LeishMANIAdb
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Putative NADH-dependent fumarate reductase

Quick info Annotations Function or PPIs Localization Phosphorylation Abundance Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Putative NADH-dependent fumarate reductase
Gene product:
NADH-dependent fumarate reductase - putative
Species:
Leishmania infantum
UniProt:
A4IB12_LEIIN
TriTrypDb:
LINF_350016600
Length:
1147

Annotations

Annotations by Jardim et al.

Tricarboxylic acid cycle, NADH-dependent fumarate reductase

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. yes yes: 15
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 16
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 19
NetGPI no yes: 0, no: 19
Cellular components
Term Name Level Count
GO:0005737 cytoplasm 2 1
GO:0005777 peroxisome 6 1
GO:0005815 microtubule organizing center 2 1
GO:0020015 glycosome 7 1
GO:0036064 ciliary basal body 3 1
GO:0042579 microbody 5 1
GO:0043226 organelle 2 1
GO:0043227 membrane-bounded organelle 3 1
GO:0043229 intracellular organelle 3 1
GO:0043231 intracellular membrane-bounded organelle 4 1
GO:0110165 cellular anatomical entity 1 1

Phosphorylation

Promastigote/Amastigote: 9

Abundance

Amastigote (protein)
Source Evidence on protein Close homologs
Pescher et al. (upgregulation) no yes: 0
Promastigote and amastigote
Source Evidence on protein Close homologs
Lahav et al.
- mRNA
- Protein

Expansion

Sequence features

A4IB12
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4IB12

Function

Biological processes
Term Name Level Count
GO:0006807 nitrogen compound metabolic process 2 20
GO:0008152 metabolic process 1 20
GO:0017013 protein flavinylation 5 20
GO:0019538 protein metabolic process 3 20
GO:0036211 protein modification process 4 20
GO:0043170 macromolecule metabolic process 3 20
GO:0043412 macromolecule modification 4 20
GO:0044238 primary metabolic process 2 20
GO:0071704 organic substance metabolic process 2 20
GO:1901564 organonitrogen compound metabolic process 3 20
Molecular functions
Term Name Level Count
GO:0000166 nucleotide binding 3 19
GO:0003824 catalytic activity 1 20
GO:0005488 binding 1 20
GO:0010181 FMN binding 4 19
GO:0016491 oxidoreductase activity 2 20
GO:0016740 transferase activity 2 20
GO:0032553 ribonucleotide binding 3 19
GO:0036094 small molecule binding 2 19
GO:0043167 ion binding 2 20
GO:0043168 anion binding 3 19
GO:0043169 cation binding 3 20
GO:0046872 metal ion binding 4 20
GO:0097159 organic cyclic compound binding 2 19
GO:0097367 carbohydrate derivative binding 2 19
GO:1901265 nucleoside phosphate binding 3 19
GO:1901363 heterocyclic compound binding 2 19
GO:0016156 fumarate reductase (NADH) activity 5 1
GO:0016627 oxidoreductase activity, acting on the CH-CH group of donors 3 1
GO:0016628 oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor 4 1

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 511 515 PF00656 0.299
CLV_NRD_NRD_1 1006 1008 PF00675 0.337
CLV_NRD_NRD_1 182 184 PF00675 0.334
CLV_NRD_NRD_1 338 340 PF00675 0.400
CLV_NRD_NRD_1 502 504 PF00675 0.297
CLV_NRD_NRD_1 832 834 PF00675 0.364
CLV_NRD_NRD_1 992 994 PF00675 0.434
CLV_PCSK_FUR_1 378 382 PF00082 0.441
CLV_PCSK_KEX2_1 257 259 PF00082 0.259
CLV_PCSK_KEX2_1 338 340 PF00082 0.312
CLV_PCSK_KEX2_1 380 382 PF00082 0.433
CLV_PCSK_KEX2_1 504 506 PF00082 0.289
CLV_PCSK_KEX2_1 832 834 PF00082 0.364
CLV_PCSK_KEX2_1 992 994 PF00082 0.506
CLV_PCSK_PC1ET2_1 257 259 PF00082 0.259
CLV_PCSK_PC1ET2_1 380 382 PF00082 0.433
CLV_PCSK_PC1ET2_1 504 506 PF00082 0.238
CLV_PCSK_SKI1_1 1008 1012 PF00082 0.320
CLV_PCSK_SKI1_1 1055 1059 PF00082 0.317
CLV_PCSK_SKI1_1 1118 1122 PF00082 0.319
CLV_PCSK_SKI1_1 130 134 PF00082 0.436
CLV_PCSK_SKI1_1 27 31 PF00082 0.479
CLV_PCSK_SKI1_1 298 302 PF00082 0.248
CLV_PCSK_SKI1_1 338 342 PF00082 0.322
CLV_PCSK_SKI1_1 363 367 PF00082 0.514
CLV_PCSK_SKI1_1 380 384 PF00082 0.367
CLV_PCSK_SKI1_1 538 542 PF00082 0.370
CLV_PCSK_SKI1_1 565 569 PF00082 0.387
CLV_PCSK_SKI1_1 727 731 PF00082 0.358
CLV_PCSK_SKI1_1 783 787 PF00082 0.354
CLV_PCSK_SKI1_1 833 837 PF00082 0.339
CLV_PCSK_SKI1_1 872 876 PF00082 0.338
CLV_PCSK_SKI1_1 997 1001 PF00082 0.339
DEG_SPOP_SBC_1 288 292 PF00917 0.450
DOC_ANK_TNKS_1 555 562 PF00023 0.227
DOC_CKS1_1 800 805 PF01111 0.299
DOC_CYCLIN_RxL_1 1052 1062 PF00134 0.364
DOC_CYCLIN_RxL_1 295 305 PF00134 0.307
DOC_CYCLIN_yClb1_LxF_4 727 733 PF00134 0.307
DOC_CYCLIN_yCln2_LP_2 488 494 PF00134 0.259
DOC_MAPK_DCC_7 512 522 PF00069 0.348
DOC_MAPK_gen_1 1002 1011 PF00069 0.452
DOC_MAPK_gen_1 257 263 PF00069 0.404
DOC_MAPK_gen_1 556 564 PF00069 0.324
DOC_MAPK_gen_1 832 838 PF00069 0.280
DOC_MAPK_MEF2A_6 483 492 PF00069 0.364
DOC_MAPK_MEF2A_6 628 637 PF00069 0.408
DOC_PIKK_1 529 536 PF02985 0.280
DOC_PP1_RVXF_1 906 913 PF00149 0.310
DOC_PP2B_LxvP_1 488 491 PF13499 0.259
DOC_PP4_FxxP_1 912 915 PF00568 0.299
DOC_USP7_MATH_1 309 313 PF00917 0.340
DOC_USP7_MATH_1 398 402 PF00917 0.408
DOC_USP7_MATH_1 510 514 PF00917 0.364
DOC_USP7_MATH_1 550 554 PF00917 0.407
DOC_USP7_UBL2_3 1121 1125 PF12436 0.348
DOC_USP7_UBL2_3 628 632 PF12436 0.396
DOC_USP7_UBL2_3 64 68 PF12436 0.280
DOC_USP7_UBL2_3 723 727 PF12436 0.417
DOC_WW_Pin1_4 33 38 PF00397 0.582
DOC_WW_Pin1_4 513 518 PF00397 0.299
DOC_WW_Pin1_4 596 601 PF00397 0.460
DOC_WW_Pin1_4 799 804 PF00397 0.299
DOC_WW_Pin1_4 812 817 PF00397 0.299
DOC_WW_Pin1_4 826 831 PF00397 0.310
DOC_WW_Pin1_4 942 947 PF00397 0.310
LIG_14-3-3_CanoR_1 207 212 PF00244 0.238
LIG_14-3-3_CanoR_1 538 543 PF00244 0.374
LIG_14-3-3_CanoR_1 571 581 PF00244 0.364
LIG_14-3-3_CanoR_1 690 698 PF00244 0.404
LIG_Actin_WH2_2 1083 1098 PF00022 0.364
LIG_Actin_WH2_2 41 59 PF00022 0.373
LIG_BIR_II_1 1 5 PF00653 0.693
LIG_BRCT_BRCA1_1 1038 1042 PF00533 0.408
LIG_BRCT_BRCA1_1 1066 1070 PF00533 0.344
LIG_BRCT_BRCA1_1 289 293 PF00533 0.364
LIG_Clathr_ClatBox_1 637 641 PF01394 0.299
LIG_FHA_1 1082 1088 PF00498 0.316
LIG_FHA_1 1090 1096 PF00498 0.312
LIG_FHA_1 324 330 PF00498 0.272
LIG_FHA_1 428 434 PF00498 0.255
LIG_FHA_1 471 477 PF00498 0.366
LIG_FHA_1 53 59 PF00498 0.359
LIG_FHA_1 552 558 PF00498 0.284
LIG_FHA_1 615 621 PF00498 0.437
LIG_FHA_1 646 652 PF00498 0.299
LIG_FHA_1 658 664 PF00498 0.299
LIG_FHA_1 800 806 PF00498 0.299
LIG_FHA_1 843 849 PF00498 0.299
LIG_FHA_1 889 895 PF00498 0.337
LIG_FHA_2 1054 1060 PF00498 0.305
LIG_FHA_2 1134 1140 PF00498 0.423
LIG_FHA_2 271 277 PF00498 0.299
LIG_FHA_2 302 308 PF00498 0.414
LIG_FHA_2 348 354 PF00498 0.427
LIG_FHA_2 547 553 PF00498 0.332
LIG_FHA_2 634 640 PF00498 0.327
LIG_FHA_2 946 952 PF00498 0.259
LIG_Integrin_RGD_1 932 934 PF01839 0.409
LIG_Integrin_RGDW_4 932 935 PF00362 0.409
LIG_LIR_Apic_2 660 665 PF02991 0.324
LIG_LIR_Gen_1 210 218 PF02991 0.259
LIG_LIR_Gen_1 259 266 PF02991 0.335
LIG_LIR_Gen_1 274 284 PF02991 0.277
LIG_LIR_Gen_1 886 897 PF02991 0.364
LIG_LIR_Nem_3 1051 1057 PF02991 0.322
LIG_LIR_Nem_3 210 216 PF02991 0.421
LIG_LIR_Nem_3 259 263 PF02991 0.335
LIG_LIR_Nem_3 274 280 PF02991 0.277
LIG_LIR_Nem_3 342 347 PF02991 0.429
LIG_LIR_Nem_3 352 357 PF02991 0.348
LIG_LIR_Nem_3 886 892 PF02991 0.403
LIG_OCRL_FandH_1 993 1005 PF00620 0.467
LIG_PCNA_yPIPBox_3 853 864 PF02747 0.296
LIG_Pex14_2 1070 1074 PF04695 0.327
LIG_Pex14_2 725 729 PF04695 0.280
LIG_PTB_Apo_2 340 347 PF02174 0.503
LIG_PTB_Phospho_1 340 346 PF10480 0.503
LIG_REV1ctd_RIR_1 450 459 PF16727 0.386
LIG_REV1ctd_RIR_1 997 1006 PF16727 0.325
LIG_SH2_CRK 1054 1058 PF00017 0.392
LIG_SH2_CRK 714 718 PF00017 0.334
LIG_SH2_CRK 944 948 PF00017 0.334
LIG_SH2_GRB2like 277 280 PF00017 0.305
LIG_SH2_GRB2like 733 736 PF00017 0.319
LIG_SH2_NCK_1 213 217 PF00017 0.408
LIG_SH2_NCK_1 944 948 PF00017 0.334
LIG_SH2_PTP2 797 800 PF00017 0.358
LIG_SH2_SRC 320 323 PF00017 0.299
LIG_SH2_STAP1 1061 1065 PF00017 0.374
LIG_SH2_STAP1 277 281 PF00017 0.310
LIG_SH2_STAP1 289 293 PF00017 0.310
LIG_SH2_STAP1 316 320 PF00017 0.302
LIG_SH2_STAP1 54 58 PF00017 0.334
LIG_SH2_STAT3 607 610 PF00017 0.408
LIG_SH2_STAT5 203 206 PF00017 0.330
LIG_SH2_STAT5 346 349 PF00017 0.421
LIG_SH2_STAT5 354 357 PF00017 0.358
LIG_SH2_STAT5 54 57 PF00017 0.369
LIG_SH2_STAT5 662 665 PF00017 0.334
LIG_SH2_STAT5 714 717 PF00017 0.337
LIG_SH2_STAT5 797 800 PF00017 0.304
LIG_SH2_STAT5 807 810 PF00017 0.290
LIG_SH3_3 1026 1032 PF00018 0.280
LIG_SH3_3 1096 1102 PF00018 0.297
LIG_SH3_3 238 244 PF00018 0.321
LIG_SH3_3 57 63 PF00018 0.384
LIG_SH3_3 650 656 PF00018 0.299
LIG_SH3_3 828 834 PF00018 0.408
LIG_SUMO_SIM_par_1 366 374 PF11976 0.408
LIG_SUMO_SIM_par_1 412 417 PF11976 0.333
LIG_SUMO_SIM_par_1 472 480 PF11976 0.318
LIG_SUMO_SIM_par_1 490 496 PF11976 0.192
LIG_SUMO_SIM_par_1 890 896 PF11976 0.422
LIG_SUMO_SIM_par_1 9 14 PF11976 0.570
LIG_SUMO_SIM_par_1 945 952 PF11976 0.272
LIG_TRAF2_2 1080 1085 PF00917 0.400
LIG_TYR_ITIM 1052 1057 PF00017 0.334
LIG_TYR_ITIM 211 216 PF00017 0.403
LIG_UBA3_1 189 197 PF00899 0.396
MOD_CDK_SPxK_1 826 832 PF00069 0.408
MOD_CDK_SPxxK_3 33 40 PF00069 0.475
MOD_CDK_SPxxK_3 826 833 PF00069 0.408
MOD_CK1_1 1036 1042 PF00069 0.438
MOD_CK1_1 1050 1056 PF00069 0.284
MOD_CK1_1 164 170 PF00069 0.344
MOD_CK1_1 475 481 PF00069 0.299
MOD_CK1_1 513 519 PF00069 0.364
MOD_CK1_1 576 582 PF00069 0.435
MOD_CK1_1 613 619 PF00069 0.380
MOD_CK1_1 657 663 PF00069 0.437
MOD_CK1_1 691 697 PF00069 0.299
MOD_CK1_1 707 713 PF00069 0.299
MOD_CK1_1 826 832 PF00069 0.435
MOD_CK1_1 945 951 PF00069 0.274
MOD_CK1_1 95 101 PF00069 0.299
MOD_CK2_1 1053 1059 PF00069 0.324
MOD_CK2_1 1133 1139 PF00069 0.426
MOD_CK2_1 546 552 PF00069 0.324
MOD_CK2_1 855 861 PF00069 0.299
MOD_CK2_1 882 888 PF00069 0.501
MOD_GlcNHglycan 1096 1099 PF01048 0.388
MOD_GlcNHglycan 111 114 PF01048 0.312
MOD_GlcNHglycan 1143 1146 PF01048 0.655
MOD_GlcNHglycan 16 19 PF01048 0.429
MOD_GlcNHglycan 226 229 PF01048 0.319
MOD_GlcNHglycan 273 276 PF01048 0.299
MOD_GlcNHglycan 400 403 PF01048 0.260
MOD_GlcNHglycan 425 428 PF01048 0.299
MOD_GlcNHglycan 430 433 PF01048 0.299
MOD_GlcNHglycan 459 462 PF01048 0.296
MOD_GlcNHglycan 575 578 PF01048 0.417
MOD_GlcNHglycan 6 9 PF01048 0.534
MOD_GlcNHglycan 670 673 PF01048 0.299
MOD_GlcNHglycan 706 709 PF01048 0.337
MOD_GlcNHglycan 816 819 PF01048 0.309
MOD_GlcNHglycan 824 828 PF01048 0.311
MOD_GlcNHglycan 971 974 PF01048 0.307
MOD_GSK3_1 1053 1060 PF00069 0.344
MOD_GSK3_1 1133 1140 PF00069 0.434
MOD_GSK3_1 164 171 PF00069 0.334
MOD_GSK3_1 283 290 PF00069 0.379
MOD_GSK3_1 349 356 PF00069 0.414
MOD_GSK3_1 423 430 PF00069 0.246
MOD_GSK3_1 472 479 PF00069 0.392
MOD_GSK3_1 48 55 PF00069 0.396
MOD_GSK3_1 520 527 PF00069 0.259
MOD_GSK3_1 534 541 PF00069 0.285
MOD_GSK3_1 546 553 PF00069 0.284
MOD_GSK3_1 572 579 PF00069 0.240
MOD_GSK3_1 588 595 PF00069 0.305
MOD_GSK3_1 609 616 PF00069 0.324
MOD_GSK3_1 801 808 PF00069 0.262
MOD_GSK3_1 819 826 PF00069 0.299
MOD_GSK3_1 878 885 PF00069 0.428
MOD_N-GLC_1 126 131 PF02516 0.377
MOD_N-GLC_1 168 173 PF02516 0.355
MOD_N-GLC_1 229 234 PF02516 0.392
MOD_N-GLC_1 534 539 PF02516 0.278
MOD_N-GLC_1 657 662 PF02516 0.349
MOD_N-GLC_1 717 722 PF02516 0.400
MOD_NEK2_1 1089 1094 PF00069 0.345
MOD_NEK2_1 168 173 PF00069 0.397
MOD_NEK2_1 470 475 PF00069 0.351
MOD_NEK2_1 48 53 PF00069 0.376
MOD_NEK2_1 551 556 PF00069 0.359
MOD_NEK2_1 572 577 PF00069 0.272
MOD_NEK2_1 633 638 PF00069 0.287
MOD_NEK2_1 668 673 PF00069 0.299
MOD_NEK2_1 717 722 PF00069 0.428
MOD_NEK2_1 918 923 PF00069 0.278
MOD_NEK2_2 309 314 PF00069 0.319
MOD_PIKK_1 493 499 PF00454 0.238
MOD_PIKK_1 691 697 PF00454 0.392
MOD_PIKK_1 789 795 PF00454 0.397
MOD_PK_1 472 478 PF00069 0.322
MOD_PK_1 742 748 PF00069 0.259
MOD_PKA_1 879 885 PF00069 0.495
MOD_PKA_2 224 230 PF00069 0.310
MOD_PKA_2 347 353 PF00069 0.413
MOD_PKA_2 454 460 PF00069 0.299
MOD_PKA_2 668 674 PF00069 0.299
MOD_Plk_1 1050 1056 PF00069 0.322
MOD_Plk_1 168 174 PF00069 0.348
MOD_Plk_1 352 358 PF00069 0.415
MOD_Plk_1 887 893 PF00069 0.464
MOD_Plk_1 95 101 PF00069 0.307
MOD_Plk_2-3 369 375 PF00069 0.563
MOD_Plk_2-3 819 825 PF00069 0.227
MOD_Plk_4 490 496 PF00069 0.291
MOD_Plk_4 538 544 PF00069 0.350
MOD_Plk_4 576 582 PF00069 0.390
MOD_Plk_4 599 605 PF00069 0.308
MOD_Plk_4 6 12 PF00069 0.601
MOD_Plk_4 633 639 PF00069 0.327
MOD_Plk_4 83 89 PF00069 0.337
MOD_Plk_4 855 861 PF00069 0.299
MOD_Plk_4 872 878 PF00069 0.344
MOD_Plk_4 888 894 PF00069 0.348
MOD_ProDKin_1 33 39 PF00069 0.576
MOD_ProDKin_1 513 519 PF00069 0.299
MOD_ProDKin_1 596 602 PF00069 0.460
MOD_ProDKin_1 799 805 PF00069 0.299
MOD_ProDKin_1 812 818 PF00069 0.299
MOD_ProDKin_1 826 832 PF00069 0.310
MOD_ProDKin_1 942 948 PF00069 0.310
MOD_SUMO_rev_2 417 422 PF00179 0.307
MOD_SUMO_rev_2 978 984 PF00179 0.330
TRG_DiLeu_BaEn_2 1037 1043 PF01217 0.408
TRG_DiLeu_BaLyEn_6 568 573 PF01217 0.259
TRG_DiLeu_BaLyEn_6 936 941 PF01217 0.259
TRG_ENDOCYTIC_2 1054 1057 PF00928 0.324
TRG_ENDOCYTIC_2 213 216 PF00928 0.372
TRG_ENDOCYTIC_2 277 280 PF00928 0.308
TRG_ENDOCYTIC_2 316 319 PF00928 0.316
TRG_ENDOCYTIC_2 714 717 PF00928 0.334
TRG_ENDOCYTIC_2 767 770 PF00928 0.312
TRG_ENDOCYTIC_2 797 800 PF00928 0.275
TRG_ENDOCYTIC_2 944 947 PF00928 0.334
TRG_ER_diArg_1 337 339 PF00400 0.336
TRG_ER_diArg_1 556 559 PF00400 0.245
TRG_ER_diArg_1 831 833 PF00400 0.366
TRG_ER_diArg_1 992 994 PF00400 0.469
TRG_NLS_MonoExtN_4 378 384 PF00514 0.512
TRG_Pf-PMV_PEXEL_1 1055 1059 PF00026 0.379
TRG_Pf-PMV_PEXEL_1 142 146 PF00026 0.332
TRG_Pf-PMV_PEXEL_1 298 302 PF00026 0.359
TRG_Pf-PMV_PEXEL_1 483 487 PF00026 0.386
TRG_PTS1 1144 1147 PF00515 0.648

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N0P690 Leptomonas seymouri 80% 100%
A0A0N1I186 Leptomonas seymouri 59% 93%
A0A0S4IK89 Bodo saltans 55% 96%
A0A0S4IZL1 Bodo saltans 56% 96%
A0A1X0NJ99 Trypanosomatidae 60% 93%
A0A3Q8IJ78 Leishmania donovani 100% 100%
A0A3S5H7Y6 Leishmania donovani 59% 96%
A0A422NIA0 Trypanosoma rangeli 62% 89%
A4HMB4 Leishmania braziliensis 59% 100%
A4HMD9 Leishmania braziliensis 90% 100%
A4IAY0 Leishmania infantum 59% 100%
C9ZNL3 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 58% 100%
D0A275 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 59% 93%
E9AEQ8 Leishmania major 60% 100%
E9AEU1 Leishmania major 98% 100%
E9B5W3 Leishmania mexicana (strain MHOM/GT/2001/U1103) 59% 100%
E9B5Z7 Leishmania mexicana (strain MHOM/GT/2001/U1103) 96% 100%
V5DJK9 Trypanosoma cruzi 62% 94%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS