RRM domain-containing protein

Quick info Annotations Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Nup53/35/40-type RNA recognition motif containing protein - putative

Species:

Leishmania infantum

UniProt:

A4IAW0_LEIIN

TriTrypDb:

LINF_350011000

Length:

597

Annotations

Annotations by Jardim et al.

Uncharacterized Protein, Uncharacterized

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	4
GO:0110165	cellular anatomical entity	1	4

Expansion

Sequence features

A4IAW0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4IAW0

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	31	35	PF00656	0.589
CLV_NRD_NRD_1	12	14	PF00675	0.671
CLV_NRD_NRD_1	16	18	PF00675	0.704
CLV_NRD_NRD_1	197	199	PF00675	0.615
CLV_NRD_NRD_1	411	413	PF00675	0.584
CLV_NRD_NRD_1	445	447	PF00675	0.407
CLV_PCSK_FUR_1	13	17	PF00082	0.673
CLV_PCSK_FUR_1	195	199	PF00082	0.595
CLV_PCSK_FUR_1	443	447	PF00082	0.480
CLV_PCSK_KEX2_1	12	14	PF00082	0.671
CLV_PCSK_KEX2_1	15	17	PF00082	0.693
CLV_PCSK_KEX2_1	197	199	PF00082	0.610
CLV_PCSK_KEX2_1	411	413	PF00082	0.584
CLV_PCSK_KEX2_1	445	447	PF00082	0.411
CLV_PCSK_PC7_1	12	18	PF00082	0.759
CLV_PCSK_PC7_1	193	199	PF00082	0.584
CLV_PCSK_PC7_1	407	413	PF00082	0.523
CLV_PCSK_PC7_1	441	447	PF00082	0.418
CLV_PCSK_SKI1_1	198	202	PF00082	0.632
CLV_PCSK_SKI1_1	281	285	PF00082	0.678
CLV_PCSK_SKI1_1	41	45	PF00082	0.704
CLV_PCSK_SKI1_1	501	505	PF00082	0.501
DEG_APCC_DBOX_1	562	570	PF00400	0.688
DEG_Nend_Nbox_1	1	3	PF02207	0.486
DEG_SCF_TRCP1_1	332	337	PF00400	0.439
DEG_SPOP_SBC_1	119	123	PF00917	0.251
DEG_SPOP_SBC_1	142	146	PF00917	0.478
DEG_SPOP_SBC_1	361	365	PF00917	0.432
DOC_ANK_TNKS_1	519	526	PF00023	0.676
DOC_CYCLIN_RxL_1	193	202	PF00134	0.389
DOC_CYCLIN_yCln2_LP_2	374	380	PF00134	0.354
DOC_MAPK_gen_1	172	181	PF00069	0.539
DOC_MAPK_gen_1	501	509	PF00069	0.661
DOC_MAPK_gen_1	561	570	PF00069	0.645
DOC_MAPK_MEF2A_6	125	132	PF00069	0.271
DOC_MAPK_MEF2A_6	172	181	PF00069	0.494
DOC_MAPK_MEF2A_6	561	570	PF00069	0.652
DOC_MAPK_MEF2A_6	580	588	PF00069	0.296
DOC_PP1_SILK_1	37	42	PF00149	0.581
DOC_PP2B_LxvP_1	430	433	PF13499	0.721
DOC_PP4_FxxP_1	132	135	PF00568	0.305
DOC_PP4_FxxP_1	358	361	PF00568	0.443
DOC_SPAK_OSR1_1	379	383	PF12202	0.453
DOC_USP7_MATH_1	156	160	PF00917	0.506
DOC_USP7_MATH_1	215	219	PF00917	0.532
DOC_USP7_MATH_1	243	247	PF00917	0.500
DOC_USP7_MATH_1	285	289	PF00917	0.515
DOC_USP7_MATH_1	305	309	PF00917	0.507
DOC_USP7_MATH_1	314	318	PF00917	0.503
DOC_USP7_MATH_1	35	39	PF00917	0.513
DOC_USP7_MATH_1	361	365	PF00917	0.432
DOC_USP7_MATH_1	397	401	PF00917	0.737
DOC_USP7_MATH_1	437	441	PF00917	0.704
DOC_USP7_MATH_1	496	500	PF00917	0.598
DOC_USP7_MATH_1	532	536	PF00917	0.742
DOC_USP7_MATH_1	67	71	PF00917	0.553
DOC_USP7_MATH_2	460	466	PF00917	0.678
DOC_WW_Pin1_4	131	136	PF00397	0.292
DOC_WW_Pin1_4	21	26	PF00397	0.603
DOC_WW_Pin1_4	362	367	PF00397	0.521
DOC_WW_Pin1_4	428	433	PF00397	0.749
DOC_WW_Pin1_4	456	461	PF00397	0.621
LIG_14-3-3_CanoR_1	143	148	PF00244	0.481
LIG_14-3-3_CanoR_1	204	213	PF00244	0.479
LIG_14-3-3_CanoR_1	232	236	PF00244	0.558
LIG_14-3-3_CanoR_1	349	355	PF00244	0.437
LIG_14-3-3_CanoR_1	443	449	PF00244	0.621
LIG_14-3-3_CanoR_1	512	521	PF00244	0.605
LIG_14-3-3_CanoR_1	580	585	PF00244	0.453
LIG_APCC_ABBAyCdc20_2	185	191	PF00400	0.462
LIG_BRCT_BRCA1_1	145	149	PF00533	0.473
LIG_BRCT_BRCA1_1	332	336	PF00533	0.441
LIG_BRCT_BRCA1_1	355	359	PF00533	0.450
LIG_eIF4E_1	581	587	PF01652	0.335
LIG_FHA_1	223	229	PF00498	0.496
LIG_FHA_1	273	279	PF00498	0.497
LIG_FHA_1	34	40	PF00498	0.581
LIG_FHA_1	350	356	PF00498	0.523
LIG_FHA_1	369	375	PF00498	0.470
LIG_FHA_1	425	431	PF00498	0.730
LIG_FHA_1	516	522	PF00498	0.658
LIG_FHA_1	85	91	PF00498	0.376
LIG_FHA_2	153	159	PF00498	0.478
LIG_FHA_2	250	256	PF00498	0.515
LIG_FHA_2	3	9	PF00498	0.457
LIG_FHA_2	536	542	PF00498	0.724
LIG_FHA_2	550	556	PF00498	0.636
LIG_FHA_2	71	77	PF00498	0.560
LIG_IBAR_NPY_1	493	495	PF08397	0.656
LIG_LIR_Apic_2	356	361	PF02991	0.448
LIG_LIR_Gen_1	126	136	PF02991	0.292
LIG_LIR_Gen_1	367	378	PF02991	0.438
LIG_LIR_Gen_1	387	397	PF02991	0.246
LIG_LIR_Gen_1	459	469	PF02991	0.596
LIG_LIR_Gen_1	487	496	PF02991	0.612
LIG_LIR_Gen_1	535	545	PF02991	0.714
LIG_LIR_Gen_1	585	594	PF02991	0.366
LIG_LIR_Gen_1	70	80	PF02991	0.538
LIG_LIR_Gen_1	86	96	PF02991	0.243
LIG_LIR_Nem_3	104	109	PF02991	0.192
LIG_LIR_Nem_3	126	132	PF02991	0.292
LIG_LIR_Nem_3	319	325	PF02991	0.610
LIG_LIR_Nem_3	367	373	PF02991	0.489
LIG_LIR_Nem_3	387	392	PF02991	0.195
LIG_LIR_Nem_3	462	466	PF02991	0.584
LIG_LIR_Nem_3	487	491	PF02991	0.604
LIG_LIR_Nem_3	535	540	PF02991	0.663
LIG_LIR_Nem_3	585	590	PF02991	0.366
LIG_LIR_Nem_3	70	75	PF02991	0.558
LIG_LIR_Nem_3	86	91	PF02991	0.243
LIG_MLH1_MIPbox_1	332	336	PF16413	0.441
LIG_MLH1_MIPbox_1	355	359	PF16413	0.450
LIG_PCNA_yPIPBox_3	74	84	PF02747	0.515
LIG_Pex14_1	577	581	PF04695	0.335
LIG_SH2_CRK	469	473	PF00017	0.577
LIG_SH2_CRK	581	585	PF00017	0.335
LIG_SH2_NCK_1	325	329	PF00017	0.540
LIG_SH2_STAP1	147	151	PF00017	0.388
LIG_SH2_STAT3	495	498	PF00017	0.712
LIG_SH2_STAT5	105	108	PF00017	0.352
LIG_SH2_STAT5	109	112	PF00017	0.320
LIG_SH2_STAT5	117	120	PF00017	0.265
LIG_SH2_STAT5	129	132	PF00017	0.315
LIG_SH2_STAT5	471	474	PF00017	0.621
LIG_SH2_STAT5	72	75	PF00017	0.562
LIG_SH3_1	470	476	PF00018	0.584
LIG_SH3_2	170	175	PF14604	0.548
LIG_SH3_2	429	434	PF14604	0.723
LIG_SH3_3	167	173	PF00018	0.573
LIG_SH3_3	19	25	PF00018	0.497
LIG_SH3_3	260	266	PF00018	0.527
LIG_SH3_3	426	432	PF00018	0.707
LIG_SH3_3	470	476	PF00018	0.584
LIG_SUMO_SIM_par_1	380	385	PF11976	0.339
LIG_SUMO_SIM_par_1	97	104	PF11976	0.292
LIG_TYR_ITIM	467	472	PF00017	0.570
LIG_WRC_WIRS_1	463	468	PF05994	0.664
LIG_WW_3	172	176	PF00397	0.531
LIG_WW_3	431	435	PF00397	0.720
MOD_CDC14_SPxK_1	431	434	PF00782	0.721
MOD_CDK_SPxK_1	428	434	PF00069	0.724
MOD_CDK_SPxxK_3	362	369	PF00069	0.508
MOD_CK1_1	123	129	PF00069	0.355
MOD_CK1_1	145	151	PF00069	0.477
MOD_CK1_1	159	165	PF00069	0.451
MOD_CK1_1	230	236	PF00069	0.643
MOD_CK1_1	238	244	PF00069	0.504
MOD_CK1_1	279	285	PF00069	0.523
MOD_CK1_1	290	296	PF00069	0.483
MOD_CK1_1	297	303	PF00069	0.478
MOD_CK1_1	364	370	PF00069	0.475
MOD_CK1_1	515	521	PF00069	0.655
MOD_CK1_1	535	541	PF00069	0.668
MOD_CK1_1	582	588	PF00069	0.349
MOD_CK1_1	70	76	PF00069	0.531
MOD_CK2_1	152	158	PF00069	0.474
MOD_CK2_1	456	462	PF00069	0.616
MOD_CK2_1	535	541	PF00069	0.720
MOD_CK2_1	549	555	PF00069	0.636
MOD_CK2_1	70	76	PF00069	0.572
MOD_CMANNOS	386	389	PF00535	0.453
MOD_GlcNHglycan	122	125	PF01048	0.508
MOD_GlcNHglycan	233	236	PF01048	0.771
MOD_GlcNHglycan	240	244	PF01048	0.846
MOD_GlcNHglycan	272	275	PF01048	0.809
MOD_GlcNHglycan	281	284	PF01048	0.706
MOD_GlcNHglycan	296	299	PF01048	0.790
MOD_GlcNHglycan	307	310	PF01048	0.671
MOD_GlcNHglycan	31	34	PF01048	0.747
MOD_GlcNHglycan	316	319	PF01048	0.741
MOD_GlcNHglycan	332	335	PF01048	0.615
MOD_GlcNHglycan	366	369	PF01048	0.696
MOD_GlcNHglycan	399	402	PF01048	0.512
MOD_GlcNHglycan	456	459	PF01048	0.425
MOD_GlcNHglycan	514	517	PF01048	0.485
MOD_GlcNHglycan	54	57	PF01048	0.710
MOD_GlcNHglycan	91	94	PF01048	0.615
MOD_GSK3_1	119	126	PF00069	0.361
MOD_GSK3_1	141	148	PF00069	0.383
MOD_GSK3_1	152	159	PF00069	0.462
MOD_GSK3_1	223	230	PF00069	0.544
MOD_GSK3_1	231	238	PF00069	0.509
MOD_GSK3_1	239	246	PF00069	0.462
MOD_GSK3_1	270	277	PF00069	0.570
MOD_GSK3_1	281	288	PF00069	0.487
MOD_GSK3_1	29	36	PF00069	0.505
MOD_GSK3_1	290	297	PF00069	0.540
MOD_GSK3_1	330	337	PF00069	0.468
MOD_GSK3_1	349	356	PF00069	0.417
MOD_GSK3_1	360	367	PF00069	0.426
MOD_GSK3_1	424	431	PF00069	0.768
MOD_GSK3_1	444	451	PF00069	0.511
MOD_GSK3_1	532	539	PF00069	0.706
MOD_NEK2_1	120	125	PF00069	0.370
MOD_NEK2_1	239	244	PF00069	0.533
MOD_NEK2_1	292	297	PF00069	0.598
MOD_NEK2_1	340	345	PF00069	0.574
MOD_NEK2_1	384	389	PF00069	0.504
MOD_NEK2_1	444	449	PF00069	0.656
MOD_NEK2_1	503	508	PF00069	0.624
MOD_NEK2_1	83	88	PF00069	0.455
MOD_NEK2_2	156	161	PF00069	0.511
MOD_NEK2_2	496	501	PF00069	0.652
MOD_PIKK_1	204	210	PF00454	0.513
MOD_PIKK_1	272	278	PF00454	0.495
MOD_PIKK_1	285	291	PF00454	0.552
MOD_PIKK_1	424	430	PF00454	0.779
MOD_PIKK_1	532	538	PF00454	0.629
MOD_PIKK_1	67	73	PF00454	0.488
MOD_PKA_2	142	148	PF00069	0.475
MOD_PKA_2	231	237	PF00069	0.567
MOD_PKA_2	243	249	PF00069	0.505
MOD_PKA_2	270	276	PF00069	0.645
MOD_PKA_2	290	296	PF00069	0.483
MOD_PKA_2	368	374	PF00069	0.471
MOD_PKA_2	444	450	PF00069	0.692
MOD_PKA_2	549	555	PF00069	0.755
MOD_PKA_2	579	585	PF00069	0.453
MOD_PKB_1	510	518	PF00069	0.639
MOD_Plk_1	532	538	PF00069	0.674
MOD_Plk_4	35	41	PF00069	0.581
MOD_Plk_4	350	356	PF00069	0.523
MOD_Plk_4	462	468	PF00069	0.619
MOD_Plk_4	503	509	PF00069	0.625
MOD_Plk_4	582	588	PF00069	0.335
MOD_Plk_4	84	90	PF00069	0.276
MOD_ProDKin_1	131	137	PF00069	0.292
MOD_ProDKin_1	21	27	PF00069	0.602
MOD_ProDKin_1	362	368	PF00069	0.514
MOD_ProDKin_1	428	434	PF00069	0.749
MOD_ProDKin_1	456	462	PF00069	0.616
TRG_DiLeu_BaEn_1	565	570	PF01217	0.647
TRG_DiLeu_BaEn_2	461	467	PF01217	0.585
TRG_DiLeu_BaLyEn_6	260	265	PF01217	0.528
TRG_DiLeu_BaLyEn_6	498	503	PF01217	0.670
TRG_ENDOCYTIC_2	117	120	PF00928	0.350
TRG_ENDOCYTIC_2	129	132	PF00928	0.245
TRG_ENDOCYTIC_2	375	378	PF00928	0.335
TRG_ENDOCYTIC_2	463	466	PF00928	0.581
TRG_ENDOCYTIC_2	469	472	PF00928	0.577
TRG_ENDOCYTIC_2	581	584	PF00928	0.335
TRG_ENDOCYTIC_2	72	75	PF00928	0.562
TRG_ER_diArg_1	12	15	PF00400	0.473
TRG_ER_diArg_1	195	198	PF00400	0.407
TRG_ER_diArg_1	266	269	PF00400	0.507
TRG_ER_diArg_1	442	445	PF00400	0.697
TRG_ER_diArg_1	509	512	PF00400	0.610
TRG_Pf-PMV_PEXEL_1	198	202	PF00026	0.625
TRG_Pf-PMV_PEXEL_1	434	438	PF00026	0.504
TRG_Pf-PMV_PEXEL_1	501	505	PF00026	0.501

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HRZ6	Leptomonas seymouri	47%	100%
A0A3S7X8T0	Leishmania donovani	99%	100%
A4HM96	Leishmania braziliensis	79%	100%
E9AEN8	Leishmania major	91%	100%
E9B5U4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%