LeishMANIAdb
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Uncharacterized protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Uncharacterized protein
Gene product:
Thioredoxin - putative
Species:
Leishmania infantum
UniProt:
A4IB27_LEIIN
TriTrypDb:
LINF_350018200
Length:
559

Annotations

LeishMANIAdb annotations

Contains a thioredoxin domain. Homologous to ER-associated disulphide isomerases in other Eukaryotes.. Localization: ER (by homology)

Annotations by Jardim et al.

Redox homeostasis, Disulfide isomerase Uncharacterized

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 9
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 yes yes: 11, no: 0
NetGPI no yes: 0, no: 11
Cellular components
Term Name Level Count
GO:0005783 endoplasmic reticulum 5 1
GO:0016020 membrane 2 10
GO:0043226 organelle 2 1
GO:0043227 membrane-bounded organelle 3 1
GO:0043229 intracellular organelle 3 1
GO:0043231 intracellular membrane-bounded organelle 4 1
GO:0110165 cellular anatomical entity 1 10

Expansion

Sequence features

A4IB27
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4IB27

Function

Biological processes
Term Name Level Count
GO:0006457 protein folding 2 1
GO:0006950 response to stress 2 1
GO:0009987 cellular process 1 1
GO:0033554 cellular response to stress 3 1
GO:0034976 response to endoplasmic reticulum stress 4 1
GO:0050896 response to stimulus 1 1
GO:0051716 cellular response to stimulus 2 1
Molecular functions
Term Name Level Count
GO:0003756 protein disulfide isomerase activity 3 8
GO:0003824 catalytic activity 1 8
GO:0016853 isomerase activity 2 8
GO:0016860 intramolecular oxidoreductase activity 3 8
GO:0016864 intramolecular oxidoreductase activity, transposing S-S bonds 4 8
GO:0140096 catalytic activity, acting on a protein 2 8

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_NRD_NRD_1 6 8 PF00675 0.684
CLV_PCSK_KEX2_1 438 440 PF00082 0.507
CLV_PCSK_KEX2_1 557 559 PF00082 0.473
CLV_PCSK_KEX2_1 6 8 PF00082 0.639
CLV_PCSK_KEX2_1 72 74 PF00082 0.566
CLV_PCSK_PC1ET2_1 438 440 PF00082 0.594
CLV_PCSK_PC1ET2_1 557 559 PF00082 0.500
CLV_PCSK_PC1ET2_1 72 74 PF00082 0.546
CLV_PCSK_SKI1_1 376 380 PF00082 0.538
CLV_PCSK_SKI1_1 441 445 PF00082 0.510
CLV_PCSK_SKI1_1 72 76 PF00082 0.561
CLV_PCSK_SKI1_1 77 81 PF00082 0.465
CLV_PCSK_SKI1_1 92 96 PF00082 0.381
DEG_APCC_DBOX_1 6 14 PF00400 0.543
DEG_SCF_FBW7_1 1 8 PF00400 0.482
DEG_SCF_FBW7_1 400 406 PF00400 0.309
DEG_SPOP_SBC_1 205 209 PF00917 0.409
DOC_CDC14_PxL_1 369 377 PF14671 0.308
DOC_CKS1_1 400 405 PF01111 0.312
DOC_CKS1_1 457 462 PF01111 0.411
DOC_MAPK_gen_1 3 13 PF00069 0.591
DOC_MAPK_gen_1 388 396 PF00069 0.400
DOC_MAPK_gen_1 419 426 PF00069 0.346
DOC_MAPK_MEF2A_6 352 359 PF00069 0.366
DOC_MAPK_MEF2A_6 6 15 PF00069 0.542
DOC_MAPK_RevD_3 424 439 PF00069 0.313
DOC_PP1_RVXF_1 402 408 PF00149 0.375
DOC_SPAK_OSR1_1 234 238 PF12202 0.266
DOC_USP7_MATH_1 205 209 PF00917 0.393
DOC_USP7_MATH_1 228 232 PF00917 0.304
DOC_USP7_MATH_1 303 307 PF00917 0.511
DOC_USP7_MATH_1 403 407 PF00917 0.384
DOC_USP7_UBL2_3 257 261 PF12436 0.326
DOC_USP7_UBL2_3 551 555 PF12436 0.647
DOC_WW_Pin1_4 1 6 PF00397 0.562
DOC_WW_Pin1_4 399 404 PF00397 0.326
DOC_WW_Pin1_4 456 461 PF00397 0.394
DOC_WW_Pin1_4 72 77 PF00397 0.377
DOC_WW_Pin1_4 82 87 PF00397 0.281
LIG_14-3-3_CanoR_1 404 410 PF00244 0.289
LIG_APCC_ABBA_1 279 284 PF00400 0.307
LIG_BRCT_BRCA1_1 126 130 PF00533 0.295
LIG_BRCT_BRCA1_1 340 344 PF00533 0.339
LIG_BRCT_BRCA1_1 65 69 PF00533 0.296
LIG_CaM_NSCaTE_8 220 227 PF13499 0.372
LIG_eIF4E_1 501 507 PF01652 0.372
LIG_FHA_1 17 23 PF00498 0.513
LIG_FHA_1 193 199 PF00498 0.449
LIG_FHA_1 308 314 PF00498 0.499
LIG_FHA_1 400 406 PF00498 0.357
LIG_FHA_1 47 53 PF00498 0.400
LIG_FHA_1 6 12 PF00498 0.534
LIG_FHA_2 320 326 PF00498 0.339
LIG_FHA_2 377 383 PF00498 0.356
LIG_FHA_2 435 441 PF00498 0.376
LIG_LIR_Apic_2 283 289 PF02991 0.297
LIG_LIR_Apic_2 47 53 PF02991 0.404
LIG_LIR_Apic_2 65 70 PF02991 0.212
LIG_LIR_Gen_1 113 120 PF02991 0.291
LIG_LIR_Gen_1 184 191 PF02991 0.340
LIG_LIR_Gen_1 325 335 PF02991 0.388
LIG_LIR_Gen_1 341 351 PF02991 0.340
LIG_LIR_Gen_1 406 417 PF02991 0.378
LIG_LIR_Gen_1 515 525 PF02991 0.267
LIG_LIR_Gen_1 529 538 PF02991 0.353
LIG_LIR_LC3C_4 277 281 PF02991 0.376
LIG_LIR_Nem_3 113 118 PF02991 0.383
LIG_LIR_Nem_3 127 132 PF02991 0.256
LIG_LIR_Nem_3 133 138 PF02991 0.255
LIG_LIR_Nem_3 184 189 PF02991 0.337
LIG_LIR_Nem_3 252 258 PF02991 0.311
LIG_LIR_Nem_3 325 330 PF02991 0.370
LIG_LIR_Nem_3 341 347 PF02991 0.340
LIG_LIR_Nem_3 368 374 PF02991 0.392
LIG_LIR_Nem_3 406 412 PF02991 0.356
LIG_LIR_Nem_3 499 504 PF02991 0.347
LIG_LIR_Nem_3 515 521 PF02991 0.242
LIG_LIR_Nem_3 529 533 PF02991 0.299
LIG_MLH1_MIPbox_1 126 130 PF16413 0.295
LIG_PCNA_yPIPBox_3 122 130 PF02747 0.339
LIG_Pex14_1 418 422 PF04695 0.297
LIG_Pex14_2 528 532 PF04695 0.279
LIG_PTB_Apo_2 229 236 PF02174 0.305
LIG_PTB_Apo_2 58 65 PF02174 0.339
LIG_REV1ctd_RIR_1 440 449 PF16727 0.326
LIG_SH2_CRK 255 259 PF00017 0.347
LIG_SH2_PTP2 201 204 PF00017 0.317
LIG_SH2_PTP2 409 412 PF00017 0.318
LIG_SH2_SRC 201 204 PF00017 0.288
LIG_SH2_SRC 409 412 PF00017 0.366
LIG_SH2_STAP1 422 426 PF00017 0.390
LIG_SH2_STAP1 513 517 PF00017 0.313
LIG_SH2_STAT3 483 486 PF00017 0.345
LIG_SH2_STAT5 129 132 PF00017 0.276
LIG_SH2_STAT5 140 143 PF00017 0.207
LIG_SH2_STAT5 166 169 PF00017 0.322
LIG_SH2_STAT5 201 204 PF00017 0.281
LIG_SH2_STAT5 354 357 PF00017 0.281
LIG_SH2_STAT5 409 412 PF00017 0.366
LIG_SH2_STAT5 497 500 PF00017 0.332
LIG_SH2_STAT5 67 70 PF00017 0.296
LIG_SH3_3 199 205 PF00018 0.297
LIG_SH3_3 534 540 PF00018 0.289
LIG_SH3_3 83 89 PF00018 0.327
LIG_SUMO_SIM_anti_2 408 414 PF11976 0.332
LIG_SUMO_SIM_anti_2 519 524 PF11976 0.417
LIG_SUMO_SIM_anti_2 8 14 PF11976 0.555
LIG_SUMO_SIM_par_1 36 44 PF11976 0.422
LIG_TRAF2_1 395 398 PF00917 0.386
LIG_TYR_ITIM 506 511 PF00017 0.398
LIG_UBA3_1 343 352 PF00899 0.401
LIG_WRC_WIRS_1 527 532 PF05994 0.417
MOD_CDK_SPK_2 1 6 PF00069 0.452
MOD_CDK_SPK_2 399 404 PF00069 0.318
MOD_CDK_SPK_2 72 77 PF00069 0.274
MOD_CDK_SPxK_1 1 7 PF00069 0.449
MOD_CDK_SPxK_1 456 462 PF00069 0.405
MOD_CK1_1 193 199 PF00069 0.336
MOD_CK1_1 214 220 PF00069 0.444
MOD_CK1_1 43 49 PF00069 0.399
MOD_CK2_1 172 178 PF00069 0.359
MOD_CK2_1 207 213 PF00069 0.388
MOD_CK2_1 239 245 PF00069 0.406
MOD_CK2_1 319 325 PF00069 0.429
MOD_CK2_1 376 382 PF00069 0.373
MOD_GlcNHglycan 190 195 PF01048 0.616
MOD_GlcNHglycan 209 212 PF01048 0.547
MOD_GlcNHglycan 271 274 PF01048 0.567
MOD_GlcNHglycan 292 295 PF01048 0.625
MOD_GlcNHglycan 33 38 PF01048 0.658
MOD_GlcNHglycan 340 343 PF01048 0.573
MOD_GSK3_1 1 8 PF00069 0.616
MOD_GSK3_1 134 141 PF00069 0.274
MOD_GSK3_1 16 23 PF00069 0.596
MOD_GSK3_1 170 177 PF00069 0.386
MOD_GSK3_1 207 214 PF00069 0.400
MOD_GSK3_1 298 305 PF00069 0.455
MOD_GSK3_1 314 321 PF00069 0.287
MOD_GSK3_1 399 406 PF00069 0.377
MOD_GSK3_1 40 47 PF00069 0.404
MOD_GSK3_1 68 75 PF00069 0.306
MOD_N-GLC_1 99 104 PF02516 0.448
MOD_NEK2_1 138 143 PF00069 0.234
MOD_NEK2_1 16 21 PF00069 0.557
MOD_NEK2_1 161 166 PF00069 0.393
MOD_NEK2_1 318 323 PF00069 0.397
MOD_NEK2_1 343 348 PF00069 0.360
MOD_NEK2_1 99 104 PF00069 0.316
MOD_PIKK_1 153 159 PF00454 0.322
MOD_PIKK_1 211 217 PF00454 0.430
MOD_PIKK_1 239 245 PF00454 0.398
MOD_PIKK_1 376 382 PF00454 0.331
MOD_PKA_2 303 309 PF00069 0.455
MOD_PKA_2 403 409 PF00069 0.293
MOD_Plk_1 181 187 PF00069 0.341
MOD_Plk_1 298 304 PF00069 0.441
MOD_Plk_1 33 39 PF00069 0.455
MOD_Plk_1 99 105 PF00069 0.280
MOD_Plk_2-3 172 178 PF00069 0.318
MOD_Plk_4 134 140 PF00069 0.258
MOD_Plk_4 162 168 PF00069 0.344
MOD_Plk_4 52 58 PF00069 0.350
MOD_Plk_4 63 69 PF00069 0.235
MOD_Plk_4 90 96 PF00069 0.258
MOD_ProDKin_1 1 7 PF00069 0.559
MOD_ProDKin_1 399 405 PF00069 0.320
MOD_ProDKin_1 456 462 PF00069 0.397
MOD_ProDKin_1 72 78 PF00069 0.377
MOD_ProDKin_1 82 88 PF00069 0.281
MOD_SUMO_rev_2 184 193 PF00179 0.298
TRG_DiLeu_BaEn_1 466 471 PF01217 0.379
TRG_DiLeu_BaLyEn_6 6 11 PF01217 0.582
TRG_ENDOCYTIC_2 129 132 PF00928 0.265
TRG_ENDOCYTIC_2 201 204 PF00928 0.339
TRG_ENDOCYTIC_2 255 258 PF00928 0.308
TRG_ENDOCYTIC_2 354 357 PF00928 0.274
TRG_ENDOCYTIC_2 409 412 PF00928 0.318
TRG_ENDOCYTIC_2 501 504 PF00928 0.359
TRG_ENDOCYTIC_2 508 511 PF00928 0.323
TRG_ENDOCYTIC_2 513 516 PF00928 0.318
TRG_ER_diArg_1 418 421 PF00400 0.393
TRG_ER_diArg_1 5 7 PF00400 0.551
TRG_ER_diLys_1 555 559 PF00400 0.625
TRG_Pf-PMV_PEXEL_1 362 366 PF00026 0.607
TRG_Pf-PMV_PEXEL_1 376 380 PF00026 0.441

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1HYT4 Leptomonas seymouri 65% 100%
A0A0S4KJA1 Bodo saltans 27% 98%
A0A1X0NH48 Trypanosomatidae 38% 99%
A0A3S7X8Z9 Leishmania donovani 100% 100%
A0A422N9H3 Trypanosoma rangeli 39% 100%
A4HMF5 Leishmania braziliensis 83% 100%
C9ZNM3 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 34% 95%
E9B612 Leishmania mexicana (strain MHOM/GT/2001/U1103) 91% 100%
Q9GRP8 Leishmania major 95% 100%
V5ASA4 Trypanosoma cruzi 42% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS