Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

KRI1-like family/KRI1-like family C-terminal - putative

Species:

Leishmania infantum

UniProt:

A4IB05_LEIIN

TriTrypDb:

LINF_350015500

Length:

1051

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005730	nucleolus	5	1
GO:0030684	preribosome	3	1
GO:0030686	90S preribosome	4	1
GO:0032991	protein-containing complex	1	1
GO:0043226	organelle	2	1
GO:0043228	non-membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043232	intracellular non-membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1
GO:1990904	ribonucleoprotein complex	2	1

Expansion

Sequence features

A4IB05

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4IB05

Function

Biological processes
Term	Name	Level	Count
GO:0000447	endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	10	1
GO:0000469	cleavage involved in rRNA processing	7	1
GO:0000478	endonucleolytic cleavage involved in rRNA processing	8	1
GO:0000479	endonucleolytic cleavage of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	9	1
GO:0006139	nucleobase-containing compound metabolic process	3	1
GO:0006725	cellular aromatic compound metabolic process	3	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008152	metabolic process	1	1
GO:0009987	cellular process	1	1
GO:0016070	RNA metabolic process	5	1
GO:0034641	cellular nitrogen compound metabolic process	3	1
GO:0043170	macromolecule metabolic process	3	1
GO:0044237	cellular metabolic process	2	1
GO:0044238	primary metabolic process	2	1
GO:0046483	heterocycle metabolic process	3	1
GO:0071704	organic substance metabolic process	2	1
GO:0090304	nucleic acid metabolic process	4	1
GO:0090305	nucleic acid phosphodiester bond hydrolysis	5	1
GO:0090501	RNA phosphodiester bond hydrolysis	6	1
GO:0090502	RNA phosphodiester bond hydrolysis, endonucleolytic	7	1
GO:1901360	organic cyclic compound metabolic process	3	1

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	101	105	PF00656	0.683
CLV_C14_Caspase3-7	110	114	PF00656	0.693
CLV_C14_Caspase3-7	26	30	PF00656	0.666
CLV_C14_Caspase3-7	528	532	PF00656	0.826
CLV_C14_Caspase3-7	615	619	PF00656	0.573
CLV_C14_Caspase3-7	832	836	PF00656	0.663
CLV_C14_Caspase3-7	981	985	PF00656	0.613
CLV_MEL_PAP_1	276	282	PF00089	0.665
CLV_NRD_NRD_1	1000	1002	PF00675	0.799
CLV_NRD_NRD_1	157	159	PF00675	0.768
CLV_NRD_NRD_1	205	207	PF00675	0.496
CLV_NRD_NRD_1	271	273	PF00675	0.493
CLV_NRD_NRD_1	343	345	PF00675	0.575
CLV_NRD_NRD_1	391	393	PF00675	0.616
CLV_NRD_NRD_1	450	452	PF00675	0.407
CLV_NRD_NRD_1	510	512	PF00675	0.595
CLV_NRD_NRD_1	52	54	PF00675	0.568
CLV_NRD_NRD_1	609	611	PF00675	0.558
CLV_NRD_NRD_1	615	617	PF00675	0.518
CLV_NRD_NRD_1	623	625	PF00675	0.520
CLV_NRD_NRD_1	645	647	PF00675	0.359
CLV_NRD_NRD_1	702	704	PF00675	0.449
CLV_NRD_NRD_1	924	926	PF00675	0.414
CLV_NRD_NRD_1	929	931	PF00675	0.334
CLV_NRD_NRD_1	944	946	PF00675	0.545
CLV_PCSK_FUR_1	50	54	PF00082	0.570
CLV_PCSK_FUR_1	620	624	PF00082	0.536
CLV_PCSK_FUR_1	921	925	PF00082	0.447
CLV_PCSK_FUR_1	998	1002	PF00082	0.590
CLV_PCSK_KEX2_1	1000	1002	PF00082	0.590
CLV_PCSK_KEX2_1	157	159	PF00082	0.778
CLV_PCSK_KEX2_1	205	207	PF00082	0.493
CLV_PCSK_KEX2_1	343	345	PF00082	0.520
CLV_PCSK_KEX2_1	348	350	PF00082	0.496
CLV_PCSK_KEX2_1	365	367	PF00082	0.506
CLV_PCSK_KEX2_1	450	452	PF00082	0.475
CLV_PCSK_KEX2_1	457	459	PF00082	0.436
CLV_PCSK_KEX2_1	52	54	PF00082	0.554
CLV_PCSK_KEX2_1	622	624	PF00082	0.522
CLV_PCSK_KEX2_1	639	641	PF00082	0.335
CLV_PCSK_KEX2_1	645	647	PF00082	0.335
CLV_PCSK_KEX2_1	923	925	PF00082	0.408
CLV_PCSK_KEX2_1	928	930	PF00082	0.447
CLV_PCSK_KEX2_1	944	946	PF00082	0.545
CLV_PCSK_KEX2_1	974	976	PF00082	0.519
CLV_PCSK_KEX2_1	993	995	PF00082	0.580
CLV_PCSK_PC1ET2_1	205	207	PF00082	0.493
CLV_PCSK_PC1ET2_1	348	350	PF00082	0.521
CLV_PCSK_PC1ET2_1	365	367	PF00082	0.506
CLV_PCSK_PC1ET2_1	457	459	PF00082	0.466
CLV_PCSK_PC1ET2_1	639	641	PF00082	0.359
CLV_PCSK_PC1ET2_1	645	647	PF00082	0.309
CLV_PCSK_PC1ET2_1	974	976	PF00082	0.620
CLV_PCSK_PC1ET2_1	993	995	PF00082	0.738
CLV_PCSK_PC7_1	344	350	PF00082	0.651
CLV_PCSK_PC7_1	924	930	PF00082	0.381
CLV_PCSK_PC7_1	996	1002	PF00082	0.588
CLV_PCSK_SKI1_1	116	120	PF00082	0.742
CLV_PCSK_SKI1_1	168	172	PF00082	0.762
CLV_PCSK_SKI1_1	17	21	PF00082	0.654
CLV_PCSK_SKI1_1	266	270	PF00082	0.420
CLV_PCSK_SKI1_1	272	276	PF00082	0.439
CLV_PCSK_SKI1_1	365	369	PF00082	0.581
CLV_PCSK_SKI1_1	405	409	PF00082	0.536
CLV_PCSK_SKI1_1	42	46	PF00082	0.638
CLV_PCSK_SKI1_1	423	427	PF00082	0.538
CLV_PCSK_SKI1_1	457	461	PF00082	0.455
CLV_PCSK_SKI1_1	497	501	PF00082	0.427
CLV_PCSK_SKI1_1	639	643	PF00082	0.351
CLV_PCSK_SKI1_1	663	667	PF00082	0.477
CLV_Separin_Metazoa	420	424	PF03568	0.725
DEG_APCC_DBOX_1	387	395	PF00400	0.708
DEG_Kelch_Keap1_1	520	525	PF01344	0.723
DEG_Kelch_Keap1_1	732	737	PF01344	0.402
DEG_SPOP_SBC_1	2	6	PF00917	0.789
DEG_SPOP_SBC_1	949	953	PF00917	0.513
DOC_ANK_TNKS_1	137	144	PF00023	0.707
DOC_CYCLIN_yCln2_LP_2	692	698	PF00134	0.447
DOC_MAPK_gen_1	220	229	PF00069	0.728
DOC_MAPK_gen_1	272	280	PF00069	0.607
DOC_MAPK_gen_1	776	786	PF00069	0.689
DOC_MAPK_gen_1	998	1007	PF00069	0.585
DOC_MAPK_MEF2A_6	272	280	PF00069	0.640
DOC_PP1_RVXF_1	15	21	PF00149	0.750
DOC_PP2B_LxvP_1	692	695	PF13499	0.447
DOC_PP2B_LxvP_1	987	990	PF13499	0.696
DOC_PP4_FxxP_1	326	329	PF00568	0.449
DOC_PP4_FxxP_1	597	600	PF00568	0.595
DOC_USP7_MATH_1	291	295	PF00917	0.775
DOC_USP7_MATH_1	3	7	PF00917	0.793
DOC_USP7_MATH_1	305	309	PF00917	0.704
DOC_USP7_MATH_1	353	357	PF00917	0.628
DOC_USP7_MATH_1	428	432	PF00917	0.718
DOC_USP7_MATH_1	433	437	PF00917	0.723
DOC_USP7_MATH_1	473	477	PF00917	0.622
DOC_USP7_MATH_1	527	531	PF00917	0.757
DOC_USP7_MATH_1	745	749	PF00917	0.668
DOC_USP7_MATH_1	756	760	PF00917	0.631
DOC_USP7_MATH_1	862	866	PF00917	0.480
DOC_USP7_MATH_1	870	874	PF00917	0.348
DOC_USP7_UBL2_3	112	116	PF12436	0.728
DOC_USP7_UBL2_3	216	220	PF12436	0.595
DOC_USP7_UBL2_3	351	355	PF12436	0.691
DOC_USP7_UBL2_3	474	478	PF12436	0.696
DOC_USP7_UBL2_3	774	778	PF12436	0.719
DOC_WW_Pin1_4	130	135	PF00397	0.719
DOC_WW_Pin1_4	298	303	PF00397	0.806
DOC_WW_Pin1_4	953	958	PF00397	0.383
LIG_14-3-3_CanoR_1	1009	1014	PF00244	0.572
LIG_14-3-3_CanoR_1	124	134	PF00244	0.783
LIG_14-3-3_CanoR_1	272	277	PF00244	0.495
LIG_14-3-3_CanoR_1	423	433	PF00244	0.689
LIG_14-3-3_CanoR_1	450	459	PF00244	0.610
LIG_14-3-3_CanoR_1	841	847	PF00244	0.570
LIG_Actin_WH2_2	264	281	PF00022	0.613
LIG_AP2alpha_1	786	790	PF02296	0.767
LIG_APCC_ABBAyCdc20_2	53	59	PF00400	0.537
LIG_BIR_III_4	533	537	PF00653	0.668
LIG_BRCT_BRCA1_1	491	495	PF00533	0.624
LIG_BRCT_BRCA1_1	872	876	PF00533	0.402
LIG_CtBP_PxDLS_1	1004	1008	PF00389	0.578
LIG_FHA_1	146	152	PF00498	0.787
LIG_FHA_1	273	279	PF00498	0.603
LIG_FHA_1	287	293	PF00498	0.755
LIG_FHA_1	416	422	PF00498	0.609
LIG_FHA_1	604	610	PF00498	0.696
LIG_FHA_1	797	803	PF00498	0.583
LIG_FHA_1	885	891	PF00498	0.335
LIG_FHA_1	950	956	PF00498	0.507
LIG_FHA_2	105	111	PF00498	0.735
LIG_FHA_2	210	216	PF00498	0.647
LIG_FHA_2	357	363	PF00498	0.497
LIG_FHA_2	488	494	PF00498	0.635
LIG_FHA_2	613	619	PF00498	0.580
LIG_FHA_2	832	838	PF00498	0.643
LIG_GBD_Chelix_1	968	976	PF00786	0.616
LIG_IRF3_LxIS_1	464	469	PF10401	0.378
LIG_LIR_Apic_2	596	600	PF02991	0.614
LIG_LIR_Gen_1	416	425	PF02991	0.700
LIG_LIR_Gen_1	542	551	PF02991	0.546
LIG_LIR_Nem_3	155	159	PF02991	0.735
LIG_LIR_Nem_3	416	422	PF02991	0.682
LIG_LIR_Nem_3	542	547	PF02991	0.549
LIG_LIR_Nem_3	850	856	PF02991	0.335
LIG_LIR_Nem_3	943	949	PF02991	0.506
LIG_LYPXL_L_2	805	814	PF13949	0.609
LIG_PCNA_yPIPBox_3	816	825	PF02747	0.451
LIG_Pex14_1	566	570	PF04695	0.475
LIG_Pex14_2	495	499	PF04695	0.455
LIG_Pex14_2	786	790	PF04695	0.767
LIG_Rb_pABgroove_1	703	711	PF01858	0.480
LIG_SH2_CRK	544	548	PF00017	0.502
LIG_SH2_CRK	946	950	PF00017	0.605
LIG_SH2_GRB2like	543	546	PF00017	0.590
LIG_SH2_NCK_1	429	433	PF00017	0.701
LIG_SH2_STAP1	197	201	PF00017	0.503
LIG_SH2_STAP1	910	914	PF00017	0.335
LIG_SH2_STAT3	201	204	PF00017	0.594
LIG_SH2_STAT3	575	578	PF00017	0.567
LIG_SH2_STAT5	726	729	PF00017	0.447
LIG_SH2_STAT5	913	916	PF00017	0.335
LIG_SH3_1	67	73	PF00018	0.778
LIG_SH3_3	299	305	PF00018	0.778
LIG_SH3_3	67	73	PF00018	0.755
LIG_SH3_3	692	698	PF00018	0.447
LIG_SH3_3	980	986	PF00018	0.666
LIG_SUMO_SIM_anti_2	799	806	PF11976	0.512
LIG_SUMO_SIM_par_1	884	892	PF11976	0.337
LIG_TRAF2_1	317	320	PF00917	0.575
LIG_TRAF2_1	329	332	PF00917	0.417
LIG_TRAF2_1	452	455	PF00917	0.602
LIG_TRAF2_1	523	526	PF00917	0.731
LIG_TRAF2_1	551	554	PF00917	0.570
LIG_TRAF2_1	580	583	PF00917	0.685
LIG_TRAF2_1	759	762	PF00917	0.559
LIG_TRAF2_1	889	892	PF00917	0.335
LIG_TRAF2_2	957	962	PF00917	0.702
LIG_UBA3_1	838	847	PF00899	0.578
LIG_WW_3	64	68	PF00397	0.598
MOD_CK1_1	123	129	PF00069	0.719
MOD_CK1_1	183	189	PF00069	0.676
MOD_CK1_1	22	28	PF00069	0.601
MOD_CK1_1	301	307	PF00069	0.783
MOD_CK1_1	308	314	PF00069	0.761
MOD_CK1_1	356	362	PF00069	0.563
MOD_CK1_1	415	421	PF00069	0.557
MOD_CK1_1	520	526	PF00069	0.719
MOD_CK1_1	539	545	PF00069	0.605
MOD_CK1_1	6	12	PF00069	0.765
MOD_CK1_1	74	80	PF00069	0.716
MOD_CK1_1	939	945	PF00069	0.586
MOD_CK1_1	953	959	PF00069	0.609
MOD_CK1_1	98	104	PF00069	0.687
MOD_CK2_1	100	106	PF00069	0.747
MOD_CK2_1	181	187	PF00069	0.798
MOD_CK2_1	209	215	PF00069	0.644
MOD_CK2_1	239	245	PF00069	0.728
MOD_CK2_1	25	31	PF00069	0.773
MOD_CK2_1	439	445	PF00069	0.660
MOD_CK2_1	450	456	PF00069	0.491
MOD_CK2_1	487	493	PF00069	0.682
MOD_CK2_1	520	526	PF00069	0.673
MOD_CK2_1	756	762	PF00069	0.563
MOD_CK2_1	831	837	PF00069	0.654
MOD_CK2_1	886	892	PF00069	0.335
MOD_Cter_Amidation	165	168	PF01082	0.756
MOD_Cter_Amidation	476	479	PF01082	0.726
MOD_Cter_Amidation	998	1001	PF01082	0.592
MOD_GlcNHglycan	1029	1032	PF01048	0.754
MOD_GlcNHglycan	282	285	PF01048	0.711
MOD_GlcNHglycan	293	296	PF01048	0.777
MOD_GlcNHglycan	426	429	PF01048	0.729
MOD_GlcNHglycan	430	433	PF01048	0.770
MOD_GlcNHglycan	440	444	PF01048	0.708
MOD_GlcNHglycan	468	471	PF01048	0.552
MOD_GlcNHglycan	475	478	PF01048	0.644
MOD_GlcNHglycan	483	486	PF01048	0.564
MOD_GlcNHglycan	522	525	PF01048	0.738
MOD_GlcNHglycan	537	541	PF01048	0.740
MOD_GlcNHglycan	589	592	PF01048	0.757
MOD_GlcNHglycan	59	62	PF01048	0.708
MOD_GlcNHglycan	73	76	PF01048	0.686
MOD_GlcNHglycan	734	737	PF01048	0.402
MOD_GlcNHglycan	747	750	PF01048	0.684
MOD_GlcNHglycan	8	11	PF01048	0.789
MOD_GlcNHglycan	864	867	PF01048	0.418
MOD_GlcNHglycan	872	875	PF01048	0.410
MOD_GSK3_1	1005	1012	PF00069	0.769
MOD_GSK3_1	116	123	PF00069	0.814
MOD_GSK3_1	124	131	PF00069	0.743
MOD_GSK3_1	19	26	PF00069	0.552
MOD_GSK3_1	2	9	PF00069	0.777
MOD_GSK3_1	301	308	PF00069	0.763
MOD_GSK3_1	424	431	PF00069	0.768
MOD_GSK3_1	507	514	PF00069	0.638
MOD_GSK3_1	71	78	PF00069	0.705
MOD_GSK3_1	796	803	PF00069	0.632
MOD_GSK3_1	825	832	PF00069	0.671
MOD_GSK3_1	86	93	PF00069	0.608
MOD_GSK3_1	936	943	PF00069	0.562
MOD_GSK3_1	949	956	PF00069	0.497
MOD_GSK3_1	95	102	PF00069	0.717
MOD_N-GLC_1	1005	1010	PF02516	0.504
MOD_N-GLC_1	260	265	PF02516	0.558
MOD_N-GLC_1	487	492	PF02516	0.602
MOD_N-GLC_1	970	975	PF02516	0.594
MOD_NEK2_1	278	283	PF00069	0.692
MOD_NEK2_1	368	373	PF00069	0.618
MOD_NEK2_1	464	469	PF00069	0.563
MOD_NEK2_1	655	660	PF00069	0.335
MOD_NEK2_1	824	829	PF00069	0.661
MOD_NEK2_1	842	847	PF00069	0.526
MOD_NEK2_2	75	80	PF00069	0.635
MOD_PKA_1	272	278	PF00069	0.516
MOD_PKA_1	450	456	PF00069	0.351
MOD_PKA_1	511	517	PF00069	0.616
MOD_PKA_2	1027	1033	PF00069	0.749
MOD_PKA_2	123	129	PF00069	0.739
MOD_PKA_2	278	284	PF00069	0.696
MOD_PKA_2	450	456	PF00069	0.477
MOD_PKA_2	940	946	PF00069	0.521
MOD_Plk_1	260	266	PF00069	0.564
MOD_Plk_1	884	890	PF00069	0.335
MOD_Plk_2-3	104	110	PF00069	0.726
MOD_Plk_2-3	209	215	PF00069	0.612
MOD_Plk_4	311	317	PF00069	0.624
MOD_Plk_4	539	545	PF00069	0.641
MOD_Plk_4	762	768	PF00069	0.551
MOD_Plk_4	800	806	PF00069	0.611
MOD_Plk_4	950	956	PF00069	0.543
MOD_ProDKin_1	130	136	PF00069	0.719
MOD_ProDKin_1	298	304	PF00069	0.808
MOD_ProDKin_1	953	959	PF00069	0.390
MOD_SUMO_for_1	317	320	PF00179	0.633
MOD_SUMO_rev_2	104	114	PF00179	0.779
MOD_SUMO_rev_2	362	367	PF00179	0.632
MOD_SUMO_rev_2	38	47	PF00179	0.466
MOD_SUMO_rev_2	400	404	PF00179	0.540
MOD_SUMO_rev_2	453	459	PF00179	0.532
MOD_SUMO_rev_2	636	641	PF00179	0.447
MOD_SUMO_rev_2	697	706	PF00179	0.341
MOD_SUMO_rev_2	958	968	PF00179	0.674
TRG_DiLeu_BaEn_1	455	460	PF01217	0.493
TRG_DiLeu_BaEn_3	761	767	PF01217	0.539
TRG_DiLeu_BaEn_4	455	461	PF01217	0.551
TRG_DiLeu_BaEn_4	636	642	PF01217	0.447
TRG_DiLeu_BaEn_4	851	857	PF01217	0.447
TRG_DiLeu_BaEn_4	891	897	PF01217	0.447
TRG_DiLeu_LyEn_5	455	460	PF01217	0.467
TRG_ENDOCYTIC_2	544	547	PF00928	0.509
TRG_ENDOCYTIC_2	853	856	PF00928	0.335
TRG_ENDOCYTIC_2	878	881	PF00928	0.335
TRG_ENDOCYTIC_2	946	949	PF00928	0.494
TRG_ER_diArg_1	156	158	PF00400	0.725
TRG_ER_diArg_1	343	345	PF00400	0.640
TRG_ER_diArg_1	62	65	PF00400	0.736
TRG_ER_diArg_1	620	623	PF00400	0.516
TRG_ER_diArg_1	923	925	PF00400	0.367
TRG_ER_diArg_1	928	930	PF00400	0.344
TRG_ER_diArg_1	944	946	PF00400	0.532
TRG_ER_diArg_1	998	1001	PF00400	0.592
TRG_NLS_Bipartite_1	272	289	PF00514	0.626
TRG_NLS_Bipartite_1	622	643	PF00514	0.447
TRG_NLS_MonoExtC_3	391	396	PF00514	0.691
TRG_NLS_MonoExtC_3	510	515	PF00514	0.692
TRG_NLS_MonoExtC_3	775	780	PF00514	0.753
TRG_NLS_MonoExtN_4	511	516	PF00514	0.636
TRG_NLS_MonoExtN_4	774	781	PF00514	0.751
TRG_NLS_MonoExtN_4	990	997	PF00514	0.757
TRG_Pf-PMV_PEXEL_1	392	397	PF00026	0.622
TRG_Pf-PMV_PEXEL_1	457	461	PF00026	0.497
TRG_Pf-PMV_PEXEL_1	599	603	PF00026	0.567
TRG_Pf-PMV_PEXEL_1	974	978	PF00026	0.545

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HZY8	Leptomonas seymouri	61%	100%
A0A1X0NGP0	Trypanosomatidae	39%	100%
A0A3R7NCJ6	Trypanosoma rangeli	41%	100%
A0A3S7X904	Leishmania donovani	99%	100%
A4HFF6	Leishmania braziliensis	79%	100%
C9ZNK6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	41%	100%
E9AET3	Leishmania major	93%	100%
E9B5Y8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%
V5ATL2	Trypanosoma cruzi	37%	100%