Putative mitochondrial processing peptidase, beta subunit

Quick info Annotations Localization Abundance Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

mitochondrial processing peptidase - beta subunit - putative

Species:

Leishmania infantum

UniProt:

A4IB31_LEIIN

TriTrypDb:

LINF_350018700

Length:

490

Annotations

Annotations by Jardim et al.

Electron Transport Chain (see tricarboxylic acid section for Complex II), mitochondrial processing peptidase, beta subunit

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 25

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 7

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	yes	yes: 14

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

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Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0005739	mitochondrion	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

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Abundance

Amastigote (protein)


Source	Evidence on protein	Close homologs
Pescher et al. (upgregulation)	no	yes: 0

Promastigote and amastigote


Source	Evidence on protein	Close homologs
Lahav et al. - mRNA - Protein

Expansion

Sequence features

A4IB31

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4IB31

Function

Could not find GO biological_process term for this entry.

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Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	7
GO:0004175	endopeptidase activity	4	1
GO:0004222	metalloendopeptidase activity	5	1
GO:0005488	binding	1	12
GO:0008233	peptidase activity	3	1
GO:0008237	metallopeptidase activity	4	1
GO:0016491	oxidoreductase activity	2	6
GO:0016787	hydrolase activity	2	1
GO:0043167	ion binding	2	12
GO:0043169	cation binding	3	12

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Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	432	434	PF00675	0.293
CLV_NRD_NRD_1	461	463	PF00675	0.314
CLV_PCSK_KEX2_1	432	434	PF00082	0.293
CLV_PCSK_SKI1_1	176	180	PF00082	0.276
CLV_PCSK_SKI1_1	198	202	PF00082	0.352
CLV_PCSK_SKI1_1	233	237	PF00082	0.304
CLV_PCSK_SKI1_1	248	252	PF00082	0.221
CLV_PCSK_SKI1_1	25	29	PF00082	0.466
CLV_PCSK_SKI1_1	316	320	PF00082	0.230
CLV_PCSK_SKI1_1	425	429	PF00082	0.297

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P575	Leptomonas seymouri	28%	99%
A0A0N1PEB5	Leptomonas seymouri	90%	100%
A0A0S4IUJ1	Bodo saltans	31%	95%
A0A0S4KFV6	Bodo saltans	65%	98%
A0A1X0NHX2	Trypanosomatidae	68%	95%
A0A1X0P2L6	Trypanosomatidae	28%	96%
A0A3S7X938	Leishmania donovani	100%	100%
A0A422N9N5	Trypanosoma rangeli	75%	100%
A0A422NGW3	Trypanosoma rangeli	29%	100%
A0A451EJB9	Leishmania donovani	30%	99%

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