LeishMANIAdb
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Putative peroxisome targeting signal 1 receptor

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Putative peroxisome targeting signal 1 receptor
Gene product:
peroxisome targeting signal 1 receptor - putative
Species:
Leishmania infantum
UniProt:
A4IB35_LEIIN
TriTrypDb:
LINF_350019100
Length:
625

Annotations

Annotations by Jardim et al.

Glycosome membrane, Peroxin 5 peroxisome targeting signal 1 receptor

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 9
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 11
NetGPI no yes: 0, no: 11
Cellular components
Term Name Level Count
GO:0005737 cytoplasm 2 11
GO:0016020 membrane 2 12
GO:0110165 cellular anatomical entity 1 12
GO:0005778 peroxisomal membrane 6 1
GO:0005829 cytosol 2 1
GO:0031090 organelle membrane 3 1
GO:0031903 microbody membrane 5 1
GO:0042579 microbody 5 1
GO:0043226 organelle 2 1
GO:0043227 membrane-bounded organelle 3 1
GO:0043229 intracellular organelle 3 1
GO:0043231 intracellular membrane-bounded organelle 4 1
GO:0098588 bounding membrane of organelle 4 1

Expansion

Sequence features

A4IB35
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4IB35

Function

Biological processes
Term Name Level Count
GO:0008104 protein localization 4 2
GO:0009987 cellular process 1 2
GO:0016560 protein import into peroxisome matrix, docking 5 1
GO:0033036 macromolecule localization 2 2
GO:0051179 localization 1 2
GO:0051641 cellular localization 2 2
GO:0070727 cellular macromolecule localization 3 2
GO:0006810 transport 3 1
GO:0015031 protein transport 4 1
GO:0045184 establishment of protein localization 3 1
GO:0051234 establishment of localization 2 1
GO:0071702 organic substance transport 4 1
GO:0071705 nitrogen compound transport 4 1
Molecular functions
Term Name Level Count
GO:0000268 peroxisome targeting sequence binding 5 1
GO:0005048 signal sequence binding 4 1
GO:0005052 peroxisome matrix targeting signal-1 binding 6 1
GO:0005488 binding 1 1
GO:0033218 amide binding 2 1
GO:0042277 peptide binding 3 1

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 31 35 PF00656 0.617
CLV_NRD_NRD_1 384 386 PF00675 0.443
CLV_NRD_NRD_1 494 496 PF00675 0.326
CLV_PCSK_SKI1_1 15 19 PF00082 0.506
CLV_PCSK_SKI1_1 215 219 PF00082 0.426
CLV_PCSK_SKI1_1 90 94 PF00082 0.493
DEG_APCC_DBOX_1 591 599 PF00400 0.304
DEG_Nend_UBRbox_2 1 3 PF02207 0.487
DOC_CDC14_PxL_1 138 146 PF14671 0.547
DOC_PP2B_LxvP_1 252 255 PF13499 0.457
DOC_PP4_FxxP_1 186 189 PF00568 0.614
DOC_PP4_FxxP_1 259 262 PF00568 0.501
DOC_PP4_FxxP_1 447 450 PF00568 0.387
DOC_USP7_MATH_1 116 120 PF00917 0.554
DOC_USP7_MATH_1 162 166 PF00917 0.628
DOC_USP7_MATH_1 411 415 PF00917 0.328
DOC_USP7_MATH_1 429 433 PF00917 0.381
DOC_USP7_MATH_1 448 452 PF00917 0.403
DOC_USP7_MATH_1 468 472 PF00917 0.211
DOC_USP7_MATH_1 565 569 PF00917 0.466
DOC_USP7_MATH_1 86 90 PF00917 0.549
DOC_USP7_UBL2_3 506 510 PF12436 0.295
DOC_WW_Pin1_4 258 263 PF00397 0.496
DOC_WW_Pin1_4 267 272 PF00397 0.586
LIG_14-3-3_CanoR_1 592 596 PF00244 0.328
LIG_APCC_ABBA_1 498 503 PF00400 0.235
LIG_BRCT_BRCA1_1 470 474 PF00533 0.444
LIG_FHA_1 592 598 PF00498 0.395
LIG_FHA_2 193 199 PF00498 0.459
LIG_FHA_2 365 371 PF00498 0.306
LIG_FHA_2 456 462 PF00498 0.502
LIG_FHA_2 605 611 PF00498 0.411
LIG_FXI_DFP_1 323 327 PF00024 0.378
LIG_IBAR_NPY_1 319 321 PF08397 0.321
LIG_LIR_Apic_2 185 189 PF02991 0.614
LIG_LIR_Apic_2 256 262 PF02991 0.489
LIG_LIR_Apic_2 444 450 PF02991 0.460
LIG_LIR_Gen_1 177 188 PF02991 0.598
LIG_LIR_Gen_1 296 304 PF02991 0.462
LIG_LIR_Gen_1 358 369 PF02991 0.464
LIG_LIR_Gen_1 424 433 PF02991 0.505
LIG_LIR_Gen_1 471 480 PF02991 0.487
LIG_LIR_Nem_3 136 141 PF02991 0.606
LIG_LIR_Nem_3 177 183 PF02991 0.572
LIG_LIR_Nem_3 202 208 PF02991 0.402
LIG_LIR_Nem_3 358 364 PF02991 0.326
LIG_LIR_Nem_3 424 428 PF02991 0.477
LIG_LIR_Nem_3 471 477 PF02991 0.491
LIG_Pex14_1 176 180 PF04695 0.512
LIG_Pex14_1 293 297 PF04695 0.461
LIG_Pex14_1 53 57 PF04695 0.423
LIG_Pex14_2 615 619 PF04695 0.311
LIG_PTB_Apo_2 532 539 PF02174 0.236
LIG_PTB_Phospho_1 532 538 PF10480 0.236
LIG_SH2_CRK 138 142 PF00017 0.607
LIG_SH2_CRK 180 184 PF00017 0.648
LIG_SH2_GRB2like 549 552 PF00017 0.309
LIG_SH2_NCK_1 180 184 PF00017 0.537
LIG_SH2_NCK_1 555 559 PF00017 0.386
LIG_SH2_STAP1 425 429 PF00017 0.485
LIG_SH2_STAP1 460 464 PF00017 0.390
LIG_SH2_STAT3 608 611 PF00017 0.379
LIG_SH2_STAT5 242 245 PF00017 0.449
LIG_SH2_STAT5 279 282 PF00017 0.703
LIG_SH2_STAT5 538 541 PF00017 0.258
LIG_SH3_3 224 230 PF00018 0.440
LIG_SH3_3 231 237 PF00018 0.495
LIG_SH3_3 311 317 PF00018 0.375
LIG_SH3_3 417 423 PF00018 0.436
LIG_SH3_3 428 434 PF00018 0.458
LIG_SH3_3 499 505 PF00018 0.381
LIG_SUMO_SIM_anti_2 374 380 PF11976 0.330
LIG_TRAF2_1 195 198 PF00917 0.459
LIG_TYR_ITSM 176 183 PF00017 0.647
LIG_UBA3_1 378 386 PF00899 0.431
LIG_WRC_WIRS_1 183 188 PF05994 0.617
MOD_CK1_1 550 556 PF00069 0.429
MOD_CK2_1 192 198 PF00069 0.467
MOD_CK2_1 352 358 PF00069 0.401
MOD_CK2_1 364 370 PF00069 0.256
MOD_CK2_1 455 461 PF00069 0.444
MOD_CK2_1 604 610 PF00069 0.481
MOD_GlcNHglycan 144 147 PF01048 0.639
MOD_GlcNHglycan 164 167 PF01048 0.611
MOD_GlcNHglycan 186 189 PF01048 0.508
MOD_GlcNHglycan 26 29 PF01048 0.669
MOD_GlcNHglycan 265 268 PF01048 0.608
MOD_GlcNHglycan 575 578 PF01048 0.496
MOD_GSK3_1 11 18 PF00069 0.629
MOD_GSK3_1 174 181 PF00069 0.617
MOD_GSK3_1 24 31 PF00069 0.731
MOD_GSK3_1 254 261 PF00069 0.466
MOD_GSK3_1 263 270 PF00069 0.577
MOD_GSK3_1 396 403 PF00069 0.447
MOD_GSK3_1 468 475 PF00069 0.381
MOD_GSK3_1 573 580 PF00069 0.419
MOD_N-GLC_1 142 147 PF02516 0.661
MOD_N-GLC_1 308 313 PF02516 0.387
MOD_N-GLC_1 550 555 PF02516 0.412
MOD_NEK2_1 364 369 PF00069 0.314
MOD_NEK2_1 398 403 PF00069 0.313
MOD_NEK2_1 511 516 PF00069 0.236
MOD_NEK2_1 591 596 PF00069 0.326
MOD_NEK2_1 76 81 PF00069 0.484
MOD_NEK2_2 411 416 PF00069 0.351
MOD_PIKK_1 116 122 PF00454 0.623
MOD_PIKK_1 133 139 PF00454 0.676
MOD_PIKK_1 169 175 PF00454 0.640
MOD_PIKK_1 178 184 PF00454 0.650
MOD_PIKK_1 364 370 PF00454 0.311
MOD_PIKK_1 468 474 PF00454 0.385
MOD_PIKK_1 550 556 PF00454 0.405
MOD_PIKK_1 565 571 PF00454 0.337
MOD_PIKK_1 76 82 PF00454 0.669
MOD_PKA_2 591 597 PF00069 0.327
MOD_Plk_1 142 148 PF00069 0.699
MOD_Plk_1 15 21 PF00069 0.516
MOD_Plk_1 178 184 PF00069 0.598
MOD_Plk_1 192 198 PF00069 0.411
MOD_Plk_1 550 556 PF00069 0.415
MOD_Plk_2-3 192 198 PF00069 0.545
MOD_Plk_2-3 455 461 PF00069 0.532
MOD_Plk_4 108 114 PF00069 0.642
MOD_Plk_4 15 21 PF00069 0.676
MOD_Plk_4 254 260 PF00069 0.568
MOD_Plk_4 441 447 PF00069 0.547
MOD_Plk_4 577 583 PF00069 0.434
MOD_ProDKin_1 258 264 PF00069 0.504
MOD_ProDKin_1 267 273 PF00069 0.580
MOD_SUMO_rev_2 187 196 PF00179 0.598
MOD_SUMO_rev_2 503 507 PF00179 0.284
TRG_DiLeu_BaEn_1 222 227 PF01217 0.512
TRG_DiLeu_BaEn_1 32 37 PF01217 0.495
TRG_DiLeu_BaEn_2 203 209 PF01217 0.454
TRG_ENDOCYTIC_2 138 141 PF00928 0.719
TRG_ENDOCYTIC_2 180 183 PF00928 0.559
TRG_ENDOCYTIC_2 206 209 PF00928 0.404
TRG_ENDOCYTIC_2 297 300 PF00928 0.479
TRG_ENDOCYTIC_2 425 428 PF00928 0.329
TRG_ENDOCYTIC_2 549 552 PF00928 0.309
TRG_NES_CRM1_1 610 622 PF08389 0.385
TRG_Pf-PMV_PEXEL_1 457 461 PF00026 0.476

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1PBT5 Leptomonas seymouri 82% 100%
A0A0S4KFV0 Bodo saltans 47% 99%
A0A1X0NH73 Trypanosomatidae 50% 96%
A0A3S7X906 Leishmania donovani 100% 100%
A0A422N9P3 Trypanosoma rangeli 58% 95%
A4HMG4 Leishmania braziliensis 86% 100%
C9ZNN6 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 48% 95%
E9AEW5 Leishmania major 95% 100%
E9B621 Leishmania mexicana (strain MHOM/GT/2001/U1103) 95% 100%
O09012 Mus musculus 32% 98%
O70525 Cavia porcellus 32% 98%
Q1RMV0 Bos taurus 33% 98%
Q2M2R8 Rattus norvegicus 31% 98%
Q920N5 Cricetulus griseus 30% 98%
Q9FMA3 Arabidopsis thaliana 34% 86%
V5B7T1 Trypanosoma cruzi 48% 94%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS