Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Generative cell specific 1 protein - putative

Species:

Leishmania infantum

UniProt:

A4IAU5_LEIIN

TriTrypDb:

LINF_350009700

Length:

917

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 10

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005886	plasma membrane	3	7
GO:0016020	membrane	2	7
GO:0110165	cellular anatomical entity	1	7

Expansion

Sequence features

A4IAU5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4IAU5

Function

Biological processes
Term	Name	Level	Count
GO:0007338	single fertilization	3	7
GO:0009566	fertilization	2	7
GO:0022414	reproductive process	1	7

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	7
GO:0008289	lipid binding	2	7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	100	102	PF00675	0.438
CLV_NRD_NRD_1	61	63	PF00675	0.278
CLV_NRD_NRD_1	654	656	PF00675	0.477
CLV_NRD_NRD_1	696	698	PF00675	0.477
CLV_NRD_NRD_1	718	720	PF00675	0.504
CLV_PCSK_KEX2_1	100	102	PF00082	0.438
CLV_PCSK_KEX2_1	653	655	PF00082	0.473
CLV_PCSK_KEX2_1	696	698	PF00082	0.477
CLV_PCSK_KEX2_1	717	719	PF00082	0.508
CLV_PCSK_PC1ET2_1	717	719	PF00082	0.494
CLV_PCSK_SKI1_1	101	105	PF00082	0.299
CLV_PCSK_SKI1_1	127	131	PF00082	0.697
CLV_PCSK_SKI1_1	373	377	PF00082	0.528
DEG_APCC_DBOX_1	100	108	PF00400	0.433
DEG_APCC_DBOX_1	203	211	PF00400	0.367
DEG_APCC_DBOX_1	37	45	PF00400	0.433
DEG_SCF_FBW7_1	872	878	PF00400	0.742
DOC_CKS1_1	762	767	PF01111	0.611
DOC_CKS1_1	872	877	PF01111	0.743
DOC_CYCLIN_yCln2_LP_2	122	128	PF00134	0.569
DOC_CYCLIN_yCln2_LP_2	375	381	PF00134	0.274
DOC_CYCLIN_yCln2_LP_2	808	811	PF00134	0.653
DOC_MAPK_gen_1	151	159	PF00069	0.272
DOC_MAPK_gen_1	62	70	PF00069	0.345
DOC_MAPK_gen_1	653	662	PF00069	0.391
DOC_MAPK_HePTP_8	652	664	PF00069	0.384
DOC_MAPK_MEF2A_6	151	159	PF00069	0.272
DOC_MAPK_MEF2A_6	62	71	PF00069	0.335
DOC_MAPK_MEF2A_6	655	664	PF00069	0.293
DOC_PP1_RVXF_1	601	608	PF00149	0.274
DOC_PP2B_LxvP_1	375	378	PF13499	0.274
DOC_PP2B_LxvP_1	395	398	PF13499	0.181
DOC_PP2B_LxvP_1	796	799	PF13499	0.674
DOC_PP2B_LxvP_1	808	811	PF13499	0.692
DOC_PP4_FxxP_1	789	792	PF00568	0.644
DOC_PP4_FxxP_1	846	849	PF00568	0.674
DOC_PP4_MxPP_1	809	812	PF00568	0.684
DOC_USP7_MATH_1	129	133	PF00917	0.464
DOC_USP7_MATH_1	23	27	PF00917	0.758
DOC_USP7_MATH_1	418	422	PF00917	0.274
DOC_USP7_MATH_1	61	65	PF00917	0.229
DOC_USP7_MATH_1	782	786	PF00917	0.728
DOC_USP7_MATH_1	840	844	PF00917	0.674
DOC_USP7_MATH_1	875	879	PF00917	0.744
DOC_WW_Pin1_4	187	192	PF00397	0.274
DOC_WW_Pin1_4	336	341	PF00397	0.274
DOC_WW_Pin1_4	471	476	PF00397	0.277
DOC_WW_Pin1_4	480	485	PF00397	0.302
DOC_WW_Pin1_4	747	752	PF00397	0.715
DOC_WW_Pin1_4	761	766	PF00397	0.638
DOC_WW_Pin1_4	787	792	PF00397	0.739
DOC_WW_Pin1_4	836	841	PF00397	0.671
DOC_WW_Pin1_4	868	873	PF00397	0.740
DOC_WW_Pin1_4	880	885	PF00397	0.658
DOC_WW_Pin1_4	889	894	PF00397	0.667
DOC_WW_Pin1_4	900	905	PF00397	0.594
DOC_WW_Pin1_4	906	911	PF00397	0.676
DOC_WW_Pin1_4	93	98	PF00397	0.704
LIG_14-3-3_CanoR_1	193	201	PF00244	0.328
LIG_14-3-3_CanoR_1	38	42	PF00244	0.493
LIG_14-3-3_CanoR_1	603	608	PF00244	0.328
LIG_14-3-3_CanoR_1	877	885	PF00244	0.756
LIG_14-3-3_CanoR_1	898	904	PF00244	0.715
LIG_14-3-3_CanoR_1	90	94	PF00244	0.678
LIG_BIR_III_4	246	250	PF00653	0.328
LIG_BRCT_BRCA1_1	168	172	PF00533	0.328
LIG_BRCT_BRCA1_1	254	258	PF00533	0.274
LIG_BRCT_BRCA1_1	610	614	PF00533	0.328
LIG_BRCT_BRCA1_1	842	846	PF00533	0.712
LIG_Clathr_ClatBox_1	401	405	PF01394	0.274
LIG_Clathr_ClatBox_1	659	663	PF01394	0.289
LIG_CtBP_PxDLS_1	367	371	PF00389	0.274
LIG_EVH1_1	796	800	PF00568	0.731
LIG_FHA_1	106	112	PF00498	0.453
LIG_FHA_1	154	160	PF00498	0.328
LIG_FHA_1	238	244	PF00498	0.282
LIG_FHA_1	265	271	PF00498	0.328
LIG_FHA_1	311	317	PF00498	0.274
LIG_FHA_1	397	403	PF00498	0.328
LIG_FHA_1	441	447	PF00498	0.274
LIG_FHA_1	499	505	PF00498	0.395
LIG_FHA_1	50	56	PF00498	0.332
LIG_FHA_1	527	533	PF00498	0.365
LIG_FHA_1	537	543	PF00498	0.233
LIG_FHA_1	570	576	PF00498	0.327
LIG_FHA_1	587	593	PF00498	0.259
LIG_FHA_1	643	649	PF00498	0.275
LIG_FHA_1	788	794	PF00498	0.777
LIG_FHA_2	344	350	PF00498	0.285
LIG_LIR_Apic_2	788	792	PF02991	0.674
LIG_LIR_Apic_2	843	849	PF02991	0.678
LIG_LIR_Gen_1	349	358	PF02991	0.328
LIG_LIR_Gen_1	393	402	PF02991	0.274
LIG_LIR_Gen_1	415	420	PF02991	0.274
LIG_LIR_Gen_1	663	673	PF02991	0.379
LIG_LIR_LC3C_4	539	544	PF02991	0.259
LIG_LIR_LC3C_4	64	68	PF02991	0.229
LIG_LIR_Nem_3	310	314	PF02991	0.274
LIG_LIR_Nem_3	360	364	PF02991	0.276
LIG_LIR_Nem_3	393	397	PF02991	0.274
LIG_LIR_Nem_3	415	419	PF02991	0.274
LIG_LIR_Nem_3	460	465	PF02991	0.297
LIG_LIR_Nem_3	473	479	PF02991	0.281
LIG_LIR_Nem_3	572	576	PF02991	0.287
LIG_LIR_Nem_3	663	668	PF02991	0.379
LIG_NRBOX	65	71	PF00104	0.356
LIG_PAM2_1	752	764	PF00658	0.612
LIG_PCNA_PIPBox_1	658	667	PF02747	0.293
LIG_PCNA_yPIPBox_3	653	665	PF02747	0.293
LIG_Pex14_1	299	303	PF04695	0.274
LIG_Pex14_2	295	299	PF04695	0.274
LIG_Pex14_2	680	684	PF04695	0.330
LIG_Pex14_2	896	900	PF04695	0.736
LIG_PTAP_UEV_1	753	758	PF05743	0.615
LIG_REV1ctd_RIR_1	677	686	PF16727	0.338
LIG_SH2_CRK	203	207	PF00017	0.274
LIG_SH2_NCK_1	245	249	PF00017	0.293
LIG_SH2_NCK_1	287	291	PF00017	0.274
LIG_SH2_NCK_1	361	365	PF00017	0.293
LIG_SH2_NCK_1	768	772	PF00017	0.688
LIG_SH2_SRC	361	364	PF00017	0.328
LIG_SH2_SRC	768	771	PF00017	0.642
LIG_SH2_STAP1	218	222	PF00017	0.274
LIG_SH2_STAP1	312	316	PF00017	0.328
LIG_SH2_STAP1	416	420	PF00017	0.275
LIG_SH2_STAT5	138	141	PF00017	0.344
LIG_SH2_STAT5	209	212	PF00017	0.274
LIG_SH2_STAT5	287	290	PF00017	0.274
LIG_SH2_STAT5	303	306	PF00017	0.340
LIG_SH2_STAT5	312	315	PF00017	0.309
LIG_SH2_STAT5	476	479	PF00017	0.274
LIG_SH2_STAT5	48	51	PF00017	0.253
LIG_SH2_STAT5	5	8	PF00017	0.656
LIG_SH2_STAT5	500	503	PF00017	0.277
LIG_SH2_STAT5	576	579	PF00017	0.276
LIG_SH2_STAT5	667	670	PF00017	0.307
LIG_SH2_STAT5	689	692	PF00017	0.656
LIG_SH2_STAT5	761	764	PF00017	0.674
LIG_SH2_STAT5	84	87	PF00017	0.767
LIG_SH3_2	872	877	PF14604	0.743
LIG_SH3_3	361	367	PF00018	0.336
LIG_SH3_3	375	381	PF00018	0.235
LIG_SH3_3	745	751	PF00018	0.679
LIG_SH3_3	759	765	PF00018	0.627
LIG_SH3_3	794	800	PF00018	0.676
LIG_SH3_3	834	840	PF00018	0.716
LIG_SH3_3	847	853	PF00018	0.647
LIG_SH3_3	869	875	PF00018	0.695
LIG_SH3_3	901	907	PF00018	0.736
LIG_SH3_4	516	523	PF00018	0.276
LIG_SUMO_SIM_anti_2	36	43	PF11976	0.493
LIG_SUMO_SIM_anti_2	64	70	PF11976	0.263
LIG_SUMO_SIM_par_1	153	158	PF11976	0.277
LIG_SUMO_SIM_par_1	365	372	PF11976	0.276
LIG_SUMO_SIM_par_1	399	405	PF11976	0.274
LIG_SUMO_SIM_par_1	487	492	PF11976	0.274
LIG_SUMO_SIM_par_1	658	663	PF11976	0.293
LIG_TRAF2_1	165	168	PF00917	0.302
LIG_TRAF2_1	631	634	PF00917	0.259
LIG_TRAF2_1	878	881	PF00917	0.743
LIG_WRC_WIRS_1	841	846	PF05994	0.647
LIG_WW_3	810	814	PF00397	0.689
MOD_CDC14_SPxK_1	190	193	PF00782	0.328
MOD_CDK_SPK_2	889	894	PF00069	0.731
MOD_CDK_SPK_2	900	905	PF00069	0.658
MOD_CDK_SPK_2	93	98	PF00069	0.652
MOD_CDK_SPxK_1	187	193	PF00069	0.328
MOD_CDK_SPxK_1	871	877	PF00069	0.744
MOD_CDK_SPxxK_3	93	100	PF00069	0.658
MOD_CK1_1	134	140	PF00069	0.340
MOD_CK1_1	301	307	PF00069	0.274
MOD_CK1_1	37	43	PF00069	0.505
MOD_CK1_1	432	438	PF00069	0.276
MOD_CK1_1	580	586	PF00069	0.307
MOD_CK1_1	636	642	PF00069	0.297
MOD_CK1_1	722	728	PF00069	0.699
MOD_CK1_1	736	742	PF00069	0.596
MOD_CK1_1	785	791	PF00069	0.643
MOD_CK1_1	866	872	PF00069	0.708
MOD_CK1_1	876	882	PF00069	0.681
MOD_CK1_1	89	95	PF00069	0.657
MOD_CK1_1	899	905	PF00069	0.740
MOD_CK2_1	139	145	PF00069	0.414
MOD_CK2_1	343	349	PF00069	0.278
MOD_CK2_1	433	439	PF00069	0.274
MOD_CK2_1	628	634	PF00069	0.261
MOD_CK2_1	696	702	PF00069	0.695
MOD_CK2_1	875	881	PF00069	0.784
MOD_GlcNHglycan	141	144	PF01048	0.634
MOD_GlcNHglycan	174	177	PF01048	0.474
MOD_GlcNHglycan	198	201	PF01048	0.474
MOD_GlcNHglycan	30	33	PF01048	0.474
MOD_GlcNHglycan	300	303	PF01048	0.474
MOD_GlcNHglycan	322	325	PF01048	0.496
MOD_GlcNHglycan	493	496	PF01048	0.516
MOD_GlcNHglycan	505	508	PF01048	0.474
MOD_GlcNHglycan	510	513	PF01048	0.494
MOD_GlcNHglycan	582	585	PF01048	0.461
MOD_GlcNHglycan	621	624	PF01048	0.530
MOD_GlcNHglycan	625	629	PF01048	0.516
MOD_GlcNHglycan	63	66	PF01048	0.434
MOD_GlcNHglycan	633	638	PF01048	0.464
MOD_GlcNHglycan	698	701	PF01048	0.490
MOD_GlcNHglycan	721	724	PF01048	0.573
MOD_GlcNHglycan	735	738	PF01048	0.444
MOD_GlcNHglycan	754	757	PF01048	0.367
MOD_GlcNHglycan	776	779	PF01048	0.496
MOD_GlcNHglycan	784	787	PF01048	0.452
MOD_GlcNHglycan	865	868	PF01048	0.482
MOD_GSK3_1	130	137	PF00069	0.355
MOD_GSK3_1	192	199	PF00069	0.378
MOD_GSK3_1	218	225	PF00069	0.351
MOD_GSK3_1	260	267	PF00069	0.283
MOD_GSK3_1	310	317	PF00069	0.274
MOD_GSK3_1	33	40	PF00069	0.642
MOD_GSK3_1	396	403	PF00069	0.290
MOD_GSK3_1	429	436	PF00069	0.280
MOD_GSK3_1	471	478	PF00069	0.274
MOD_GSK3_1	480	487	PF00069	0.274
MOD_GSK3_1	532	539	PF00069	0.322
MOD_GSK3_1	580	587	PF00069	0.283
MOD_GSK3_1	603	610	PF00069	0.314
MOD_GSK3_1	615	622	PF00069	0.257
MOD_GSK3_1	624	631	PF00069	0.264
MOD_GSK3_1	632	639	PF00069	0.213
MOD_GSK3_1	719	726	PF00069	0.669
MOD_GSK3_1	781	788	PF00069	0.721
MOD_GSK3_1	836	843	PF00069	0.658
MOD_GSK3_1	871	878	PF00069	0.717
MOD_GSK3_1	89	96	PF00069	0.708
MOD_GSK3_1	896	903	PF00069	0.693
MOD_LATS_1	20	26	PF00433	0.738
MOD_N-GLC_1	145	150	PF02516	0.455
MOD_N-GLC_1	182	187	PF02516	0.483
MOD_N-GLC_1	314	319	PF02516	0.474
MOD_N-GLC_1	320	325	PF02516	0.474
MOD_N-GLC_1	547	552	PF02516	0.562
MOD_N-GLC_1	615	620	PF02516	0.474
MOD_N-GLC_2	228	230	PF02516	0.474
MOD_N-GLC_2	424	426	PF02516	0.474
MOD_N-GLC_2	862	864	PF02516	0.429
MOD_NEK2_1	114	119	PF00069	0.338
MOD_NEK2_1	130	135	PF00069	0.425
MOD_NEK2_1	153	158	PF00069	0.322
MOD_NEK2_1	172	177	PF00069	0.336
MOD_NEK2_1	192	197	PF00069	0.312
MOD_NEK2_1	264	269	PF00069	0.274
MOD_NEK2_1	316	321	PF00069	0.280
MOD_NEK2_1	368	373	PF00069	0.323
MOD_NEK2_1	458	463	PF00069	0.330
MOD_NEK2_1	49	54	PF00069	0.304
MOD_NEK2_1	498	503	PF00069	0.311
MOD_NEK2_1	896	901	PF00069	0.821
MOD_NEK2_2	218	223	PF00069	0.274
MOD_NEK2_2	569	574	PF00069	0.233
MOD_OFUCOSY	426	433	PF10250	0.474
MOD_PIKK_1	252	258	PF00454	0.274
MOD_PIKK_1	418	424	PF00454	0.292
MOD_PIKK_1	433	439	PF00454	0.274
MOD_PIKK_1	615	621	PF00454	0.279
MOD_PIKK_1	876	882	PF00454	0.745
MOD_PKA_1	696	702	PF00069	0.674
MOD_PKA_2	192	198	PF00069	0.369
MOD_PKA_2	23	29	PF00069	0.647
MOD_PKA_2	37	43	PF00069	0.512
MOD_PKA_2	532	538	PF00069	0.306
MOD_PKA_2	61	67	PF00069	0.255
MOD_PKA_2	696	702	PF00069	0.662
MOD_PKA_2	728	734	PF00069	0.809
MOD_PKA_2	74	80	PF00069	0.493
MOD_PKA_2	876	882	PF00069	0.745
MOD_PKA_2	89	95	PF00069	0.658
MOD_Plk_1	166	172	PF00069	0.274
MOD_Plk_1	177	183	PF00069	0.274
MOD_Plk_1	218	224	PF00069	0.293
MOD_Plk_1	260	266	PF00069	0.275
MOD_Plk_1	314	320	PF00069	0.274
MOD_Plk_1	498	504	PF00069	0.328
MOD_Plk_1	707	713	PF00069	0.701
MOD_Plk_4	114	120	PF00069	0.360
MOD_Plk_4	131	137	PF00069	0.424
MOD_Plk_4	166	172	PF00069	0.274
MOD_Plk_4	222	228	PF00069	0.340
MOD_Plk_4	307	313	PF00069	0.274
MOD_Plk_4	37	43	PF00069	0.493
MOD_Plk_4	484	490	PF00069	0.328
MOD_Plk_4	526	532	PF00069	0.290
MOD_Plk_4	586	592	PF00069	0.266
MOD_ProDKin_1	187	193	PF00069	0.274
MOD_ProDKin_1	336	342	PF00069	0.274
MOD_ProDKin_1	471	477	PF00069	0.277
MOD_ProDKin_1	480	486	PF00069	0.302
MOD_ProDKin_1	747	753	PF00069	0.713
MOD_ProDKin_1	761	767	PF00069	0.640
MOD_ProDKin_1	787	793	PF00069	0.730
MOD_ProDKin_1	836	842	PF00069	0.671
MOD_ProDKin_1	868	874	PF00069	0.741
MOD_ProDKin_1	880	886	PF00069	0.658
MOD_ProDKin_1	889	895	PF00069	0.665
MOD_ProDKin_1	900	906	PF00069	0.593
MOD_ProDKin_1	93	99	PF00069	0.703
MOD_SUMO_for_1	705	708	PF00179	0.700
MOD_SUMO_rev_2	726	736	PF00179	0.705
TRG_DiLeu_BaEn_3	167	173	PF01217	0.328
TRG_ENDOCYTIC_2	205	208	PF00928	0.274
TRG_ENDOCYTIC_2	361	364	PF00928	0.328
TRG_ENDOCYTIC_2	416	419	PF00928	0.274
TRG_ENDOCYTIC_2	48	51	PF00928	0.253
TRG_ENDOCYTIC_2	667	670	PF00928	0.307
TRG_ER_diArg_1	652	655	PF00400	0.290
TRG_ER_diArg_1	99	101	PF00400	0.647
TRG_NES_CRM1_1	456	470	PF08389	0.328

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P372	Leptomonas seymouri	52%	94%
A0A3S7X8Q7	Leishmania donovani	100%	100%
A4GRC6	Chlamydomonas reinhardtii	27%	81%
A4HM81	Leishmania braziliensis	72%	98%
E9AEM3	Leishmania major	92%	100%
E9B5T2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%