Proteophosphoglycan ppg1

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Protein of unknown function (DUF2946), putative

Species:

Leishmania infantum

UniProt:

A4IAV2_LEIIN

TriTrypDb:

Length:

906

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 2
NetGPI	no	yes: 0, no: 2

Cellular components
Term	Name	Level	Count
GO:0005929	cilium	4	1
GO:0016020	membrane	2	1
GO:0042995	cell projection	2	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0110165	cellular anatomical entity	1	1
GO:0120025	plasma membrane bounded cell projection	3	1

Expansion

Sequence features

A4IAV2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4IAV2

Function

Biological processes
Term	Name	Level	Count
GO:0002218	activation of innate immune response	3	1
GO:0002221	pattern recognition receptor signaling pathway	5	1
GO:0002224	toll-like receptor signaling pathway	6	1
GO:0002253	activation of immune response	2	1
GO:0002376	immune system process	1	1
GO:0002682	regulation of immune system process	3	1
GO:0002684	positive regulation of immune system process	4	1
GO:0002757	immune response-activating signaling pathway	3	1
GO:0002758	innate immune response-activating signaling pathway	4	1
GO:0002764	immune response-regulating signaling pathway	3	1
GO:0002831	regulation of response to biotic stimulus	4	1
GO:0002833	positive regulation of response to biotic stimulus	5	1
GO:0006955	immune response	2	1
GO:0007165	signal transduction	2	1
GO:0009987	cellular process	1	1
GO:0031347	regulation of defense response	5	1
GO:0031349	positive regulation of defense response	5	1
GO:0032101	regulation of response to external stimulus	4	1
GO:0032103	positive regulation of response to external stimulus	5	1
GO:0045088	regulation of innate immune response	5	1
GO:0045089	positive regulation of innate immune response	6	1
GO:0048518	positive regulation of biological process	3	1
GO:0048583	regulation of response to stimulus	3	1
GO:0048584	positive regulation of response to stimulus	4	1
GO:0050776	regulation of immune response	4	1
GO:0050778	positive regulation of immune response	5	1
GO:0050789	regulation of biological process	2	1
GO:0050794	regulation of cellular process	3	1
GO:0050896	response to stimulus	1	1
GO:0065007	biological regulation	1	1
GO:0080134	regulation of response to stress	4	1

Molecular functions
Term	Name	Level	Count
GO:0004888	transmembrane signaling receptor activity	3	1
GO:0038023	signaling receptor activity	2	1
GO:0060089	molecular transducer activity	1	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	883	885	PF00675	0.553
CLV_PCSK_KEX2_1	883	885	PF00082	0.553
DEG_Nend_UBRbox_3	1	2	PF02207	0.498
DOC_MAPK_MEF2A_6	123	132	PF00069	0.497
DOC_MAPK_MEF2A_6	3	12	PF00069	0.470
LIG_14-3-3_CanoR_1	138	143	PF00244	0.627
LIG_14-3-3_CanoR_1	153	158	PF00244	0.438
LIG_14-3-3_CanoR_1	168	173	PF00244	0.511
LIG_14-3-3_CanoR_1	303	308	PF00244	0.473
LIG_14-3-3_CanoR_1	378	383	PF00244	0.482
LIG_14-3-3_CanoR_1	468	473	PF00244	0.476
LIG_14-3-3_CanoR_1	483	488	PF00244	0.400
LIG_14-3-3_CanoR_1	498	503	PF00244	0.390
LIG_14-3-3_CanoR_1	528	533	PF00244	0.457
LIG_14-3-3_CanoR_1	588	593	PF00244	0.448
LIG_14-3-3_CanoR_1	693	698	PF00244	0.426
LIG_14-3-3_CanoR_1	723	728	PF00244	0.427
LIG_14-3-3_CanoR_1	78	83	PF00244	0.525
LIG_14-3-3_CanoR_1	883	887	PF00244	0.610
LIG_14-3-3_CanoR_1	93	98	PF00244	0.500
LIG_Actin_WH2_2	122	140	PF00022	0.704
LIG_Actin_WH2_2	152	170	PF00022	0.607
LIG_Actin_WH2_2	182	200	PF00022	0.576
LIG_Actin_WH2_2	2	20	PF00022	0.586
LIG_Actin_WH2_2	212	230	PF00022	0.558
LIG_Actin_WH2_2	242	260	PF00022	0.559
LIG_Actin_WH2_2	272	290	PF00022	0.568
LIG_Actin_WH2_2	302	320	PF00022	0.581
LIG_Actin_WH2_2	32	50	PF00022	0.711
LIG_Actin_WH2_2	332	350	PF00022	0.578
LIG_Actin_WH2_2	362	380	PF00022	0.614
LIG_Actin_WH2_2	392	410	PF00022	0.612
LIG_Actin_WH2_2	422	440	PF00022	0.600
LIG_Actin_WH2_2	452	470	PF00022	0.614
LIG_Actin_WH2_2	482	500	PF00022	0.626
LIG_Actin_WH2_2	512	530	PF00022	0.605
LIG_Actin_WH2_2	542	560	PF00022	0.594
LIG_Actin_WH2_2	572	590	PF00022	0.594
LIG_Actin_WH2_2	602	620	PF00022	0.578
LIG_Actin_WH2_2	62	80	PF00022	0.746
LIG_Actin_WH2_2	632	650	PF00022	0.568
LIG_Actin_WH2_2	677	695	PF00022	0.483
LIG_Actin_WH2_2	707	725	PF00022	0.661
LIG_Actin_WH2_2	737	755	PF00022	0.485
LIG_Actin_WH2_2	782	800	PF00022	0.543
LIG_Actin_WH2_2	812	830	PF00022	0.542
LIG_Actin_WH2_2	842	860	PF00022	0.553
LIG_Actin_WH2_2	92	110	PF00022	0.756
LIG_APCC_ABBA_1	875	880	PF00400	0.537
LIG_EH1_1	602	610	PF00400	0.424
LIG_EH1_1	677	685	PF00400	0.408
LIG_EH1_1	707	715	PF00400	0.414
LIG_FHA_1	872	878	PF00498	0.521
LIG_LIR_LC3C_4	156	160	PF02991	0.489
LIG_LIR_LC3C_4	171	175	PF02991	0.476
LIG_LIR_LC3C_4	306	310	PF02991	0.435
LIG_LIR_LC3C_4	81	85	PF02991	0.497
LIG_LIR_LC3C_4	96	100	PF02991	0.476
LIG_PDZ_Class_2	901	906	PF00595	0.526
LIG_SUMO_SIM_anti_2	141	146	PF11976	0.588
LIG_SUMO_SIM_anti_2	156	161	PF11976	0.400
LIG_SUMO_SIM_anti_2	171	176	PF11976	0.477
LIG_SUMO_SIM_anti_2	306	311	PF11976	0.436
LIG_SUMO_SIM_anti_2	381	386	PF11976	0.444
LIG_SUMO_SIM_anti_2	471	476	PF11976	0.440
LIG_SUMO_SIM_anti_2	486	491	PF11976	0.357
LIG_SUMO_SIM_anti_2	501	506	PF11976	0.352
LIG_SUMO_SIM_anti_2	531	536	PF11976	0.429
LIG_SUMO_SIM_anti_2	591	596	PF11976	0.422
LIG_SUMO_SIM_anti_2	696	701	PF11976	0.404
LIG_SUMO_SIM_anti_2	726	731	PF11976	0.406
LIG_SUMO_SIM_anti_2	81	86	PF11976	0.493
LIG_SUMO_SIM_anti_2	96	101	PF11976	0.469
LIG_SUMO_SIM_par_1	606	612	PF11976	0.422
LIG_SUMO_SIM_par_1	681	687	PF11976	0.409
LIG_SUMO_SIM_par_1	711	717	PF11976	0.410
LIG_SUMO_SIM_par_1	756	762	PF11976	0.647
LIG_SUMO_SIM_par_1	771	777	PF11976	0.386
LIG_SUMO_SIM_par_1	786	792	PF11976	0.358
LIG_SUMO_SIM_par_1	831	837	PF11976	0.420
LIG_SUMO_SIM_par_1	873	881	PF11976	0.533
LIG_SUMO_SIM_par_1	896	901	PF11976	0.489
MOD_CK1_1	887	893	PF00069	0.581
MOD_GlcNHglycan	886	889	PF01048	0.568
MOD_GlcNHglycan	890	893	PF01048	0.513
MOD_GlcNHglycan	900	903	PF01048	0.531
MOD_GSK3_1	884	891	PF00069	0.585
MOD_PK_1	138	144	PF00069	0.619
MOD_PK_1	153	159	PF00069	0.431
MOD_PK_1	168	174	PF00069	0.505
MOD_PK_1	303	309	PF00069	0.467
MOD_PK_1	378	384	PF00069	0.476
MOD_PK_1	468	474	PF00069	0.471
MOD_PK_1	483	489	PF00069	0.393
MOD_PK_1	498	504	PF00069	0.384
MOD_PK_1	528	534	PF00069	0.454
MOD_PK_1	588	594	PF00069	0.445
MOD_PK_1	693	699	PF00069	0.424
MOD_PK_1	723	729	PF00069	0.425
MOD_PK_1	78	84	PF00069	0.519
MOD_PK_1	93	99	PF00069	0.494
MOD_PKA_2	882	888	PF00069	0.549
MOD_Plk_4	138	144	PF00069	0.619
MOD_Plk_4	153	159	PF00069	0.431
MOD_Plk_4	168	174	PF00069	0.505
MOD_Plk_4	303	309	PF00069	0.467
MOD_Plk_4	378	384	PF00069	0.476
MOD_Plk_4	468	474	PF00069	0.471
MOD_Plk_4	483	489	PF00069	0.393
MOD_Plk_4	498	504	PF00069	0.384
MOD_Plk_4	528	534	PF00069	0.454
MOD_Plk_4	588	594	PF00069	0.445
MOD_Plk_4	693	699	PF00069	0.424
MOD_Plk_4	723	729	PF00069	0.425
MOD_Plk_4	78	84	PF00069	0.519
MOD_Plk_4	93	99	PF00069	0.494
TRG_ER_diArg_1	882	884	PF00400	0.558

Homologs


Protein	Taxonomy	Sequence identity	Coverage
E9AHU2	Leishmania infantum	58%	100%