Uncharacterized protein

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

RNA binding protein - putative

Species:

Leishmania infantum

UniProt:

A4IB33_LEIIN

TriTrypDb:

LINF_350018900

Length:

232

Annotations

Annotations by Jardim et al.

Nucleic acid binding, Uncharacterized

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

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Cellular components
Term	Name	Level	Count
GO:0005730	nucleolus	5	1
GO:0043226	organelle	2	1
GO:0043228	non-membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043232	intracellular non-membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

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Expansion

Sequence features

A4IB33

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4IB33

Function

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Biological processes
Term	Name	Level	Count
GO:0000447	endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	10	1
GO:0000469	cleavage involved in rRNA processing	7	1
GO:0000472	endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	10	1
GO:0000478	endonucleolytic cleavage involved in rRNA processing	8	1
GO:0000479	endonucleolytic cleavage of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	9	1
GO:0000480	endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	10	1
GO:0000966	RNA 5'-end processing	7	1
GO:0000967	rRNA 5'-end processing	9	1
GO:0006139	nucleobase-containing compound metabolic process	3	1
GO:0006364	rRNA processing	8	1

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Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	8
GO:0003723	RNA binding	4	7
GO:0005488	binding	1	8
GO:0097159	organic cyclic compound binding	2	8
GO:1901363	heterocyclic compound binding	2	8

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Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	170	174	PF00656	0.701
CLV_C14_Caspase3-7	74	78	PF00656	0.573
CLV_NRD_NRD_1	124	126	PF00675	0.517
CLV_NRD_NRD_1	127	129	PF00675	0.503
CLV_NRD_NRD_1	135	137	PF00675	0.481
CLV_NRD_NRD_1	146	148	PF00675	0.455
CLV_NRD_NRD_1	155	157	PF00675	0.383
CLV_NRD_NRD_1	160	162	PF00675	0.478
CLV_NRD_NRD_1	229	231	PF00675	0.749
CLV_NRD_NRD_1	42	44	PF00675	0.503

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A1X0NJ36	Trypanosomatidae	52%	85%
A0A3R7N8I1	Trypanosoma rangeli	56%	100%
A0A3S7X912	Leishmania donovani	100%	100%
A3LVD5	Scheffersomyces stipitis (strain ATCC 58785 / CBS 6054 / NBRC 10063 / NRRL Y-11545)	25%	67%
A4HMG2	Leishmania braziliensis	84%	100%
E9AEW3	Leishmania major	95%	100%
E9B619	Leishmania mexicana (strain MHOM/GT/2001/U1103)	94%	100%
O74362	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	30%	69%
P53743	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	31%	73%
Q0UM32	Phaeosphaeria nodorum (strain SN15 / ATCC MYA-4574 / FGSC 10173)	29%	71%

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