Putative NADH-dependent fumarate reductase

Quick info Annotations Localization Phosphorylation Abundance Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

NADH-dependent fumarate reductase - putative

Species:

Leishmania infantum

UniProt:

A4IB12_LEIIN

TriTrypDb:

LINF_350016600

Length:

1147

Annotations

Annotations by Jardim et al.

Tricarboxylic acid cycle, NADH-dependent fumarate reductase

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 15

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 16

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 19
NetGPI	no	yes: 0, no: 19

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Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0005777	peroxisome	6	1
GO:0005815	microtubule organizing center	2	1
GO:0020015	glycosome	7	1
GO:0036064	ciliary basal body	3	1
GO:0042579	microbody	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1

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Phosphorylation

Promastigote/Amastigote: 9

Abundance

Amastigote (protein)


Source	Evidence on protein	Close homologs
Pescher et al. (upgregulation)	no	yes: 0

Promastigote and amastigote


Source	Evidence on protein	Close homologs
Lahav et al. - mRNA - Protein

Expansion

Sequence features

A4IB12

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4IB12

Function

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Biological processes
Term	Name	Level	Count
GO:0006807	nitrogen compound metabolic process	2	20
GO:0008152	metabolic process	1	20
GO:0017013	protein flavinylation	5	20
GO:0019538	protein metabolic process	3	20
GO:0036211	protein modification process	4	20
GO:0043170	macromolecule metabolic process	3	20
GO:0043412	macromolecule modification	4	20
GO:0044238	primary metabolic process	2	20
GO:0071704	organic substance metabolic process	2	20
GO:1901564	organonitrogen compound metabolic process	3	20

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Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	19
GO:0003824	catalytic activity	1	20
GO:0005488	binding	1	20
GO:0010181	FMN binding	4	19
GO:0016156	fumarate reductase (NADH) activity	5	1
GO:0016491	oxidoreductase activity	2	20
GO:0016627	oxidoreductase activity, acting on the CH-CH group of donors	3	1
GO:0016628	oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor	4	1
GO:0016740	transferase activity	2	20
GO:0032553	ribonucleotide binding	3	19

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Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	511	515	PF00656	0.299
CLV_NRD_NRD_1	1006	1008	PF00675	0.337
CLV_NRD_NRD_1	182	184	PF00675	0.334
CLV_NRD_NRD_1	338	340	PF00675	0.400
CLV_NRD_NRD_1	502	504	PF00675	0.297
CLV_NRD_NRD_1	832	834	PF00675	0.364
CLV_NRD_NRD_1	992	994	PF00675	0.434
CLV_PCSK_FUR_1	378	382	PF00082	0.441
CLV_PCSK_KEX2_1	257	259	PF00082	0.259
CLV_PCSK_KEX2_1	338	340	PF00082	0.312

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P690	Leptomonas seymouri	80%	100%
A0A0N1I186	Leptomonas seymouri	59%	93%
A0A0S4IK89	Bodo saltans	55%	96%
A0A0S4IZL1	Bodo saltans	56%	96%
A0A1X0NJ99	Trypanosomatidae	60%	93%
A0A3Q8IJ78	Leishmania donovani	100%	100%
A0A3S5H7Y6	Leishmania donovani	59%	96%
A0A422NIA0	Trypanosoma rangeli	62%	89%
A4HMB4	Leishmania braziliensis	59%	100%
A4HMD9	Leishmania braziliensis	90%	100%

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