Methyltransf_11 domain-containing protein

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Methyltransferase domain/ubiE/COQ5 methyltransferase family - putative

Species:

Leishmania infantum

UniProt:

A4IB48_LEIIN

TriTrypDb:

LINF_350020700

Length:

295

Annotations

LeishMANIAdb annotations

Homologous to yeast mitochondrial OMS1 methyltransferase, but many Kinetoplastid homologs lack the transit signal.. One sub-group of these proteins have an N-terminal membrane anchor, while others might possess an internal Tm segment potentially targeted to mitochondria.. Localization: Mitochondrial (by homology) / Others (by feature)

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 12
NetGPI	no	yes: 0, no: 12

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	12
GO:0110165	cellular anatomical entity	1	12
GO:0005737	cytoplasm	2	1

Expansion

Sequence features

A4IB48

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4IB48

Function

Biological processes
Term	Name	Level	Count
GO:0008152	metabolic process	1	2
GO:0032259	methylation	2	2

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	3
GO:0008168	methyltransferase activity	4	3
GO:0016740	transferase activity	2	3
GO:0016741	transferase activity, transferring one-carbon groups	3	3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	164	168	PF00656	0.331
CLV_PCSK_FUR_1	56	60	PF00082	0.389
CLV_PCSK_KEX2_1	159	161	PF00082	0.453
CLV_PCSK_KEX2_1	58	60	PF00082	0.383
CLV_PCSK_PC1ET2_1	159	161	PF00082	0.539
CLV_PCSK_PC1ET2_1	58	60	PF00082	0.383
CLV_PCSK_SKI1_1	198	202	PF00082	0.453
CLV_PCSK_SKI1_1	35	39	PF00082	0.393
CLV_PCSK_SKI1_1	59	63	PF00082	0.383
DEG_Nend_UBRbox_3	1	3	PF02207	0.497
DOC_CYCLIN_yCln2_LP_2	186	192	PF00134	0.237
DOC_MAPK_gen_1	198	208	PF00069	0.253
DOC_MAPK_gen_1	58	67	PF00069	0.560
DOC_MAPK_MEF2A_6	201	209	PF00069	0.253
DOC_PP1_RVXF_1	3	10	PF00149	0.485
DOC_USP7_UBL2_3	155	159	PF12436	0.339
DOC_USP7_UBL2_3	279	283	PF12436	0.464
DOC_USP7_UBL2_3	289	293	PF12436	0.428
DOC_USP7_UBL2_3	58	62	PF12436	0.578
DOC_WW_Pin1_4	211	216	PF00397	0.253
DOC_WW_Pin1_4	238	243	PF00397	0.277
LIG_14-3-3_CanoR_1	147	156	PF00244	0.253
LIG_14-3-3_CanoR_1	160	169	PF00244	0.253
LIG_14-3-3_CterR_2	291	295	PF00244	0.384
LIG_AP2alpha_1	222	226	PF02296	0.277
LIG_FHA_1	263	269	PF00498	0.274
LIG_FHA_1	28	34	PF00498	0.553
LIG_LIR_Gen_1	171	181	PF02991	0.253
LIG_LIR_Nem_3	106	110	PF02991	0.264
LIG_LIR_Nem_3	151	156	PF02991	0.253
LIG_LIR_Nem_3	171	177	PF02991	0.122
LIG_LIR_Nem_3	214	219	PF02991	0.255
LIG_LIR_Nem_3	264	269	PF02991	0.272
LIG_LIR_Nem_3	50	54	PF02991	0.563
LIG_LIR_Nem_3	83	87	PF02991	0.460
LIG_LYPXL_SIV_4	215	223	PF13949	0.264
LIG_LYPXL_yS_3	216	219	PF13949	0.277
LIG_LYPXL_yS_3	271	274	PF13949	0.313
LIG_NRP_CendR_1	293	295	PF00754	0.595
LIG_PCNA_yPIPBox_3	238	247	PF02747	0.252
LIG_Pex14_1	221	225	PF04695	0.255
LIG_Pex14_1	41	45	PF04695	0.542
LIG_Pex14_2	222	226	PF04695	0.253
LIG_Pex14_2	84	88	PF04695	0.440
LIG_PTB_Apo_2	256	263	PF02174	0.310
LIG_PTB_Phospho_1	256	262	PF10480	0.313
LIG_REV1ctd_RIR_1	82	90	PF16727	0.457
LIG_SH2_CRK	107	111	PF00017	0.253
LIG_SH2_CRK	146	150	PF00017	0.253
LIG_SH2_STAT3	225	228	PF00017	0.294
LIG_SH2_STAT3	45	48	PF00017	0.535
LIG_SH2_STAT5	225	228	PF00017	0.270
LIG_SH2_STAT5	246	249	PF00017	0.264
LIG_SH2_STAT5	267	270	PF00017	0.266
LIG_SH2_STAT5	51	54	PF00017	0.553
LIG_SH3_3	196	202	PF00018	0.262
LIG_SH3_3	212	218	PF00018	0.221
LIG_SH3_3	266	272	PF00018	0.273
LIG_SH3_3	86	92	PF00018	0.328
LIG_SUMO_SIM_par_1	203	210	PF11976	0.254
LIG_TYR_ITIM	269	274	PF00017	0.298
LIG_TYR_ITSM	262	269	PF00017	0.281
LIG_WRC_WIRS_1	81	86	PF05994	0.330
MOD_CDC14_SPxK_1	241	244	PF00782	0.277
MOD_CDK_SPxK_1	238	244	PF00069	0.277
MOD_CK1_1	10	16	PF00069	0.637
MOD_CK2_1	247	253	PF00069	0.264
MOD_GlcNHglycan	202	205	PF01048	0.464
MOD_GSK3_1	7	14	PF00069	0.660
MOD_NEK2_1	103	108	PF00069	0.264
MOD_NEK2_1	133	138	PF00069	0.264
MOD_NEK2_1	247	252	PF00069	0.264
MOD_NEK2_2	80	85	PF00069	0.391
MOD_PKB_1	160	168	PF00069	0.339
MOD_Plk_4	262	268	PF00069	0.283
MOD_Plk_4	80	86	PF00069	0.318
MOD_ProDKin_1	211	217	PF00069	0.253
MOD_ProDKin_1	238	244	PF00069	0.277
MOD_SUMO_rev_2	249	257	PF00179	0.264
TRG_ENDOCYTIC_2	107	110	PF00928	0.253
TRG_ENDOCYTIC_2	216	219	PF00928	0.253
TRG_ENDOCYTIC_2	266	269	PF00928	0.267
TRG_ENDOCYTIC_2	271	274	PF00928	0.309
TRG_ENDOCYTIC_2	51	54	PF00928	0.564
TRG_NLS_MonoExtC_3	158	164	PF00514	0.339
TRG_Pf-PMV_PEXEL_1	59	63	PF00026	0.383
TRG_Pf-PMV_PEXEL_1	93	97	PF00026	0.465

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I341	Leptomonas seymouri	90%	73%
A0A0S4J626	Bodo saltans	74%	75%
A0A1X0P6L5	Trypanosomatidae	81%	75%
A0A3Q8IIX0	Leishmania donovani	99%	84%
A0A422NQ76	Trypanosoma rangeli	78%	78%
A4HMH8	Leishmania braziliensis	93%	100%
A4IB58	Leishmania infantum	99%	84%
A9WRT1	Renibacterium salmoninarum (strain ATCC 33209 / DSM 20767 / JCM 11484 / NBRC 15589 / NCIMB 2235)	28%	100%
C9ZZG6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	78%	76%
E9AEX9	Leishmania major	97%	100%
E9B635	Leishmania mexicana (strain MHOM/GT/2001/U1103)	96%	100%
Q5YPB0	Nocardia farcinica (strain IFM 10152)	28%	100%
V5DKE6	Trypanosoma cruzi	79%	78%