Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4IAU6_LEIIN

TriTrypDb:

LINF_350009900

Length:

200

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 4
NetGPI	no	yes: 0, no: 4

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4IAU6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4IAU6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	133	135	PF00675	0.699
CLV_NRD_NRD_1	146	148	PF00675	0.681
CLV_PCSK_KEX2_1	133	135	PF00082	0.699
CLV_PCSK_KEX2_1	146	148	PF00082	0.687
CLV_PCSK_KEX2_1	166	168	PF00082	0.679
CLV_PCSK_PC1ET2_1	166	168	PF00082	0.731
CLV_PCSK_SKI1_1	161	165	PF00082	0.633
CLV_PCSK_SKI1_1	88	92	PF00082	0.291
DEG_Nend_UBRbox_2	1	3	PF02207	0.662
DOC_CYCLIN_yCln2_LP_2	14	20	PF00134	0.626
DOC_MAPK_gen_1	88	94	PF00069	0.530
DOC_PP2B_LxvP_1	14	17	PF13499	0.679
DOC_PP4_FxxP_1	107	110	PF00568	0.509
DOC_USP7_MATH_1	188	192	PF00917	0.452
DOC_USP7_MATH_2	50	56	PF00917	0.636
DOC_WW_Pin1_4	190	195	PF00397	0.533
DOC_WW_Pin1_4	20	25	PF00397	0.692
DOC_WW_Pin1_4	61	66	PF00397	0.656
LIG_14-3-3_CanoR_1	10	15	PF00244	0.740
LIG_14-3-3_CanoR_1	190	194	PF00244	0.447
LIG_Actin_WH2_2	93	111	PF00022	0.272
LIG_FHA_1	103	109	PF00498	0.345
LIG_FHA_1	176	182	PF00498	0.459
LIG_FHA_1	49	55	PF00498	0.687
LIG_FHA_2	175	181	PF00498	0.436
LIG_LIR_Apic_2	105	110	PF02991	0.506
LIG_LIR_Apic_2	132	138	PF02991	0.466
LIG_SH2_CRK	115	119	PF00017	0.412
LIG_SH2_SRC	135	138	PF00017	0.469
LIG_SH2_STAP1	115	119	PF00017	0.412
LIG_SH2_STAT5	106	109	PF00017	0.664
LIG_SH2_STAT5	115	118	PF00017	0.420
LIG_SH2_STAT5	135	138	PF00017	0.521
LIG_SH3_3	191	197	PF00018	0.527
LIG_SH3_3	44	50	PF00018	0.643
LIG_SH3_3	64	70	PF00018	0.678
LIG_SUMO_SIM_anti_2	74	81	PF11976	0.607
LIG_TRFH_1	106	110	PF08558	0.509
LIG_TYR_ITIM	113	118	PF00017	0.407
LIG_UBA3_1	80	89	PF00899	0.564
LIG_WRC_WIRS_1	114	119	PF05994	0.415
MOD_CDK_SPxxK_3	20	27	PF00069	0.686
MOD_CK1_1	121	127	PF00069	0.410
MOD_CK1_1	142	148	PF00069	0.484
MOD_CK1_1	172	178	PF00069	0.509
MOD_CK1_1	31	37	PF00069	0.705
MOD_CK1_1	98	104	PF00069	0.272
MOD_CK2_1	174	180	PF00069	0.434
MOD_CK2_1	20	26	PF00069	0.682
MOD_DYRK1A_RPxSP_1	190	194	PF00069	0.447
MOD_GlcNHglycan	10	13	PF01048	0.550
MOD_GlcNHglycan	120	123	PF01048	0.576
MOD_GlcNHglycan	148	151	PF01048	0.718
MOD_GlcNHglycan	155	158	PF01048	0.706
MOD_GlcNHglycan	33	36	PF01048	0.593
MOD_GlcNHglycan	37	40	PF01048	0.579
MOD_GlcNHglycan	54	57	PF01048	0.479
MOD_GSK3_1	113	120	PF00069	0.358
MOD_GSK3_1	121	128	PF00069	0.399
MOD_GSK3_1	142	149	PF00069	0.481
MOD_GSK3_1	153	160	PF00069	0.417
MOD_GSK3_1	16	23	PF00069	0.683
MOD_GSK3_1	172	179	PF00069	0.471
MOD_GSK3_1	29	36	PF00069	0.675
MOD_GSK3_1	48	55	PF00069	0.600
MOD_GSK3_1	95	102	PF00069	0.272
MOD_LATS_1	137	143	PF00433	0.446
MOD_NEK2_1	117	122	PF00069	0.326
MOD_NEK2_1	151	156	PF00069	0.466
MOD_NEK2_1	29	34	PF00069	0.711
MOD_NEK2_1	99	104	PF00069	0.276
MOD_PIKK_1	108	114	PF00454	0.415
MOD_PKA_1	146	152	PF00069	0.526
MOD_PKA_2	108	114	PF00069	0.394
MOD_PKA_2	146	152	PF00069	0.526
MOD_PKA_2	183	189	PF00069	0.556
MOD_Plk_4	10	16	PF00069	0.754
MOD_Plk_4	102	108	PF00069	0.320
MOD_Plk_4	113	119	PF00069	0.322
MOD_Plk_4	121	127	PF00069	0.394
MOD_Plk_4	95	101	PF00069	0.320
MOD_ProDKin_1	190	196	PF00069	0.532
MOD_ProDKin_1	20	26	PF00069	0.692
MOD_ProDKin_1	61	67	PF00069	0.655
TRG_DiLeu_BaEn_1	74	79	PF01217	0.590
TRG_DiLeu_BaEn_2	86	92	PF01217	0.602
TRG_DiLeu_BaLyEn_6	73	78	PF01217	0.669
TRG_ENDOCYTIC_2	115	118	PF00928	0.467
TRG_ER_diArg_1	133	135	PF00400	0.455
TRG_ER_diArg_1	146	148	PF00400	0.413
TRG_NES_CRM1_1	75	87	PF08389	0.577

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3S7X8T7	Leishmania donovani	100%	91%
A4HM82	Leishmania braziliensis	47%	100%
E9AEM4	Leishmania major	79%	100%