TPR_REGION domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Tetratricopeptide repeat/TPR repeat - putative

Species:

Leishmania infantum

UniProt:

A4IAW6_LEIIN

TriTrypDb:

LINF_350011500

Length:

622

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4IAW6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4IAW6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	165	167	PF00675	0.489
CLV_NRD_NRD_1	182	184	PF00675	0.245
CLV_NRD_NRD_1	305	307	PF00675	0.489
CLV_NRD_NRD_1	335	337	PF00675	0.454
CLV_NRD_NRD_1	352	354	PF00675	0.295
CLV_NRD_NRD_1	36	38	PF00675	0.306
CLV_NRD_NRD_1	377	379	PF00675	0.442
CLV_NRD_NRD_1	522	524	PF00675	0.324
CLV_NRD_NRD_1	561	563	PF00675	0.430
CLV_PCSK_KEX2_1	165	167	PF00082	0.531
CLV_PCSK_KEX2_1	182	184	PF00082	0.238
CLV_PCSK_KEX2_1	305	307	PF00082	0.489
CLV_PCSK_KEX2_1	335	337	PF00082	0.440
CLV_PCSK_KEX2_1	36	38	PF00082	0.306
CLV_PCSK_KEX2_1	377	379	PF00082	0.417
CLV_PCSK_KEX2_1	522	524	PF00082	0.372
CLV_PCSK_KEX2_1	548	550	PF00082	0.412
CLV_PCSK_KEX2_1	561	563	PF00082	0.344
CLV_PCSK_PC1ET2_1	548	550	PF00082	0.412
CLV_PCSK_SKI1_1	111	115	PF00082	0.441
CLV_PCSK_SKI1_1	182	186	PF00082	0.370
CLV_PCSK_SKI1_1	188	192	PF00082	0.434
CLV_PCSK_SKI1_1	256	260	PF00082	0.358
CLV_PCSK_SKI1_1	429	433	PF00082	0.332
CLV_PCSK_SKI1_1	555	559	PF00082	0.346
DOC_MAPK_gen_1	111	119	PF00069	0.362
DOC_MAPK_gen_1	252	261	PF00069	0.384
DOC_MAPK_gen_1	302	310	PF00069	0.486
DOC_PP1_RVXF_1	186	193	PF00149	0.505
DOC_PP1_RVXF_1	559	566	PF00149	0.350
DOC_PP4_MxPP_1	585	588	PF00568	0.573
DOC_USP7_MATH_1	147	151	PF00917	0.385
DOC_USP7_MATH_1	241	245	PF00917	0.330
DOC_USP7_MATH_1	611	615	PF00917	0.683
DOC_USP7_UBL2_3	354	358	PF12436	0.548
DOC_USP7_UBL2_3	548	552	PF12436	0.372
DOC_WW_Pin1_4	135	140	PF00397	0.602
LIG_14-3-3_CanoR_1	351	361	PF00244	0.552
LIG_14-3-3_CanoR_1	404	414	PF00244	0.354
LIG_14-3-3_CanoR_1	542	548	PF00244	0.325
LIG_APCC_ABBA_1	117	122	PF00400	0.341
LIG_APCC_ABBA_1	259	264	PF00400	0.384
LIG_APCC_ABBA_1	343	348	PF00400	0.436
LIG_BIR_III_4	212	216	PF00653	0.384
LIG_Clathr_ClatBox_1	387	391	PF01394	0.364
LIG_Clathr_ClatBox_1	416	420	PF01394	0.325
LIG_eIF4E_1	453	459	PF01652	0.325
LIG_FHA_1	266	272	PF00498	0.304
LIG_FHA_1	406	412	PF00498	0.346
LIG_FHA_1	570	576	PF00498	0.493
LIG_FHA_2	435	441	PF00498	0.348
LIG_FHA_2	522	528	PF00498	0.316
LIG_FHA_2	591	597	PF00498	0.575
LIG_Integrin_RGD_1	525	527	PF01839	0.384
LIG_LIR_Gen_1	452	461	PF02991	0.306
LIG_LIR_Nem_3	327	332	PF02991	0.373
LIG_LIR_Nem_3	38	43	PF02991	0.325
LIG_LIR_Nem_3	383	388	PF02991	0.385
LIG_LIR_Nem_3	420	424	PF02991	0.306
LIG_LIR_Nem_3	452	456	PF02991	0.306
LIG_PDZ_Class_1	617	622	PF00595	0.757
LIG_Pex14_2	417	421	PF04695	0.384
LIG_SH2_CRK	329	333	PF00017	0.365
LIG_SH2_CRK	367	371	PF00017	0.344
LIG_SH2_CRK	40	44	PF00017	0.325
LIG_SH2_GRB2like	453	456	PF00017	0.306
LIG_SH2_GRB2like	466	469	PF00017	0.306
LIG_SH2_NCK_1	424	428	PF00017	0.325
LIG_SH2_NCK_1	78	82	PF00017	0.325
LIG_SH2_SRC	262	265	PF00017	0.325
LIG_SH2_SRC	89	92	PF00017	0.362
LIG_SH2_STAP1	186	190	PF00017	0.532
LIG_SH2_STAP1	269	273	PF00017	0.390
LIG_SH2_STAP1	29	33	PF00017	0.306
LIG_SH2_STAP1	453	457	PF00017	0.306
LIG_SH2_STAP1	89	93	PF00017	0.338
LIG_SH2_STAT3	365	368	PF00017	0.398
LIG_SH2_STAT3	502	505	PF00017	0.430
LIG_SH2_STAT5	100	103	PF00017	0.354
LIG_SH2_STAT5	365	368	PF00017	0.398
LIG_SH2_STAT5	385	388	PF00017	0.361
LIG_SH2_STAT5	418	421	PF00017	0.306
LIG_SH2_STAT5	460	463	PF00017	0.325
LIG_SH2_STAT5	544	547	PF00017	0.306
LIG_SH3_1	137	143	PF00018	0.598
LIG_SH3_2	140	145	PF14604	0.600
LIG_SH3_3	137	143	PF00018	0.563
LIG_SUMO_SIM_anti_2	91	97	PF11976	0.351
LIG_SUMO_SIM_par_1	386	391	PF11976	0.376
LIG_TRAF2_1	588	591	PF00917	0.576
LIG_TRAF2_1	593	596	PF00917	0.569
MOD_CK1_1	265	271	PF00069	0.350
MOD_CK2_1	434	440	PF00069	0.348
MOD_CK2_1	590	596	PF00069	0.558
MOD_GlcNHglycan	149	152	PF01048	0.397
MOD_GlcNHglycan	354	357	PF01048	0.490
MOD_GlcNHglycan	608	611	PF01048	0.711
MOD_GlcNHglycan	613	616	PF01048	0.714
MOD_GSK3_1	235	242	PF00069	0.329
MOD_GSK3_1	324	331	PF00069	0.376
MOD_GSK3_1	445	452	PF00069	0.313
MOD_GSK3_1	521	528	PF00069	0.317
MOD_GSK3_1	611	618	PF00069	0.740
MOD_N-GLC_1	128	133	PF02516	0.563
MOD_N-GLC_1	395	400	PF02516	0.480
MOD_N-GLC_2	221	223	PF02516	0.362
MOD_NEK2_1	113	118	PF00069	0.372
MOD_NEK2_1	184	189	PF00069	0.425
MOD_NEK2_1	328	333	PF00069	0.362
MOD_NEK2_1	402	407	PF00069	0.390
MOD_NEK2_1	98	103	PF00069	0.357
MOD_NEK2_2	300	305	PF00069	0.423
MOD_NEK2_2	47	52	PF00069	0.306
MOD_PIKK_1	503	509	PF00454	0.409
MOD_PIKK_1	569	575	PF00454	0.513
MOD_PKA_2	352	358	PF00069	0.537
MOD_PKA_2	521	527	PF00069	0.317
MOD_PKB_1	523	531	PF00069	0.306
MOD_Plk_1	128	134	PF00069	0.465
MOD_Plk_1	300	306	PF00069	0.413
MOD_Plk_1	395	401	PF00069	0.485
MOD_Plk_1	83	89	PF00069	0.505
MOD_Plk_2-3	24	30	PF00069	0.325
MOD_Plk_4	128	134	PF00069	0.428
MOD_Plk_4	324	330	PF00069	0.351
MOD_ProDKin_1	135	141	PF00069	0.607
MOD_SUMO_for_1	580	583	PF00179	0.474
MOD_SUMO_rev_2	131	139	PF00179	0.569
TRG_DiLeu_BaEn_1	383	388	PF01217	0.366
TRG_DiLeu_BaEn_1	559	564	PF01217	0.423
TRG_DiLeu_BaEn_1	91	96	PF01217	0.335
TRG_DiLeu_BaEn_2	179	185	PF01217	0.369
TRG_DiLeu_BaEn_4	7	13	PF01217	0.313
TRG_ENDOCYTIC_2	100	103	PF00928	0.354
TRG_ENDOCYTIC_2	329	332	PF00928	0.368
TRG_ENDOCYTIC_2	367	370	PF00928	0.347
TRG_ENDOCYTIC_2	385	388	PF00928	0.361
TRG_ENDOCYTIC_2	40	43	PF00928	0.325
TRG_ENDOCYTIC_2	418	421	PF00928	0.306
TRG_ENDOCYTIC_2	453	456	PF00928	0.306
TRG_ENDOCYTIC_2	544	547	PF00928	0.306
TRG_ENDOCYTIC_2	554	557	PF00928	0.306
TRG_ENDOCYTIC_2	78	81	PF00928	0.306
TRG_ER_diArg_1	164	166	PF00400	0.540
TRG_ER_diArg_1	181	183	PF00400	0.232
TRG_ER_diArg_1	304	306	PF00400	0.486
TRG_ER_diArg_1	335	337	PF00400	0.539
TRG_ER_diArg_1	35	37	PF00400	0.306
TRG_ER_diArg_1	350	353	PF00400	0.348
TRG_ER_diArg_1	376	378	PF00400	0.430
TRG_ER_diArg_1	521	523	PF00400	0.320
TRG_ER_diArg_1	561	563	PF00400	0.430
TRG_NES_CRM1_1	409	420	PF08389	0.325
TRG_Pf-PMV_PEXEL_1	104	108	PF00026	0.471
TRG_Pf-PMV_PEXEL_1	335	340	PF00026	0.464
TRG_Pf-PMV_PEXEL_1	561	566	PF00026	0.462

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IK39	Leptomonas seymouri	88%	89%
A0A0S4J9A2	Bodo saltans	64%	96%
A0A1X0NJ22	Trypanosomatidae	68%	83%
A0A3S7X8T6	Leishmania donovani	100%	100%
A4HMA1	Leishmania braziliensis	95%	100%
D0A290	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	69%	89%
E9AEP4	Leishmania major	98%	100%
E9B5U9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	98%	100%
V5BIM5	Trypanosoma cruzi	72%	89%