LeishMANIAdb
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Putative NADH-dependent fumarate reductase

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Putative NADH-dependent fumarate reductase
Gene product:
NADH-dependent fumarate reductase - putative
Species:
Leishmania infantum
UniProt:
A4IB13_LEIIN
TriTrypDb:
LINF_350016700
Length:
495

Annotations

Annotations by Jardim et al.

Tricarboxylic acid cycle, NADH-dependent fumarate reductase

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 9
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 10
NetGPI no yes: 0, no: 10
Cellular components
Term Name Level Count
GO:0005737 cytoplasm 2 1
GO:0005777 peroxisome 6 1
GO:0005815 microtubule organizing center 2 1
GO:0020015 glycosome 7 1
GO:0036064 ciliary basal body 3 1
GO:0042579 microbody 5 1
GO:0043226 organelle 2 1
GO:0043227 membrane-bounded organelle 3 1
GO:0043229 intracellular organelle 3 1
GO:0043231 intracellular membrane-bounded organelle 4 1
GO:0110165 cellular anatomical entity 1 2
GO:0016020 membrane 2 1

Expansion

Sequence features

A4IB13
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4IB13

Function

Could not find GO biological_process term for this entry.
Molecular functions
Term Name Level Count
GO:0000166 nucleotide binding 3 11
GO:0003824 catalytic activity 1 11
GO:0005488 binding 1 11
GO:0010181 FMN binding 4 11
GO:0016156 fumarate reductase (NADH) activity 5 5
GO:0016491 oxidoreductase activity 2 11
GO:0016627 oxidoreductase activity, acting on the CH-CH group of donors 3 6
GO:0016628 oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor 4 5
GO:0032553 ribonucleotide binding 3 11
GO:0036094 small molecule binding 2 11
GO:0043167 ion binding 2 11
GO:0043168 anion binding 3 11
GO:0097159 organic cyclic compound binding 2 11
GO:0097367 carbohydrate derivative binding 2 11
GO:1901265 nucleoside phosphate binding 3 11
GO:1901363 heterocyclic compound binding 2 11
GO:0000104 succinate dehydrogenase activity 4 1
GO:0008177 succinate dehydrogenase (ubiquinone) activity 5 1
GO:0016635 oxidoreductase activity, acting on the CH-CH group of donors, quinone or related compound as acceptor 4 1

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 133 137 PF00656 0.325
CLV_NRD_NRD_1 124 126 PF00675 0.325
CLV_NRD_NRD_1 331 333 PF00675 0.382
CLV_NRD_NRD_1 394 396 PF00675 0.376
CLV_PCSK_KEX2_1 126 128 PF00082 0.325
CLV_PCSK_KEX2_1 331 333 PF00082 0.382
CLV_PCSK_PC1ET2_1 126 128 PF00082 0.325
CLV_PCSK_SKI1_1 280 284 PF00082 0.382
CLV_PCSK_SKI1_1 403 407 PF00082 0.327
CLV_Separin_Metazoa 91 95 PF03568 0.469
DOC_CKS1_1 420 425 PF01111 0.325
DOC_MAPK_gen_1 249 258 PF00069 0.382
DOC_MAPK_MEF2A_6 249 258 PF00069 0.382
DOC_PP4_FxxP_1 110 113 PF00568 0.425
DOC_PP4_FxxP_1 283 286 PF00568 0.325
DOC_USP7_MATH_1 141 145 PF00917 0.388
DOC_USP7_MATH_1 19 23 PF00917 0.332
DOC_USP7_UBL2_3 396 400 PF12436 0.268
DOC_WW_Pin1_4 135 140 PF00397 0.325
DOC_WW_Pin1_4 217 222 PF00397 0.382
DOC_WW_Pin1_4 419 424 PF00397 0.319
DOC_WW_Pin1_4 432 437 PF00397 0.306
LIG_14-3-3_CanoR_1 169 174 PF00244 0.406
LIG_14-3-3_CanoR_1 311 319 PF00244 0.382
LIG_14-3-3_CanoR_1 348 352 PF00244 0.302
LIG_APCC_ABBA_1 358 363 PF00400 0.382
LIG_APCC_ABBAyCdc20_2 357 363 PF00400 0.382
LIG_BIR_II_1 1 5 PF00653 0.624
LIG_BIR_III_4 344 348 PF00653 0.268
LIG_BRCT_BRCA1_1 349 353 PF00533 0.382
LIG_Clathr_ClatBox_1 258 262 PF01394 0.325
LIG_deltaCOP1_diTrp_1 105 110 PF00928 0.382
LIG_FHA_1 159 165 PF00498 0.415
LIG_FHA_1 198 204 PF00498 0.382
LIG_FHA_1 236 242 PF00498 0.461
LIG_FHA_1 267 273 PF00498 0.306
LIG_FHA_1 279 285 PF00498 0.306
LIG_FHA_1 420 426 PF00498 0.306
LIG_FHA_1 456 462 PF00498 0.325
LIG_FHA_1 50 56 PF00498 0.269
LIG_FHA_2 382 388 PF00498 0.385
LIG_FHA_2 93 99 PF00498 0.387
LIG_LIR_Apic_2 108 113 PF02991 0.425
LIG_LIR_Apic_2 281 286 PF02991 0.327
LIG_LIR_Nem_3 386 391 PF02991 0.325
LIG_LIR_Nem_3 404 409 PF02991 0.196
LIG_LRP6_Inhibitor_1 149 155 PF00058 0.469
LIG_PCNA_PIPBox_1 445 454 PF02747 0.268
LIG_PCNA_yPIPBox_3 167 177 PF02747 0.377
LIG_PCNA_yPIPBox_3 466 477 PF02747 0.310
LIG_Pex14_1 106 110 PF04695 0.425
LIG_SH2_CRK 335 339 PF00017 0.382
LIG_SH2_NCK_1 388 392 PF00017 0.382
LIG_SH2_PTP2 417 420 PF00017 0.325
LIG_SH2_STAP1 333 337 PF00017 0.302
LIG_SH2_STAT3 189 192 PF00017 0.469
LIG_SH2_STAT3 228 231 PF00017 0.382
LIG_SH2_STAT5 153 156 PF00017 0.425
LIG_SH2_STAT5 335 338 PF00017 0.382
LIG_SH2_STAT5 417 420 PF00017 0.315
LIG_SH2_STAT5 427 430 PF00017 0.290
LIG_SH3_3 129 135 PF00018 0.425
LIG_SH3_3 271 277 PF00018 0.306
LIG_SH3_4 396 403 PF00018 0.268
LIG_SUMO_SIM_anti_2 34 39 PF11976 0.350
LIG_SUMO_SIM_par_1 10 16 PF11976 0.400
LIG_SUMO_SIM_par_1 159 166 PF11976 0.302
LIG_SUMO_SIM_par_1 34 39 PF11976 0.291
LIG_TRAF2_1 195 198 PF00917 0.250
LIG_UBA3_1 170 177 PF00899 0.471
LIG_UBA3_1 381 390 PF00899 0.235
LIG_WRC_WIRS_1 107 112 PF05994 0.425
MOD_CK1_1 234 240 PF00069 0.362
MOD_CK1_1 312 318 PF00069 0.325
MOD_CK1_1 97 103 PF00069 0.309
MOD_CK2_1 192 198 PF00069 0.191
MOD_CK2_1 381 387 PF00069 0.351
MOD_CK2_1 398 404 PF00069 0.298
MOD_CK2_1 468 474 PF00069 0.325
MOD_Cter_Amidation 393 396 PF01082 0.235
MOD_GlcNHglycan 15 18 PF01048 0.303
MOD_GlcNHglycan 158 161 PF01048 0.389
MOD_GlcNHglycan 194 197 PF01048 0.408
MOD_GlcNHglycan 21 24 PF01048 0.281
MOD_GlcNHglycan 291 294 PF01048 0.341
MOD_GlcNHglycan 392 395 PF01048 0.371
MOD_GlcNHglycan 400 403 PF01048 0.351
MOD_GlcNHglycan 47 50 PF01048 0.282
MOD_GlcNHglycan 52 55 PF01048 0.293
MOD_GlcNHglycan 70 73 PF01048 0.415
MOD_GlcNHglycan 81 84 PF01048 0.261
MOD_GlcNHglycan 98 102 PF01048 0.195
MOD_GSK3_1 169 176 PF00069 0.428
MOD_GSK3_1 188 195 PF00069 0.382
MOD_GSK3_1 209 216 PF00069 0.337
MOD_GSK3_1 230 237 PF00069 0.327
MOD_GSK3_1 377 384 PF00069 0.290
MOD_GSK3_1 421 428 PF00069 0.350
MOD_GSK3_1 45 52 PF00069 0.269
MOD_N-GLC_1 156 161 PF02516 0.452
MOD_NEK2_1 158 163 PF00069 0.410
MOD_NEK2_1 289 294 PF00069 0.325
MOD_NEK2_1 346 351 PF00069 0.302
MOD_NEK2_1 381 386 PF00069 0.290
MOD_NEK2_1 92 97 PF00069 0.350
MOD_PIKK_1 115 121 PF00454 0.325
MOD_PIKK_1 188 194 PF00454 0.469
MOD_PIKK_1 312 318 PF00454 0.382
MOD_PIKK_1 409 415 PF00454 0.325
MOD_PKA_2 289 295 PF00069 0.306
MOD_PKA_2 347 353 PF00069 0.382
MOD_Plk_1 377 383 PF00069 0.356
MOD_Plk_4 142 148 PF00069 0.430
MOD_Plk_4 158 164 PF00069 0.234
MOD_Plk_4 220 226 PF00069 0.306
MOD_Plk_4 278 284 PF00069 0.378
MOD_Plk_4 377 383 PF00069 0.235
MOD_Plk_4 468 474 PF00069 0.306
MOD_Plk_4 76 82 PF00069 0.302
MOD_ProDKin_1 135 141 PF00069 0.325
MOD_ProDKin_1 217 223 PF00069 0.382
MOD_ProDKin_1 419 425 PF00069 0.319
MOD_ProDKin_1 432 438 PF00069 0.306
TRG_DiLeu_BaEn_2 75 81 PF01217 0.302
TRG_DiLeu_BaLyEn_6 166 171 PF01217 0.469
TRG_ENDOCYTIC_2 335 338 PF00928 0.382
TRG_ENDOCYTIC_2 388 391 PF00928 0.350
TRG_ENDOCYTIC_2 417 420 PF00928 0.338
TRG_ER_diArg_1 331 333 PF00400 0.382
TRG_Pf-PMV_PEXEL_1 94 98 PF00026 0.404

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1I5C0 Leptomonas seymouri 78% 82%
A0A0S4IHN0 Bodo saltans 59% 100%
A0A0S4KND3 Bodo saltans 39% 95%
A0A1S3YEG8 Nicotiana tabacum 27% 77%
A0A1S4BJT3 Nicotiana tabacum 28% 76%
A0A1X0NPF8 Trypanosomatidae 36% 73%
A0A3S7WPX2 Leishmania donovani 35% 74%
A0A3S7X915 Leishmania donovani 100% 100%
A0A422MX37 Trypanosoma rangeli 63% 75%
A0R4S9 Mycolicibacterium smegmatis (strain ATCC 700084 / mc(2)155) 24% 87%
A4HME0 Leishmania braziliensis 80% 100%
A4HME1 Leishmania braziliensis 79% 100%
A4HTA6 Leishmania infantum 34% 100%
B2GCE0 Limosilactobacillus fermentum (strain NBRC 3956 / LMG 18251) 28% 80%
C8WLE3 Eggerthella lenta (strain ATCC 25559 / DSM 2243 / CCUG 17323 / JCM 9979 / KCTC 3265 / NCTC 11813 / VPI 0255 / 1899 B) 30% 82%
C8WLM1 Eggerthella lenta (strain ATCC 25559 / DSM 2243 / CCUG 17323 / JCM 9979 / KCTC 3265 / NCTC 11813 / VPI 0255 / 1899 B) 25% 88%
D9PU00 Methanothermobacter marburgensis (strain ATCC BAA-927 / DSM 2133 / JCM 14651 / NBRC 100331 / OCM 82 / Marburg) 28% 90%
E9AEU2 Leishmania major 96% 100%
E9AL95 Leishmania mexicana (strain MHOM/GT/2001/U1103) 36% 100%
E9B5Z8 Leishmania mexicana (strain MHOM/GT/2001/U1103) 94% 100%
G4V4G6 Serratia sp. (strain ATCC 39006) 27% 84%
O06913 Helicobacter pylori (strain ATCC 700392 / 26695) 29% 69%
O13755 Schizosaccharomyces pombe (strain 972 / ATCC 24843) 39% 96%
P00363 Escherichia coli (strain K12) 29% 82%
P08065 Bacillus subtilis (strain 168) 25% 84%
P0AC41 Escherichia coli (strain K12) 30% 84%
P0AC42 Escherichia coli O6:H1 (strain CFT073 / ATCC 700928 / UPEC) 30% 84%
P0AC43 Escherichia coli O157:H7 30% 84%
P0C278 Shewanella frigidimarina 37% 87%
P10902 Escherichia coli (strain K12) 27% 92%
P20922 Proteus vulgaris 29% 83%
P21375 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 38% 99%
P32614 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 37% 100%
P38032 Bacillus subtilis (strain 168) 25% 93%
P44894 Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd) 27% 83%
P64175 Mycobacterium bovis (strain ATCC BAA-935 / AF2122/97) 27% 85%
P65500 Mycobacterium bovis (strain ATCC BAA-935 / AF2122/97) 25% 94%
P71864 Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) 26% 88%
P74562 Synechocystis sp. (strain PCC 6803 / Kazusa) 28% 90%
P83223 Shewanella oneidensis (strain MR-1) 33% 83%
P9WJJ8 Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh) 25% 94%
P9WJJ9 Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) 25% 94%
P9WN90 Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh) 27% 85%
P9WN91 Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) 27% 85%
Q07WU7 Shewanella frigidimarina (strain NCIMB 400) 37% 83%
Q49617 Mycobacterium leprae (strain TN) 27% 94%
Q4QIK9 Leishmania major 36% 100%
Q4WR24 Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100) 25% 83%
Q51363 Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1) 28% 92%
Q60356 Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440) 28% 92%
Q6Z836 Oryza sativa subsp. japonica 27% 77%
Q7D5C1 Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh) 26% 87%
Q7M827 Wolinella succinogenes (strain ATCC 29543 / DSM 1740 / LMG 7466 / NCTC 11488 / FDC 602W) 29% 81%
Q8CVD0 Shewanella oneidensis (strain MR-1) 34% 85%
Q8U8J4 Agrobacterium fabrum (strain C58 / ATCC 33970) 29% 95%
Q8XA23 Escherichia coli O157:H7 27% 92%
Q8XNE2 Clostridium perfringens (strain 13 / Type A) 27% 100%
Q8XQG4 Ralstonia solanacearum (strain GMI1000) 25% 92%
Q8XWM7 Ralstonia solanacearum (strain GMI1000) 29% 93%
Q8YXJ6 Nostoc sp. (strain PCC 7120 / SAG 25.82 / UTEX 2576) 29% 86%
Q8Z4K0 Salmonella typhi 26% 92%
Q8ZD80 Yersinia pestis 26% 93%
Q8ZMX9 Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720) 26% 92%
Q8ZQU3 Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720) 30% 84%
Q92R32 Rhizobium meliloti (strain 1021) 28% 93%
Q94AY1 Arabidopsis thaliana 28% 76%
Q97K95 Clostridium acetobutylicum (strain ATCC 824 / DSM 792 / JCM 1419 / LMG 5710 / VKM B-1787) 26% 100%
Q9A4C3 Caulobacter vibrioides (strain ATCC 19089 / CB15) 27% 97%
Q9HNZ0 Halobacterium salinarum (strain ATCC 700922 / JCM 11081 / NRC-1) 27% 97%
Q9KPA4 Vibrio cholerae serotype O1 (strain ATCC 39315 / El Tor Inaba N16961) 27% 93%
Q9X8N8 Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145) 27% 85%
Q9Z4P0 Shewanella frigidimarina (strain NCIMB 400) 35% 84%
Q9ZMP0 Helicobacter pylori (strain J99 / ATCC 700824) 29% 69%
V3TQ67 Serratia sp. (strain ATCC 39006) 28% 83%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS