Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Zinc finger C-x8-C-x5-C-x3-H type (and similar) - putative

Species:

Leishmania infantum

UniProt:

A4IAZ9_LEIIN

TriTrypDb:

LINF_350014900

Length:

435

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4IAZ9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4IAZ9

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	6
GO:0003723	RNA binding	4	6
GO:0003729	mRNA binding	5	6
GO:0005488	binding	1	7
GO:0043167	ion binding	2	7
GO:0043169	cation binding	3	7
GO:0046872	metal ion binding	4	7
GO:0097159	organic cyclic compound binding	2	6
GO:1901363	heterocyclic compound binding	2	6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	104	108	PF00656	0.516
CLV_C14_Caspase3-7	24	28	PF00656	0.656
CLV_NRD_NRD_1	25	27	PF00675	0.614
CLV_NRD_NRD_1	252	254	PF00675	0.546
CLV_PCSK_KEX2_1	141	143	PF00082	0.318
CLV_PCSK_KEX2_1	25	27	PF00082	0.614
CLV_PCSK_PC1ET2_1	141	143	PF00082	0.318
CLV_PCSK_SKI1_1	157	161	PF00082	0.350
CLV_PCSK_SKI1_1	367	371	PF00082	0.571
CLV_PCSK_SKI1_1	97	101	PF00082	0.601
DEG_APCC_DBOX_1	366	374	PF00400	0.565
DEG_SCF_FBW7_1	1	7	PF00400	0.581
DEG_SPOP_SBC_1	17	21	PF00917	0.626
DEG_SPOP_SBC_1	344	348	PF00917	0.612
DOC_CKS1_1	1	6	PF01111	0.578
DOC_PP4_FxxP_1	371	374	PF00568	0.520
DOC_USP7_MATH_1	110	114	PF00917	0.758
DOC_USP7_MATH_1	124	128	PF00917	0.549
DOC_USP7_MATH_1	17	21	PF00917	0.585
DOC_USP7_MATH_1	187	191	PF00917	0.581
DOC_USP7_MATH_1	213	217	PF00917	0.550
DOC_USP7_MATH_1	220	224	PF00917	0.555
DOC_USP7_MATH_1	262	266	PF00917	0.577
DOC_USP7_MATH_1	294	298	PF00917	0.602
DOC_USP7_MATH_1	306	310	PF00917	0.502
DOC_USP7_MATH_1	36	40	PF00917	0.467
DOC_USP7_MATH_1	413	417	PF00917	0.521
DOC_USP7_MATH_1	88	92	PF00917	0.671
DOC_USP7_MATH_1	95	99	PF00917	0.599
DOC_USP7_UBL2_3	97	101	PF12436	0.601
DOC_WW_Pin1_4	114	119	PF00397	0.757
DOC_WW_Pin1_4	253	258	PF00397	0.664
DOC_WW_Pin1_4	345	350	PF00397	0.517
DOC_WW_Pin1_4	51	56	PF00397	0.593
DOC_WW_Pin1_4	68	73	PF00397	0.766
DOC_WW_Pin1_4	86	91	PF00397	0.504
LIG_14-3-3_CanoR_1	222	229	PF00244	0.550
LIG_BRCT_BRCA1_1	367	371	PF00533	0.571
LIG_DLG_GKlike_1	25	33	PF00625	0.601
LIG_FHA_1	1	7	PF00498	0.604
LIG_FHA_1	187	193	PF00498	0.569
LIG_FHA_1	246	252	PF00498	0.604
LIG_FHA_2	17	23	PF00498	0.622
LIG_LIR_Apic_2	368	374	PF02991	0.565
LIG_LIR_Gen_1	33	40	PF02991	0.667
LIG_LIR_Gen_1	339	349	PF02991	0.551
LIG_LIR_Gen_1	398	404	PF02991	0.606
LIG_LIR_Gen_1	71	81	PF02991	0.654
LIG_LIR_Nem_3	149	154	PF02991	0.310
LIG_LIR_Nem_3	164	170	PF02991	0.524
LIG_LIR_Nem_3	33	37	PF02991	0.665
LIG_LIR_Nem_3	339	344	PF02991	0.617
LIG_LIR_Nem_3	71	77	PF02991	0.753
LIG_LYPXL_yS_3	65	68	PF13949	0.632
LIG_NRBOX	356	362	PF00104	0.477
LIG_SH2_STAP1	208	212	PF00017	0.440
LIG_SH2_STAT3	170	173	PF00017	0.536
LIG_SH2_STAT5	170	173	PF00017	0.474
LIG_SH2_STAT5	392	395	PF00017	0.545
LIG_SH2_STAT5	418	421	PF00017	0.542
LIG_SH3_1	254	260	PF00018	0.544
LIG_SH3_3	118	124	PF00018	0.646
LIG_SH3_3	244	250	PF00018	0.655
LIG_SH3_3	254	260	PF00018	0.567
LIG_SH3_3	409	415	PF00018	0.602
LIG_SUMO_SIM_par_1	325	331	PF11976	0.613
LIG_SUMO_SIM_par_1	346	353	PF11976	0.494
LIG_TRAF2_1	78	81	PF00917	0.725
MOD_CK1_1	103	109	PF00069	0.587
MOD_CK1_1	111	117	PF00069	0.760
MOD_CK1_1	128	134	PF00069	0.478
MOD_CK1_1	21	27	PF00069	0.606
MOD_CK1_1	261	267	PF00069	0.612
MOD_CK1_1	330	336	PF00069	0.477
MOD_CK1_1	398	404	PF00069	0.490
MOD_CK1_1	416	422	PF00069	0.552
MOD_CK1_1	7	13	PF00069	0.607
MOD_CK1_1	70	76	PF00069	0.610
MOD_CK2_1	16	22	PF00069	0.595
MOD_CK2_1	7	13	PF00069	0.652
MOD_CK2_1	75	81	PF00069	0.729
MOD_GlcNHglycan	107	111	PF01048	0.563
MOD_GlcNHglycan	127	130	PF01048	0.572
MOD_GlcNHglycan	147	151	PF01048	0.238
MOD_GlcNHglycan	214	218	PF01048	0.493
MOD_GlcNHglycan	224	227	PF01048	0.554
MOD_GlcNHglycan	264	267	PF01048	0.660
MOD_GlcNHglycan	332	335	PF01048	0.524
MOD_GlcNHglycan	415	418	PF01048	0.702
MOD_GlcNHglycan	419	422	PF01048	0.697
MOD_GlcNHglycan	90	93	PF01048	0.605
MOD_GlcNHglycan	97	100	PF01048	0.606
MOD_GSK3_1	106	113	PF00069	0.657
MOD_GSK3_1	124	131	PF00069	0.585
MOD_GSK3_1	133	140	PF00069	0.448
MOD_GSK3_1	17	24	PF00069	0.679
MOD_GSK3_1	241	248	PF00069	0.671
MOD_GSK3_1	258	265	PF00069	0.542
MOD_GSK3_1	413	420	PF00069	0.536
MOD_GSK3_1	75	82	PF00069	0.585
MOD_GSK3_1	95	102	PF00069	0.615
MOD_N-GLC_1	111	116	PF02516	0.577
MOD_N-GLC_1	241	246	PF02516	0.675
MOD_N-GLC_1	7	12	PF02516	0.542
MOD_N-GLC_1	95	100	PF02516	0.585
MOD_NEK2_1	146	151	PF00069	0.304
MOD_NEK2_1	278	283	PF00069	0.608
MOD_NEK2_1	327	332	PF00069	0.641
MOD_NEK2_1	336	341	PF00069	0.513
MOD_PIKK_1	255	261	PF00454	0.606
MOD_PIKK_1	265	271	PF00454	0.593
MOD_PIKK_1	306	312	PF00454	0.644
MOD_PIKK_1	43	49	PF00454	0.601
MOD_PKA_1	25	31	PF00069	0.605
MOD_PKA_2	25	31	PF00069	0.605
MOD_Plk_1	95	101	PF00069	0.620
MOD_Plk_4	30	36	PF00069	0.665
MOD_ProDKin_1	114	120	PF00069	0.759
MOD_ProDKin_1	253	259	PF00069	0.663
MOD_ProDKin_1	345	351	PF00069	0.517
MOD_ProDKin_1	51	57	PF00069	0.593
MOD_ProDKin_1	68	74	PF00069	0.771
MOD_ProDKin_1	86	92	PF00069	0.505
TRG_DiLeu_BaLyEn_6	323	328	PF01217	0.573
TRG_ENDOCYTIC_2	399	402	PF00928	0.608
TRG_ENDOCYTIC_2	65	68	PF00928	0.774
TRG_NLS_MonoExtN_4	139	145	PF00514	0.304

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P318	Leptomonas seymouri	42%	75%
A0A3S7X8W6	Leishmania donovani	99%	100%
A4HMD2	Leishmania braziliensis	55%	99%
E9AES7	Leishmania major	89%	99%
E9B5Y2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	87%	99%