PF00069	0.540
DOC_MAPK_MEF2A_6	120	128	PF00069	0.475
DOC_MAPK_MEF2A_6	28	37	PF00069	0.372
DOC_PP1_RVXF_1	246	252	PF00149	0.531
DOC_PP2B_LxvP_1	58	61	PF13499	0.431
DOC_USP7_MATH_1	196	200	PF00917	0.630
DOC_USP7_MATH_1	20	24	PF00917	0.364
DOC_USP7_MATH_1	201	205	PF00917	0.602
DOC_USP7_MATH_1	237	241	PF00917	0.667
DOC_USP7_MATH_1	373	377	PF00917	0.646
DOC_USP7_MATH_1	483	487	PF00917	0.585
DOC_USP7_MATH_1	6	10	PF00917	0.449
DOC_USP7_UBL2_3	86	90	PF12436	0.544
DOC_USP7_UBL2_3	95	99	PF12436	0.508
DOC_WW_Pin1_4	192	197	PF00397	0.656
DOC_WW_Pin1_4	241	246	PF00397	0.721
DOC_WW_Pin1_4	347	352	PF00397	0.695
DOC_WW_Pin1_4	419	424	PF00397	0.558
DOC_WW_Pin1_4	479	484	PF00397	0.606
DOC_WW_Pin1_4	68	73	PF00397	0.517
LIG_14-3-3_CanoR_1	154	163	PF00244	0.627
LIG_14-3-3_CanoR_1	231	238	PF00244	0.621
LIG_14-3-3_CanoR_1	248	252	PF00244	0.532
LIG_14-3-3_CanoR_1	267	271	PF00244	0.473
LIG_14-3-3_CanoR_1	277	282	PF00244	0.425
LIG_14-3-3_CanoR_1	28	37	PF00244	0.363
LIG_14-3-3_CanoR_1	293	298	PF00244	0.556
LIG_14-3-3_CanoR_1	315	323	PF00244	0.505
LIG_14-3-3_CanoR_1	465	473	PF00244	0.441
LIG_BIR_III_4	97	101	PF00653	0.518
LIG_CtBP_PxDLS_1	405	409	PF00389	0.462
LIG_CtBP_PxDLS_1	490	494	PF00389	0.448
LIG_deltaCOP1_diTrp_1	159	163	PF00928	0.635
LIG_EVH1_2	60	64	PF00568	0.477
LIG_FHA_1	13	19	PF00498	0.426
LIG_FHA_1	179	185	PF00498	0.637
LIG_FHA_1	233	239	PF00498	0.597
LIG_FHA_1	258	264	PF00498	0.527
LIG_FHA_1	335	341	PF00498	0.506
LIG_FHA_1	354	360	PF00498	0.567
LIG_FHA_1	462	468	PF00498	0.489
LIG_FHA_1	492	498	PF00498	0.475
LIG_FHA_1	82	88	PF00498	0.520
LIG_FHA_2	214	220	PF00498	0.679
LIG_Integrin_RGD_1	272	274	PF01839	0.528
LIG_LIR_Gen_1	187	196	PF02991	0.630
LIG_LIR_Gen_1	27	38	PF02991	0.358
LIG_LIR_Gen_1	46	55	PF02991	0.355
LIG_LIR_Nem_3	187	192	PF02991	0.635
LIG_LIR_Nem_3	27	33	PF02991	0.363
LIG_LIR_Nem_3	358	363	PF02991	0.583
LIG_LIR_Nem_3	36	41	PF02991	0.334
LIG_LIR_Nem_3	46	51	PF02991	0.375
LIG_MYND_1	75	79	PF01753	0.525
LIG_Pex14_1	448	452	PF04695	0.478
LIG_Pex14_2	287	291	PF04695	0.490
LIG_Pex14_2	64	68	PF04695	0.503
LIG_RPA_C_Fungi	226	238	PF08784	0.597
LIG_SH2_CRK	48	52	PF00017	0.363
LIG_SH2_PTP2	189	192	PF00017	0.644
LIG_SH2_PTP2	38	41	PF00017	0.357
LIG_SH2_STAP1	225	229	PF00017	0.670
LIG_SH2_STAP1	391	395	PF00017	0.551
LIG_SH2_STAP1	48	52	PF00017	0.352
LIG_SH2_STAT5	189	192	PF00017	0.667
LIG_SH2_STAT5	289	292	PF00017	0.511
LIG_SH2_STAT5	38	41	PF00017	0.383
LIG_SH2_STAT5	391	394	PF00017	0.474
LIG_SH2_STAT5	475	478	PF00017	0.636
LIG_SH3_3	187	193	PF00018	0.648
LIG_SH3_3	69	75	PF00018	0.518
LIG_SUMO_SIM_par_1	259	265	PF11976	0.513
LIG_SUMO_SIM_par_1	355	361	PF11976	0.612
LIG_TRFH_1	68	72	PF08558	0.516
LIG_WRC_WIRS_1	44	49	PF05994	0.382
LIG_WW_3	59	63	PF00397	0.469
MOD_CDK_SPK_2	68	73	PF00069	0.494
MOD_CDK_SPxxK_3	241	248	PF00069	0.601
MOD_CK1_1	105	111	PF00069	0.501
MOD_CK1_1	194	200	PF00069	0.660
MOD_CK1_1	202	208	PF00069	0.623
MOD_CK1_1	212	218	PF00069	0.535
MOD_CK1_1	257	263	PF00069	0.573
MOD_CK1_1	321	327	PF00069	0.620
MOD_CK1_1	342	348	PF00069	0.629
MOD_CK1_1	414	420	PF00069	0.643
MOD_CK2_1	100	106	PF00069	0.515
MOD_CK2_1	124	130	PF00069	0.501
MOD_CK2_1	355	361	PF00069	0.612
MOD_CK2_1	483	489	PF00069	0.616
MOD_Cter_Amidation	275	278	PF01082	0.433
MOD_GlcNHglycan	164	168	PF01048	0.650
MOD_GlcNHglycan	227	230	PF01048	0.665
MOD_GlcNHglycan	232	235	PF01048	0.608
MOD_GlcNHglycan	239	242	PF01048	0.545
MOD_GlcNHglycan	274	277	PF01048	0.617
MOD_GlcNHglycan	327	330	PF01048	0.653
MOD_GlcNHglycan	344	347	PF01048	0.571
MOD_GlcNHglycan	375	378	PF01048	0.724
MOD_GlcNHglycan	412	416	PF01048	0.585
MOD_GlcNHglycan	479	482	PF01048	0.636
MOD_GSK3_1	101	108	PF00069	0.511
MOD_GSK3_1	120	127	PF00069	0.442
MOD_GSK3_1	14	21	PF00069	0.418
MOD_GSK3_1	155	162	PF00069	0.627
MOD_GSK3_1	191	198	PF00069	0.681
MOD_GSK3_1	209	216	PF00069	0.690
MOD_GSK3_1	232	239	PF00069	0.761
MOD_GSK3_1	24	31	PF00069	0.375
MOD_GSK3_1	243	250	PF00069	0.530
MOD_GSK3_1	262	269	PF00069	0.410
MOD_GSK3_1	283	290	PF00069	0.446
MOD_GSK3_1	293	300	PF00069	0.526
MOD_GSK3_1	317	324	PF00069	0.584
MOD_GSK3_1	340	347	PF00069	0.667
MOD_GSK3_1	373	380	PF00069	0.695
MOD_GSK3_1	389	396	PF00069	0.487
MOD_GSK3_1	400	407	PF00069	0.461
MOD_GSK3_1	413	420	PF00069	0.460
MOD_GSK3_1	461	468	PF00069	0.489
MOD_GSK3_1	479	486	PF00069	0.614
MOD_N-GLC_1	254	259	PF02516	0.532
MOD_N-GLC_1	297	302	PF02516	0.594
MOD_N-GLC_1	81	86	PF02516	0.516
MOD_NEK2_1	115	120	PF00069	0.545
MOD_NEK2_1	124	129	PF00069	0.473
MOD_NEK2_1	163	168	PF00069	0.673
MOD_NEK2_1	232	237	PF00069	0.632
MOD_NEK2_1	259	264	PF00069	0.518
MOD_NEK2_1	287	292	PF00069	0.593
MOD_NEK2_1	310	315	PF00069	0.458
MOD_NEK2_1	33	38	PF00069	0.373
MOD_NEK2_1	411	416	PF00069	0.580
MOD_PIKK_1	321	327	PF00454	0.487
MOD_PIKK_1	393	399	PF00454	0.523
MOD_PK_1	400	406	PF00069	0.584
MOD_PKA_1	277	283	PF00069	0.430
MOD_PKA_1	293	299	PF00069	0.560
MOD_PKA_2	153	159	PF00069	0.613
MOD_PKA_2	230	236	PF00069	0.619
MOD_PKA_2	247	253	PF00069	0.596
MOD_PKA_2	266	272	PF00069	0.470
MOD_PKA_2	277	283	PF00069	0.410
MOD_PKA_2	292	298	PF00069	0.472
MOD_PKA_2	316	322	PF00069	0.520
MOD_PKB_1	315	323	PF00069	0.529
MOD_PKB_1	463	471	PF00069	0.437
MOD_Plk_1	210	216	PF00069	0.622
MOD_Plk_1	393	399	PF00069	0.523
MOD_Plk_2-3	159	165	PF00069	0.592
MOD_Plk_2-3	389	395	PF00069	0.533
MOD_Plk_4	14	20	PF00069	0.423
MOD_Plk_4	266	272	PF00069	0.564
MOD_Plk_4	277	283	PF00069	0.439
MOD_Plk_4	318	324	PF00069	0.410
MOD_Plk_4	33	39	PF00069	0.358
MOD_Plk_4	355	361	PF00069	0.624
MOD_ProDKin_1	192	198	PF00069	0.657
MOD_ProDKin_1	241	247	PF00069	0.722
MOD_ProDKin_1	347	353	PF00069	0.698
MOD_ProDKin_1	419	425	PF00069	0.549
MOD_ProDKin_1	479	485	PF00069	0.606
MOD_ProDKin_1	68	74	PF00069	0.518
MOD_SUMO_rev_2	250	260	PF00179	0.533
MOD_SUMO_rev_2	89	96	PF00179	0.511
TRG_DiLeu_BaLyEn_6	462	467	PF01217	0.487
TRG_DiLeu_BaLyEn_6	72	77	PF01217	0.498
TRG_ENDOCYTIC_2	189	192	PF00928	0.655
TRG_ENDOCYTIC_2	38	41	PF00928	0.380
TRG_ENDOCYTIC_2	48	51	PF00928	0.345
TRG_ER_diArg_1	134	136	PF00400	0.497
TRG_ER_diArg_1	314	317	PF00400	0.500
TRG_ER_diArg_1	452	455	PF00400	0.448
TRG_ER_diArg_1	463	466	PF00400	0.406
TRG_Pf-PMV_PEXEL_1	207	211	PF00026	0.637
TRG_Pf-PMV_PEXEL_1	465	469	PF00026	0.517

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3Q8II56	Leishmania donovani	98%	100%
A4HMH4	Leishmania braziliensis	66%	97%
E9AEX5	Leishmania major	88%	99%
E9B631	Leishmania mexicana (strain MHOM/GT/2001/U1103)	83%	99%