Conserved RING finger protein

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

RING finger protein - conserved

Species:

Leishmania infantum

UniProt:

A4IAW3_LEIIN

TriTrypDb:

LINF_350011200

Length:

1279

Annotations

Annotations by Jardim et al.

Intracellular protein trafficking, Conserved RING finger

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

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Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

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Expansion

Sequence features

A4IAW3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4IAW3

Function

Could not find GO biological_process term for this entry.

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Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	4
GO:0043167	ion binding	2	4
GO:0043169	cation binding	3	4
GO:0046872	metal ion binding	4	4

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Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	1025	1029	PF00656	0.531
CLV_C14_Caspase3-7	1037	1041	PF00656	0.416
CLV_C14_Caspase3-7	422	426	PF00656	0.672
CLV_C14_Caspase3-7	585	589	PF00656	0.618
CLV_C14_Caspase3-7	632	636	PF00656	0.572
CLV_C14_Caspase3-7	697	701	PF00656	0.634
CLV_C14_Caspase3-7	756	760	PF00656	0.546
CLV_C14_Caspase3-7	985	989	PF00656	0.636
CLV_NRD_NRD_1	1053	1055	PF00675	0.693
CLV_NRD_NRD_1	1144	1146	PF00675	0.542

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A3S7X911	Leishmania donovani	100%	100%
A4HM98	Leishmania braziliensis	67%	98%
E9AEP1	Leishmania major	90%	100%
E9B5U6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	83%	98%

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