Histone H4

Quick info Annotations Localization Abundance Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Histone H4

Gene product:

histone H4

Species:

Leishmania infantum

UniProt:

A4IB25_LEIIN

TriTrypDb:

LINF_350018000

Length:

100

Annotations

LeishMANIAdb annotations

Histone H4 protein, nuclear without any membrane association

Annotations by Jardim et al.

Histone/chromosome structure, Histone H4

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 1
Forrest at al. (metacyclic)	no	yes: 4
Forrest at al. (procyclic)	no	yes: 2
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 40

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 8

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 4

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 29
NetGPI	no	yes: 0, no: 29

Cellular components
Term	Name	Level	Count
GO:0000786	nucleosome	3	30
GO:0005634	nucleus	5	30
GO:0032991	protein-containing complex	1	30
GO:0032993	protein-DNA complex	2	30
GO:0043226	organelle	2	30
GO:0043227	membrane-bounded organelle	3	30
GO:0043229	intracellular organelle	3	30
GO:0043231	intracellular membrane-bounded organelle	4	30
GO:0044815	DNA packaging complex	2	30
GO:0110165	cellular anatomical entity	1	30

Abundance

Amastigote (protein)


Source	Evidence on protein	Close homologs
Pescher et al. (upgregulation)	no	yes: 0

Promastigote and amastigote


Source	Evidence on protein	Close homologs
Lahav et al. - mRNA - Protein

Expansion

Sequence features

A4IB25

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4IB25

Function

Biological processes
Term	Name	Level	Count
GO:0006325	chromatin organization	4	3
GO:0006334	nucleosome assembly	7	3
GO:0006338	chromatin remodeling	5	3
GO:0009987	cellular process	1	3
GO:0016043	cellular component organization	3	3
GO:0022607	cellular component assembly	4	3
GO:0034728	nucleosome organization	6	3
GO:0043933	protein-containing complex organization	4	3
GO:0065003	protein-containing complex assembly	5	3
GO:0065004	protein-DNA complex assembly	6	3
GO:0071824	protein-DNA complex subunit organization	5	3
GO:0071840	cellular component organization or biogenesis	2	3

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	30
GO:0003677	DNA binding	4	30
GO:0005198	structural molecule activity	1	30
GO:0005488	binding	1	30
GO:0005515	protein binding	2	30
GO:0030527	structural constituent of chromatin	2	30
GO:0046982	protein heterodimerization activity	4	30
GO:0046983	protein dimerization activity	3	30
GO:0097159	organic cyclic compound binding	2	30
GO:1901363	heterocyclic compound binding	2	30

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	34	36	PF00675	0.417
CLV_NRD_NRD_1	38	40	PF00675	0.423
CLV_NRD_NRD_1	54	56	PF00675	0.193
CLV_NRD_NRD_1	75	77	PF00675	0.402
CLV_NRD_NRD_1	89	91	PF00675	0.407
CLV_PCSK_KEX2_1	15	17	PF00082	0.408
CLV_PCSK_KEX2_1	34	36	PF00082	0.408
CLV_PCSK_KEX2_1	38	40	PF00082	0.415
CLV_PCSK_KEX2_1	43	45	PF00082	0.409
CLV_PCSK_KEX2_1	5	7	PF00082	0.645
CLV_PCSK_KEX2_1	54	56	PF00082	0.193
CLV_PCSK_PC1ET2_1	15	17	PF00082	0.408
CLV_PCSK_PC1ET2_1	43	45	PF00082	0.411
CLV_PCSK_PC1ET2_1	5	7	PF00082	0.645
CLV_PCSK_PC7_1	30	36	PF00082	0.396
CLV_PCSK_PC7_1	39	45	PF00082	0.415
CLV_PCSK_SKI1_1	18	22	PF00082	0.461
CLV_PCSK_SKI1_1	26	30	PF00082	0.401
CLV_PCSK_SKI1_1	54	58	PF00082	0.412
CLV_PCSK_SKI1_1	78	82	PF00082	0.453
DOC_USP7_MATH_1	10	14	PF00917	0.673
DOC_USP7_UBL2_3	11	15	PF12436	0.493
LIG_14-3-3_CanoR_1	44	53	PF00244	0.440
LIG_14-3-3_CanoR_1	66	74	PF00244	0.410
LIG_14-3-3_CanoR_1	76	81	PF00244	0.343
LIG_BIR_II_1	1	5	PF00653	0.583
LIG_BIR_III_4	9	13	PF00653	0.637
LIG_FHA_2	79	85	PF00498	0.388
LIG_LIR_Gen_1	47	57	PF02991	0.501
LIG_LIR_Nem_3	47	53	PF02991	0.551
LIG_LIR_Nem_3	68	74	PF02991	0.391
LIG_SH2_SRC	50	53	PF00017	0.360
LIG_SH2_STAP1	71	75	PF00017	0.455
LIG_SH2_STAT5	60	63	PF00017	0.419
LIG_SH2_STAT5	71	74	PF00017	0.314
MOD_Cter_Amidation	3	6	PF01082	0.559
MOD_GlcNHglycan	6	9	PF01048	0.539
MOD_GSK3_1	65	72	PF00069	0.443
MOD_PIKK_1	10	16	PF00454	0.565
MOD_PKA_1	43	49	PF00069	0.412
MOD_PKA_1	76	82	PF00069	0.405
MOD_PKA_2	43	49	PF00069	0.412
MOD_PKA_2	65	71	PF00069	0.509
MOD_SUMO_rev_2	7	13	PF00179	0.568
TRG_ENDOCYTIC_2	50	53	PF00928	0.370
TRG_ER_diArg_1	33	35	PF00400	0.395
TRG_ER_diArg_1	53	55	PF00400	0.489
TRG_NLS_Bipartite_1	5	19	PF00514	0.485
TRG_NLS_Bipartite_1	76	94	PF00514	0.329
TRG_NLS_MonoExtC_3	14	19	PF00514	0.457

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A1X0NJN5	Trypanosomatidae	76%	100%
A0A1X0P2G0	Trypanosomatidae	75%	100%
A0A3Q8IFP7	Leishmania donovani	98%	100%
A0A3R7MKW7	Trypanosoma rangeli	75%	86%
A0A3S7WPA9	Leishmania donovani	96%	100%
A0A3S7WTF1	Leishmania donovani	96%	100%
A0A3S7X8Y8	Leishmania donovani	100%	100%
A0A451EJE0	Leishmania donovani	96%	100%
A4H399	Leishmania braziliensis	95%	100%
A4H3A0	Leishmania braziliensis	95%	100%
A4H7X1	Leishmania braziliensis	95%	100%
A4HD43	Leishmania braziliensis	94%	100%
A4HHY8	Leishmania braziliensis	62%	100%
A4HMF3	Leishmania braziliensis	94%	100%
A4HNK8	Leishmania braziliensis	94%	100%
A4HSP4	Leishmania infantum	96%	100%
A4HW98	Leishmania infantum	97%	100%
C9ZJ36	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	73%	100%
C9ZPV8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	78%	88%
E9AKM9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	94%	100%
E9APZ8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	95%	100%
E9ASB9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	98%	100%
E9AUW4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	100%
P02309	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	60%	97%
P02310	Tetrahymena pyriformis	58%	97%
P04914	Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)	58%	97%
P04915	Physarum polycephalum	61%	97%
P08436	Volvox carteri	62%	97%
P09322	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	54%	97%
P0CG89	Glycine max	61%	97%
P23750	Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)	58%	97%
P23751	Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)	58%	97%
P27996	Solaster stimpsoni	58%	97%
P35057	Solanum lycopersicum	62%	97%
P35059	Acropora formosa	59%	97%
P40287	Entamoeba histolytica	49%	85%
P50566	Chlamydomonas reinhardtii	62%	97%
P59259	Arabidopsis thaliana	61%	97%
P62776	Holothuria tubulosa	59%	97%
P62777	Pisaster brevispinus	59%	97%
P62778	Pisaster ochraceus	59%	97%
P62779	Pycnopodia helianthoides	59%	97%
P62780	Paracentrotus lividus	59%	97%
P62781	Psammechinus miliaris	59%	97%
P62782	Lytechinus pictus	59%	97%
P62783	Strongylocentrotus purpuratus	59%	97%
P62784	Caenorhabditis elegans	59%	97%
P62785	Triticum aestivum	61%	97%
P62786	Triticum aestivum	61%	97%
P62787	Zea mays	61%	97%
P62788	Pisum sativum	61%	97%
P62790	Sterkiella nova	55%	96%
P62791	Stylonychia lemnae	55%	96%
P62792	Phanerodontia chrysosporium	60%	97%
P62793	Agaricus bisporus	60%	97%
P62794	Urechis caupo	60%	97%
P62795	Platynereis dumerilii	60%	97%
P62796	Oreochromis niloticus	60%	97%
P62797	Oncorhynchus mykiss	60%	97%
P62798	Xenopus borealis	60%	97%
P62799	Xenopus laevis	60%	97%
P62800	Cairina moschata	60%	97%
P62801	Gallus gallus	60%	97%
P62802	Sus scrofa	60%	97%
P62803	Bos taurus	60%	97%
P62804	Rattus norvegicus	60%	97%
P62805	Homo sapiens	60%	97%
P62806	Mus musculus	60%	97%
P62887	Lolium temulentum	61%	97%
P69151	Tetrahymena pyriformis	58%	97%
P69152	Tetrahymena thermophila (strain SB210)	58%	97%
P70081	Gallus gallus	59%	97%
P80737	Blepharisma japonicum	56%	100%
P80739	Euplotes crassus	59%	93%
P82888	Olisthodiscus luteus	60%	97%
P83865	Penaeus vannamei	59%	97%
P84040	Drosophila melanogaster	60%	97%
P84041	Drosophila erecta	60%	97%
P84042	Drosophila hydei	60%	97%
P84043	Drosophila simulans	60%	97%
P84044	Drosophila yakuba	60%	97%
P84045	Tigriopus californicus	60%	97%
P84046	Chironomus thummi thummi	60%	97%
P84047	Asellus aquaticus	60%	97%
P84048	Acrolepiopsis assectella	60%	97%
P84049	Myrmica ruginodis	60%	97%
P84050	Rhynchosciara americana	60%	97%
P90516	Blepharisma japonicum	52%	100%
P91849	Apis mellifera	58%	97%
P91882	Diadromus pulchellus	59%	97%
P91890	Trichogramma cacaeciae	60%	97%
Q27443	Ascaris suum	59%	97%
Q27765	Styela plicata	60%	97%
Q28DR4	Xenopus tropicalis	60%	97%
Q41811	Zea mays	60%	97%
Q43083	Pyrenomonas salina	61%	97%
Q4JHM5	Leishmania donovani	97%	100%
Q4Q277	Leishmania major	95%	100%
Q4QFI3	Leishmania major	95%	100%
Q4QJ78	Leishmania major	95%	100%
Q4R362	Macaca fascicularis	60%	97%
Q5RCS7	Pongo abelii	60%	97%
Q6LAF1	Dendronephthya klunzingeri	59%	97%
Q6LAF3	Flaveria trinervia	61%	97%
Q6PMI5	Chelidonium majus	61%	97%
Q6V9I2	Solanum chacoense	62%	97%
Q6WV72	Mytilus trossulus	60%	97%
Q6WV73	Mytilus californianus	60%	97%
Q6WV74	Mytilus chilensis	59%	97%
Q6WV90	Mytilus galloprovincialis	60%	97%
Q6WZ83	Eucalyptus globulus	61%	97%
Q6ZXX3	Ustilago maydis (strain 521 / FGSC 9021)	58%	97%
Q711M0	Talaromyces funiculosus	58%	97%
Q71V09	Capsicum annuum	62%	97%
Q757K0	Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)	58%	97%
Q75AX1	Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)	58%	97%
Q76FD9	Drosophila sechellia	60%	97%
Q76FE7	Drosophila mauritiana	60%	97%
Q76FF1	Drosophila orena	60%	97%
Q76FF5	Drosophila teissieri	60%	97%
Q76H85	Silene latifolia	61%	97%
Q76MU7	Aspergillus oryzae (strain ATCC 42149 / RIB 40)	58%	97%
Q76NW2	Dictyostelium discoideum	55%	93%
Q7K8C0	Mytilus edulis	60%	97%
Q7KQD1	Chaetopterus variopedatus	60%	97%
Q7LKT3	Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100)	58%	97%
Q8I0Y4	Oikopleura dioica	60%	97%
Q8J1L3	Blastobotrys adeninivorans	58%	97%
Q8MTV8	Aplysia californica	60%	97%
Q8NIG3	Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65)	59%	97%
Q8NIQ8	Talaromyces funiculosus	58%	97%
Q8SQP4	Encephalitozoon cuniculi (strain GB-M1)	35%	97%
Q8T7J8	Eimeria tenella	60%	97%
Q99525	Homo sapiens	51%	100%
Q9HDF5	Mortierella alpina	58%	97%
Q9U7D0	Mastigamoeba balamuthi	63%	93%
R9TL77	Trypanosoma rangeli	76%	100%
V5BAE8	Trypanosoma cruzi	75%	100%