LeishMANIAdb
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Conserved CBS domain protein

Quick info Annotations Function or PPIs Localization Phosphorylation Abundance Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Conserved CBS domain protein
Gene product:
AMP-activated protein kinase - gamma regulatory subunit
Species:
Leishmania infantum
UniProt:
A4IAX4_LEIIN
TriTrypDb:
LINF_350012200
Length:
481

Annotations

Annotations by Jardim et al.

Intracellular protein trafficking, Conserved CBS domain

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. yes yes: 10
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 8
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 10
NetGPI no yes: 0, no: 10
Cellular components
Term Name Level Count
GO:0005634 nucleus 5 1
GO:0005737 cytoplasm 2 1
GO:0031588 nucleotide-activated protein kinase complex 3 1
GO:0032991 protein-containing complex 1 1
GO:0043226 organelle 2 1
GO:0043227 membrane-bounded organelle 3 1
GO:0043229 intracellular organelle 3 1
GO:0043231 intracellular membrane-bounded organelle 4 1
GO:0061695 transferase complex, transferring phosphorus-containing groups 4 1
GO:0110165 cellular anatomical entity 1 1
GO:0140535 intracellular protein-containing complex 2 1
GO:1902494 catalytic complex 2 1
GO:1902911 protein kinase complex 5 1
GO:1990234 transferase complex 3 1

Phosphorylation

Promastigote/Amastigote: 271

Abundance

Amastigote (protein)
Source Evidence on protein Close homologs
Pescher et al. (upgregulation) no yes: 0
Promastigote and amastigote
Source Evidence on protein Close homologs
Lahav et al.
- mRNA
- Protein

Expansion

Sequence features

A4IAX4
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4IAX4

Function

Biological processes
Term Name Level Count
GO:0006468 protein phosphorylation 5 1
GO:0006793 phosphorus metabolic process 3 1
GO:0006796 phosphate-containing compound metabolic process 4 1
GO:0006807 nitrogen compound metabolic process 2 1
GO:0006950 response to stress 2 1
GO:0007154 cell communication 2 1
GO:0008152 metabolic process 1 1
GO:0009267 cellular response to starvation 4 1
GO:0009605 response to external stimulus 2 1
GO:0009987 cellular process 1 1
GO:0009991 response to extracellular stimulus 3 1
GO:0016310 phosphorylation 5 1
GO:0019538 protein metabolic process 3 1
GO:0031667 response to nutrient levels 4 1
GO:0031668 cellular response to extracellular stimulus 3 1
GO:0031669 cellular response to nutrient levels 4 1
GO:0033554 cellular response to stress 3 1
GO:0036211 protein modification process 4 1
GO:0042149 cellular response to glucose starvation 5 1
GO:0042594 response to starvation 3 1
GO:0043170 macromolecule metabolic process 3 1
GO:0043412 macromolecule modification 4 1
GO:0044237 cellular metabolic process 2 1
GO:0044238 primary metabolic process 2 1
GO:0050790 regulation of catalytic activity 3 1
GO:0050896 response to stimulus 1 1
GO:0051716 cellular response to stimulus 2 1
GO:0065007 biological regulation 1 1
GO:0065009 regulation of molecular function 2 1
GO:0071496 cellular response to external stimulus 3 1
GO:0071704 organic substance metabolic process 2 1
GO:1901564 organonitrogen compound metabolic process 3 1
Molecular functions
Term Name Level Count
GO:0000166 nucleotide binding 3 1
GO:0005488 binding 1 1
GO:0005515 protein binding 2 1
GO:0016208 AMP binding 4 1
GO:0017076 purine nucleotide binding 4 1
GO:0019207 kinase regulator activity 3 1
GO:0019887 protein kinase regulator activity 4 1
GO:0019899 enzyme binding 3 1
GO:0019900 kinase binding 4 1
GO:0019901 protein kinase binding 5 1
GO:0030234 enzyme regulator activity 2 1
GO:0030554 adenyl nucleotide binding 5 1
GO:0032553 ribonucleotide binding 3 1
GO:0032555 purine ribonucleotide binding 4 1
GO:0032559 adenyl ribonucleotide binding 5 1
GO:0036094 small molecule binding 2 1
GO:0043167 ion binding 2 1
GO:0043168 anion binding 3 1
GO:0043169 cation binding 3 1
GO:0097159 organic cyclic compound binding 2 1
GO:0097367 carbohydrate derivative binding 2 1
GO:0098772 molecular function regulator activity 1 1
GO:1901265 nucleoside phosphate binding 3 1
GO:1901363 heterocyclic compound binding 2 1

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 232 236 PF00656 0.722
CLV_NRD_NRD_1 180 182 PF00675 0.315
CLV_NRD_NRD_1 355 357 PF00675 0.371
CLV_NRD_NRD_1 447 449 PF00675 0.447
CLV_NRD_NRD_1 93 95 PF00675 0.537
CLV_PCSK_KEX2_1 180 182 PF00082 0.295
CLV_PCSK_KEX2_1 355 357 PF00082 0.407
CLV_PCSK_KEX2_1 446 448 PF00082 0.453
CLV_PCSK_KEX2_1 95 97 PF00082 0.519
CLV_PCSK_PC1ET2_1 95 97 PF00082 0.519
CLV_PCSK_SKI1_1 357 361 PF00082 0.450
CLV_PCSK_SKI1_1 417 421 PF00082 0.395
CLV_PCSK_SKI1_1 438 442 PF00082 0.332
CLV_PCSK_SKI1_1 447 451 PF00082 0.379
DEG_APCC_DBOX_1 397 405 PF00400 0.405
DEG_SPOP_SBC_1 101 105 PF00917 0.378
DEG_SPOP_SBC_1 229 233 PF00917 0.698
DOC_CYCLIN_RxL_1 446 456 PF00134 0.345
DOC_MAPK_gen_1 94 101 PF00069 0.494
DOC_MAPK_MEF2A_6 366 375 PF00069 0.360
DOC_MAPK_MEF2A_6 388 395 PF00069 0.362
DOC_PP2B_LxvP_1 148 151 PF13499 0.686
DOC_PP2B_LxvP_1 41 44 PF13499 0.363
DOC_PP4_FxxP_1 341 344 PF00568 0.372
DOC_USP7_MATH_1 16 20 PF00917 0.499
DOC_USP7_MATH_1 218 222 PF00917 0.610
DOC_USP7_MATH_1 229 233 PF00917 0.618
DOC_USP7_MATH_1 264 268 PF00917 0.759
DOC_USP7_MATH_1 318 322 PF00917 0.615
DOC_USP7_MATH_1 336 340 PF00917 0.422
DOC_USP7_MATH_1 419 423 PF00917 0.450
DOC_USP7_MATH_1 44 48 PF00917 0.401
DOC_WW_Pin1_4 268 273 PF00397 0.700
DOC_WW_Pin1_4 383 388 PF00397 0.362
LIG_14-3-3_CanoR_1 50 58 PF00244 0.374
LIG_14-3-3_CanoR_1 84 93 PF00244 0.467
LIG_APCC_ABBA_1 428 433 PF00400 0.407
LIG_BIR_II_1 1 5 PF00653 0.610
LIG_BIR_III_4 235 239 PF00653 0.668
LIG_BRCT_BRCA1_1 281 285 PF00533 0.768
LIG_BRCT_BRCA1_1 337 341 PF00533 0.454
LIG_BRCT_BRCA1_1 73 77 PF00533 0.417
LIG_CaM_IQ_9 409 425 PF13499 0.511
LIG_Clathr_ClatBox_1 401 405 PF01394 0.407
LIG_Clathr_ClatBox_1 452 456 PF01394 0.328
LIG_EH1_1 176 184 PF00400 0.362
LIG_FHA_1 103 109 PF00498 0.309
LIG_FHA_1 258 264 PF00498 0.614
LIG_FHA_1 370 376 PF00498 0.370
LIG_FHA_1 377 383 PF00498 0.387
LIG_FHA_1 457 463 PF00498 0.373
LIG_FHA_1 60 66 PF00498 0.392
LIG_FHA_2 101 107 PF00498 0.442
LIG_FHA_2 311 317 PF00498 0.504
LIG_FHA_2 32 38 PF00498 0.482
LIG_FHA_2 413 419 PF00498 0.352
LIG_FHA_2 434 440 PF00498 0.439
LIG_LIR_Apic_2 300 305 PF02991 0.537
LIG_LIR_Apic_2 338 344 PF02991 0.414
LIG_LIR_Gen_1 104 113 PF02991 0.323
LIG_LIR_Gen_1 130 138 PF02991 0.490
LIG_LIR_Gen_1 191 201 PF02991 0.407
LIG_LIR_Gen_1 342 353 PF02991 0.361
LIG_LIR_Gen_1 439 449 PF02991 0.357
LIG_LIR_Gen_1 470 479 PF02991 0.435
LIG_LIR_Gen_1 53 60 PF02991 0.438
LIG_LIR_Nem_3 104 110 PF02991 0.321
LIG_LIR_Nem_3 130 135 PF02991 0.472
LIG_LIR_Nem_3 191 196 PF02991 0.407
LIG_LIR_Nem_3 206 210 PF02991 0.443
LIG_LIR_Nem_3 282 288 PF02991 0.728
LIG_LIR_Nem_3 342 348 PF02991 0.349
LIG_LIR_Nem_3 426 432 PF02991 0.414
LIG_LIR_Nem_3 439 444 PF02991 0.242
LIG_LIR_Nem_3 470 476 PF02991 0.333
LIG_LIR_Nem_3 53 58 PF02991 0.368
LIG_PCNA_yPIPBox_3 461 472 PF02747 0.324
LIG_Pex14_2 341 345 PF04695 0.371
LIG_SH2_CRK 337 341 PF00017 0.348
LIG_SH2_CRK 55 59 PF00017 0.384
LIG_SH2_NCK_1 337 341 PF00017 0.426
LIG_SH2_PTP2 107 110 PF00017 0.272
LIG_SH2_PTP2 302 305 PF00017 0.512
LIG_SH2_PTP2 98 101 PF00017 0.392
LIG_SH2_STAP1 337 341 PF00017 0.454
LIG_SH2_STAP1 410 414 PF00017 0.425
LIG_SH2_STAT3 347 350 PF00017 0.378
LIG_SH2_STAT3 410 413 PF00017 0.488
LIG_SH2_STAT5 107 110 PF00017 0.272
LIG_SH2_STAT5 113 116 PF00017 0.274
LIG_SH2_STAT5 207 210 PF00017 0.329
LIG_SH2_STAT5 25 28 PF00017 0.378
LIG_SH2_STAT5 302 305 PF00017 0.466
LIG_SH2_STAT5 307 310 PF00017 0.476
LIG_SH2_STAT5 347 350 PF00017 0.377
LIG_SH2_STAT5 473 476 PF00017 0.419
LIG_SH2_STAT5 98 101 PF00017 0.392
LIG_SH3_3 148 154 PF00018 0.637
LIG_SH3_3 241 247 PF00018 0.573
LIG_SH3_3 300 306 PF00018 0.429
LIG_SH3_3 381 387 PF00018 0.394
LIG_SH3_3 66 72 PF00018 0.417
LIG_SUMO_SIM_anti_2 368 376 PF11976 0.382
LIG_SUMO_SIM_anti_2 61 68 PF11976 0.376
LIG_SUMO_SIM_par_1 181 187 PF11976 0.321
LIG_SUMO_SIM_par_1 371 376 PF11976 0.426
LIG_SUMO_SIM_par_1 391 397 PF11976 0.110
LIG_SUMO_SIM_par_1 61 68 PF11976 0.376
LIG_TRAF2_1 34 37 PF00917 0.434
LIG_TRAF2_1 79 82 PF00917 0.372
LIG_TRFH_1 302 306 PF08558 0.520
LIG_TYR_ITIM 205 210 PF00017 0.441
LIG_TYR_ITSM 103 110 PF00017 0.323
LIG_UBA3_1 182 188 PF00899 0.362
LIG_UBA3_1 211 217 PF00899 0.490
LIG_UBA3_1 359 366 PF00899 0.440
LIG_WRC_WIRS_1 45 50 PF05994 0.401
MOD_CDK_SPK_2 383 388 PF00069 0.362
MOD_CK1_1 252 258 PF00069 0.700
MOD_CK1_1 267 273 PF00069 0.747
MOD_CK1_1 310 316 PF00069 0.486
MOD_CK1_1 422 428 PF00069 0.483
MOD_CK2_1 31 37 PF00069 0.383
MOD_CK2_1 310 316 PF00069 0.481
MOD_CK2_1 383 389 PF00069 0.362
MOD_CK2_1 412 418 PF00069 0.380
MOD_CK2_1 433 439 PF00069 0.447
MOD_GlcNHglycan 1 4 PF01048 0.586
MOD_GlcNHglycan 13 16 PF01048 0.395
MOD_GlcNHglycan 155 158 PF01048 0.543
MOD_GlcNHglycan 320 323 PF01048 0.629
MOD_GSK3_1 11 18 PF00069 0.454
MOD_GSK3_1 153 160 PF00069 0.539
MOD_GSK3_1 249 256 PF00069 0.692
MOD_GSK3_1 264 271 PF00069 0.602
MOD_GSK3_1 365 372 PF00069 0.386
MOD_GSK3_1 80 87 PF00069 0.490
MOD_N-GLC_1 229 234 PF02516 0.697
MOD_N-GLC_1 250 255 PF02516 0.684
MOD_N-GLC_1 258 263 PF02516 0.672
MOD_N-GLC_1 274 279 PF02516 0.758
MOD_N-GLC_1 50 55 PF02516 0.464
MOD_NEK2_1 58 63 PF00069 0.405
MOD_NEK2_2 157 162 PF00069 0.455
MOD_NEK2_2 336 341 PF00069 0.418
MOD_PIKK_1 310 316 PF00454 0.529
MOD_PIKK_1 409 415 PF00454 0.482
MOD_PIKK_1 59 65 PF00454 0.394
MOD_PKA_2 31 37 PF00069 0.506
MOD_Plk_1 163 169 PF00069 0.338
MOD_Plk_1 191 197 PF00069 0.315
MOD_Plk_1 250 256 PF00069 0.719
MOD_Plk_1 258 264 PF00069 0.706
MOD_Plk_1 50 56 PF00069 0.466
MOD_Plk_2-3 433 439 PF00069 0.447
MOD_Plk_4 21 27 PF00069 0.540
MOD_Plk_4 307 313 PF00069 0.474
MOD_Plk_4 336 342 PF00069 0.456
MOD_Plk_4 369 375 PF00069 0.407
MOD_Plk_4 44 50 PF00069 0.403
MOD_Plk_4 6 12 PF00069 0.527
MOD_ProDKin_1 268 274 PF00069 0.699
MOD_ProDKin_1 383 389 PF00069 0.362
TRG_AP2beta_CARGO_1 439 448 PF09066 0.337
TRG_DiLeu_BaEn_1 191 196 PF01217 0.407
TRG_DiLeu_BaEn_1 369 374 PF01217 0.338
TRG_DiLeu_BaEn_2 469 475 PF01217 0.315
TRG_DiLeu_BaEn_4 36 42 PF01217 0.378
TRG_DiLeu_BaLyEn_6 458 463 PF01217 0.481
TRG_ENDOCYTIC_2 107 110 PF00928 0.272
TRG_ENDOCYTIC_2 207 210 PF00928 0.441
TRG_ENDOCYTIC_2 337 340 PF00928 0.352
TRG_ENDOCYTIC_2 473 476 PF00928 0.419
TRG_ENDOCYTIC_2 55 58 PF00928 0.360
TRG_ENDOCYTIC_2 98 101 PF00928 0.392
TRG_ER_diArg_1 179 181 PF00400 0.320
TRG_ER_diArg_1 445 448 PF00400 0.366
TRG_ER_diArg_1 93 96 PF00400 0.544
TRG_NES_CRM1_1 56 68 PF08389 0.447
TRG_NLS_MonoExtN_4 93 98 PF00514 0.537
TRG_Pf-PMV_PEXEL_1 461 465 PF00026 0.446

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1PCX9 Leptomonas seymouri 75% 99%
A0A1X0NKG9 Trypanosomatidae 44% 90%
A0A3Q8ILV4 Leishmania donovani 100% 100%
A0A422NI77 Trypanosoma rangeli 48% 96%
A4HMA8 Leishmania braziliensis 84% 99%
D0A281 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 41% 96%
E9AEQ1 Leishmania major 97% 100%
E9B5V6 Leishmania mexicana (strain MHOM/GT/2001/U1103) 96% 100%
V5BSS4 Trypanosoma cruzi 49% 96%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS