LeishMANIAdb
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Spc7 domain-containing protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
Spc7 domain-containing protein
Gene product:
hypothetical protein - conserved
Species:
Leishmania infantum
UniProt:
A4IB06_LEIIN
TriTrypDb:
LINF_350015600
Length:
692

Annotations

Annotations by Jardim et al.

Uncharacterized Protein, Uncharacterized

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 5
NetGPI no yes: 0, no: 5
Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4IB06
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4IB06

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 211 215 PF00656 0.612
CLV_NRD_NRD_1 101 103 PF00675 0.614
CLV_NRD_NRD_1 142 144 PF00675 0.737
CLV_NRD_NRD_1 152 154 PF00675 0.561
CLV_NRD_NRD_1 234 236 PF00675 0.641
CLV_NRD_NRD_1 394 396 PF00675 0.646
CLV_NRD_NRD_1 48 50 PF00675 0.693
CLV_NRD_NRD_1 566 568 PF00675 0.493
CLV_NRD_NRD_1 607 609 PF00675 0.683
CLV_NRD_NRD_1 629 631 PF00675 0.781
CLV_NRD_NRD_1 643 645 PF00675 0.516
CLV_NRD_NRD_1 662 664 PF00675 0.617
CLV_PCSK_FUR_1 140 144 PF00082 0.668
CLV_PCSK_FUR_1 674 678 PF00082 0.457
CLV_PCSK_KEX2_1 10 12 PF00082 0.611
CLV_PCSK_KEX2_1 103 105 PF00082 0.609
CLV_PCSK_KEX2_1 139 141 PF00082 0.597
CLV_PCSK_KEX2_1 142 144 PF00082 0.737
CLV_PCSK_KEX2_1 152 154 PF00082 0.561
CLV_PCSK_KEX2_1 234 236 PF00082 0.636
CLV_PCSK_KEX2_1 394 396 PF00082 0.606
CLV_PCSK_KEX2_1 48 50 PF00082 0.686
CLV_PCSK_KEX2_1 565 567 PF00082 0.470
CLV_PCSK_KEX2_1 607 609 PF00082 0.683
CLV_PCSK_KEX2_1 643 645 PF00082 0.574
CLV_PCSK_KEX2_1 662 664 PF00082 0.617
CLV_PCSK_KEX2_1 676 678 PF00082 0.514
CLV_PCSK_PC1ET2_1 10 12 PF00082 0.611
CLV_PCSK_PC1ET2_1 103 105 PF00082 0.609
CLV_PCSK_PC1ET2_1 139 141 PF00082 0.574
CLV_PCSK_PC1ET2_1 676 678 PF00082 0.459
CLV_PCSK_PC7_1 135 141 PF00082 0.511
CLV_PCSK_SKI1_1 135 139 PF00082 0.568
CLV_PCSK_SKI1_1 578 582 PF00082 0.438
DEG_SCF_FBW7_1 78 85 PF00400 0.575
DEG_SIAH_1 549 557 PF03145 0.645
DEG_SPOP_SBC_1 356 360 PF00917 0.644
DEG_SPOP_SBC_1 386 390 PF00917 0.650
DEG_SPOP_SBC_1 39 43 PF00917 0.599
DEG_SPOP_SBC_1 600 604 PF00917 0.626
DOC_CKS1_1 190 195 PF01111 0.621
DOC_CKS1_1 226 231 PF01111 0.618
DOC_CKS1_1 303 308 PF01111 0.623
DOC_CKS1_1 498 503 PF01111 0.612
DOC_CYCLIN_RxL_1 410 421 PF00134 0.641
DOC_CYCLIN_yCln2_LP_2 226 232 PF00134 0.618
DOC_MAPK_gen_1 507 515 PF00069 0.566
DOC_MAPK_MEF2A_6 428 435 PF00069 0.650
DOC_PP2B_LxvP_1 408 411 PF13499 0.574
DOC_PP2B_LxvP_1 596 599 PF13499 0.645
DOC_PP4_MxPP_1 1 4 PF00568 0.646
DOC_USP7_MATH_1 105 109 PF00917 0.754
DOC_USP7_MATH_1 141 145 PF00917 0.666
DOC_USP7_MATH_1 245 249 PF00917 0.661
DOC_USP7_MATH_1 255 259 PF00917 0.724
DOC_USP7_MATH_1 262 266 PF00917 0.686
DOC_USP7_MATH_1 322 326 PF00917 0.641
DOC_USP7_MATH_1 350 354 PF00917 0.784
DOC_USP7_MATH_1 377 381 PF00917 0.673
DOC_USP7_MATH_1 402 406 PF00917 0.662
DOC_USP7_MATH_1 411 415 PF00917 0.592
DOC_USP7_MATH_1 480 484 PF00917 0.560
DOC_USP7_MATH_1 496 500 PF00917 0.591
DOC_USP7_MATH_1 509 513 PF00917 0.555
DOC_USP7_MATH_1 601 605 PF00917 0.598
DOC_USP7_MATH_1 629 633 PF00917 0.798
DOC_USP7_MATH_1 635 639 PF00917 0.713
DOC_USP7_MATH_1 661 665 PF00917 0.579
DOC_USP7_MATH_1 94 98 PF00917 0.639
DOC_USP7_MATH_2 28 34 PF00917 0.657
DOC_WW_Pin1_4 120 125 PF00397 0.610
DOC_WW_Pin1_4 154 159 PF00397 0.615
DOC_WW_Pin1_4 182 187 PF00397 0.671
DOC_WW_Pin1_4 189 194 PF00397 0.669
DOC_WW_Pin1_4 225 230 PF00397 0.599
DOC_WW_Pin1_4 24 29 PF00397 0.659
DOC_WW_Pin1_4 246 251 PF00397 0.787
DOC_WW_Pin1_4 258 263 PF00397 0.584
DOC_WW_Pin1_4 299 304 PF00397 0.553
DOC_WW_Pin1_4 497 502 PF00397 0.610
DOC_WW_Pin1_4 518 523 PF00397 0.551
DOC_WW_Pin1_4 591 596 PF00397 0.584
DOC_WW_Pin1_4 653 658 PF00397 0.612
DOC_WW_Pin1_4 76 81 PF00397 0.699
DOC_WW_Pin1_4 85 90 PF00397 0.814
LIG_14-3-3_CanoR_1 116 124 PF00244 0.614
LIG_14-3-3_CanoR_1 269 277 PF00244 0.677
LIG_14-3-3_CanoR_1 357 362 PF00244 0.643
LIG_14-3-3_CanoR_1 507 515 PF00244 0.603
LIG_14-3-3_CanoR_1 545 550 PF00244 0.561
LIG_14-3-3_CanoR_1 608 616 PF00244 0.554
LIG_14-3-3_CanoR_1 630 639 PF00244 0.650
LIG_14-3-3_CanoR_1 643 652 PF00244 0.549
LIG_14-3-3_CanoR_1 662 672 PF00244 0.562
LIG_Actin_WH2_2 557 574 PF00022 0.383
LIG_BIR_III_2 214 218 PF00653 0.604
LIG_BIR_III_2 585 589 PF00653 0.563
LIG_BRCT_BRCA1_1 143 147 PF00533 0.672
LIG_BRCT_BRCA1_1 664 668 PF00533 0.504
LIG_FHA_1 128 134 PF00498 0.620
LIG_FHA_1 155 161 PF00498 0.634
LIG_FHA_1 192 198 PF00498 0.627
LIG_FHA_1 287 293 PF00498 0.601
LIG_FHA_1 356 362 PF00498 0.648
LIG_FHA_1 483 489 PF00498 0.696
LIG_FHA_1 93 99 PF00498 0.531
LIG_FHA_2 387 393 PF00498 0.673
LIG_FHA_2 62 68 PF00498 0.703
LIG_LIR_Gen_1 305 313 PF02991 0.593
LIG_LIR_Gen_1 521 530 PF02991 0.504
LIG_LIR_Gen_1 665 675 PF02991 0.472
LIG_LIR_Nem_3 305 311 PF02991 0.590
LIG_LIR_Nem_3 521 526 PF02991 0.517
LIG_LIR_Nem_3 577 583 PF02991 0.435
LIG_LIR_Nem_3 665 671 PF02991 0.488
LIG_PTAP_UEV_1 123 128 PF05743 0.601
LIG_SH2_CRK 206 210 PF00017 0.655
LIG_SH2_CRK 298 302 PF00017 0.556
LIG_SH2_CRK 523 527 PF00017 0.565
LIG_SH2_NCK_1 298 302 PF00017 0.688
LIG_SH2_STAT3 610 613 PF00017 0.562
LIG_SH2_STAT5 298 301 PF00017 0.596
LIG_SH3_3 121 127 PF00018 0.672
LIG_SH3_3 158 164 PF00018 0.568
LIG_SH3_3 214 220 PF00018 0.676
LIG_SH3_3 297 303 PF00018 0.570
LIG_SH3_3 381 387 PF00018 0.651
LIG_SH3_3 592 598 PF00018 0.588
LIG_SH3_3 651 657 PF00018 0.642
LIG_SH3_3 74 80 PF00018 0.669
LIG_SUMO_SIM_par_1 21 27 PF11976 0.633
LIG_TRAF2_1 216 219 PF00917 0.813
MOD_CDC14_SPxK_1 502 505 PF00782 0.615
MOD_CDC14_SPxK_1 594 597 PF00782 0.595
MOD_CDK_SPxK_1 499 505 PF00069 0.611
MOD_CDK_SPxK_1 591 597 PF00069 0.585
MOD_CK1_1 146 152 PF00069 0.624
MOD_CK1_1 207 213 PF00069 0.718
MOD_CK1_1 248 254 PF00069 0.740
MOD_CK1_1 258 264 PF00069 0.664
MOD_CK1_1 265 271 PF00069 0.594
MOD_CK1_1 302 308 PF00069 0.586
MOD_CK1_1 372 378 PF00069 0.640
MOD_CK1_1 483 489 PF00069 0.574
MOD_CK1_1 499 505 PF00069 0.578
MOD_CK1_1 50 56 PF00069 0.625
MOD_CK1_1 521 527 PF00069 0.492
MOD_CK1_1 6 12 PF00069 0.774
MOD_CK1_1 61 67 PF00069 0.799
MOD_CK1_1 614 620 PF00069 0.649
MOD_CK1_1 623 629 PF00069 0.689
MOD_CK1_1 90 96 PF00069 0.690
MOD_CK2_1 24 30 PF00069 0.695
MOD_CK2_1 269 275 PF00069 0.616
MOD_CK2_1 386 392 PF00069 0.660
MOD_CK2_1 61 67 PF00069 0.735
MOD_CK2_1 663 669 PF00069 0.697
MOD_Cter_Amidation 150 153 PF01082 0.581
MOD_Cter_Amidation 46 49 PF01082 0.623
MOD_GlcNHglycan 107 110 PF01048 0.723
MOD_GlcNHglycan 124 127 PF01048 0.791
MOD_GlcNHglycan 143 146 PF01048 0.650
MOD_GlcNHglycan 154 157 PF01048 0.551
MOD_GlcNHglycan 206 209 PF01048 0.686
MOD_GlcNHglycan 257 260 PF01048 0.736
MOD_GlcNHglycan 265 268 PF01048 0.534
MOD_GlcNHglycan 324 327 PF01048 0.726
MOD_GlcNHglycan 352 355 PF01048 0.731
MOD_GlcNHglycan 367 370 PF01048 0.574
MOD_GlcNHglycan 379 382 PF01048 0.562
MOD_GlcNHglycan 482 485 PF01048 0.701
MOD_GlcNHglycan 49 52 PF01048 0.688
MOD_GlcNHglycan 494 497 PF01048 0.560
MOD_GlcNHglycan 54 57 PF01048 0.605
MOD_GlcNHglycan 60 63 PF01048 0.673
MOD_GlcNHglycan 613 616 PF01048 0.692
MOD_GlcNHglycan 646 649 PF01048 0.584
MOD_GlcNHglycan 665 668 PF01048 0.501
MOD_GlcNHglycan 689 692 PF01048 0.619
MOD_GlcNHglycan 92 95 PF01048 0.624
MOD_GSK3_1 111 118 PF00069 0.680
MOD_GSK3_1 122 129 PF00069 0.602
MOD_GSK3_1 178 185 PF00069 0.580
MOD_GSK3_1 192 199 PF00069 0.771
MOD_GSK3_1 24 31 PF00069 0.651
MOD_GSK3_1 245 252 PF00069 0.671
MOD_GSK3_1 258 265 PF00069 0.570
MOD_GSK3_1 318 325 PF00069 0.692
MOD_GSK3_1 34 41 PF00069 0.580
MOD_GSK3_1 365 372 PF00069 0.602
MOD_GSK3_1 43 50 PF00069 0.578
MOD_GSK3_1 492 499 PF00069 0.668
MOD_GSK3_1 540 547 PF00069 0.579
MOD_GSK3_1 631 638 PF00069 0.603
MOD_GSK3_1 642 649 PF00069 0.561
MOD_GSK3_1 66 73 PF00069 0.659
MOD_GSK3_1 682 689 PF00069 0.546
MOD_GSK3_1 78 85 PF00069 0.715
MOD_GSK3_1 90 97 PF00069 0.596
MOD_N-GLC_1 37 42 PF02516 0.606
MOD_N-GLC_1 372 377 PF02516 0.661
MOD_N-GLC_1 402 407 PF02516 0.652
MOD_N-GLC_1 496 501 PF02516 0.544
MOD_N-GLC_1 71 76 PF02516 0.598
MOD_N-GLC_2 165 167 PF02516 0.565
MOD_NEK2_1 176 181 PF00069 0.754
MOD_NEK2_1 334 339 PF00069 0.742
MOD_NEK2_1 34 39 PF00069 0.613
MOD_NEK2_1 447 452 PF00069 0.525
MOD_NEK2_1 589 594 PF00069 0.594
MOD_NEK2_1 84 89 PF00069 0.671
MOD_PIKK_1 115 121 PF00454 0.672
MOD_PIKK_1 192 198 PF00454 0.618
MOD_PIKK_1 334 340 PF00454 0.584
MOD_PIKK_1 436 442 PF00454 0.751
MOD_PIKK_1 449 455 PF00454 0.445
MOD_PIKK_1 521 527 PF00454 0.549
MOD_PIKK_1 558 564 PF00454 0.496
MOD_PIKK_1 601 607 PF00454 0.779
MOD_PIKK_1 609 615 PF00454 0.609
MOD_PKA_1 152 158 PF00069 0.574
MOD_PKA_1 662 668 PF00069 0.584
MOD_PKA_2 105 111 PF00069 0.613
MOD_PKA_2 115 121 PF00069 0.621
MOD_PKA_2 141 147 PF00069 0.606
MOD_PKA_2 152 158 PF00069 0.600
MOD_PKA_2 268 274 PF00069 0.696
MOD_PKA_2 322 328 PF00069 0.647
MOD_PKA_2 356 362 PF00069 0.606
MOD_PKA_2 47 53 PF00069 0.624
MOD_PKA_2 509 515 PF00069 0.622
MOD_PKA_2 544 550 PF00069 0.627
MOD_PKA_2 58 64 PF00069 0.572
MOD_PKA_2 620 626 PF00069 0.762
MOD_PKA_2 629 635 PF00069 0.565
MOD_PKA_2 642 648 PF00069 0.522
MOD_PKA_2 661 667 PF00069 0.593
MOD_PKA_2 686 692 PF00069 0.547
MOD_Plk_1 372 378 PF00069 0.567
MOD_Plk_1 66 72 PF00069 0.675
MOD_Plk_4 337 343 PF00069 0.663
MOD_Plk_4 357 363 PF00069 0.578
MOD_Plk_4 483 489 PF00069 0.563
MOD_Plk_4 637 643 PF00069 0.756
MOD_ProDKin_1 120 126 PF00069 0.610
MOD_ProDKin_1 154 160 PF00069 0.615
MOD_ProDKin_1 182 188 PF00069 0.672
MOD_ProDKin_1 189 195 PF00069 0.668
MOD_ProDKin_1 225 231 PF00069 0.599
MOD_ProDKin_1 24 30 PF00069 0.660
MOD_ProDKin_1 246 252 PF00069 0.787
MOD_ProDKin_1 258 264 PF00069 0.585
MOD_ProDKin_1 299 305 PF00069 0.549
MOD_ProDKin_1 497 503 PF00069 0.612
MOD_ProDKin_1 518 524 PF00069 0.542
MOD_ProDKin_1 591 597 PF00069 0.585
MOD_ProDKin_1 653 659 PF00069 0.610
MOD_ProDKin_1 76 82 PF00069 0.699
MOD_ProDKin_1 85 91 PF00069 0.814
MOD_SUMO_rev_2 346 353 PF00179 0.554
TRG_DiLeu_BaLyEn_6 329 334 PF01217 0.680
TRG_ENDOCYTIC_2 206 209 PF00928 0.658
TRG_ENDOCYTIC_2 523 526 PF00928 0.568
TRG_ER_diArg_1 140 143 PF00400 0.668
TRG_ER_diArg_1 152 154 PF00400 0.597
TRG_ER_diArg_1 234 236 PF00400 0.636
TRG_ER_diArg_1 394 396 PF00400 0.606
TRG_ER_diArg_1 469 472 PF00400 0.576
TRG_ER_diArg_1 564 567 PF00400 0.472
TRG_ER_diArg_1 606 608 PF00400 0.695
TRG_ER_diArg_1 642 644 PF00400 0.576
TRG_NLS_MonoCore_2 138 143 PF00514 0.511
TRG_NLS_MonoExtC_3 101 106 PF00514 0.612
TRG_NLS_MonoExtC_3 138 143 PF00514 0.511
TRG_NLS_MonoExtN_4 629 634 PF00514 0.624

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1PCI7 Leptomonas seymouri 43% 100%
A0A3S7X8Y6 Leishmania donovani 99% 100%
E9AET4 Leishmania major 87% 98%
E9B5Y9 Leishmania mexicana (strain MHOM/GT/2001/U1103) 83% 97%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS