LeishMANIAdb
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Putative mitochondrial processing peptidase, beta subunit

Quick info Annotations Function or PPIs Localization Abundance Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Putative mitochondrial processing peptidase, beta subunit
Gene product:
mitochondrial processing peptidase - beta subunit - putative
Species:
Leishmania infantum
UniProt:
A4IB31_LEIIN
TriTrypDb:
LINF_350018700
Length:
490

Annotations

Annotations by Jardim et al.

Electron Transport Chain (see tricarboxylic acid section for Complex II), mitochondrial processing peptidase, beta subunit

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. yes yes: 25
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 7
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. yes yes: 14
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 11
NetGPI no yes: 0, no: 11
Cellular components
Term Name Level Count
GO:0005737 cytoplasm 2 1
GO:0005739 mitochondrion 5 1
GO:0043226 organelle 2 1
GO:0043227 membrane-bounded organelle 3 1
GO:0043229 intracellular organelle 3 1
GO:0043231 intracellular membrane-bounded organelle 4 1
GO:0110165 cellular anatomical entity 1 1

Abundance

Amastigote (protein)
Source Evidence on protein Close homologs
Pescher et al. (upgregulation) no yes: 0
Promastigote and amastigote
Source Evidence on protein Close homologs
Lahav et al.
- mRNA
- Protein

Expansion

Sequence features

A4IB31
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4IB31

Function

Could not find GO biological_process term for this entry.
Molecular functions
Term Name Level Count
GO:0003824 catalytic activity 1 7
GO:0005488 binding 1 12
GO:0016491 oxidoreductase activity 2 6
GO:0043167 ion binding 2 12
GO:0043169 cation binding 3 12
GO:0046872 metal ion binding 4 12
GO:0004175 endopeptidase activity 4 1
GO:0004222 metalloendopeptidase activity 5 1
GO:0008233 peptidase activity 3 1
GO:0008237 metallopeptidase activity 4 1
GO:0016787 hydrolase activity 2 1
GO:0140096 catalytic activity, acting on a protein 2 1

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_NRD_NRD_1 432 434 PF00675 0.293
CLV_NRD_NRD_1 461 463 PF00675 0.314
CLV_PCSK_KEX2_1 432 434 PF00082 0.293
CLV_PCSK_SKI1_1 176 180 PF00082 0.276
CLV_PCSK_SKI1_1 198 202 PF00082 0.352
CLV_PCSK_SKI1_1 233 237 PF00082 0.304
CLV_PCSK_SKI1_1 248 252 PF00082 0.221
CLV_PCSK_SKI1_1 25 29 PF00082 0.466
CLV_PCSK_SKI1_1 316 320 PF00082 0.230
CLV_PCSK_SKI1_1 425 429 PF00082 0.297
CLV_PCSK_SKI1_1 54 58 PF00082 0.290
DEG_APCC_DBOX_1 24 32 PF00400 0.468
DEG_APCC_DBOX_1 432 440 PF00400 0.305
DEG_APCC_KENBOX_2 123 127 PF00400 0.376
DOC_CKS1_1 186 191 PF01111 0.310
DOC_MAPK_JIP1_4 165 171 PF00069 0.251
DOC_MAPK_MEF2A_6 54 62 PF00069 0.290
DOC_PIKK_1 167 174 PF02985 0.246
DOC_USP7_MATH_1 178 182 PF00917 0.230
DOC_USP7_MATH_1 234 238 PF00917 0.244
DOC_USP7_UBL2_3 402 406 PF12436 0.307
DOC_WW_Pin1_4 179 184 PF00397 0.276
DOC_WW_Pin1_4 185 190 PF00397 0.279
DOC_WW_Pin1_4 325 330 PF00397 0.242
LIG_14-3-3_CanoR_1 209 214 PF00244 0.324
LIG_14-3-3_CanoR_1 269 274 PF00244 0.230
LIG_14-3-3_CanoR_1 316 322 PF00244 0.230
LIG_14-3-3_CanoR_1 433 443 PF00244 0.400
LIG_APCC_ABBAyCdc20_2 152 158 PF00400 0.358
LIG_BIR_II_1 1 5 PF00653 0.512
LIG_BRCT_BRCA1_1 1 5 PF00533 0.493
LIG_BRCT_BRCA1_1 20 24 PF00533 0.417
LIG_Clathr_ClatBox_1 410 414 PF01394 0.351
LIG_deltaCOP1_diTrp_1 479 484 PF00928 0.307
LIG_EH_1 342 346 PF12763 0.246
LIG_FHA_1 270 276 PF00498 0.230
LIG_FHA_1 55 61 PF00498 0.247
LIG_FHA_1 74 80 PF00498 0.150
LIG_FHA_2 227 233 PF00498 0.230
LIG_FHA_2 379 385 PF00498 0.246
LIG_LIR_Gen_1 114 122 PF02991 0.269
LIG_LIR_Gen_1 2 12 PF02991 0.501
LIG_LIR_Gen_1 320 329 PF02991 0.230
LIG_LIR_Gen_1 384 393 PF02991 0.231
LIG_LIR_Gen_1 437 448 PF02991 0.328
LIG_LIR_Nem_3 116 122 PF02991 0.267
LIG_LIR_Nem_3 2 8 PF02991 0.494
LIG_LIR_Nem_3 21 27 PF02991 0.410
LIG_LIR_Nem_3 237 242 PF02991 0.248
LIG_LIR_Nem_3 320 324 PF02991 0.230
LIG_LIR_Nem_3 348 352 PF02991 0.404
LIG_LIR_Nem_3 384 388 PF02991 0.231
LIG_LIR_Nem_3 437 443 PF02991 0.312
LIG_LIR_Nem_3 467 471 PF02991 0.256
LIG_LIR_Nem_3 66 71 PF02991 0.381
LIG_PCNA_PIPBox_1 452 461 PF02747 0.296
LIG_PCNA_yPIPBox_3 304 318 PF02747 0.230
LIG_PCNA_yPIPBox_3 452 463 PF02747 0.299
LIG_Pex14_1 266 270 PF04695 0.246
LIG_Pex14_1 484 488 PF04695 0.314
LIG_PTB_Apo_2 264 271 PF02174 0.246
LIG_PTB_Phospho_1 264 270 PF10480 0.246
LIG_Rb_pABgroove_1 434 442 PF01858 0.457
LIG_SH2_CRK 119 123 PF00017 0.290
LIG_SH2_CRK 270 274 PF00017 0.246
LIG_SH2_CRK 466 470 PF00017 0.261
LIG_SH2_NCK_1 380 384 PF00017 0.246
LIG_SH2_NCK_1 440 444 PF00017 0.325
LIG_SH2_NCK_1 68 72 PF00017 0.376
LIG_SH2_SRC 68 71 PF00017 0.376
LIG_SH2_STAT5 117 120 PF00017 0.324
LIG_SH2_STAT5 238 241 PF00017 0.290
LIG_SH2_STAT5 258 261 PF00017 0.264
LIG_SH2_STAT5 358 361 PF00017 0.253
LIG_SH2_STAT5 380 383 PF00017 0.246
LIG_SH2_STAT5 458 461 PF00017 0.301
LIG_SH2_STAT5 468 471 PF00017 0.251
LIG_SH3_2 243 248 PF14604 0.251
LIG_SH3_3 183 189 PF00018 0.396
LIG_SH3_3 240 246 PF00018 0.318
LIG_SUMO_SIM_par_1 217 223 PF11976 0.247
LIG_TRAF2_1 46 49 PF00917 0.264
LIG_TRAF2_1 99 102 PF00917 0.358
LIG_TYR_ITIM 268 273 PF00017 0.246
LIG_WRC_WIRS_1 318 323 PF05994 0.230
MOD_CK1_1 327 333 PF00069 0.239
MOD_CK1_1 338 344 PF00069 0.216
MOD_CK1_1 4 10 PF00069 0.550
MOD_CK1_1 416 422 PF00069 0.295
MOD_CK2_1 226 232 PF00069 0.230
MOD_CK2_1 302 308 PF00069 0.230
MOD_CK2_1 378 384 PF00069 0.230
MOD_CK2_1 63 69 PF00069 0.246
MOD_Cter_Amidation 430 433 PF01082 0.315
MOD_Cter_Amidation 460 463 PF01082 0.376
MOD_GlcNHglycan 20 23 PF01048 0.544
MOD_GlcNHglycan 222 225 PF01048 0.276
MOD_GlcNHglycan 414 418 PF01048 0.340
MOD_GSK3_1 120 127 PF00069 0.376
MOD_GSK3_1 13 20 PF00069 0.502
MOD_GSK3_1 298 305 PF00069 0.376
MOD_GSK3_1 31 38 PF00069 0.342
MOD_GSK3_1 320 327 PF00069 0.234
MOD_GSK3_1 478 485 PF00069 0.300
MOD_GSK3_1 50 57 PF00069 0.328
MOD_GSK3_1 85 92 PF00069 0.298
MOD_N-GLC_1 34 39 PF02516 0.405
MOD_N-GLC_1 89 94 PF02516 0.264
MOD_NEK2_1 1 6 PF00069 0.549
MOD_NEK2_1 107 112 PF00069 0.408
MOD_NEK2_1 302 307 PF00069 0.230
MOD_NEK2_1 324 329 PF00069 0.246
MOD_NEK2_1 345 350 PF00069 0.395
MOD_NEK2_1 378 383 PF00069 0.230
MOD_NEK2_1 413 418 PF00069 0.340
MOD_NEK2_1 85 90 PF00069 0.302
MOD_PIKK_1 302 308 PF00454 0.237
MOD_PIKK_1 478 484 PF00454 0.317
MOD_PKA_1 198 204 PF00069 0.352
MOD_PKA_2 208 214 PF00069 0.254
MOD_PKB_1 11 19 PF00069 0.517
MOD_Plk_1 107 113 PF00069 0.266
MOD_Plk_1 226 232 PF00069 0.243
MOD_Plk_1 335 341 PF00069 0.346
MOD_Plk_1 34 40 PF00069 0.393
MOD_Plk_4 113 119 PF00069 0.316
MOD_Plk_4 226 232 PF00069 0.366
MOD_Plk_4 234 240 PF00069 0.380
MOD_Plk_4 248 254 PF00069 0.376
MOD_Plk_4 4 10 PF00069 0.501
MOD_Plk_4 464 470 PF00069 0.260
MOD_ProDKin_1 179 185 PF00069 0.276
MOD_ProDKin_1 325 331 PF00069 0.242
TRG_DiLeu_BaEn_2 80 86 PF01217 0.324
TRG_ENDOCYTIC_2 117 120 PF00928 0.269
TRG_ENDOCYTIC_2 270 273 PF00928 0.246
TRG_ENDOCYTIC_2 349 352 PF00928 0.387
TRG_ENDOCYTIC_2 440 443 PF00928 0.308
TRG_ENDOCYTIC_2 466 469 PF00928 0.260
TRG_ENDOCYTIC_2 68 71 PF00928 0.377
TRG_ER_diArg_1 11 14 PF00400 0.561
TRG_ER_diArg_1 432 434 PF00400 0.293

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N0P575 Leptomonas seymouri 28% 99%
A0A0N1PEB5 Leptomonas seymouri 90% 100%
A0A0S4IUJ1 Bodo saltans 31% 95%
A0A0S4KFV6 Bodo saltans 65% 98%
A0A1X0NHX2 Trypanosomatidae 68% 95%
A0A1X0P2L6 Trypanosomatidae 28% 96%
A0A3S7X938 Leishmania donovani 100% 100%
A0A422N9N5 Trypanosoma rangeli 75% 100%
A0A422NGW3 Trypanosoma rangeli 29% 100%
A0A451EJB9 Leishmania donovani 30% 99%
A4HMG0 Leishmania braziliensis 93% 100%
A4HRI8 Leishmania infantum 30% 100%
C9ZNM7 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 73% 100%
C9ZXM0 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 30% 100%
E9AC56 Leishmania major 30% 100%
E9AEW1 Leishmania major 99% 100%
E9AJF2 Leishmania mexicana (strain MHOM/GT/2001/U1103) 30% 100%
E9B617 Leishmania mexicana (strain MHOM/GT/2001/U1103) 97% 100%
O04308 Arabidopsis thaliana 25% 98%
O25656 Helicobacter pylori (strain ATCC 700392 / 26695) 22% 100%
O32965 Mycobacterium leprae (strain TN) 26% 100%
O60044 Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987) 25% 100%
O75439 Homo sapiens 31% 100%
O86835 Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145) 24% 100%
O94745 Schizosaccharomyces pombe (strain 972 / ATCC 24843) 25% 98%
P07256 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 26% 100%
P0A5S9 Mycobacterium bovis (strain ATCC BAA-935 / AF2122/97) 26% 100%
P10507 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 28% 100%
P11913 Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987) 29% 100%
P11914 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 23% 100%
P20069 Rattus norvegicus 26% 94%
P22695 Homo sapiens 25% 100%
P23004 Bos taurus 25% 100%
P29677 Solanum tuberosum 27% 97%
P31800 Bos taurus 31% 100%
P31930 Homo sapiens 29% 100%
P32551 Rattus norvegicus 26% 100%
P43264 Euglena gracilis 31% 99%
P55679 Sinorhizobium fredii (strain NBRC 101917 / NGR234) 24% 96%
P97997 Blastocladiella emersonii 25% 100%
P98080 Caenorhabditis elegans 28% 100%
P9WHT4 Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh) 25% 100%
P9WHT5 Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) 26% 100%
Q00302 Blastocladiella emersonii 29% 100%
Q03346 Rattus norvegicus 31% 100%
Q0P5M8 Bos taurus 27% 93%
Q10713 Homo sapiens 26% 93%
Q1RJ61 Rickettsia bellii (strain RML369-C) 22% 100%
Q23295 Caenorhabditis elegans 29% 100%
Q3SZ71 Bos taurus 31% 100%
Q42290 Arabidopsis thaliana 32% 92%
Q4UML9 Rickettsia felis (strain ATCC VR-1525 / URRWXCal2) 23% 100%
Q4W6B5 Dictyostelium discoideum 28% 100%
Q5R513 Pongo abelii 26% 93%
Q5REK3 Pongo abelii 31% 100%
Q68FY0 Rattus norvegicus 30% 100%
Q6C2E3 Yarrowia lipolytica (strain CLIB 122 / E 150) 22% 100%
Q95XN2 Caenorhabditis elegans 24% 95%
Q9CXT8 Mus musculus 31% 100%
Q9CZ13 Mus musculus 30% 100%
Q9DB77 Mus musculus 26% 100%
Q9DC61 Mus musculus 27% 94%
Q9P7X1 Schizosaccharomyces pombe (strain 972 / ATCC 24843) 29% 100%
Q9Y8B5 Lentinula edodes 30% 100%
Q9ZU25 Arabidopsis thaliana 24% 97%
V5BGV2 Trypanosoma cruzi 77% 100%
V5BH27 Trypanosoma cruzi 30% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS