LeishMANIAdb
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Membrane-associated protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
Membrane-associated protein
Gene product:
hypothetical protein - conserved
Species:
Leishmania infantum
UniProt:
A4IB51_LEIIN
TriTrypDb:
LINF_350020000 *
Length:
384

Annotations

LeishMANIAdb annotations

Secreted protein with ER retention signal

Annotations by Jardim et al.

Uncharacterized Protein, Uncharacterized

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. yes yes: 5
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 3, no: 4
NetGPI no yes: 0, no: 7
Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4IB51
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4IB51

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 50 54 PF00656 0.771
CLV_NRD_NRD_1 185 187 PF00675 0.644
CLV_NRD_NRD_1 20 22 PF00675 0.572
CLV_NRD_NRD_1 321 323 PF00675 0.640
CLV_NRD_NRD_1 68 70 PF00675 0.526
CLV_PCSK_KEX2_1 185 187 PF00082 0.643
CLV_PCSK_KEX2_1 20 22 PF00082 0.572
CLV_PCSK_KEX2_1 68 70 PF00082 0.526
CLV_PCSK_SKI1_1 138 142 PF00082 0.531
DEG_Nend_UBRbox_1 1 4 PF02207 0.525
DOC_CKS1_1 143 148 PF01111 0.588
DOC_MAPK_gen_1 20 28 PF00069 0.584
DOC_MAPK_MEF2A_6 20 28 PF00069 0.574
DOC_PP4_FxxP_1 143 146 PF00568 0.557
DOC_PP4_FxxP_1 181 184 PF00568 0.420
DOC_PP4_FxxP_1 266 269 PF00568 0.538
DOC_PP4_FxxP_1 311 314 PF00568 0.463
DOC_PP4_FxxP_1 361 364 PF00568 0.544
DOC_WW_Pin1_4 142 147 PF00397 0.564
DOC_WW_Pin1_4 210 215 PF00397 0.644
LIG_14-3-3_CanoR_1 124 132 PF00244 0.530
LIG_14-3-3_CanoR_1 186 196 PF00244 0.614
LIG_14-3-3_CanoR_1 20 25 PF00244 0.434
LIG_14-3-3_CanoR_1 342 352 PF00244 0.682
LIG_14-3-3_CanoR_1 4 10 PF00244 0.738
LIG_Actin_WH2_2 306 324 PF00022 0.559
LIG_Clathr_ClatBox_1 293 297 PF01394 0.511
LIG_eIF4E_1 210 216 PF01652 0.589
LIG_FHA_1 126 132 PF00498 0.537
LIG_FHA_1 173 179 PF00498 0.552
LIG_FHA_1 211 217 PF00498 0.631
LIG_FHA_1 316 322 PF00498 0.620
LIG_FHA_1 347 353 PF00498 0.729
LIG_FHA_1 355 361 PF00498 0.537
LIG_FHA_1 85 91 PF00498 0.450
LIG_FHA_2 276 282 PF00498 0.733
LIG_GBD_Chelix_1 24 32 PF00786 0.475
LIG_LIR_Apic_2 255 261 PF02991 0.600
LIG_LIR_Apic_2 309 314 PF02991 0.465
LIG_LIR_Apic_2 359 364 PF02991 0.561
LIG_LIR_Nem_3 217 223 PF02991 0.475
LIG_LIR_Nem_3 295 301 PF02991 0.420
LIG_PCNA_PIPBox_1 102 111 PF02747 0.601
LIG_Pex14_1 287 291 PF04695 0.666
LIG_Pex14_2 361 365 PF04695 0.585
LIG_SH2_CRK 291 295 PF00017 0.510
LIG_SH2_NCK_1 258 262 PF00017 0.583
LIG_SH2_SRC 258 261 PF00017 0.593
LIG_SH2_STAP1 7 11 PF00017 0.514
LIG_SH2_STAP1 86 90 PF00017 0.314
LIG_SH2_STAT3 123 126 PF00017 0.608
LIG_SH2_STAT3 67 70 PF00017 0.534
LIG_SH2_STAT5 109 112 PF00017 0.486
LIG_SH2_STAT5 11 14 PF00017 0.495
LIG_SH2_STAT5 173 176 PF00017 0.586
LIG_SH2_STAT5 187 190 PF00017 0.502
LIG_SH2_STAT5 221 224 PF00017 0.518
LIG_SH2_STAT5 7 10 PF00017 0.510
LIG_SH2_STAT5 86 89 PF00017 0.314
LIG_SH3_3 38 44 PF00018 0.521
LIG_SH3_3 70 76 PF00018 0.493
LIG_SUMO_SIM_anti_2 23 29 PF11976 0.472
LIG_SUMO_SIM_par_1 292 297 PF11976 0.427
LIG_SUMO_SIM_par_1 349 357 PF11976 0.670
LIG_SUMO_SIM_par_1 84 93 PF11976 0.332
LIG_TRAF2_1 278 281 PF00917 0.691
LIG_TRAF2_1 331 334 PF00917 0.688
MOD_CK1_1 191 197 PF00069 0.554
MOD_CK1_1 243 249 PF00069 0.620
MOD_CK1_1 251 257 PF00069 0.473
MOD_CK1_1 326 332 PF00069 0.764
MOD_CK1_1 346 352 PF00069 0.729
MOD_CK1_1 54 60 PF00069 0.571
MOD_CK2_1 187 193 PF00069 0.624
MOD_CK2_1 202 208 PF00069 0.500
MOD_CK2_1 243 249 PF00069 0.620
MOD_CK2_1 275 281 PF00069 0.636
MOD_CK2_1 57 63 PF00069 0.569
MOD_GlcNHglycan 146 149 PF01048 0.689
MOD_GlcNHglycan 204 207 PF01048 0.493
MOD_GlcNHglycan 241 245 PF01048 0.592
MOD_GlcNHglycan 328 331 PF01048 0.691
MOD_GlcNHglycan 333 338 PF01048 0.705
MOD_GlcNHglycan 345 348 PF01048 0.744
MOD_GSK3_1 187 194 PF00069 0.589
MOD_GSK3_1 275 282 PF00069 0.671
MOD_GSK3_1 322 329 PF00069 0.690
MOD_GSK3_1 342 349 PF00069 0.771
MOD_GSK3_1 5 12 PF00069 0.509
MOD_GSK3_1 51 58 PF00069 0.689
MOD_N-GLC_1 223 228 PF02516 0.526
MOD_N-GLC_1 369 374 PF02516 0.682
MOD_N-GLC_1 5 10 PF02516 0.505
MOD_N-GLC_2 14 16 PF02516 0.512
MOD_NEK2_1 172 177 PF00069 0.517
MOD_NEK2_1 240 245 PF00069 0.587
MOD_NEK2_1 248 253 PF00069 0.533
MOD_NEK2_1 274 279 PF00069 0.598
MOD_NEK2_1 82 87 PF00069 0.330
MOD_PIKK_1 100 106 PF00454 0.404
MOD_PK_1 20 26 PF00069 0.485
MOD_PKA_1 185 191 PF00069 0.531
MOD_PKA_1 20 26 PF00069 0.485
MOD_PKA_1 322 328 PF00069 0.686
MOD_PKA_2 126 132 PF00069 0.551
MOD_PKA_2 185 191 PF00069 0.634
MOD_PKA_2 20 26 PF00069 0.647
MOD_PKA_2 202 208 PF00069 0.327
MOD_PKA_2 54 60 PF00069 0.571
MOD_PKB_1 340 348 PF00069 0.684
MOD_Plk_1 216 222 PF00069 0.514
MOD_Plk_1 254 260 PF00069 0.599
MOD_Plk_1 333 339 PF00069 0.643
MOD_Plk_1 369 375 PF00069 0.544
MOD_Plk_1 5 11 PF00069 0.509
MOD_Plk_2-3 292 298 PF00069 0.502
MOD_Plk_2-3 354 360 PF00069 0.589
MOD_Plk_4 126 132 PF00069 0.453
MOD_Plk_4 191 197 PF00069 0.526
MOD_Plk_4 20 26 PF00069 0.426
MOD_Plk_4 216 222 PF00069 0.478
MOD_Plk_4 36 42 PF00069 0.469
MOD_Plk_4 5 11 PF00069 0.680
MOD_ProDKin_1 142 148 PF00069 0.574
MOD_ProDKin_1 210 216 PF00069 0.635
TRG_DiLeu_BaEn_4 333 339 PF01217 0.629
TRG_DiLeu_BaLyEn_6 348 353 PF01217 0.700
TRG_ENDOCYTIC_2 291 294 PF00928 0.608
TRG_ENDOCYTIC_2 7 10 PF00928 0.510
TRG_ER_diArg_1 1 4 PF00400 0.741
TRG_ER_diArg_1 165 168 PF00400 0.622
TRG_ER_diArg_1 184 186 PF00400 0.311
TRG_ER_diArg_1 67 69 PF00400 0.544

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1I5Y1 Leptomonas seymouri 53% 100%
A0A1X0P5P8 Trypanosomatidae 30% 100%
A0A3Q8IHV2 Leishmania donovani 100% 100%
A4HMH1 Leishmania braziliensis 74% 100%
C9ZZF6 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 31% 100%
E9B628 Leishmania mexicana (strain MHOM/GT/2001/U1103) 89% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS