Uncharacterized protein

Quick info Annotations Localization Abundance Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

zinc finger protein family member - putative

Species:

Leishmania infantum

UniProt:

A4IB00_LEIIN

TriTrypDb:

LINF_350015000

Length:

217

Annotations

Annotations by Jardim et al.

Metal Binding, zinc finger family member, putative

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 5

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Could not find GO cellular_component term for this entry.

Abundance

Amastigote (protein)


Source	Evidence on protein	Close homologs
Pescher et al. (upgregulation)	no	yes: 0

Promastigote and amastigote


Source	Evidence on protein	Close homologs
Lahav et al. - mRNA - Protein

Expansion

Sequence features

A4IB00

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4IB00

PDB structure(s): 3m3i_A , 3m3i_B , 3m3i_C , 3m3i_D , 3m3i_E , 3m3i_F , 3m3i_G , 3m3i_H

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	155	159	PF00656	0.292
CLV_NRD_NRD_1	124	126	PF00675	0.316
CLV_NRD_NRD_1	48	50	PF00675	0.334
CLV_PCSK_KEX2_1	124	126	PF00082	0.316
CLV_PCSK_KEX2_1	18	20	PF00082	0.292
CLV_PCSK_KEX2_1	48	50	PF00082	0.334
CLV_PCSK_PC1ET2_1	18	20	PF00082	0.292
CLV_PCSK_SKI1_1	124	128	PF00082	0.316
CLV_Separin_Metazoa	33	37	PF03568	0.219
DOC_CKS1_1	58	63	PF01111	0.311
DOC_WW_Pin1_4	168	173	PF00397	0.224
DOC_WW_Pin1_4	57	62	PF00397	0.317
LIG_14-3-3_CanoR_1	49	58	PF00244	0.274
LIG_14-3-3_CanoR_1	69	78	PF00244	0.256
LIG_APCC_ABBA_1	22	27	PF00400	0.274
LIG_BRCT_BRCA1_1	170	174	PF00533	0.240
LIG_LIR_Gen_1	178	187	PF02991	0.290
LIG_LIR_Nem_3	175	179	PF02991	0.274
LIG_PCNA_PIPBox_1	184	193	PF02747	0.324
LIG_PCNA_yPIPBox_3	177	191	PF02747	0.309
LIG_PDZ_Class_1	212	217	PF00595	0.506
LIG_SH2_CRK	123	127	PF00017	0.334
LIG_SH2_CRK	140	144	PF00017	0.334
LIG_SH2_CRK	163	167	PF00017	0.334
LIG_SH2_CRK	52	56	PF00017	0.240
LIG_SH2_NCK_1	140	144	PF00017	0.334
LIG_SH2_NCK_1	163	167	PF00017	0.324
LIG_SH2_NCK_1	52	56	PF00017	0.274
LIG_SH2_STAP1	31	35	PF00017	0.243
LIG_SH2_STAP1	52	56	PF00017	0.308
LIG_SH2_STAT5	140	143	PF00017	0.334
LIG_SH2_STAT5	52	55	PF00017	0.240
LIG_SH2_STAT5	56	59	PF00017	0.240
LIG_SH3_3	101	107	PF00018	0.299
LIG_SH3_3	20	26	PF00018	0.297
LIG_SH3_3	58	64	PF00018	0.311
LIG_SH3_5	172	176	PF00018	0.251
MOD_CK1_1	164	170	PF00069	0.252
MOD_CK1_1	72	78	PF00069	0.334
MOD_GlcNHglycan	36	39	PF01048	0.316
MOD_GSK3_1	164	171	PF00069	0.265
MOD_LATS_1	209	215	PF00433	0.433
MOD_NEK2_1	138	143	PF00069	0.334
MOD_NEK2_1	148	153	PF00069	0.334
MOD_NEK2_1	212	217	PF00069	0.446
MOD_NEK2_2	51	56	PF00069	0.274
MOD_PIKK_1	180	186	PF00454	0.336
MOD_Plk_1	72	78	PF00069	0.334
MOD_Plk_4	161	167	PF00069	0.334
MOD_Plk_4	51	57	PF00069	0.274
MOD_Plk_4	72	78	PF00069	0.334
MOD_ProDKin_1	168	174	PF00069	0.224
MOD_ProDKin_1	57	63	PF00069	0.317
TRG_DiLeu_BaEn_1	133	138	PF01217	0.268
TRG_ENDOCYTIC_2	123	126	PF00928	0.308
TRG_ENDOCYTIC_2	163	166	PF00928	0.289
TRG_ENDOCYTIC_2	176	179	PF00928	0.183
TRG_ENDOCYTIC_2	203	206	PF00928	0.322
TRG_ENDOCYTIC_2	31	34	PF00928	0.301
TRG_ENDOCYTIC_2	52	55	PF00928	0.240
TRG_ER_diArg_1	123	125	PF00400	0.316

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IHB1	Leptomonas seymouri	73%	100%
A0A1X0NZ51	Trypanosomatidae	42%	100%
A0A3Q8IIT6	Leishmania donovani	100%	100%
A0A422P1M2	Trypanosoma rangeli	41%	100%
A4HMD3	Leishmania braziliensis	78%	100%
E9AES8	Leishmania major	98%	100%
E9B5Y3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	100%