CX9C domain-containing protein

Quick info Annotations Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4IAY6_LEIIN

TriTrypDb:

LINF_350013600

Length:

165

Annotations

Annotations by Jardim et al.

Uncharacterized Protein, Uncharacterized

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0031974	membrane-enclosed lumen	2	1
GO:0031981	nuclear lumen	5	1
GO:0032838	plasma membrane bounded cell projection cytoplasm	4	1
GO:0043233	organelle lumen	3	1
GO:0070013	intracellular organelle lumen	4	1
GO:0097014	ciliary plasm	5	1
GO:0099568	cytoplasmic region	3	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4IAY6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4IAY6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
DEG_Nend_Nbox_1	1	3	PF02207	0.757
DEG_SPOP_SBC_1	77	81	PF00917	0.672
DOC_CYCLIN_yCln2_LP_2	47	53	PF00134	0.523
DOC_PP2B_LxvP_1	111	114	PF13499	0.564
DOC_USP7_MATH_1	153	157	PF00917	0.541
DOC_USP7_MATH_1	24	28	PF00917	0.563
DOC_USP7_MATH_1	83	87	PF00917	0.708
DOC_USP7_UBL2_3	159	163	PF12436	0.620
DOC_WW_Pin1_4	4	9	PF00397	0.664
DOC_WW_Pin1_4	46	51	PF00397	0.512
DOC_WW_Pin1_4	85	90	PF00397	0.745
LIG_Actin_RPEL_3	139	158	PF02755	0.412
LIG_LIR_Gen_1	108	115	PF02991	0.577
LIG_LIR_Nem_3	108	113	PF02991	0.512
LIG_LIR_Nem_3	27	32	PF02991	0.465
LIG_SH2_CRK	69	73	PF00017	0.555
LIG_SH2_STAP1	119	123	PF00017	0.416
LIG_SH3_3	86	92	PF00018	0.771
LIG_SUMO_SIM_par_1	138	144	PF11976	0.510
MOD_CK1_1	35	41	PF00069	0.579
MOD_CK1_1	4	10	PF00069	0.724
MOD_CK1_1	76	82	PF00069	0.682
MOD_CK1_1	85	91	PF00069	0.673
MOD_CK1_1	99	105	PF00069	0.642
MOD_GlcNHglycan	75	78	PF01048	0.580
MOD_GlcNHglycan	85	88	PF01048	0.641
MOD_GSK3_1	72	79	PF00069	0.559
MOD_GSK3_1	94	101	PF00069	0.698
MOD_N-GLC_1	35	40	PF02516	0.454
MOD_NEK2_1	1	6	PF00069	0.749
MOD_NEK2_1	51	56	PF00069	0.537
MOD_NEK2_1	72	77	PF00069	0.547
MOD_PIKK_1	145	151	PF00454	0.540
MOD_PKA_2	145	151	PF00069	0.613
MOD_Plk_1	129	135	PF00069	0.452
MOD_Plk_1	35	41	PF00069	0.473
MOD_Plk_4	153	159	PF00069	0.633
MOD_Plk_4	35	41	PF00069	0.582
MOD_ProDKin_1	4	10	PF00069	0.666
MOD_ProDKin_1	46	52	PF00069	0.516
MOD_ProDKin_1	85	91	PF00069	0.744
MOD_SUMO_rev_2	27	32	PF00179	0.573
MOD_SUMO_rev_2	97	102	PF00179	0.736
TRG_ENDOCYTIC_2	69	72	PF00928	0.549
TRG_NES_CRM1_1	131	144	PF08389	0.376

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P3P8	Leptomonas seymouri	65%	93%
A0A1X0NIU2	Trypanosomatidae	37%	100%
A0A3R7KNC4	Trypanosoma rangeli	36%	96%
A0A3S7X8W7	Leishmania donovani	99%	100%
A4HMC0	Leishmania braziliensis	78%	100%
C9ZNI3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	40%	100%
E9AER4	Leishmania major	93%	100%
E9B5W9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%
V5D1X1	Trypanosoma cruzi	35%	99%