Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4IAZ0_LEIIN

TriTrypDb:

LINF_350014000

Length:

169

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	8
GO:0110165	cellular anatomical entity	1	8

Expansion

Sequence features

A4IAZ0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4IAZ0

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	136	138	PF00675	0.371
CLV_NRD_NRD_1	91	93	PF00675	0.328
CLV_PCSK_KEX2_1	135	137	PF00082	0.369
CLV_PCSK_KEX2_1	91	93	PF00082	0.328
CLV_PCSK_PC1ET2_1	135	137	PF00082	0.431
CLV_PCSK_PC7_1	132	138	PF00082	0.375
CLV_PCSK_SKI1_1	146	150	PF00082	0.290
CLV_Separin_Metazoa	88	92	PF03568	0.563
DOC_MAPK_MEF2A_6	146	154	PF00069	0.465
DOC_USP7_MATH_1	21	25	PF00917	0.741
DOC_USP7_UBL2_3	115	119	PF12436	0.632
DOC_WW_Pin1_4	121	126	PF00397	0.565
DOC_WW_Pin1_4	14	19	PF00397	0.631
DOC_WW_Pin1_4	22	27	PF00397	0.743
DOC_WW_Pin1_4	92	97	PF00397	0.606
LIG_14-3-3_CanoR_1	91	95	PF00244	0.602
LIG_BIR_II_1	1	5	PF00653	0.664
LIG_BRCT_BRCA1_1	156	160	PF00533	0.352
LIG_BRCT_BRCA1_1	31	35	PF00533	0.684
LIG_deltaCOP1_diTrp_1	143	148	PF00928	0.579
LIG_FHA_1	145	151	PF00498	0.526
LIG_FHA_2	54	60	PF00498	0.664
LIG_LIR_Gen_1	147	155	PF02991	0.382
LIG_LIR_Nem_3	143	148	PF02991	0.551
LIG_LIR_Nem_3	163	168	PF02991	0.496
LIG_LIR_Nem_3	97	102	PF02991	0.546
LIG_Pex14_1	144	148	PF04695	0.539
LIG_REV1ctd_RIR_1	165	169	PF16727	0.477
LIG_SH2_STAT3	67	70	PF00017	0.581
LIG_SUMO_SIM_anti_2	147	153	PF11976	0.289
LIG_SUMO_SIM_anti_2	86	91	PF11976	0.626
LIG_SxIP_EBH_1	45	57	PF03271	0.528
LIG_TRAF2_1	56	59	PF00917	0.569
LIG_UBA3_1	161	169	PF00899	0.343
LIG_WRC_WIRS_1	145	150	PF05994	0.517
MOD_CK1_1	17	23	PF00069	0.734
MOD_CK1_1	29	35	PF00069	0.591
MOD_CK1_1	69	75	PF00069	0.577
MOD_CK1_1	95	101	PF00069	0.528
MOD_CK2_1	121	127	PF00069	0.604
MOD_CK2_1	53	59	PF00069	0.562
MOD_CK2_1	95	101	PF00069	0.635
MOD_DYRK1A_RPxSP_1	92	96	PF00069	0.605
MOD_GlcNHglycan	19	22	PF01048	0.492
MOD_GSK3_1	17	24	PF00069	0.752
MOD_GSK3_1	90	97	PF00069	0.529
MOD_NEK2_1	160	165	PF00069	0.399
MOD_NEK2_1	90	95	PF00069	0.620
MOD_PIKK_1	66	72	PF00454	0.610
MOD_PKA_2	90	96	PF00069	0.603
MOD_Plk_4	144	150	PF00069	0.468
MOD_ProDKin_1	121	127	PF00069	0.565
MOD_ProDKin_1	14	20	PF00069	0.630
MOD_ProDKin_1	22	28	PF00069	0.741
MOD_ProDKin_1	92	98	PF00069	0.603
MOD_SUMO_for_1	114	117	PF00179	0.595
MOD_SUMO_rev_2	116	121	PF00179	0.678
TRG_ENDOCYTIC_2	145	148	PF00928	0.544
TRG_ER_diArg_1	90	92	PF00400	0.529
TRG_NLS_MonoCore_2	133	138	PF00514	0.611
TRG_NLS_MonoExtN_4	132	139	PF00514	0.616

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PCT3	Leptomonas seymouri	56%	79%
A0A0S4IZW1	Bodo saltans	27%	100%
A0A3Q8IV31	Leishmania donovani	99%	100%
A0A3R7JZ23	Trypanosoma rangeli	38%	91%
A4HMC4	Leishmania braziliensis	76%	100%
C9ZNI8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	29%	81%
E9AER8	Leishmania major	91%	100%
E9B5X3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	99%