NLI interacting factor-like phosphatase family protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

NLI interacting factor-like phosphatase/Zinc finger C-x8-C-x5-C-x3-H type (and similar) - putative

Species:

Leishmania infantum

UniProt:

A4IB52_LEIIN

TriTrypDb:

LINF_350020100

Length:

584

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4IB52

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4IB52

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	7
GO:0043167	ion binding	2	7
GO:0043169	cation binding	3	7
GO:0046872	metal ion binding	4	7
GO:0003676	nucleic acid binding	3	1
GO:0003723	RNA binding	4	1
GO:0003824	catalytic activity	1	1
GO:0004721	phosphoprotein phosphatase activity	3	1
GO:0016787	hydrolase activity	2	1
GO:0016788	hydrolase activity, acting on ester bonds	3	1
GO:0016791	phosphatase activity	5	1
GO:0042578	phosphoric ester hydrolase activity	4	1
GO:0097159	organic cyclic compound binding	2	1
GO:0140096	catalytic activity, acting on a protein	2	1
GO:1901363	heterocyclic compound binding	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	520	524	PF00656	0.679
CLV_C14_Caspase3-7	566	570	PF00656	0.672
CLV_NRD_NRD_1	2	4	PF00675	0.558
CLV_NRD_NRD_1	220	222	PF00675	0.576
CLV_NRD_NRD_1	321	323	PF00675	0.601
CLV_NRD_NRD_1	346	348	PF00675	0.592
CLV_NRD_NRD_1	349	351	PF00675	0.594
CLV_NRD_NRD_1	385	387	PF00675	0.710
CLV_NRD_NRD_1	418	420	PF00675	0.705
CLV_NRD_NRD_1	528	530	PF00675	0.757
CLV_NRD_NRD_1	54	56	PF00675	0.434
CLV_NRD_NRD_1	550	552	PF00675	0.761
CLV_PCSK_KEX2_1	2	4	PF00082	0.558
CLV_PCSK_KEX2_1	220	222	PF00082	0.576
CLV_PCSK_KEX2_1	346	348	PF00082	0.608
CLV_PCSK_KEX2_1	384	386	PF00082	0.711
CLV_PCSK_KEX2_1	418	420	PF00082	0.700
CLV_PCSK_KEX2_1	528	530	PF00082	0.757
CLV_PCSK_KEX2_1	54	56	PF00082	0.455
CLV_PCSK_KEX2_1	550	552	PF00082	0.761
CLV_PCSK_PC7_1	380	386	PF00082	0.706
CLV_PCSK_SKI1_1	117	121	PF00082	0.412
CLV_PCSK_SKI1_1	203	207	PF00082	0.514
CLV_PCSK_SKI1_1	54	58	PF00082	0.442
CLV_PCSK_SKI1_1	86	90	PF00082	0.412
DEG_APCC_DBOX_1	54	62	PF00400	0.412
DEG_Nend_UBRbox_1	1	4	PF02207	0.521
DEG_SPOP_SBC_1	477	481	PF00917	0.665
DOC_MAPK_gen_1	332	342	PF00069	0.738
DOC_MAPK_gen_1	54	61	PF00069	0.433
DOC_MAPK_MEF2A_6	170	178	PF00069	0.412
DOC_MAPK_MEF2A_6	493	501	PF00069	0.688
DOC_MAPK_MEF2A_6	54	63	PF00069	0.412
DOC_PP4_FxxP_1	183	186	PF00568	0.387
DOC_SPAK_OSR1_1	5	9	PF12202	0.491
DOC_USP7_MATH_1	131	135	PF00917	0.481
DOC_USP7_MATH_1	255	259	PF00917	0.787
DOC_USP7_MATH_1	269	273	PF00917	0.554
DOC_USP7_MATH_1	375	379	PF00917	0.748
DOC_USP7_MATH_1	461	465	PF00917	0.718
DOC_USP7_MATH_1	477	481	PF00917	0.648
DOC_USP7_MATH_1	554	558	PF00917	0.758
DOC_USP7_MATH_1	79	83	PF00917	0.514
DOC_WW_Pin1_4	164	169	PF00397	0.353
LIG_14-3-3_CanoR_1	13	23	PF00244	0.433
LIG_14-3-3_CanoR_1	151	157	PF00244	0.412
LIG_14-3-3_CanoR_1	35	39	PF00244	0.550
LIG_14-3-3_CanoR_1	418	423	PF00244	0.757
LIG_14-3-3_CanoR_1	78	88	PF00244	0.397
LIG_APCC_ABBA_1	122	127	PF00400	0.412
LIG_BRCT_BRCA1_1	470	474	PF00533	0.685
LIG_Clathr_ClatBox_1	58	62	PF01394	0.412
LIG_deltaCOP1_diTrp_1	394	402	PF00928	0.700
LIG_EH1_1	156	164	PF00400	0.412
LIG_eIF4E_1	116	122	PF01652	0.412
LIG_FHA_1	159	165	PF00498	0.390
LIG_FHA_1	196	202	PF00498	0.405
LIG_FHA_1	48	54	PF00498	0.484
LIG_FHA_1	490	496	PF00498	0.695
LIG_FHA_1	569	575	PF00498	0.689
LIG_FHA_1	96	102	PF00498	0.499
LIG_FHA_2	25	31	PF00498	0.488
LIG_FHA_2	334	340	PF00498	0.636
LIG_GBD_Chelix_1	573	581	PF00786	0.603
LIG_GBD_Chelix_1	59	67	PF00786	0.412
LIG_IBAR_NPY_1	137	139	PF08397	0.412
LIG_Integrin_RGD_1	304	306	PF01839	0.404
LIG_LIR_Gen_1	155	164	PF02991	0.412
LIG_LIR_Gen_1	407	414	PF02991	0.688
LIG_LIR_Gen_1	82	92	PF02991	0.353
LIG_LIR_Gen_1	9	16	PF02991	0.564
LIG_LIR_Nem_3	110	116	PF02991	0.412
LIG_LIR_Nem_3	155	159	PF02991	0.448
LIG_LIR_Nem_3	82	87	PF02991	0.353
LIG_LIR_Nem_3	9	14	PF02991	0.550
LIG_MLH1_MIPbox_1	470	474	PF16413	0.685
LIG_MYND_1	485	489	PF01753	0.779
LIG_PCNA_yPIPBox_3	103	113	PF02747	0.385
LIG_SH2_GRB2like	410	413	PF00017	0.689
LIG_SH2_PTP2	11	14	PF00017	0.437
LIG_SH2_STAP1	410	414	PF00017	0.686
LIG_SH2_STAP1	44	48	PF00017	0.507
LIG_SH2_STAT5	11	14	PF00017	0.419
LIG_SH3_2	371	376	PF14604	0.688
LIG_SH3_3	247	253	PF00018	0.699
LIG_SH3_3	261	267	PF00018	0.623
LIG_SH3_3	368	374	PF00018	0.735
LIG_SH3_3	43	49	PF00018	0.507
LIG_SH3_3	483	489	PF00018	0.772
LIG_SH3_3	491	497	PF00018	0.646
LIG_SH3_4	373	380	PF00018	0.704
LIG_SUMO_SIM_anti_2	204	210	PF11976	0.591
LIG_SUMO_SIM_par_1	160	167	PF11976	0.390
LIG_SUMO_SIM_par_1	204	210	PF11976	0.488
LIG_SUMO_SIM_par_1	497	503	PF11976	0.702
LIG_SUMO_SIM_par_1	57	62	PF11976	0.412
LIG_SUMO_SIM_par_1	92	99	PF11976	0.412
LIG_TRAF2_1	336	339	PF00917	0.625
LIG_TRFH_1	75	79	PF08558	0.412
LIG_UBA3_1	195	203	PF00899	0.514
LIG_WW_3	373	377	PF00397	0.694
MOD_CDC14_SPxK_1	167	170	PF00782	0.412
MOD_CDK_SPxK_1	164	170	PF00069	0.412
MOD_CK1_1	155	161	PF00069	0.514
MOD_CK1_1	248	254	PF00069	0.713
MOD_CK1_1	321	327	PF00069	0.619
MOD_CK1_1	421	427	PF00069	0.633
MOD_CK1_1	448	454	PF00069	0.803
MOD_CK1_1	464	470	PF00069	0.756
MOD_CK2_1	333	339	PF00069	0.643
MOD_GlcNHglycan	133	136	PF01048	0.440
MOD_GlcNHglycan	209	212	PF01048	0.463
MOD_GlcNHglycan	250	253	PF01048	0.626
MOD_GlcNHglycan	257	260	PF01048	0.661
MOD_GlcNHglycan	323	326	PF01048	0.733
MOD_GlcNHglycan	420	423	PF01048	0.711
MOD_GlcNHglycan	448	451	PF01048	0.779
MOD_GlcNHglycan	480	483	PF01048	0.709
MOD_GlcNHglycan	50	53	PF01048	0.465
MOD_GlcNHglycan	519	522	PF01048	0.745
MOD_GlcNHglycan	98	101	PF01048	0.373
MOD_GSK3_1	251	258	PF00069	0.748
MOD_GSK3_1	269	276	PF00069	0.519
MOD_GSK3_1	375	382	PF00069	0.793
MOD_GSK3_1	396	403	PF00069	0.709
MOD_GSK3_1	421	428	PF00069	0.646
MOD_GSK3_1	44	51	PF00069	0.500
MOD_GSK3_1	460	467	PF00069	0.768
MOD_GSK3_1	473	480	PF00069	0.604
MOD_N-GLC_1	523	528	PF02516	0.699
MOD_N-GLC_1	79	84	PF02516	0.454
MOD_NEK2_1	101	106	PF00069	0.412
MOD_NEK2_1	120	125	PF00069	0.501
MOD_NEK2_1	207	212	PF00069	0.464
MOD_NEK2_1	288	293	PF00069	0.391
MOD_NEK2_1	437	442	PF00069	0.740
MOD_NEK2_1	473	478	PF00069	0.693
MOD_NEK2_1	517	522	PF00069	0.632
MOD_NEK2_1	87	92	PF00069	0.412
MOD_NEK2_2	269	274	PF00069	0.568
MOD_PIKK_1	357	363	PF00454	0.619
MOD_PIKK_1	461	467	PF00454	0.797
MOD_PIKK_1	503	509	PF00454	0.639
MOD_PIKK_1	554	560	PF00454	0.754
MOD_PKA_1	418	424	PF00069	0.692
MOD_PKA_2	102	108	PF00069	0.412
MOD_PKA_2	14	20	PF00069	0.502
MOD_PKA_2	245	251	PF00069	0.671
MOD_PKA_2	321	327	PF00069	0.619
MOD_PKA_2	34	40	PF00069	0.551
MOD_PKA_2	375	381	PF00069	0.786
MOD_PKA_2	418	424	PF00069	0.692
MOD_PKA_2	515	521	PF00069	0.657
MOD_PKA_2	71	77	PF00069	0.340
MOD_Plk_1	44	50	PF00069	0.499
MOD_Plk_1	568	574	PF00069	0.750
MOD_Plk_2-3	34	40	PF00069	0.489
MOD_Plk_4	158	164	PF00069	0.507
MOD_Plk_4	269	275	PF00069	0.676
MOD_Plk_4	468	474	PF00069	0.787
MOD_Plk_4	71	77	PF00069	0.379
MOD_ProDKin_1	164	170	PF00069	0.353
TRG_DiLeu_BaLyEn_6	210	215	PF01217	0.481
TRG_ENDOCYTIC_2	11	14	PF00928	0.437
TRG_ENDOCYTIC_2	116	119	PF00928	0.412
TRG_ENDOCYTIC_2	410	413	PF00928	0.689
TRG_ER_diArg_1	1	3	PF00400	0.598
TRG_ER_diArg_1	12	15	PF00400	0.380
TRG_ER_diArg_1	220	222	PF00400	0.636
TRG_ER_diArg_1	353	356	PF00400	0.639
TRG_ER_diArg_1	384	386	PF00400	0.711
TRG_ER_diArg_1	53	55	PF00400	0.457
TRG_NES_CRM1_1	197	209	PF08389	0.412
TRG_Pf-PMV_PEXEL_1	220	224	PF00026	0.646

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P590	Leptomonas seymouri	50%	88%
A0A3Q8IM24	Leishmania donovani	100%	100%
A4HMH2	Leishmania braziliensis	78%	100%
E9AEX3	Leishmania major	94%	100%
E9B629	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	100%