Uncharacterized protein

Quick info Localization Phosphorylation Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4IAZ6_LEIIN

TriTrypDb:

LINF_350014600

Length:

836

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Cellular components
Term	Name	Level	Count
GO:0005654	nucleoplasm	2	1
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Phosphorylation

Amastigote: 61
Promastigote: 601, 602

Expansion

Sequence features

A4IAZ6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4IAZ6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	303	307	PF00656	0.633
CLV_C14_Caspase3-7	328	332	PF00656	0.652
CLV_C14_Caspase3-7	601	605	PF00656	0.591
CLV_C14_Caspase3-7	81	85	PF00656	0.628
CLV_NRD_NRD_1	569	571	PF00675	0.470
CLV_NRD_NRD_1	663	665	PF00675	0.677
CLV_NRD_NRD_1	773	775	PF00675	0.598
CLV_NRD_NRD_1	797	799	PF00675	0.770
CLV_NRD_NRD_1	810	812	PF00675	0.657
CLV_PCSK_FUR_1	771	775	PF00082	0.588
CLV_PCSK_KEX2_1	569	571	PF00082	0.499
CLV_PCSK_KEX2_1	663	665	PF00082	0.669
CLV_PCSK_KEX2_1	745	747	PF00082	0.661
CLV_PCSK_KEX2_1	773	775	PF00082	0.598
CLV_PCSK_KEX2_1	797	799	PF00082	0.685
CLV_PCSK_KEX2_1	810	812	PF00082	0.618
CLV_PCSK_PC1ET2_1	745	747	PF00082	0.617
CLV_PCSK_SKI1_1	152	156	PF00082	0.367
CLV_PCSK_SKI1_1	359	363	PF00082	0.550
CLV_PCSK_SKI1_1	620	624	PF00082	0.676
DEG_COP1_1	130	140	PF00400	0.484
DEG_Nend_Nbox_1	1	3	PF02207	0.464
DEG_SPOP_SBC_1	467	471	PF00917	0.695
DEG_SPOP_SBC_1	699	703	PF00917	0.591
DOC_CYCLIN_yCln2_LP_2	107	113	PF00134	0.491
DOC_CYCLIN_yCln2_LP_2	18	24	PF00134	0.409
DOC_MAPK_HePTP_8	160	172	PF00069	0.365
DOC_MAPK_MEF2A_6	152	159	PF00069	0.392
DOC_MAPK_MEF2A_6	163	172	PF00069	0.395
DOC_PP1_RVXF_1	376	383	PF00149	0.514
DOC_PP4_FxxP_1	204	207	PF00568	0.462
DOC_USP7_MATH_1	100	104	PF00917	0.637
DOC_USP7_MATH_1	119	123	PF00917	0.346
DOC_USP7_MATH_1	14	18	PF00917	0.373
DOC_USP7_MATH_1	141	145	PF00917	0.418
DOC_USP7_MATH_1	244	248	PF00917	0.662
DOC_USP7_MATH_1	468	472	PF00917	0.653
DOC_USP7_MATH_1	603	607	PF00917	0.699
DOC_USP7_MATH_1	626	630	PF00917	0.636
DOC_USP7_MATH_1	699	703	PF00917	0.591
DOC_USP7_MATH_1	80	84	PF00917	0.724
DOC_USP7_UBL2_3	403	407	PF12436	0.586
DOC_WW_Pin1_4	174	179	PF00397	0.483
DOC_WW_Pin1_4	219	224	PF00397	0.367
DOC_WW_Pin1_4	239	244	PF00397	0.690
DOC_WW_Pin1_4	276	281	PF00397	0.567
DOC_WW_Pin1_4	397	402	PF00397	0.618
DOC_WW_Pin1_4	414	419	PF00397	0.704
DOC_WW_Pin1_4	454	459	PF00397	0.545
DOC_WW_Pin1_4	490	495	PF00397	0.659
DOC_WW_Pin1_4	512	517	PF00397	0.545
DOC_WW_Pin1_4	599	604	PF00397	0.674
DOC_WW_Pin1_4	650	655	PF00397	0.749
DOC_WW_Pin1_4	750	755	PF00397	0.582
DOC_WW_Pin1_4	825	830	PF00397	0.737
LIG_14-3-3_CanoR_1	274	281	PF00244	0.555
LIG_14-3-3_CanoR_1	293	297	PF00244	0.532
LIG_14-3-3_CanoR_1	442	446	PF00244	0.497
LIG_14-3-3_CanoR_1	520	526	PF00244	0.444
LIG_14-3-3_CanoR_1	588	595	PF00244	0.501
LIG_14-3-3_CanoR_1	663	667	PF00244	0.610
LIG_14-3-3_CanoR_1	681	688	PF00244	0.462
LIG_Actin_WH2_2	577	595	PF00022	0.430
LIG_APCC_ABBA_1	446	451	PF00400	0.491
LIG_BIR_III_2	815	819	PF00653	0.641
LIG_BIR_III_4	553	557	PF00653	0.462
LIG_BRCT_BRCA1_1	725	729	PF00533	0.665
LIG_BRCT_BRCA1_1	75	79	PF00533	0.712
LIG_FHA_1	248	254	PF00498	0.583
LIG_FHA_1	284	290	PF00498	0.567
LIG_FHA_1	311	317	PF00498	0.712
LIG_FHA_1	407	413	PF00498	0.469
LIG_FHA_1	468	474	PF00498	0.631
LIG_FHA_1	528	534	PF00498	0.408
LIG_FHA_1	725	731	PF00498	0.694
LIG_FHA_2	156	162	PF00498	0.429
LIG_FHA_2	301	307	PF00498	0.712
LIG_FHA_2	415	421	PF00498	0.673
LIG_FHA_2	425	431	PF00498	0.621
LIG_FHA_2	540	546	PF00498	0.530
LIG_FHA_2	599	605	PF00498	0.599
LIG_FHA_2	681	687	PF00498	0.582
LIG_FHA_2	89	95	PF00498	0.632
LIG_GBD_Chelix_1	156	164	PF00786	0.433
LIG_LIR_Gen_1	177	188	PF02991	0.503
LIG_LIR_Gen_1	225	235	PF02991	0.459
LIG_LIR_Gen_1	558	568	PF02991	0.491
LIG_LIR_Gen_1	59	64	PF02991	0.564
LIG_LIR_Gen_1	665	674	PF02991	0.661
LIG_LIR_Nem_3	17	23	PF02991	0.460
LIG_LIR_Nem_3	177	183	PF02991	0.495
LIG_LIR_Nem_3	225	230	PF02991	0.554
LIG_LIR_Nem_3	371	376	PF02991	0.438
LIG_LIR_Nem_3	394	399	PF02991	0.605
LIG_LIR_Nem_3	558	563	PF02991	0.453
LIG_LIR_Nem_3	59	63	PF02991	0.595
LIG_LIR_Nem_3	800	805	PF02991	0.623
LIG_LYPXL_yS_3	20	23	PF13949	0.423
LIG_MLH1_MIPbox_1	75	79	PF16413	0.619
LIG_NBox_RRM_1	183	193	PF00076	0.370
LIG_Pex14_2	446	450	PF04695	0.355
LIG_PTB_Apo_2	556	563	PF02174	0.407
LIG_RPA_C_Fungi	158	170	PF08784	0.458
LIG_RPA_C_Fungi	261	273	PF08784	0.388
LIG_SH2_CRK	227	231	PF00017	0.470
LIG_SH2_GRB2like	557	560	PF00017	0.468
LIG_SH2_NCK_1	227	231	PF00017	0.470
LIG_SH2_NCK_1	5	9	PF00017	0.507
LIG_SH2_STAP1	557	561	PF00017	0.463
LIG_SH2_STAT5	106	109	PF00017	0.475
LIG_SH2_STAT5	721	724	PF00017	0.619
LIG_SH3_3	135	141	PF00018	0.459
LIG_SH3_3	185	191	PF00018	0.524
LIG_SH3_3	314	320	PF00018	0.664
LIG_SH3_3	396	402	PF00018	0.548
LIG_SH3_3	450	456	PF00018	0.594
LIG_SH3_3	457	463	PF00018	0.604
LIG_SH3_3	502	508	PF00018	0.696
LIG_SH3_3	597	603	PF00018	0.636
LIG_SH3_3	648	654	PF00018	0.633
LIG_SH3_3	828	834	PF00018	0.668
LIG_SH3_4	403	410	PF00018	0.558
LIG_SUMO_SIM_anti_2	132	139	PF11976	0.512
LIG_SUMO_SIM_anti_2	166	171	PF11976	0.363
LIG_SUMO_SIM_par_1	212	217	PF11976	0.449
LIG_SUMO_SIM_par_1	22	28	PF11976	0.380
LIG_SUMO_SIM_par_1	593	598	PF11976	0.553
LIG_TRAF2_1	428	431	PF00917	0.484
LIG_TRAF2_1	675	678	PF00917	0.576
LIG_TRAF2_1	787	790	PF00917	0.564
LIG_TYR_ITIM	18	23	PF00017	0.415
LIG_UBA3_1	22	29	PF00899	0.426
LIG_UBA3_1	234	238	PF00899	0.401
LIG_WRC_WIRS_1	156	161	PF05994	0.430
LIG_WRC_WIRS_1	253	258	PF05994	0.521
LIG_WRC_WIRS_1	30	35	PF05994	0.536
LIG_WW_3	566	570	PF00397	0.520
MOD_CDK_SPxK_1	397	403	PF00069	0.569
MOD_CDK_SPxxK_3	650	657	PF00069	0.607
MOD_CK1_1	217	223	PF00069	0.456
MOD_CK1_1	242	248	PF00069	0.598
MOD_CK1_1	255	261	PF00069	0.524
MOD_CK1_1	279	285	PF00069	0.654
MOD_CK1_1	347	353	PF00069	0.673
MOD_CK1_1	365	371	PF00069	0.604
MOD_CK1_1	414	420	PF00069	0.671
MOD_CK1_1	44	50	PF00069	0.719
MOD_CK1_1	512	518	PF00069	0.647
MOD_CK1_1	539	545	PF00069	0.600
MOD_CK1_1	572	578	PF00069	0.472
MOD_CK1_1	607	613	PF00069	0.607
MOD_CK1_1	653	659	PF00069	0.636
MOD_CK1_1	700	706	PF00069	0.686
MOD_CK1_1	74	80	PF00069	0.743
MOD_CK1_1	820	826	PF00069	0.721
MOD_CK2_1	155	161	PF00069	0.426
MOD_CK2_1	246	252	PF00069	0.441
MOD_CK2_1	414	420	PF00069	0.653
MOD_CK2_1	424	430	PF00069	0.487
MOD_CK2_1	665	671	PF00069	0.588
MOD_CK2_1	680	686	PF00069	0.575
MOD_Cter_Amidation	714	717	PF01082	0.703
MOD_Cter_Amidation	743	746	PF01082	0.734
MOD_Cter_Amidation	808	811	PF01082	0.708
MOD_GlcNHglycan	207	210	PF01048	0.502
MOD_GlcNHglycan	216	219	PF01048	0.457
MOD_GlcNHglycan	246	249	PF01048	0.607
MOD_GlcNHglycan	276	279	PF01048	0.546
MOD_GlcNHglycan	350	353	PF01048	0.579
MOD_GlcNHglycan	413	417	PF01048	0.568
MOD_GlcNHglycan	43	46	PF01048	0.709
MOD_GlcNHglycan	470	473	PF01048	0.645
MOD_GlcNHglycan	511	514	PF01048	0.637
MOD_GlcNHglycan	53	56	PF01048	0.662
MOD_GlcNHglycan	589	592	PF01048	0.516
MOD_GlcNHglycan	775	778	PF01048	0.731
MOD_GlcNHglycan	819	822	PF01048	0.683
MOD_GSK3_1	155	162	PF00069	0.414
MOD_GSK3_1	238	245	PF00069	0.627
MOD_GSK3_1	252	259	PF00069	0.563
MOD_GSK3_1	279	286	PF00069	0.676
MOD_GSK3_1	344	351	PF00069	0.587
MOD_GSK3_1	357	364	PF00069	0.369
MOD_GSK3_1	408	415	PF00069	0.450
MOD_GSK3_1	58	65	PF00069	0.675
MOD_GSK3_1	599	606	PF00069	0.644
MOD_GSK3_1	817	824	PF00069	0.720
MOD_GSK3_1	82	89	PF00069	0.706
MOD_LATS_1	27	33	PF00433	0.496
MOD_N-GLC_1	100	105	PF02516	0.566
MOD_N-GLC_1	111	116	PF02516	0.463
MOD_N-GLC_1	119	124	PF02516	0.377
MOD_N-GLC_1	74	79	PF02516	0.520
MOD_NEK2_1	155	160	PF00069	0.374
MOD_NEK2_1	216	221	PF00069	0.455
MOD_NEK2_1	256	261	PF00069	0.503
MOD_NEK2_1	346	351	PF00069	0.577
MOD_NEK2_1	362	367	PF00069	0.456
MOD_NEK2_1	521	526	PF00069	0.491
MOD_NEK2_1	58	63	PF00069	0.674
MOD_NEK2_1	586	591	PF00069	0.441
MOD_NEK2_1	71	76	PF00069	0.567
MOD_NEK2_2	441	446	PF00069	0.382
MOD_PIKK_1	607	613	PF00454	0.577
MOD_PIKK_1	656	662	PF00454	0.645
MOD_PK_1	163	169	PF00069	0.405
MOD_PK_1	569	575	PF00069	0.450
MOD_PKA_1	569	575	PF00069	0.523
MOD_PKA_1	773	779	PF00069	0.737
MOD_PKA_2	292	298	PF00069	0.689
MOD_PKA_2	41	47	PF00069	0.556
MOD_PKA_2	441	447	PF00069	0.530
MOD_PKA_2	521	527	PF00069	0.438
MOD_PKA_2	569	575	PF00069	0.429
MOD_PKA_2	587	593	PF00069	0.443
MOD_PKA_2	607	613	PF00069	0.512
MOD_PKA_2	656	662	PF00069	0.691
MOD_PKA_2	680	686	PF00069	0.699
MOD_PKA_2	773	779	PF00069	0.620
MOD_PKB_1	272	280	PF00069	0.517
MOD_PKB_1	771	779	PF00069	0.609
MOD_Plk_1	100	106	PF00069	0.587
MOD_Plk_1	119	125	PF00069	0.356
MOD_Plk_1	74	80	PF00069	0.694
MOD_Plk_4	119	125	PF00069	0.621
MOD_Plk_4	155	161	PF00069	0.455
MOD_Plk_4	163	169	PF00069	0.371
MOD_Plk_4	222	228	PF00069	0.409
MOD_Plk_4	252	258	PF00069	0.586
MOD_Plk_4	29	35	PF00069	0.526
MOD_Plk_4	357	363	PF00069	0.556
MOD_Plk_4	368	374	PF00069	0.488
MOD_Plk_4	441	447	PF00069	0.440
MOD_Plk_4	626	632	PF00069	0.543
MOD_Plk_4	74	80	PF00069	0.629
MOD_ProDKin_1	174	180	PF00069	0.479
MOD_ProDKin_1	219	225	PF00069	0.363
MOD_ProDKin_1	239	245	PF00069	0.688
MOD_ProDKin_1	276	282	PF00069	0.570
MOD_ProDKin_1	397	403	PF00069	0.618
MOD_ProDKin_1	414	420	PF00069	0.711
MOD_ProDKin_1	454	460	PF00069	0.548
MOD_ProDKin_1	490	496	PF00069	0.660
MOD_ProDKin_1	512	518	PF00069	0.533
MOD_ProDKin_1	599	605	PF00069	0.677
MOD_ProDKin_1	650	656	PF00069	0.751
MOD_ProDKin_1	750	756	PF00069	0.576
MOD_ProDKin_1	825	831	PF00069	0.734
MOD_SUMO_for_1	508	511	PF00179	0.602
MOD_SUMO_rev_2	737	747	PF00179	0.680
TRG_DiLeu_BaEn_1	132	137	PF01217	0.508
TRG_DiLeu_BaEn_1	334	339	PF01217	0.449
TRG_DiLeu_BaLyEn_6	18	23	PF01217	0.350
TRG_DiLeu_BaLyEn_6	285	290	PF01217	0.633
TRG_DiLeu_BaLyEn_6	828	833	PF01217	0.557
TRG_ENDOCYTIC_2	180	183	PF00928	0.490
TRG_ENDOCYTIC_2	20	23	PF00928	0.423
TRG_ENDOCYTIC_2	227	230	PF00928	0.464
TRG_ENDOCYTIC_2	5	8	PF00928	0.506
TRG_ENDOCYTIC_2	557	560	PF00928	0.468
TRG_ENDOCYTIC_2	802	805	PF00928	0.623
TRG_ER_diArg_1	434	437	PF00400	0.477
TRG_ER_diArg_1	519	522	PF00400	0.427
TRG_ER_diArg_1	568	570	PF00400	0.505
TRG_ER_diArg_1	771	774	PF00400	0.584
TRG_ER_diArg_1	797	799	PF00400	0.770
TRG_ER_diArg_1	810	812	PF00400	0.657
TRG_NES_CRM1_1	6	19	PF08389	0.452
TRG_Pf-PMV_PEXEL_1	810	815	PF00026	0.716

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P319	Leptomonas seymouri	51%	92%
A0A1X0NIZ7	Trypanosomatidae	29%	100%
A0A3R7KEZ9	Trypanosoma rangeli	30%	100%
A0A3S7X8X6	Leishmania donovani	100%	100%
A4HMC9	Leishmania braziliensis	76%	100%
E9AES4	Leishmania major	90%	100%
E9B5X9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	100%