PP28 domain-containing protein

Quick info Annotations Localization Phosphorylation Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4IAY7_LEIIN

TriTrypDb:

LINF_350013700

Length:

235

Annotations

Annotations by Jardim et al.

Uncharacterized Protein, Uncharacterized

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Could not find GO cellular_component term for this entry.

Phosphorylation

Promastigote/Amastigote: 204, 205

Expansion

Sequence features

A4IAY7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4IAY7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	122	124	PF00675	0.484
CLV_NRD_NRD_1	129	131	PF00675	0.520
CLV_NRD_NRD_1	13	15	PF00675	0.588
CLV_NRD_NRD_1	163	165	PF00675	0.475
CLV_NRD_NRD_1	181	183	PF00675	0.427
CLV_NRD_NRD_1	185	187	PF00675	0.471
CLV_NRD_NRD_1	188	190	PF00675	0.471
CLV_NRD_NRD_1	33	35	PF00675	0.349
CLV_NRD_NRD_1	57	59	PF00675	0.507
CLV_PCSK_FUR_1	178	182	PF00082	0.509
CLV_PCSK_KEX2_1	122	124	PF00082	0.487
CLV_PCSK_KEX2_1	128	130	PF00082	0.523
CLV_PCSK_KEX2_1	13	15	PF00082	0.588
CLV_PCSK_KEX2_1	162	164	PF00082	0.491
CLV_PCSK_KEX2_1	174	176	PF00082	0.424
CLV_PCSK_KEX2_1	180	182	PF00082	0.373
CLV_PCSK_KEX2_1	185	187	PF00082	0.470
CLV_PCSK_KEX2_1	33	35	PF00082	0.349
CLV_PCSK_KEX2_1	57	59	PF00082	0.507
CLV_PCSK_PC1ET2_1	128	130	PF00082	0.517
CLV_PCSK_PC1ET2_1	13	15	PF00082	0.624
CLV_PCSK_PC1ET2_1	162	164	PF00082	0.546
CLV_PCSK_PC1ET2_1	174	176	PF00082	0.398
CLV_PCSK_PC7_1	181	187	PF00082	0.524
CLV_PCSK_SKI1_1	15	19	PF00082	0.558
CLV_PCSK_SKI1_1	150	154	PF00082	0.442
CLV_PCSK_SKI1_1	213	217	PF00082	0.630
CLV_PCSK_SKI1_1	33	37	PF00082	0.546
DOC_MAPK_gen_1	108	117	PF00069	0.541
DOC_PIKK_1	195	202	PF02985	0.596
DOC_USP7_UBL2_3	158	162	PF12436	0.551
DOC_USP7_UBL2_3	213	217	PF12436	0.657
DOC_USP7_UBL2_3	5	9	PF12436	0.631
DOC_WW_Pin1_4	25	30	PF00397	0.527
LIG_14-3-3_CanoR_1	141	146	PF00244	0.558
LIG_14-3-3_CanoR_1	85	89	PF00244	0.484
LIG_BIR_II_1	1	5	PF00653	0.610
LIG_FHA_2	16	22	PF00498	0.495
LIG_FHA_2	26	32	PF00498	0.436
LIG_FHA_2	6	12	PF00498	0.703
LIG_FHA_2	95	101	PF00498	0.556
LIG_LIR_Gen_1	93	104	PF02991	0.482
LIG_PCNA_yPIPBox_3	65	78	PF02747	0.473
LIG_TRAF2_1	170	173	PF00917	0.509
LIG_TRAF2_1	51	54	PF00917	0.506
MOD_CK2_1	202	208	PF00069	0.640
MOD_CK2_1	5	11	PF00069	0.631
MOD_CK2_1	94	100	PF00069	0.541
MOD_GSK3_1	5	12	PF00069	0.604
MOD_GSK3_1	80	87	PF00069	0.541
MOD_GSK3_1	94	101	PF00069	0.571
MOD_N-GLC_1	5	10	PF02516	0.630
MOD_PIKK_1	94	100	PF00454	0.476
MOD_PKA_1	9	15	PF00069	0.605
MOD_PKA_2	84	90	PF00069	0.488
MOD_Plk_1	94	100	PF00069	0.539
MOD_Plk_4	218	224	PF00069	0.473
MOD_Plk_4	73	79	PF00069	0.495
MOD_ProDKin_1	25	31	PF00069	0.525
MOD_SUMO_rev_2	166	176	PF00179	0.514
MOD_SUMO_rev_2	38	48	PF00179	0.564
TRG_DiLeu_BaEn_1	100	105	PF01217	0.479
TRG_DiLeu_BaLyEn_6	189	194	PF01217	0.544
TRG_ER_diArg_1	163	165	PF00400	0.481
TRG_ER_diArg_1	180	182	PF00400	0.446
TRG_ER_diArg_1	32	34	PF00400	0.558
TRG_NLS_Bipartite_1	174	190	PF00514	0.497
TRG_NLS_MonoExtC_3	127	133	PF00514	0.490
TRG_NLS_MonoExtC_3	185	190	PF00514	0.556
TRG_NLS_MonoExtN_4	185	190	PF00514	0.556
TRG_Pf-PMV_PEXEL_1	15	19	PF00026	0.506
TRG_Pf-PMV_PEXEL_1	163	167	PF00026	0.514
TRG_Pf-PMV_PEXEL_1	192	197	PF00026	0.558
TRG_Pf-PMV_PEXEL_1	33	37	PF00026	0.487

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PBR1	Leptomonas seymouri	71%	99%
A0A3S7X8W2	Leishmania donovani	100%	100%
A4HMC1	Leishmania braziliensis	85%	100%
E9AER5	Leishmania major	98%	100%
E9B5X0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	97%	100%
V5AL94	Trypanosoma cruzi	41%	99%