LeishMANIAdb
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Thioredoxin-like protein

Quick info Annotations Function or PPIs Localization Abundance Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Thioredoxin-like protein
Gene product:
monothiol glutaredoxin - putative
Species:
Leishmania infantum
UniProt:
A4IB19_LEIIN
TriTrypDb:
LINF_350017400
Length:
228

Annotations

Annotations by Jardim et al.

Redox homeostasis, Thioredoxin-like

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) yes yes: 3
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 8
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 10
NetGPI no yes: 0, no: 10
Cellular components
Term Name Level Count
GO:0005634 nucleus 5 1
GO:0005737 cytoplasm 2 1
GO:0005829 cytosol 2 1
GO:0031974 membrane-enclosed lumen 2 1
GO:0031981 nuclear lumen 5 1
GO:0032838 plasma membrane bounded cell projection cytoplasm 4 1
GO:0043226 organelle 2 1
GO:0043227 membrane-bounded organelle 3 1
GO:0043229 intracellular organelle 3 1
GO:0043231 intracellular membrane-bounded organelle 4 1
GO:0043233 organelle lumen 3 1
GO:0070013 intracellular organelle lumen 4 1
GO:0097014 ciliary plasm 5 1
GO:0099568 cytoplasmic region 3 1
GO:0110165 cellular anatomical entity 1 1

Abundance

Amastigote (protein)
Source Evidence on protein Close homologs
Pescher et al. (upgregulation) no yes: 0
Promastigote and amastigote
Source Evidence on protein Close homologs
Lahav et al.
- mRNA
- Protein

Expansion

Sequence features

A4IB19
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4IB19

Function

Biological processes
Term Name Level Count
GO:0006873 intracellular monoatomic ion homeostasis 4 1
GO:0006875 obsolete intracellular metal ion homeostasis 6 1
GO:0006879 intracellular iron ion homeostasis 8 1
GO:0009987 cellular process 1 1
GO:0019725 cellular homeostasis 2 1
GO:0030003 intracellular monoatomic cation homeostasis 5 1
GO:0042592 homeostatic process 3 1
GO:0045454 cell redox homeostasis 3 1
GO:0046916 obsolete intracellular transition metal ion homeostasis 7 1
GO:0048878 chemical homeostasis 4 1
GO:0050789 regulation of biological process 2 1
GO:0050794 regulation of cellular process 3 1
GO:0050801 monoatomic ion homeostasis 5 1
GO:0055065 obsolete metal ion homeostasis 7 1
GO:0055072 obsolete iron ion homeostasis 9 1
GO:0055076 obsolete transition metal ion homeostasis 8 1
GO:0055080 monoatomic cation homeostasis 6 1
GO:0055082 intracellular chemical homeostasis 3 1
GO:0065007 biological regulation 1 1
GO:0065008 regulation of biological quality 2 1
GO:0098771 inorganic ion homeostasis 6 1
Molecular functions
Term Name Level Count
GO:0003824 catalytic activity 1 11
GO:0015035 protein-disulfide reductase activity 3 11
GO:0015036 disulfide oxidoreductase activity 4 11
GO:0016491 oxidoreductase activity 2 11
GO:0016667 oxidoreductase activity, acting on a sulfur group of donors 3 11
GO:0097573 obsolete glutathione oxidoreductase activity 4 11
GO:0140096 catalytic activity, acting on a protein 2 11
GO:0004362 glutathione-disulfide reductase (NADPH) activity 2 1
GO:0005488 binding 1 9
GO:0015038 glutathione disulfide oxidoreductase activity 5 1
GO:0016209 antioxidant activity 1 1
GO:0016668 oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor 4 1
GO:0043167 ion binding 2 9
GO:0043169 cation binding 3 9
GO:0046872 metal ion binding 4 9
GO:0047134 protein-disulfide reductase (NAD(P)) activity 4 1
GO:0051536 iron-sulfur cluster binding 3 9
GO:0051540 metal cluster binding 2 9

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 48 52 PF00656 0.300
CLV_NRD_NRD_1 90 92 PF00675 0.528
CLV_PCSK_KEX2_1 139 141 PF00082 0.422
CLV_PCSK_KEX2_1 90 92 PF00082 0.498
CLV_PCSK_PC1ET2_1 139 141 PF00082 0.438
CLV_PCSK_SKI1_1 44 48 PF00082 0.193
DEG_Nend_Nbox_1 1 3 PF02207 0.451
DOC_CKS1_1 81 86 PF01111 0.423
DOC_CYCLIN_yCln2_LP_2 169 175 PF00134 0.355
DOC_MAPK_gen_1 139 147 PF00069 0.206
DOC_MAPK_gen_1 14 23 PF00069 0.362
DOC_MAPK_HePTP_8 13 25 PF00069 0.300
DOC_MAPK_MEF2A_6 16 25 PF00069 0.311
DOC_PP2B_LxvP_1 169 172 PF13499 0.355
DOC_PP4_FxxP_1 81 84 PF00568 0.387
DOC_USP7_MATH_1 17 21 PF00917 0.300
DOC_USP7_UBL2_3 223 227 PF12436 0.323
DOC_USP7_UBL2_3 3 7 PF12436 0.300
DOC_WW_Pin1_4 147 152 PF00397 0.245
DOC_WW_Pin1_4 80 85 PF00397 0.357
LIG_Actin_WH2_2 209 225 PF00022 0.300
LIG_BRCT_BRCA1_1 73 77 PF00533 0.355
LIG_eIF4E_1 201 207 PF01652 0.242
LIG_eIF4E_1 80 86 PF01652 0.467
LIG_FHA_1 108 114 PF00498 0.439
LIG_FHA_1 157 163 PF00498 0.246
LIG_FHA_1 81 87 PF00498 0.512
LIG_FHA_2 127 133 PF00498 0.439
LIG_FHA_2 28 34 PF00498 0.355
LIG_LIR_Apic_2 28 34 PF02991 0.226
LIG_LIR_Gen_1 126 134 PF02991 0.309
LIG_LIR_Gen_1 8 17 PF02991 0.306
LIG_LIR_LC3C_4 20 25 PF02991 0.300
LIG_LIR_Nem_3 126 130 PF02991 0.329
LIG_LIR_Nem_3 131 136 PF02991 0.291
LIG_LIR_Nem_3 196 200 PF02991 0.239
LIG_LIR_Nem_3 74 80 PF02991 0.288
LIG_LIR_Nem_3 8 13 PF02991 0.315
LIG_LYPXL_yS_3 197 200 PF13949 0.355
LIG_NRP_CendR_1 227 228 PF00754 0.341
LIG_Pex14_2 27 31 PF04695 0.242
LIG_Pex14_2 77 81 PF04695 0.303
LIG_SH2_GRB2like 191 194 PF00017 0.355
LIG_SH2_SRC 10 13 PF00017 0.324
LIG_SH2_SRC 201 204 PF00017 0.224
LIG_SH2_STAT5 133 136 PF00017 0.276
LIG_SH2_STAT5 201 204 PF00017 0.242
LIG_SH2_STAT5 80 83 PF00017 0.366
LIG_SH3_3 148 154 PF00018 0.263
LIG_SH3_3 192 198 PF00018 0.224
MOD_CDK_SPxK_1 147 153 PF00069 0.224
MOD_CK2_1 2 8 PF00069 0.270
MOD_CK2_1 27 33 PF00069 0.302
MOD_GlcNHglycan 27 30 PF01048 0.230
MOD_GSK3_1 145 152 PF00069 0.270
MOD_NEK2_1 145 150 PF00069 0.305
MOD_NEK2_1 2 7 PF00069 0.300
MOD_NEK2_1 222 227 PF00069 0.429
MOD_NEK2_1 27 32 PF00069 0.316
MOD_Plk_2-3 126 132 PF00069 0.451
MOD_Plk_4 109 115 PF00069 0.370
MOD_ProDKin_1 147 153 PF00069 0.245
MOD_ProDKin_1 80 86 PF00069 0.374
MOD_SUMO_rev_2 215 225 PF00179 0.327
TRG_DiLeu_BaEn_2 72 78 PF01217 0.244
TRG_ENDOCYTIC_2 10 13 PF00928 0.268
TRG_ENDOCYTIC_2 175 178 PF00928 0.226
TRG_ENDOCYTIC_2 197 200 PF00928 0.355
TRG_ER_diArg_1 90 92 PF00400 0.492
TRG_Pf-PMV_PEXEL_1 214 218 PF00026 0.437

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1IKK7 Leptomonas seymouri 78% 100%
A0A0S4JWQ4 Bodo saltans 52% 100%
A0A1X0NHB9 Trypanosomatidae 58% 100%
A0A3Q8IP85 Leishmania donovani 99% 100%
A0A422MXN1 Trypanosoma rangeli 57% 100%
A4HME7 Leishmania braziliensis 89% 100%
C9ZNL5 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 56% 100%
E9AEU8 Leishmania major 97% 100%
E9B604 Leishmania mexicana (strain MHOM/GT/2001/U1103) 96% 100%
O74790 Schizosaccharomyces pombe (strain 972 / ATCC 24843) 26% 93%
O76003 Homo sapiens 34% 68%
P32642 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 21% 93%
Q03835 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 23% 91%
Q28ID3 Xenopus tropicalis 30% 70%
Q58DA7 Bos taurus 32% 68%
Q5XJ54 Danio rerio 31% 70%
Q86H62 Dictyostelium discoideum 29% 95%
Q9CQM9 Mus musculus 32% 68%
Q9JLZ1 Rattus norvegicus 32% 68%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS