Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4IAY3_LEIIN

TriTrypDb:

LINF_350013300

Length:

428

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4IAY3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4IAY3

Function

Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	11
GO:0006396	RNA processing	6	11
GO:0006399	tRNA metabolic process	7	11
GO:0006400	tRNA modification	6	11
GO:0006725	cellular aromatic compound metabolic process	3	11
GO:0006807	nitrogen compound metabolic process	2	11
GO:0008033	tRNA processing	8	11
GO:0008152	metabolic process	1	11
GO:0009451	RNA modification	5	11
GO:0009987	cellular process	1	11
GO:0016070	RNA metabolic process	5	11
GO:0034470	ncRNA processing	7	11
GO:0034641	cellular nitrogen compound metabolic process	3	11
GO:0034660	ncRNA metabolic process	6	11
GO:0043170	macromolecule metabolic process	3	11
GO:0043412	macromolecule modification	4	11
GO:0044237	cellular metabolic process	2	11
GO:0044238	primary metabolic process	2	11
GO:0046483	heterocycle metabolic process	3	11
GO:0071704	organic substance metabolic process	2	11
GO:0090304	nucleic acid metabolic process	4	11
GO:1901360	organic cyclic compound metabolic process	3	11

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	11
GO:0003723	RNA binding	4	11
GO:0003824	catalytic activity	1	4
GO:0005488	binding	1	11
GO:0009055	electron transfer activity	3	4
GO:0016491	oxidoreductase activity	2	4
GO:0020037	heme binding	4	4
GO:0046906	tetrapyrrole binding	3	4
GO:0097159	organic cyclic compound binding	2	11
GO:1901363	heterocyclic compound binding	2	11
GO:0043167	ion binding	2	2
GO:0043169	cation binding	3	2
GO:0046872	metal ion binding	4	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	141	145	PF00656	0.645
CLV_C14_Caspase3-7	220	224	PF00656	0.773
CLV_C14_Caspase3-7	290	294	PF00656	0.528
CLV_C14_Caspase3-7	4	8	PF00656	0.697
CLV_NRD_NRD_1	156	158	PF00675	0.619
CLV_NRD_NRD_1	162	164	PF00675	0.675
CLV_NRD_NRD_1	279	281	PF00675	0.405
CLV_NRD_NRD_1	319	321	PF00675	0.550
CLV_NRD_NRD_1	390	392	PF00675	0.400
CLV_PCSK_FUR_1	153	157	PF00082	0.677
CLV_PCSK_FUR_1	317	321	PF00082	0.547
CLV_PCSK_KEX2_1	124	126	PF00082	0.703
CLV_PCSK_KEX2_1	153	155	PF00082	0.619
CLV_PCSK_KEX2_1	156	158	PF00082	0.593
CLV_PCSK_KEX2_1	162	164	PF00082	0.675
CLV_PCSK_KEX2_1	2	4	PF00082	0.713
CLV_PCSK_KEX2_1	319	321	PF00082	0.561
CLV_PCSK_KEX2_1	390	392	PF00082	0.420
CLV_PCSK_KEX2_1	66	68	PF00082	0.435
CLV_PCSK_PC1ET2_1	124	126	PF00082	0.743
CLV_PCSK_PC1ET2_1	2	4	PF00082	0.701
CLV_PCSK_PC1ET2_1	66	68	PF00082	0.435
CLV_PCSK_SKI1_1	19	23	PF00082	0.641
CLV_PCSK_SKI1_1	252	256	PF00082	0.420
CLV_PCSK_SKI1_1	280	284	PF00082	0.485
CLV_PCSK_SKI1_1	307	311	PF00082	0.399
CLV_PCSK_SKI1_1	390	394	PF00082	0.466
DEG_Nend_UBRbox_1	1	4	PF02207	0.673
DEG_SPOP_SBC_1	216	220	PF00917	0.723
DOC_CYCLIN_RxL_1	277	284	PF00134	0.357
DOC_CYCLIN_RxL_1	304	312	PF00134	0.389
DOC_MAPK_gen_1	14	22	PF00069	0.535
DOC_MAPK_gen_1	280	287	PF00069	0.413
DOC_MAPK_gen_1	317	327	PF00069	0.508
DOC_MAPK_gen_1	41	50	PF00069	0.410
DOC_MAPK_MEF2A_6	175	182	PF00069	0.344
DOC_MAPK_MEF2A_6	280	287	PF00069	0.482
DOC_MAPK_MEF2A_6	320	329	PF00069	0.408
DOC_MAPK_NFAT4_5	175	183	PF00069	0.477
DOC_MAPK_NFAT4_5	280	288	PF00069	0.489
DOC_MAPK_RevD_3	327	341	PF00069	0.433
DOC_PP2B_LxvP_1	180	183	PF13499	0.462
DOC_SPAK_OSR1_1	356	360	PF12202	0.377
DOC_USP7_MATH_1	108	112	PF00917	0.455
DOC_USP7_MATH_1	215	219	PF00917	0.702
DOC_USP7_MATH_1	234	238	PF00917	0.266
DOC_USP7_MATH_1	318	322	PF00917	0.641
DOC_USP7_MATH_1	343	347	PF00917	0.579
DOC_USP7_MATH_1	361	365	PF00917	0.368
DOC_USP7_MATH_1	80	84	PF00917	0.709
DOC_USP7_MATH_1	93	97	PF00917	0.530
DOC_WW_Pin1_4	134	139	PF00397	0.813
DOC_WW_Pin1_4	156	161	PF00397	0.648
DOC_WW_Pin1_4	414	419	PF00397	0.544
DOC_WW_Pin1_4	68	73	PF00397	0.527
LIG_14-3-3_CanoR_1	119	126	PF00244	0.623
LIG_14-3-3_CanoR_1	162	170	PF00244	0.560
LIG_14-3-3_CanoR_1	238	244	PF00244	0.567
LIG_14-3-3_CanoR_1	280	286	PF00244	0.372
LIG_14-3-3_CanoR_1	317	323	PF00244	0.526
LIG_14-3-3_CanoR_1	390	398	PF00244	0.533
LIG_14-3-3_CanoR_1	67	72	PF00244	0.472
LIG_BIR_III_2	223	227	PF00653	0.511
LIG_BIR_III_4	78	82	PF00653	0.617
LIG_BRCT_BRCA1_1	163	167	PF00533	0.551
LIG_BRCT_BRCA1_1	283	287	PF00533	0.372
LIG_FHA_1	227	233	PF00498	0.548
LIG_FHA_1	238	244	PF00498	0.486
LIG_FHA_1	322	328	PF00498	0.591
LIG_FHA_1	347	353	PF00498	0.474
LIG_FHA_1	372	378	PF00498	0.433
LIG_FHA_1	52	58	PF00498	0.518
LIG_FHA_2	218	224	PF00498	0.758
LIG_FHA_2	269	275	PF00498	0.400
LIG_FHA_2	333	339	PF00498	0.425
LIG_LIR_Apic_2	164	169	PF02991	0.548
LIG_LIR_Gen_1	241	251	PF02991	0.440
LIG_LIR_Nem_3	164	170	PF02991	0.560
LIG_LIR_Nem_3	241	247	PF02991	0.399
LIG_NRBOX	278	284	PF00104	0.415
LIG_NRBOX	98	104	PF00104	0.561
LIG_PALB2_WD40_1	162	170	PF16756	0.574
LIG_Pex14_2	255	259	PF04695	0.485
LIG_SH2_STAT5	177	180	PF00017	0.409
LIG_SH2_STAT5	49	52	PF00017	0.400
LIG_SH3_3	186	192	PF00018	0.526
LIG_SH3_3	228	234	PF00018	0.453
LIG_SH3_3	357	363	PF00018	0.397
LIG_SH3_3	87	93	PF00018	0.721
LIG_TRAF2_1	36	39	PF00917	0.453
LIG_TRFH_1	259	263	PF08558	0.329
MOD_CDK_SPK_2	414	419	PF00069	0.544
MOD_CDK_SPxK_1	156	162	PF00069	0.650
MOD_CDK_SPxxK_3	156	163	PF00069	0.649
MOD_CK1_1	237	243	PF00069	0.462
MOD_CK1_1	321	327	PF00069	0.504
MOD_CK1_1	346	352	PF00069	0.439
MOD_CK1_1	364	370	PF00069	0.391
MOD_CK1_1	51	57	PF00069	0.540
MOD_CK1_1	68	74	PF00069	0.642
MOD_CK1_1	98	104	PF00069	0.557
MOD_CK2_1	215	221	PF00069	0.646
MOD_CK2_1	268	274	PF00069	0.402
MOD_CK2_1	332	338	PF00069	0.420
MOD_CK2_1	52	58	PF00069	0.583
MOD_GlcNHglycan	110	113	PF01048	0.551
MOD_GlcNHglycan	345	348	PF01048	0.473
MOD_GlcNHglycan	73	76	PF01048	0.793
MOD_GlcNHglycan	95	98	PF01048	0.736
MOD_GSK3_1	108	115	PF00069	0.641
MOD_GSK3_1	142	149	PF00069	0.718
MOD_GSK3_1	181	188	PF00069	0.537
MOD_GSK3_1	264	271	PF00069	0.370
MOD_GSK3_1	288	295	PF00069	0.579
MOD_GSK3_1	367	374	PF00069	0.539
MOD_GSK3_1	390	397	PF00069	0.588
MOD_GSK3_1	48	55	PF00069	0.456
MOD_GSK3_1	67	74	PF00069	0.757
MOD_GSK3_1	93	100	PF00069	0.675
MOD_N-GLC_1	120	125	PF02516	0.622
MOD_N-GLC_1	185	190	PF02516	0.501
MOD_N-GLC_1	332	337	PF02516	0.402
MOD_NEK2_1	1	6	PF00069	0.709
MOD_NEK2_1	120	125	PF00069	0.658
MOD_NEK2_1	30	35	PF00069	0.411
MOD_NEK2_1	327	332	PF00069	0.491
MOD_NEK2_1	408	413	PF00069	0.549
MOD_NEK2_1	48	53	PF00069	0.547
MOD_NEK2_2	318	323	PF00069	0.514
MOD_PKA_1	390	396	PF00069	0.534
MOD_PKA_2	161	167	PF00069	0.609
MOD_PKA_2	237	243	PF00069	0.564
MOD_PKA_2	318	324	PF00069	0.526
MOD_PKA_2	390	396	PF00069	0.534
MOD_PKA_2	81	87	PF00069	0.772
MOD_Plk_1	185	191	PF00069	0.585
MOD_Plk_1	292	298	PF00069	0.570
MOD_Plk_1	332	338	PF00069	0.466
MOD_Plk_1	371	377	PF00069	0.392
MOD_Plk_1	88	94	PF00069	0.681
MOD_Plk_4	226	232	PF00069	0.485
MOD_Plk_4	98	104	PF00069	0.544
MOD_ProDKin_1	134	140	PF00069	0.811
MOD_ProDKin_1	156	162	PF00069	0.650
MOD_ProDKin_1	414	420	PF00069	0.545
MOD_ProDKin_1	68	74	PF00069	0.532
MOD_SUMO_for_1	418	421	PF00179	0.559
MOD_SUMO_rev_2	4	10	PF00179	0.683
TRG_ENDOCYTIC_2	177	180	PF00928	0.409
TRG_ER_diArg_1	153	156	PF00400	0.621
TRG_ER_diArg_1	317	320	PF00400	0.579
TRG_ER_diArg_1	390	392	PF00400	0.397
TRG_NLS_MonoCore_2	123	128	PF00514	0.720
TRG_NLS_MonoExtC_3	123	129	PF00514	0.735
TRG_Pf-PMV_PEXEL_1	423	428	PF00026	0.508

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IGK4	Leptomonas seymouri	67%	100%
A0A0S4J2S0	Bodo saltans	28%	100%
A0A1X0NJH1	Trypanosomatidae	37%	100%
A0A3Q8IHS0	Leishmania donovani	100%	100%
A0A3R7NE95	Trypanosoma rangeli	40%	100%
A4HMB7	Leishmania braziliensis	80%	99%
D0A272	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	38%	100%
E9AER1	Leishmania major	90%	99%
E9B5W6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	99%