Protein kinase domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4IB03_LEIIN

TriTrypDb:

LINF_350015300

Length:

580

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4IB03

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4IB03

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	244	248	PF00656	0.708
CLV_C14_Caspase3-7	289	293	PF00656	0.846
CLV_C14_Caspase3-7	96	100	PF00656	0.836
CLV_NRD_NRD_1	116	118	PF00675	0.746
CLV_NRD_NRD_1	122	124	PF00675	0.649
CLV_NRD_NRD_1	136	138	PF00675	0.574
CLV_NRD_NRD_1	139	141	PF00675	0.611
CLV_NRD_NRD_1	16	18	PF00675	0.847
CLV_NRD_NRD_1	162	164	PF00675	0.844
CLV_NRD_NRD_1	166	168	PF00675	0.785
CLV_NRD_NRD_1	191	193	PF00675	0.688
CLV_NRD_NRD_1	21	23	PF00675	0.758
CLV_NRD_NRD_1	220	222	PF00675	0.783
CLV_NRD_NRD_1	235	237	PF00675	0.534
CLV_NRD_NRD_1	245	247	PF00675	0.730
CLV_NRD_NRD_1	25	27	PF00675	0.686
CLV_NRD_NRD_1	278	280	PF00675	0.833
CLV_NRD_NRD_1	308	310	PF00675	0.816
CLV_NRD_NRD_1	393	395	PF00675	0.606
CLV_NRD_NRD_1	43	45	PF00675	0.569
CLV_NRD_NRD_1	574	576	PF00675	0.646
CLV_NRD_NRD_1	67	69	PF00675	0.811
CLV_PCSK_FUR_1	114	118	PF00082	0.680
CLV_PCSK_FUR_1	137	141	PF00082	0.749
CLV_PCSK_FUR_1	19	23	PF00082	0.639
CLV_PCSK_FUR_1	306	310	PF00082	0.790
CLV_PCSK_FUR_1	38	42	PF00082	0.654
CLV_PCSK_FUR_1	391	395	PF00082	0.660
CLV_PCSK_KEX2_1	114	116	PF00082	0.731
CLV_PCSK_KEX2_1	122	124	PF00082	0.616
CLV_PCSK_KEX2_1	136	138	PF00082	0.642
CLV_PCSK_KEX2_1	139	141	PF00082	0.611
CLV_PCSK_KEX2_1	144	146	PF00082	0.723
CLV_PCSK_KEX2_1	16	18	PF00082	0.676
CLV_PCSK_KEX2_1	166	168	PF00082	0.790
CLV_PCSK_KEX2_1	191	193	PF00082	0.688
CLV_PCSK_KEX2_1	21	23	PF00082	0.581
CLV_PCSK_KEX2_1	220	222	PF00082	0.783
CLV_PCSK_KEX2_1	237	239	PF00082	0.505
CLV_PCSK_KEX2_1	245	247	PF00082	0.660
CLV_PCSK_KEX2_1	25	27	PF00082	0.683
CLV_PCSK_KEX2_1	278	280	PF00082	0.833
CLV_PCSK_KEX2_1	3	5	PF00082	0.805
CLV_PCSK_KEX2_1	306	308	PF00082	0.831
CLV_PCSK_KEX2_1	393	395	PF00082	0.670
CLV_PCSK_KEX2_1	40	42	PF00082	0.543
CLV_PCSK_KEX2_1	43	45	PF00082	0.567
CLV_PCSK_KEX2_1	574	576	PF00082	0.646
CLV_PCSK_KEX2_1	67	69	PF00082	0.811
CLV_PCSK_PC1ET2_1	144	146	PF00082	0.846
CLV_PCSK_PC1ET2_1	237	239	PF00082	0.779
CLV_PCSK_PC1ET2_1	3	5	PF00082	0.787
CLV_PCSK_PC7_1	111	117	PF00082	0.673
CLV_PCSK_PC7_1	140	146	PF00082	0.831
CLV_PCSK_PC7_1	17	23	PF00082	0.759
CLV_PCSK_PC7_1	38	44	PF00082	0.647
CLV_PCSK_SKI1_1	237	241	PF00082	0.772
CLV_PCSK_SKI1_1	360	364	PF00082	0.618
CLV_PCSK_SKI1_1	397	401	PF00082	0.549
CLV_PCSK_SKI1_1	469	473	PF00082	0.704
CLV_PCSK_SKI1_1	507	511	PF00082	0.756
DEG_APCC_DBOX_1	359	367	PF00400	0.621
DEG_APCC_KENBOX_2	509	513	PF00400	0.747
DEG_SPOP_SBC_1	204	208	PF00917	0.625
DEG_SPOP_SBC_1	430	434	PF00917	0.713
DOC_ANK_TNKS_1	67	74	PF00023	0.702
DOC_CKS1_1	529	534	PF01111	0.813
DOC_CYCLIN_RxL_1	235	244	PF00134	0.773
DOC_MAPK_gen_1	236	242	PF00069	0.566
DOC_PP1_RVXF_1	236	243	PF00149	0.773
DOC_PP4_FxxP_1	534	537	PF00568	0.712
DOC_PP4_MxPP_1	270	273	PF00568	0.797
DOC_USP7_MATH_1	176	180	PF00917	0.763
DOC_USP7_MATH_1	200	204	PF00917	0.675
DOC_USP7_MATH_1	402	406	PF00917	0.679
DOC_USP7_MATH_1	419	423	PF00917	0.595
DOC_USP7_MATH_1	430	434	PF00917	0.811
DOC_USP7_MATH_1	442	446	PF00917	0.706
DOC_USP7_MATH_1	475	479	PF00917	0.665
DOC_USP7_MATH_1	559	563	PF00917	0.623
DOC_WW_Pin1_4	518	523	PF00397	0.818
DOC_WW_Pin1_4	528	533	PF00397	0.679
LIG_14-3-3_CanoR_1	125	133	PF00244	0.784
LIG_14-3-3_CanoR_1	170	174	PF00244	0.749
LIG_14-3-3_CanoR_1	309	315	PF00244	0.840
LIG_14-3-3_CanoR_1	85	95	PF00244	0.843
LIG_14-3-3_CterR_2	575	580	PF00244	0.640
LIG_BIR_III_2	519	523	PF00653	0.644
LIG_BIR_III_4	247	251	PF00653	0.803
LIG_BIR_III_4	474	478	PF00653	0.726
LIG_EVH1_1	523	527	PF00568	0.773
LIG_FHA_1	451	457	PF00498	0.674
LIG_FHA_1	555	561	PF00498	0.475
LIG_FHA_2	79	85	PF00498	0.710
LIG_Integrin_isoDGR_2	572	574	PF01839	0.681
LIG_LIR_Apic_2	335	341	PF02991	0.787
LIG_LIR_Apic_2	531	537	PF02991	0.710
LIG_LIR_Nem_3	101	107	PF02991	0.831
LIG_MAD2	85	93	PF02301	0.784
LIG_PTB_Apo_2	564	571	PF02174	0.648
LIG_PTB_Phospho_1	564	570	PF10480	0.652
LIG_RPA_C_Fungi	241	253	PF08784	0.543
LIG_SH2_GRB2like	570	573	PF00017	0.673
LIG_SH2_NCK_1	338	342	PF00017	0.773
LIG_SH2_NCK_1	406	410	PF00017	0.559
LIG_SH2_SRC	535	538	PF00017	0.767
LIG_SH2_SRC	570	573	PF00017	0.673
LIG_SH2_STAT5	209	212	PF00017	0.627
LIG_SH2_STAT5	535	538	PF00017	0.808
LIG_SH2_STAT5	570	573	PF00017	0.673
LIG_SH3_3	265	271	PF00018	0.664
LIG_SH3_3	389	395	PF00018	0.656
LIG_SH3_3	521	527	PF00018	0.681
LIG_SH3_3	539	545	PF00018	0.643
LIG_SUMO_SIM_anti_2	452	460	PF11976	0.608
LIG_SUMO_SIM_par_1	452	460	PF11976	0.608
LIG_SUMO_SIM_par_1	547	552	PF11976	0.635
MOD_CK1_1	20	26	PF00069	0.829
MOD_CK1_1	203	209	PF00069	0.770
MOD_CK1_1	330	336	PF00069	0.805
MOD_CK1_1	373	379	PF00069	0.636
MOD_CK1_1	429	435	PF00069	0.745
MOD_CK1_1	445	451	PF00069	0.741
MOD_CK1_1	78	84	PF00069	0.642
MOD_CK2_1	123	129	PF00069	0.766
MOD_CK2_1	169	175	PF00069	0.748
MOD_CK2_1	78	84	PF00069	0.711
MOD_CK2_1	97	103	PF00069	0.660
MOD_Cter_Amidation	1	4	PF01082	0.754
MOD_Cter_Amidation	137	140	PF01082	0.811
MOD_Cter_Amidation	142	145	PF01082	0.754
MOD_Cter_Amidation	161	164	PF01082	0.527
MOD_Cter_Amidation	572	575	PF01082	0.680
MOD_GlcNHglycan	202	205	PF01048	0.715
MOD_GlcNHglycan	247	251	PF01048	0.803
MOD_GlcNHglycan	295	298	PF01048	0.774
MOD_GlcNHglycan	428	431	PF01048	0.687
MOD_GlcNHglycan	433	436	PF01048	0.675
MOD_GlcNHglycan	481	484	PF01048	0.778
MOD_GlcNHglycan	492	495	PF01048	0.832
MOD_GlcNHglycan	6	9	PF01048	0.861
MOD_GlcNHglycan	69	72	PF01048	0.849
MOD_GSK3_1	200	207	PF00069	0.793
MOD_GSK3_1	211	218	PF00069	0.668
MOD_GSK3_1	326	333	PF00069	0.730
MOD_GSK3_1	366	373	PF00069	0.603
MOD_GSK3_1	419	426	PF00069	0.754
MOD_GSK3_1	440	447	PF00069	0.790
MOD_GSK3_1	457	464	PF00069	0.542
MOD_GSK3_1	475	482	PF00069	0.832
MOD_GSK3_1	74	81	PF00069	0.680
MOD_LATS_1	57	63	PF00433	0.758
MOD_LATS_1	65	71	PF00433	0.667
MOD_N-GLC_1	186	191	PF02516	0.617
MOD_N-GLC_1	280	285	PF02516	0.776
MOD_N-GLC_1	293	298	PF02516	0.619
MOD_N-GLC_1	327	332	PF02516	0.822
MOD_N-GLC_1	4	9	PF02516	0.753
MOD_N-GLC_1	445	450	PF02516	0.797
MOD_N-GLC_2	423	425	PF02516	0.611
MOD_NEK2_1	368	373	PF00069	0.667
MOD_NEK2_1	444	449	PF00069	0.722
MOD_PKA_1	43	49	PF00069	0.728
MOD_PKA_1	67	73	PF00069	0.743
MOD_PKA_2	110	116	PF00069	0.787
MOD_PKA_2	146	152	PF00069	0.766
MOD_PKA_2	169	175	PF00069	0.778
MOD_PKA_2	20	26	PF00069	0.820
MOD_PKA_2	43	49	PF00069	0.831
MOD_PKA_2	60	66	PF00069	0.523
MOD_PKA_2	67	73	PF00069	0.730
MOD_PKB_1	123	131	PF00069	0.679
MOD_PKB_1	41	49	PF00069	0.731
MOD_Plk_1	10	16	PF00069	0.755
MOD_Plk_1	280	286	PF00069	0.777
MOD_Plk_1	326	332	PF00069	0.826
MOD_Plk_1	366	372	PF00069	0.652
MOD_Plk_1	451	457	PF00069	0.800
MOD_Plk_2-3	45	51	PF00069	0.816
MOD_Plk_4	272	278	PF00069	0.615
MOD_Plk_4	333	339	PF00069	0.802
MOD_Plk_4	374	380	PF00069	0.598
MOD_Plk_4	451	457	PF00069	0.752
MOD_Plk_4	461	467	PF00069	0.611
MOD_ProDKin_1	518	524	PF00069	0.817
MOD_ProDKin_1	528	534	PF00069	0.680
TRG_ENDOCYTIC_2	104	107	PF00928	0.824
TRG_ER_diArg_1	114	117	PF00400	0.790
TRG_ER_diArg_1	136	139	PF00400	0.744
TRG_ER_diArg_1	15	17	PF00400	0.812
TRG_ER_diArg_1	19	22	PF00400	0.750
TRG_ER_diArg_1	220	223	PF00400	0.789
TRG_ER_diArg_1	236	239	PF00400	0.516
TRG_ER_diArg_1	277	279	PF00400	0.823
TRG_ER_diArg_1	282	285	PF00400	0.767
TRG_ER_diArg_1	306	309	PF00400	0.826
TRG_ER_diArg_1	38	41	PF00400	0.652
TRG_ER_diArg_1	390	393	PF00400	0.659
TRG_ER_diArg_1	42	44	PF00400	0.731
TRG_ER_diArg_1	574	576	PF00400	0.646
TRG_ER_diArg_1	92	95	PF00400	0.828
TRG_NLS_Bipartite_1	220	240	PF00514	0.589
TRG_NLS_MonoExtC_3	162	167	PF00514	0.789
TRG_Pf-PMV_PEXEL_1	227	232	PF00026	0.614

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3S7X8W4	Leishmania donovani	99%	100%
A4HFF4	Leishmania braziliensis	66%	100%
E9AET1	Leishmania major	87%	100%
E9B5Y6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	83%	100%