Putative proteasome activator protein pa26

Quick info Annotations Localization Abundance Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

proteasome activator protein pa26 - putative

Species:

Leishmania infantum

UniProt:

A4IAX3_LEIIN

TriTrypDb:

LINF_350012100

Length:

223

Annotations

Annotations by Jardim et al.

Proteasome, proteasome activator pa26

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 1
Hassani et al.	yes	yes: 2
Forrest at al. (metacyclic)	yes	yes: 2
Forrest at al. (procyclic)	yes	yes: 2
Silverman et al.	no	yes: 1
Pissara et al.	yes	yes: 5

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 3

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	yes	yes: 6

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0008537	proteasome activator complex	2	11
GO:0032991	protein-containing complex	1	11

Abundance

Amastigote (protein)


Source	Evidence on protein	Close homologs
Pescher et al. (upgregulation)	no	yes: 0

Promastigote and amastigote


Source	Evidence on protein	Close homologs
Lahav et al. - mRNA - Protein

Expansion

Sequence features

A4IAX3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4IAX3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_PCSK_SKI1_1	6	10	PF00082	0.501
DOC_CYCLIN_yCln2_LP_2	44	50	PF00134	0.551
DOC_MAPK_MEF2A_6	164	172	PF00069	0.500
DOC_MAPK_MEF2A_6	93	102	PF00069	0.495
DOC_USP7_MATH_1	144	148	PF00917	0.479
DOC_USP7_MATH_1	166	170	PF00917	0.492
LIG_14-3-3_CanoR_1	214	222	PF00244	0.641
LIG_Actin_WH2_2	95	110	PF00022	0.549
LIG_BIR_II_1	1	5	PF00653	0.461
LIG_BIR_III_3	1	5	PF00653	0.461
LIG_Clathr_ClatBox_1	182	186	PF01394	0.402
LIG_FHA_1	53	59	PF00498	0.570
LIG_FHA_2	14	20	PF00498	0.466
LIG_PCNA_yPIPBox_3	103	116	PF02747	0.491
LIG_SH2_STAP1	203	207	PF00017	0.394
LIG_SH2_STAP1	48	52	PF00017	0.532
LIG_SH2_STAT5	141	144	PF00017	0.400
LIG_SH2_STAT5	48	51	PF00017	0.466
LIG_SUMO_SIM_anti_2	14	20	PF11976	0.501
LIG_UBA3_1	109	116	PF00899	0.456
LIG_WRC_WIRS_1	196	201	PF05994	0.483
MOD_CK1_1	215	221	PF00069	0.636
MOD_CK2_1	13	19	PF00069	0.445
MOD_CK2_1	24	30	PF00069	0.320
MOD_CK2_1	60	66	PF00069	0.564
MOD_GlcNHglycan	121	124	PF01048	0.569
MOD_GlcNHglycan	156	159	PF01048	0.551
MOD_GlcNHglycan	164	167	PF01048	0.594
MOD_GlcNHglycan	186	190	PF01048	0.445
MOD_GSK3_1	162	169	PF00069	0.496
MOD_GSK3_1	187	194	PF00069	0.381
MOD_GSK3_1	20	27	PF00069	0.331
MOD_GSK3_1	52	59	PF00069	0.523
MOD_GSK3_1	7	14	PF00069	0.426
MOD_N-GLC_1	154	159	PF02516	0.499
MOD_N-GLC_1	215	220	PF02516	0.644
MOD_NEK2_1	117	122	PF00069	0.640
MOD_NEK2_1	185	190	PF00069	0.374
MOD_NEK2_2	77	82	PF00069	0.549
MOD_PIKK_1	187	193	PF00454	0.426
MOD_PKA_2	144	150	PF00069	0.424
MOD_PKA_2	31	37	PF00069	0.501
MOD_Plk_1	11	17	PF00069	0.470
MOD_Plk_2-3	7	13	PF00069	0.447
MOD_Plk_4	13	19	PF00069	0.398
MOD_Plk_4	166	172	PF00069	0.445
MOD_Plk_4	56	62	PF00069	0.484
MOD_SUMO_for_1	183	186	PF00179	0.374
MOD_SUMO_for_1	92	95	PF00179	0.473
MOD_SUMO_rev_2	111	118	PF00179	0.515
MOD_SUMO_rev_2	147	153	PF00179	0.438
MOD_SUMO_rev_2	157	163	PF00179	0.600

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I3A8	Leptomonas seymouri	73%	97%
A0A0S4JD53	Bodo saltans	36%	100%
A0A1X0NKN6	Trypanosomatidae	46%	90%
A0A3Q8IHQ9	Leishmania donovani	100%	100%
A0A3R7MG26	Trypanosoma rangeli	48%	96%
A4HMA7	Leishmania braziliensis	87%	100%
D0A282	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	51%	97%
E9AEQ0	Leishmania major	97%	100%
E9B5V5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	95%	100%