Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4IAX7_LEIIN

TriTrypDb:

LINF_350012700

Length:

998

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4IAX7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4IAX7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	533	537	PF00656	0.654
CLV_C14_Caspase3-7	939	943	PF00656	0.808
CLV_C14_Caspase3-7	951	955	PF00656	0.556
CLV_NRD_NRD_1	104	106	PF00675	0.738
CLV_NRD_NRD_1	23	25	PF00675	0.614
CLV_NRD_NRD_1	691	693	PF00675	0.693
CLV_NRD_NRD_1	879	881	PF00675	0.728
CLV_PCSK_KEX2_1	104	106	PF00082	0.749
CLV_PCSK_KEX2_1	23	25	PF00082	0.614
CLV_PCSK_KEX2_1	669	671	PF00082	0.607
CLV_PCSK_KEX2_1	691	693	PF00082	0.693
CLV_PCSK_KEX2_1	879	881	PF00082	0.728
CLV_PCSK_PC1ET2_1	669	671	PF00082	0.515
CLV_PCSK_PC7_1	665	671	PF00082	0.488
CLV_PCSK_SKI1_1	151	155	PF00082	0.693
CLV_PCSK_SKI1_1	42	46	PF00082	0.550
CLV_PCSK_SKI1_1	665	669	PF00082	0.563
CLV_PCSK_SKI1_1	670	674	PF00082	0.632
CLV_PCSK_SKI1_1	791	795	PF00082	0.674
CLV_PCSK_SKI1_1	807	811	PF00082	0.538
CLV_PCSK_SKI1_1	862	866	PF00082	0.818
CLV_PCSK_SKI1_1	990	994	PF00082	0.593
CLV_Separin_Metazoa	961	965	PF03568	0.658
DEG_COP1_1	676	686	PF00400	0.599
DEG_SCF_FBW7_1	740	745	PF00400	0.712
DEG_SPOP_SBC_1	243	247	PF00917	0.733
DEG_SPOP_SBC_1	801	805	PF00917	0.721
DOC_CKS1_1	470	475	PF01111	0.826
DOC_CKS1_1	739	744	PF01111	0.744
DOC_CYCLIN_RxL_1	39	49	PF00134	0.552
DOC_CYCLIN_yCln2_LP_2	458	464	PF00134	0.635
DOC_MAPK_DCC_7	925	935	PF00069	0.767
DOC_MAPK_gen_1	925	935	PF00069	0.743
DOC_MAPK_MEF2A_6	928	935	PF00069	0.750
DOC_PP2B_LxvP_1	458	461	PF13499	0.733
DOC_PP2B_LxvP_1	917	920	PF13499	0.736
DOC_PP4_FxxP_1	86	89	PF00568	0.804
DOC_PP4_MxPP_1	838	841	PF00568	0.753
DOC_USP7_MATH_1	111	115	PF00917	0.795
DOC_USP7_MATH_1	133	137	PF00917	0.679
DOC_USP7_MATH_1	139	143	PF00917	0.750
DOC_USP7_MATH_1	178	182	PF00917	0.792
DOC_USP7_MATH_1	243	247	PF00917	0.818
DOC_USP7_MATH_1	356	360	PF00917	0.776
DOC_USP7_MATH_1	476	480	PF00917	0.790
DOC_USP7_MATH_1	490	494	PF00917	0.737
DOC_USP7_MATH_1	511	515	PF00917	0.675
DOC_USP7_MATH_1	582	586	PF00917	0.734
DOC_USP7_MATH_1	607	611	PF00917	0.750
DOC_USP7_MATH_1	639	643	PF00917	0.838
DOC_USP7_MATH_1	648	652	PF00917	0.668
DOC_USP7_MATH_1	682	686	PF00917	0.720
DOC_USP7_MATH_1	742	746	PF00917	0.737
DOC_USP7_MATH_1	753	757	PF00917	0.775
DOC_USP7_MATH_1	759	763	PF00917	0.747
DOC_USP7_MATH_1	813	817	PF00917	0.741
DOC_USP7_MATH_1	869	873	PF00917	0.635
DOC_USP7_MATH_1	938	942	PF00917	0.754
DOC_USP7_UBL2_3	862	866	PF12436	0.527
DOC_WW_Pin1_4	199	204	PF00397	0.739
DOC_WW_Pin1_4	245	250	PF00397	0.684
DOC_WW_Pin1_4	313	318	PF00397	0.731
DOC_WW_Pin1_4	469	474	PF00397	0.734
DOC_WW_Pin1_4	486	491	PF00397	0.531
DOC_WW_Pin1_4	541	546	PF00397	0.743
DOC_WW_Pin1_4	577	582	PF00397	0.718
DOC_WW_Pin1_4	723	728	PF00397	0.837
DOC_WW_Pin1_4	738	743	PF00397	0.580
DOC_WW_Pin1_4	926	931	PF00397	0.710
DOC_WW_Pin1_4	973	978	PF00397	0.642
LIG_14-3-3_CanoR_1	220	230	PF00244	0.703
LIG_14-3-3_CanoR_1	31	37	PF00244	0.586
LIG_14-3-3_CanoR_1	345	353	PF00244	0.799
LIG_14-3-3_CanoR_1	602	607	PF00244	0.760
LIG_14-3-3_CanoR_1	691	696	PF00244	0.768
LIG_14-3-3_CanoR_1	717	727	PF00244	0.803
LIG_14-3-3_CanoR_1	791	800	PF00244	0.613
LIG_14-3-3_CanoR_1	83	89	PF00244	0.775
LIG_14-3-3_CanoR_1	966	972	PF00244	0.674
LIG_Actin_WH2_2	7	25	PF00022	0.601
LIG_BIR_II_1	1	5	PF00653	0.676
LIG_BIR_III_3	1	5	PF00653	0.778
LIG_BIR_III_4	273	277	PF00653	0.789
LIG_BIR_III_4	751	755	PF00653	0.635
LIG_BIR_III_4	828	832	PF00653	0.800
LIG_BRCT_BRCA1_1	543	547	PF00533	0.727
LIG_BRCT_BRCA1_1	785	789	PF00533	0.753
LIG_BRCT_BRCA1_1	971	975	PF00533	0.668
LIG_deltaCOP1_diTrp_1	378	386	PF00928	0.643
LIG_deltaCOP1_diTrp_1	784	789	PF00928	0.755
LIG_FHA_1	263	269	PF00498	0.692
LIG_FHA_1	36	42	PF00498	0.576
LIG_FHA_1	498	504	PF00498	0.744
LIG_FHA_1	52	58	PF00498	0.604
LIG_FHA_1	551	557	PF00498	0.585
LIG_FHA_1	592	598	PF00498	0.696
LIG_FHA_1	776	782	PF00498	0.786
LIG_FHA_1	792	798	PF00498	0.575
LIG_FHA_1	95	101	PF00498	0.834
LIG_FHA_2	152	158	PF00498	0.709
LIG_FHA_2	533	539	PF00498	0.739
LIG_FHA_2	745	751	PF00498	0.769
LIG_Integrin_RGD_1	774	776	PF01839	0.827
LIG_LIR_Apic_2	922	926	PF02991	0.728
LIG_LIR_Gen_1	784	795	PF02991	0.753
LIG_LIR_Nem_3	378	383	PF02991	0.648
LIG_LIR_Nem_3	544	550	PF02991	0.726
LIG_LIR_Nem_3	784	790	PF02991	0.754
LIG_Pex14_2	971	975	PF04695	0.629
LIG_SH2_GRB2like	37	40	PF00017	0.580
LIG_SH2_NCK_1	5	9	PF00017	0.656
LIG_SH2_NCK_1	886	890	PF00017	0.607
LIG_SH2_SRC	462	465	PF00017	0.636
LIG_SH2_SRC	577	580	PF00017	0.615
LIG_SH2_STAP1	327	331	PF00017	0.692
LIG_SH2_STAP1	37	41	PF00017	0.571
LIG_SH2_STAT3	13	16	PF00017	0.575
LIG_SH2_STAT3	232	235	PF00017	0.701
LIG_SH2_STAT5	13	16	PF00017	0.531
LIG_SH2_STAT5	37	40	PF00017	0.580
LIG_SH2_STAT5	462	465	PF00017	0.681
LIG_SH2_STAT5	5	8	PF00017	0.654
LIG_SH2_STAT5	51	54	PF00017	0.583
LIG_SH2_STAT5	577	580	PF00017	0.615
LIG_SH2_STAT5	592	595	PF00017	0.694
LIG_SH3_1	315	321	PF00018	0.826
LIG_SH3_1	576	582	PF00018	0.534
LIG_SH3_2	317	322	PF14604	0.649
LIG_SH3_3	314	320	PF00018	0.807
LIG_SH3_3	417	423	PF00018	0.693
LIG_SH3_3	436	442	PF00018	0.751
LIG_SH3_3	443	449	PF00018	0.634
LIG_SH3_3	458	464	PF00018	0.702
LIG_SH3_3	470	476	PF00018	0.676
LIG_SH3_3	54	60	PF00018	0.626
LIG_SH3_3	552	558	PF00018	0.773
LIG_SH3_3	567	573	PF00018	0.577
LIG_SH3_3	576	582	PF00018	0.695
LIG_SH3_3	584	590	PF00018	0.687
LIG_SH3_3	593	599	PF00018	0.556
LIG_SH3_3	633	639	PF00018	0.704
LIG_SH3_3	721	727	PF00018	0.820
LIG_SH3_3	912	918	PF00018	0.719
LIG_Sin3_3	593	600	PF02671	0.692
LIG_SUMO_SIM_par_1	288	295	PF11976	0.739
LIG_UBA3_1	660	669	PF00899	0.549
LIG_WW_3	88	92	PF00397	0.755
MOD_CK1_1	138	144	PF00069	0.723
MOD_CK1_1	197	203	PF00069	0.731
MOD_CK1_1	218	224	PF00069	0.713
MOD_CK1_1	226	232	PF00069	0.798
MOD_CK1_1	245	251	PF00069	0.506
MOD_CK1_1	281	287	PF00069	0.770
MOD_CK1_1	346	352	PF00069	0.710
MOD_CK1_1	361	367	PF00069	0.619
MOD_CK1_1	401	407	PF00069	0.665
MOD_CK1_1	465	471	PF00069	0.731
MOD_CK1_1	499	505	PF00069	0.690
MOD_CK1_1	532	538	PF00069	0.705
MOD_CK1_1	677	683	PF00069	0.709
MOD_CK1_1	693	699	PF00069	0.664
MOD_CK1_1	726	732	PF00069	0.745
MOD_CK1_1	820	826	PF00069	0.741
MOD_CK1_1	885	891	PF00069	0.727
MOD_CK2_1	151	157	PF00069	0.710
MOD_CK2_1	221	227	PF00069	0.740
MOD_CK2_1	386	392	PF00069	0.582
MOD_CK2_1	532	538	PF00069	0.674
MOD_CK2_1	954	960	PF00069	0.676
MOD_Cter_Amidation	102	105	PF01082	0.754
MOD_Cter_Amidation	689	692	PF01082	0.703
MOD_GlcNHglycan	107	110	PF01048	0.818
MOD_GlcNHglycan	111	114	PF01048	0.742
MOD_GlcNHglycan	118	121	PF01048	0.609
MOD_GlcNHglycan	137	140	PF01048	0.595
MOD_GlcNHglycan	141	144	PF01048	0.772
MOD_GlcNHglycan	161	164	PF01048	0.469
MOD_GlcNHglycan	180	183	PF01048	0.570
MOD_GlcNHglycan	196	199	PF01048	0.559
MOD_GlcNHglycan	270	273	PF01048	0.701
MOD_GlcNHglycan	283	286	PF01048	0.670
MOD_GlcNHglycan	294	297	PF01048	0.745
MOD_GlcNHglycan	338	341	PF01048	0.796
MOD_GlcNHglycan	345	348	PF01048	0.684
MOD_GlcNHglycan	358	361	PF01048	0.460
MOD_GlcNHglycan	403	406	PF01048	0.625
MOD_GlcNHglycan	435	438	PF01048	0.805
MOD_GlcNHglycan	439	442	PF01048	0.683
MOD_GlcNHglycan	478	481	PF01048	0.770
MOD_GlcNHglycan	513	516	PF01048	0.616
MOD_GlcNHglycan	584	587	PF01048	0.695
MOD_GlcNHglycan	641	644	PF01048	0.842
MOD_GlcNHglycan	680	683	PF01048	0.794
MOD_GlcNHglycan	684	687	PF01048	0.778
MOD_GlcNHglycan	720	723	PF01048	0.728
MOD_GlcNHglycan	744	747	PF01048	0.726
MOD_GlcNHglycan	755	758	PF01048	0.809
MOD_GlcNHglycan	832	837	PF01048	0.690
MOD_GlcNHglycan	86	89	PF01048	0.747
MOD_GlcNHglycan	871	874	PF01048	0.644
MOD_GlcNHglycan	938	941	PF01048	0.714
MOD_GlcNHglycan	950	953	PF01048	0.523
MOD_GlcNHglycan	971	974	PF01048	0.634
MOD_GSK3_1	105	112	PF00069	0.700
MOD_GSK3_1	131	138	PF00069	0.796
MOD_GSK3_1	192	199	PF00069	0.728
MOD_GSK3_1	231	238	PF00069	0.801
MOD_GSK3_1	243	250	PF00069	0.728
MOD_GSK3_1	264	271	PF00069	0.714
MOD_GSK3_1	3	10	PF00069	0.635
MOD_GSK3_1	341	348	PF00069	0.732
MOD_GSK3_1	386	393	PF00069	0.628
MOD_GSK3_1	394	401	PF00069	0.633
MOD_GSK3_1	433	440	PF00069	0.789
MOD_GSK3_1	462	469	PF00069	0.705
MOD_GSK3_1	486	493	PF00069	0.693
MOD_GSK3_1	497	504	PF00069	0.742
MOD_GSK3_1	539	546	PF00069	0.722
MOD_GSK3_1	673	680	PF00069	0.671
MOD_GSK3_1	708	715	PF00069	0.720
MOD_GSK3_1	738	745	PF00069	0.696
MOD_GSK3_1	759	766	PF00069	0.706
MOD_GSK3_1	791	798	PF00069	0.673
MOD_GSK3_1	808	815	PF00069	0.536
MOD_GSK3_1	881	888	PF00069	0.685
MOD_GSK3_1	969	976	PF00069	0.668
MOD_N-GLC_1	215	220	PF02516	0.738
MOD_N-GLC_1	432	437	PF02516	0.734
MOD_N-GLC_1	550	555	PF02516	0.585
MOD_N-GLC_1	889	894	PF02516	0.715
MOD_N-GLC_1	954	959	PF02516	0.758
MOD_N-GLC_1	973	978	PF02516	0.654
MOD_N-GLC_2	166	168	PF02516	0.721
MOD_NEK2_1	137	142	PF00069	0.729
MOD_NEK2_1	196	201	PF00069	0.727
MOD_NEK2_1	231	236	PF00069	0.805
MOD_NEK2_1	336	341	PF00069	0.687
MOD_NEK2_1	343	348	PF00069	0.668
MOD_NEK2_1	351	356	PF00069	0.562
MOD_NEK2_1	386	391	PF00069	0.581
MOD_NEK2_1	550	555	PF00069	0.585
MOD_NEK2_1	668	673	PF00069	0.630
MOD_NEK2_1	94	99	PF00069	0.756
MOD_NEK2_1	948	953	PF00069	0.621
MOD_NEK2_1	991	996	PF00069	0.707
MOD_OFUCOSY	168	174	PF10250	0.681
MOD_PIKK_1	231	237	PF00454	0.699
MOD_PIKK_1	24	30	PF00454	0.518
MOD_PIKK_1	58	64	PF00454	0.651
MOD_PIKK_1	94	100	PF00454	0.771
MOD_PKA_1	691	697	PF00069	0.691
MOD_PKA_2	159	165	PF00069	0.727
MOD_PKA_2	30	36	PF00069	0.611
MOD_PKA_2	601	607	PF00069	0.601
MOD_PKA_2	631	637	PF00069	0.771
MOD_PKA_2	690	696	PF00069	0.693
MOD_PKA_2	820	826	PF00069	0.817
MOD_PKA_2	869	875	PF00069	0.674
MOD_PKA_2	913	919	PF00069	0.693
MOD_PKA_2	967	973	PF00069	0.688
MOD_Plk_1	215	221	PF00069	0.748
MOD_Plk_1	226	232	PF00069	0.739
MOD_Plk_1	539	545	PF00069	0.595
MOD_Plk_1	550	556	PF00069	0.586
MOD_Plk_1	783	789	PF00069	0.672
MOD_Plk_1	881	887	PF00069	0.585
MOD_Plk_1	889	895	PF00069	0.534
MOD_Plk_2-3	278	284	PF00069	0.786
MOD_Plk_4	226	232	PF00069	0.810
MOD_Plk_4	264	270	PF00069	0.684
MOD_Plk_4	902	908	PF00069	0.788
MOD_Plk_4	919	925	PF00069	0.547
MOD_ProDKin_1	199	205	PF00069	0.739
MOD_ProDKin_1	245	251	PF00069	0.684
MOD_ProDKin_1	313	319	PF00069	0.728
MOD_ProDKin_1	469	475	PF00069	0.737
MOD_ProDKin_1	486	492	PF00069	0.531
MOD_ProDKin_1	541	547	PF00069	0.744
MOD_ProDKin_1	577	583	PF00069	0.718
MOD_ProDKin_1	723	729	PF00069	0.836
MOD_ProDKin_1	738	744	PF00069	0.578
MOD_ProDKin_1	926	932	PF00069	0.709
MOD_ProDKin_1	973	979	PF00069	0.634
MOD_SUMO_rev_2	762	771	PF00179	0.702
TRG_DiLeu_BaEn_1	981	986	PF01217	0.664
TRG_DiLeu_BaEn_2	381	387	PF01217	0.742
TRG_ER_diArg_1	104	106	PF00400	0.615
TRG_ER_diArg_1	22	24	PF00400	0.614
TRG_ER_diArg_1	303	306	PF00400	0.701
TRG_ER_diArg_1	560	563	PF00400	0.606
TRG_ER_diArg_1	879	881	PF00400	0.728
TRG_ER_diArg_1	90	93	PF00400	0.818
TRG_ER_diArg_1	963	966	PF00400	0.654
TRG_ER_diArg_1	988	991	PF00400	0.584

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P5D3	Leptomonas seymouri	30%	100%
A0A3S7X8V2	Leishmania donovani	99%	100%
A4HMB1	Leishmania braziliensis	57%	95%
E9AEQ5	Leishmania major	83%	99%
E9B5W0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	79%	98%