Histone H4

Quick info Annotations Localization Abundance Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Histone H4

Gene product:

histone H4

Species:

Leishmania infantum

UniProt:

A4IB25_LEIIN

TriTrypDb:

LINF_350018000

Length:

100

Annotations

LeishMANIAdb annotations

Histone H4 protein, nuclear without any membrane association

Annotations by Jardim et al.

Histone/chromosome structure, Histone H4

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 1
Forrest at al. (metacyclic)	no	yes: 4
Forrest at al. (procyclic)	no	yes: 2
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 40

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 8

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 4

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 29
NetGPI	no	yes: 0, no: 29

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Cellular components
Term	Name	Level	Count
GO:0000786	nucleosome	3	30
GO:0005634	nucleus	5	30
GO:0032991	protein-containing complex	1	30
GO:0032993	protein-DNA complex	2	30
GO:0043226	organelle	2	30
GO:0043227	membrane-bounded organelle	3	30
GO:0043229	intracellular organelle	3	30
GO:0043231	intracellular membrane-bounded organelle	4	30
GO:0044815	DNA packaging complex	2	30
GO:0110165	cellular anatomical entity	1	30

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Abundance

Amastigote (protein)


Source	Evidence on protein	Close homologs
Pescher et al. (upgregulation)	no	yes: 0

Promastigote and amastigote


Source	Evidence on protein	Close homologs
Lahav et al. - mRNA - Protein

Expansion

Sequence features

A4IB25

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4IB25

Function

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Biological processes
Term	Name	Level	Count
GO:0006325	chromatin organization	4	3
GO:0006334	nucleosome assembly	7	3
GO:0006338	chromatin remodeling	5	3
GO:0009987	cellular process	1	3
GO:0016043	cellular component organization	3	3
GO:0022607	cellular component assembly	4	3
GO:0034728	nucleosome organization	6	3
GO:0043933	protein-containing complex organization	4	3
GO:0065003	protein-containing complex assembly	5	3
GO:0065004	protein-DNA complex assembly	6	3

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Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	30
GO:0003677	DNA binding	4	30
GO:0005198	structural molecule activity	1	30
GO:0005488	binding	1	30
GO:0005515	protein binding	2	30
GO:0030527	structural constituent of chromatin	2	30
GO:0046982	protein heterodimerization activity	4	30
GO:0046983	protein dimerization activity	3	30
GO:0097159	organic cyclic compound binding	2	30
GO:1901363	heterocyclic compound binding	2	30

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Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	34	36	PF00675	0.417
CLV_NRD_NRD_1	38	40	PF00675	0.423
CLV_NRD_NRD_1	54	56	PF00675	0.193
CLV_NRD_NRD_1	75	77	PF00675	0.402
CLV_NRD_NRD_1	89	91	PF00675	0.407
CLV_PCSK_KEX2_1	15	17	PF00082	0.408
CLV_PCSK_KEX2_1	34	36	PF00082	0.408
CLV_PCSK_KEX2_1	38	40	PF00082	0.415
CLV_PCSK_KEX2_1	43	45	PF00082	0.409
CLV_PCSK_KEX2_1	5	7	PF00082	0.645

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A1X0NJN5	Trypanosomatidae	76%	100%
A0A1X0P2G0	Trypanosomatidae	75%	100%
A0A3Q8IFP7	Leishmania donovani	98%	100%
A0A3R7MKW7	Trypanosoma rangeli	75%	86%
A0A3S7WPA9	Leishmania donovani	96%	100%
A0A3S7WTF1	Leishmania donovani	96%	100%
A0A3S7X8Y8	Leishmania donovani	100%	100%
A0A451EJE0	Leishmania donovani	96%	100%
A4H399	Leishmania braziliensis	95%	100%
A4H3A0	Leishmania braziliensis	95%	100%

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