LeishMANIAdb
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Beta-fructofuranosidase-like protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Beta-fructofuranosidase-like protein
Gene product:
beta-fructofuranosidase - putative
Species:
Leishmania infantum
UniProt:
A4IAW1_LEIIN
TriTrypDb:
LINF_350011100 *
Length:
702

Annotations

LeishMANIAdb annotations

An expanded and variable family of glycosidases. Some Leishmaniid members even incorporate an extra N-terminal fructofuronidase domain after the signal peptide.. Seems to be evolving rapidly for unclear reasons

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 4
Pissara et al. yes yes: 28
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 6
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 11, no: 5
NetGPI no yes: 0, no: 16
Cellular components
Term Name Level Count
GO:0016020 membrane 2 1
GO:0110165 cellular anatomical entity 1 1

Expansion

Sequence features

A4IAW1
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4IAW1

Function

Biological processes
Term Name Level Count
GO:0005975 carbohydrate metabolic process 3 17
GO:0008152 metabolic process 1 17
GO:0044238 primary metabolic process 2 17
GO:0071704 organic substance metabolic process 2 17
Molecular functions
Term Name Level Count
GO:0003824 catalytic activity 1 17
GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds 4 17
GO:0004564 beta-fructofuranosidase activity 5 9
GO:0016787 hydrolase activity 2 17
GO:0016798 hydrolase activity, acting on glycosyl bonds 3 17

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 462 466 PF00656 0.174
CLV_C14_Caspase3-7 64 68 PF00656 0.167
CLV_NRD_NRD_1 367 369 PF00675 0.561
CLV_NRD_NRD_1 566 568 PF00675 0.356
CLV_PCSK_KEX2_1 200 202 PF00082 0.473
CLV_PCSK_KEX2_1 366 368 PF00082 0.509
CLV_PCSK_KEX2_1 566 568 PF00082 0.356
CLV_PCSK_PC1ET2_1 200 202 PF00082 0.462
CLV_PCSK_PC1ET2_1 366 368 PF00082 0.372
CLV_PCSK_SKI1_1 335 339 PF00082 0.517
CLV_PCSK_SKI1_1 344 348 PF00082 0.543
CLV_PCSK_SKI1_1 405 409 PF00082 0.497
DEG_Nend_Nbox_1 1 3 PF02207 0.489
DEG_SCF_FBW7_1 141 148 PF00400 0.156
DEG_SCF_FBW7_1 70 77 PF00400 0.158
DEG_SPOP_SBC_1 23 27 PF00917 0.465
DEG_SPOP_SBC_1 54 58 PF00917 0.167
DOC_CKS1_1 142 147 PF01111 0.156
DOC_MAPK_HePTP_8 423 435 PF00069 0.226
DOC_MAPK_MEF2A_6 426 435 PF00069 0.417
DOC_MAPK_MEF2A_6 451 459 PF00069 0.220
DOC_PP1_RVXF_1 199 206 PF00149 0.156
DOC_PP2B_LxvP_1 639 642 PF13499 0.162
DOC_PP2B_PxIxI_1 438 444 PF00149 0.220
DOC_PP4_FxxP_1 229 232 PF00568 0.242
DOC_PP4_FxxP_1 294 297 PF00568 0.360
DOC_PP4_FxxP_1 360 363 PF00568 0.361
DOC_USP7_MATH_1 240 244 PF00917 0.293
DOC_USP7_MATH_1 342 346 PF00917 0.344
DOC_USP7_MATH_1 54 58 PF00917 0.167
DOC_USP7_MATH_1 62 66 PF00917 0.160
DOC_USP7_MATH_1 74 78 PF00917 0.424
DOC_WW_Pin1_4 141 146 PF00397 0.351
DOC_WW_Pin1_4 190 195 PF00397 0.240
DOC_WW_Pin1_4 206 211 PF00397 0.200
DOC_WW_Pin1_4 435 440 PF00397 0.434
DOC_WW_Pin1_4 550 555 PF00397 0.373
DOC_WW_Pin1_4 600 605 PF00397 0.371
DOC_WW_Pin1_4 68 73 PF00397 0.159
LIG_14-3-3_CanoR_1 201 206 PF00244 0.195
LIG_14-3-3_CanoR_1 30 35 PF00244 0.438
LIG_14-3-3_CanoR_1 344 349 PF00244 0.282
LIG_14-3-3_CanoR_1 419 427 PF00244 0.278
LIG_14-3-3_CanoR_1 543 549 PF00244 0.177
LIG_Actin_WH2_2 295 313 PF00022 0.251
LIG_APCC_ABBA_1 615 620 PF00400 0.257
LIG_APCC_ABBA_1 624 629 PF00400 0.257
LIG_APCC_ABBAyCdc20_2 614 620 PF00400 0.162
LIG_BRCT_BRCA1_1 344 348 PF00533 0.315
LIG_BRCT_BRCA1_1 356 360 PF00533 0.311
LIG_Clathr_ClatBox_1 432 436 PF01394 0.226
LIG_Clathr_ClatBox_1 582 586 PF01394 0.156
LIG_deltaCOP1_diTrp_1 151 157 PF00928 0.351
LIG_EH1_1 31 39 PF00400 0.419
LIG_FHA_1 105 111 PF00498 0.323
LIG_FHA_1 14 20 PF00498 0.491
LIG_FHA_1 407 413 PF00498 0.306
LIG_FHA_1 427 433 PF00498 0.222
LIG_FHA_1 436 442 PF00498 0.363
LIG_FHA_1 456 462 PF00498 0.275
LIG_FHA_1 494 500 PF00498 0.358
LIG_FHA_1 555 561 PF00498 0.327
LIG_FHA_1 575 581 PF00498 0.167
LIG_FHA_1 634 640 PF00498 0.275
LIG_FHA_1 655 661 PF00498 0.353
LIG_FHA_1 90 96 PF00498 0.216
LIG_FHA_2 130 136 PF00498 0.255
LIG_FHA_2 146 152 PF00498 0.302
LIG_FHA_2 175 181 PF00498 0.300
LIG_FHA_2 345 351 PF00498 0.277
LIG_FHA_2 357 363 PF00498 0.251
LIG_FHA_2 372 378 PF00498 0.361
LIG_FHA_2 4 10 PF00498 0.466
LIG_FHA_2 485 491 PF00498 0.373
LIG_LIR_Apic_2 233 239 PF02991 0.218
LIG_LIR_Apic_2 291 297 PF02991 0.357
LIG_LIR_Apic_2 357 363 PF02991 0.361
LIG_LIR_Apic_2 421 427 PF02991 0.232
LIG_LIR_Gen_1 25 36 PF02991 0.424
LIG_LIR_Gen_1 307 316 PF02991 0.271
LIG_LIR_Gen_1 333 343 PF02991 0.361
LIG_LIR_Gen_1 345 354 PF02991 0.369
LIG_LIR_Gen_1 399 407 PF02991 0.297
LIG_LIR_Gen_1 492 502 PF02991 0.245
LIG_LIR_Gen_1 690 700 PF02991 0.444
LIG_LIR_Gen_1 9 19 PF02991 0.479
LIG_LIR_Nem_3 125 131 PF02991 0.253
LIG_LIR_Nem_3 155 160 PF02991 0.318
LIG_LIR_Nem_3 25 31 PF02991 0.434
LIG_LIR_Nem_3 298 302 PF02991 0.265
LIG_LIR_Nem_3 307 312 PF02991 0.280
LIG_LIR_Nem_3 320 324 PF02991 0.306
LIG_LIR_Nem_3 333 339 PF02991 0.270
LIG_LIR_Nem_3 345 351 PF02991 0.173
LIG_LIR_Nem_3 359 364 PF02991 0.235
LIG_LIR_Nem_3 385 391 PF02991 0.335
LIG_LIR_Nem_3 399 403 PF02991 0.285
LIG_LIR_Nem_3 492 497 PF02991 0.286
LIG_LIR_Nem_3 5 11 PF02991 0.464
LIG_LIR_Nem_3 515 521 PF02991 0.350
LIG_LIR_Nem_3 688 694 PF02991 0.350
LIG_LRP6_Inhibitor_1 679 685 PF00058 0.503
LIG_Pex14_1 245 249 PF04695 0.247
LIG_PTB_Apo_2 163 170 PF02174 0.278
LIG_PTB_Apo_2 686 693 PF02174 0.431
LIG_PTB_Phospho_1 163 169 PF10480 0.278
LIG_PTB_Phospho_1 686 692 PF10480 0.433
LIG_REV1ctd_RIR_1 203 209 PF16727 0.156
LIG_REV1ctd_RIR_1 297 307 PF16727 0.262
LIG_SH2_CRK 11 15 PF00017 0.471
LIG_SH2_CRK 361 365 PF00017 0.257
LIG_SH2_CRK 494 498 PF00017 0.360
LIG_SH2_CRK 692 696 PF00017 0.314
LIG_SH2_GRB2like 687 690 PF00017 0.275
LIG_SH2_GRB2like 691 694 PF00017 0.261
LIG_SH2_NCK_1 400 404 PF00017 0.302
LIG_SH2_NCK_1 424 428 PF00017 0.224
LIG_SH2_NCK_1 494 498 PF00017 0.360
LIG_SH2_PTP2 336 339 PF00017 0.360
LIG_SH2_SRC 361 364 PF00017 0.269
LIG_SH2_SRC 640 643 PF00017 0.191
LIG_SH2_STAP1 149 153 PF00017 0.156
LIG_SH2_STAP1 32 36 PF00017 0.412
LIG_SH2_STAP1 473 477 PF00017 0.156
LIG_SH2_STAP1 687 691 PF00017 0.273
LIG_SH2_STAT5 136 139 PF00017 0.242
LIG_SH2_STAT5 176 179 PF00017 0.240
LIG_SH2_STAT5 284 287 PF00017 0.360
LIG_SH2_STAT5 309 312 PF00017 0.261
LIG_SH2_STAT5 32 35 PF00017 0.460
LIG_SH2_STAT5 321 324 PF00017 0.254
LIG_SH2_STAT5 336 339 PF00017 0.189
LIG_SH2_STAT5 473 476 PF00017 0.223
LIG_SH2_STAT5 494 497 PF00017 0.257
LIG_SH2_STAT5 550 553 PF00017 0.361
LIG_SH2_STAT5 640 643 PF00017 0.257
LIG_SH2_STAT5 687 690 PF00017 0.275
LIG_SH3_2 98 103 PF14604 0.251
LIG_SH3_3 115 121 PF00018 0.150
LIG_SH3_3 139 145 PF00018 0.351
LIG_SH3_3 17 23 PF00018 0.496
LIG_SH3_3 207 213 PF00018 0.210
LIG_SH3_3 236 242 PF00018 0.352
LIG_SH3_3 496 502 PF00018 0.261
LIG_SH3_3 575 581 PF00018 0.262
LIG_SH3_3 95 101 PF00018 0.208
LIG_SUMO_SIM_anti_2 428 436 PF11976 0.319
LIG_SUMO_SIM_par_1 170 177 PF11976 0.336
LIG_SUMO_SIM_par_1 428 436 PF11976 0.260
LIG_SxIP_EBH_1 50 59 PF03271 0.356
LIG_TYR_ITIM 398 403 PF00017 0.294
LIG_TYR_ITSM 357 364 PF00017 0.320
LIG_WRC_WIRS_1 456 461 PF05994 0.162
LIG_WRC_WIRS_1 464 469 PF05994 0.191
MOD_CDC14_SPxK_1 603 606 PF00782 0.214
MOD_CDK_SPxK_1 600 606 PF00069 0.214
MOD_CK1_1 272 278 PF00069 0.309
MOD_CK1_1 463 469 PF00069 0.305
MOD_CK1_1 492 498 PF00069 0.337
MOD_CK1_1 533 539 PF00069 0.314
MOD_CK1_1 55 61 PF00069 0.167
MOD_CK1_1 553 559 PF00069 0.265
MOD_CK1_1 592 598 PF00069 0.169
MOD_CK1_1 65 71 PF00069 0.158
MOD_CK1_1 654 660 PF00069 0.230
MOD_CK1_1 670 676 PF00069 0.294
MOD_CK2_1 174 180 PF00069 0.321
MOD_CK2_1 201 207 PF00069 0.156
MOD_CK2_1 3 9 PF00069 0.469
MOD_CK2_1 371 377 PF00069 0.361
MOD_CK2_1 422 428 PF00069 0.255
MOD_CK2_1 55 61 PF00069 0.166
MOD_CK2_1 619 625 PF00069 0.366
MOD_Cter_Amidation 198 201 PF01082 0.462
MOD_GlcNHglycan 160 163 PF01048 0.451
MOD_GlcNHglycan 274 277 PF01048 0.535
MOD_GlcNHglycan 388 391 PF01048 0.451
MOD_GlcNHglycan 475 478 PF01048 0.518
MOD_GlcNHglycan 526 529 PF01048 0.560
MOD_GlcNHglycan 535 538 PF01048 0.583
MOD_GlcNHglycan 574 577 PF01048 0.493
MOD_GlcNHglycan 589 592 PF01048 0.475
MOD_GlcNHglycan 664 667 PF01048 0.429
MOD_GlcNHglycan 67 70 PF01048 0.158
MOD_GlcNHglycan 672 675 PF01048 0.419
MOD_GlcNHglycan 695 698 PF01048 0.455
MOD_GSK3_1 137 144 PF00069 0.343
MOD_GSK3_1 188 195 PF00069 0.228
MOD_GSK3_1 265 272 PF00069 0.319
MOD_GSK3_1 275 282 PF00069 0.329
MOD_GSK3_1 310 317 PF00069 0.277
MOD_GSK3_1 382 389 PF00069 0.166
MOD_GSK3_1 418 425 PF00069 0.315
MOD_GSK3_1 44 51 PF00069 0.458
MOD_GSK3_1 455 462 PF00069 0.342
MOD_GSK3_1 489 496 PF00069 0.252
MOD_GSK3_1 52 59 PF00069 0.358
MOD_GSK3_1 526 533 PF00069 0.248
MOD_GSK3_1 544 551 PF00069 0.241
MOD_GSK3_1 585 592 PF00069 0.290
MOD_GSK3_1 654 661 PF00069 0.241
MOD_GSK3_1 683 690 PF00069 0.331
MOD_GSK3_1 70 77 PF00069 0.406
MOD_LATS_1 87 93 PF00433 0.161
MOD_N-GLC_1 167 172 PF02516 0.551
MOD_N-GLC_1 3 8 PF02516 0.268
MOD_N-GLC_1 447 452 PF02516 0.515
MOD_N-GLC_1 533 538 PF02516 0.526
MOD_N-GLC_1 569 574 PF02516 0.372
MOD_N-GLC_2 46 48 PF02516 0.249
MOD_NEK2_1 174 179 PF00069 0.238
MOD_NEK2_1 279 284 PF00069 0.281
MOD_NEK2_1 310 315 PF00069 0.269
MOD_NEK2_1 354 359 PF00069 0.318
MOD_NEK2_1 418 423 PF00069 0.263
MOD_NEK2_1 459 464 PF00069 0.225
MOD_NEK2_1 484 489 PF00069 0.238
MOD_NEK2_1 585 590 PF00069 0.268
MOD_NEK2_1 683 688 PF00069 0.476
MOD_NEK2_2 356 361 PF00069 0.363
MOD_OFUCOSY 539 545 PF10250 0.362
MOD_PIKK_1 240 246 PF00454 0.186
MOD_PIKK_1 382 388 PF00454 0.209
MOD_PIKK_1 48 54 PF00454 0.488
MOD_PIKK_1 489 495 PF00454 0.363
MOD_PIKK_1 643 649 PF00454 0.177
MOD_PKA_2 418 424 PF00069 0.284
MOD_Plk_1 216 222 PF00069 0.162
MOD_Plk_1 3 9 PF00069 0.469
MOD_Plk_1 489 495 PF00069 0.359
MOD_Plk_1 514 520 PF00069 0.156
MOD_Plk_1 541 547 PF00069 0.178
MOD_Plk_1 619 625 PF00069 0.257
MOD_Plk_2-3 399 405 PF00069 0.162
MOD_Plk_2-3 667 673 PF00069 0.325
MOD_Plk_4 160 166 PF00069 0.351
MOD_Plk_4 201 207 PF00069 0.250
MOD_Plk_4 279 285 PF00069 0.321
MOD_Plk_4 3 9 PF00069 0.469
MOD_Plk_4 356 362 PF00069 0.363
MOD_Plk_4 468 474 PF00069 0.326
MOD_Plk_4 619 625 PF00069 0.273
MOD_Plk_4 687 693 PF00069 0.477
MOD_ProDKin_1 141 147 PF00069 0.351
MOD_ProDKin_1 190 196 PF00069 0.240
MOD_ProDKin_1 206 212 PF00069 0.200
MOD_ProDKin_1 435 441 PF00069 0.434
MOD_ProDKin_1 550 556 PF00069 0.373
MOD_ProDKin_1 600 606 PF00069 0.371
MOD_ProDKin_1 68 74 PF00069 0.159
MOD_SUMO_rev_2 399 407 PF00179 0.328
MOD_SUMO_rev_2 77 84 PF00179 0.281
TRG_DiLeu_BaLyEn_6 578 583 PF01217 0.359
TRG_DiLeu_BaLyEn_6 595 600 PF01217 0.156
TRG_ENDOCYTIC_2 11 14 PF00928 0.467
TRG_ENDOCYTIC_2 309 312 PF00928 0.297
TRG_ENDOCYTIC_2 336 339 PF00928 0.361
TRG_ENDOCYTIC_2 351 354 PF00928 0.280
TRG_ENDOCYTIC_2 361 364 PF00928 0.220
TRG_ENDOCYTIC_2 400 403 PF00928 0.302
TRG_ENDOCYTIC_2 494 497 PF00928 0.257
TRG_ENDOCYTIC_2 691 694 PF00928 0.468
TRG_ER_diArg_1 367 369 PF00400 0.333
TRG_ER_diArg_1 566 568 PF00400 0.156
TRG_NLS_MonoExtN_4 363 370 PF00514 0.156

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1PBT6 Leptomonas seymouri 64% 100%
A0A1X0NFY9 Trypanosomatidae 42% 100%
A0A1X0NTL0 Trypanosomatidae 42% 100%
A0A1X0NTM3 Trypanosomatidae 40% 100%
A0A1X0NY19 Trypanosomatidae 41% 100%
A0A1X0NYR4 Trypanosomatidae 38% 100%
A0A1X0P322 Trypanosomatidae 39% 100%
A0A1X0P5Y7 Trypanosomatidae 41% 100%
A0A3Q8IB13 Leishmania donovani 27% 100%
A0A3Q8IFU7 Leishmania donovani 27% 100%
A0A3S5H595 Leishmania donovani 65% 100%
A0A3S5H7I4 Leishmania donovani 26% 100%
A0A3S7WXQ4 Leishmania donovani 28% 100%
A0A3S7WXS2 Leishmania donovani 27% 100%
A4H3V1 Leishmania braziliensis 64% 100%
A4HCV9 Leishmania braziliensis 25% 100%
A4HG14 Leishmania braziliensis 27% 100%
A4HS26 Leishmania infantum 65% 100%
A4HS27 Leishmania infantum 59% 100%
A4I0D9 Leishmania infantum 27% 100%
A4I0E0 Leishmania infantum 27% 100%
A4I336 Leishmania infantum 26% 100%
E8NHF2 Leishmania mexicana (strain MHOM/GT/2001/U1103) 26% 100%
E8NHF3 Leishmania mexicana (strain MHOM/GT/2001/U1103) 26% 100%
E9ACV4 Leishmania major 26% 100%
E9AK13 Leishmania mexicana (strain MHOM/GT/2001/U1103) 64% 100%
E9AZE3 Leishmania mexicana (strain MHOM/GT/2001/U1103) 26% 100%
H2DF88 Rosa hybrid cultivar 27% 100%
P80065 Daucus carota 27% 100%
Q0J360 Oryza sativa subsp. japonica 29% 100%
Q0JDC5 Oryza sativa subsp. japonica 26% 100%
Q1PEF8 Arabidopsis thaliana 29% 100%
Q2UXF7 Triticum aestivum 28% 100%
Q43857 Vicia faba 26% 100%
Q43866 Arabidopsis thaliana 31% 100%
Q4QB75 Leishmania major 28% 100%
Q4QB76 Leishmania major 26% 100%
Q56UD0 Oryza sativa subsp. japonica 29% 100%
Q56UD1 Oryza sativa subsp. japonica 25% 100%
Q5FC15 Asparagus officinalis 28% 100%
Q9LIB9 Arabidopsis thaliana 29% 100%
Q9XTP3 Leishmania major 65% 100%
Q9XZX0 Leishmania major 61% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS