Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Arrestin (or S-antigen) - N-terminal domain containing protein - putative

Species:

Leishmania infantum

UniProt:

A4IAU3_LEIIN

TriTrypDb:

LINF_350009500

Length:

637

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4IAU3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4IAU3

Function

Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	1
GO:0008104	protein localization	4	1
GO:0009987	cellular process	1	1
GO:0015031	protein transport	4	1
GO:0033036	macromolecule localization	2	1
GO:0045184	establishment of protein localization	3	1
GO:0051179	localization	1	1
GO:0051234	establishment of localization	2	1
GO:0051641	cellular localization	2	1
GO:0070727	cellular macromolecule localization	3	1
GO:0071702	organic substance transport	4	1
GO:0071705	nitrogen compound transport	4	1

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	279	281	PF00675	0.651
CLV_NRD_NRD_1	306	308	PF00675	0.626
CLV_NRD_NRD_1	333	335	PF00675	0.574
CLV_NRD_NRD_1	377	379	PF00675	0.622
CLV_NRD_NRD_1	570	572	PF00675	0.562
CLV_PCSK_FUR_1	568	572	PF00082	0.545
CLV_PCSK_KEX2_1	277	279	PF00082	0.653
CLV_PCSK_KEX2_1	281	283	PF00082	0.646
CLV_PCSK_KEX2_1	306	308	PF00082	0.615
CLV_PCSK_KEX2_1	333	335	PF00082	0.574
CLV_PCSK_KEX2_1	376	378	PF00082	0.656
CLV_PCSK_KEX2_1	570	572	PF00082	0.562
CLV_PCSK_PC1ET2_1	277	279	PF00082	0.685
CLV_PCSK_PC1ET2_1	281	283	PF00082	0.665
CLV_PCSK_SKI1_1	306	310	PF00082	0.662
CLV_PCSK_SKI1_1	442	446	PF00082	0.516
CLV_PCSK_SKI1_1	46	50	PF00082	0.377
CLV_PCSK_SKI1_1	529	533	PF00082	0.583
CLV_PCSK_SKI1_1	80	84	PF00082	0.445
DEG_APCC_DBOX_1	517	525	PF00400	0.458
DEG_SIAH_1	112	120	PF03145	0.569
DOC_CKS1_1	490	495	PF01111	0.621
DOC_CKS1_1	531	536	PF01111	0.525
DOC_CYCLIN_yCln2_LP_2	469	475	PF00134	0.670
DOC_CYCLIN_yCln2_LP_2	579	582	PF00134	0.507
DOC_CYCLIN_yCln2_LP_2	630	636	PF00134	0.530
DOC_MAPK_gen_1	303	313	PF00069	0.579
DOC_MAPK_MEF2A_6	25	34	PF00069	0.293
DOC_MAPK_MEF2A_6	5	13	PF00069	0.400
DOC_MAPK_MEF2A_6	518	527	PF00069	0.468
DOC_PP1_RVXF_1	29	35	PF00149	0.465
DOC_PP1_RVXF_1	44	50	PF00149	0.359
DOC_PP2B_LxvP_1	474	477	PF13499	0.598
DOC_PP2B_LxvP_1	579	582	PF13499	0.506
DOC_PP2B_LxvP_1	630	633	PF13499	0.521
DOC_PP4_FxxP_1	208	211	PF00568	0.307
DOC_USP7_MATH_1	362	366	PF00917	0.699
DOC_USP7_MATH_1	461	465	PF00917	0.657
DOC_USP7_UBL2_3	277	281	PF12436	0.648
DOC_WW_Pin1_4	109	114	PF00397	0.560
DOC_WW_Pin1_4	16	21	PF00397	0.390
DOC_WW_Pin1_4	479	484	PF00397	0.664
DOC_WW_Pin1_4	489	494	PF00397	0.467
DOC_WW_Pin1_4	530	535	PF00397	0.532
LIG_14-3-3_CanoR_1	186	196	PF00244	0.529
LIG_14-3-3_CanoR_1	306	312	PF00244	0.657
LIG_14-3-3_CanoR_1	459	469	PF00244	0.599
LIG_14-3-3_CanoR_1	80	85	PF00244	0.426
LIG_14-3-3_CterR_2	635	637	PF00244	0.549
LIG_BRCT_BRCA1_1	245	249	PF00533	0.620
LIG_BRCT_BRCA1_1	591	595	PF00533	0.447
LIG_CSL_BTD_1	212	215	PF09270	0.307
LIG_eIF4E_1	130	136	PF01652	0.494
LIG_eIF4E_1	314	320	PF01652	0.421
LIG_eIF4E_1	42	48	PF01652	0.373
LIG_FHA_1	343	349	PF00498	0.604
LIG_FHA_1	393	399	PF00498	0.648
LIG_FHA_1	441	447	PF00498	0.516
LIG_FHA_1	498	504	PF00498	0.503
LIG_FHA_1	509	515	PF00498	0.415
LIG_FHA_1	546	552	PF00498	0.404
LIG_FHA_1	620	626	PF00498	0.620
LIG_FHA_1	95	101	PF00498	0.514
LIG_FHA_2	129	135	PF00498	0.577
LIG_FHA_2	188	194	PF00498	0.585
LIG_FHA_2	256	262	PF00498	0.585
LIG_FHA_2	572	578	PF00498	0.548
LIG_FHA_2	603	609	PF00498	0.487
LIG_FHA_2	87	93	PF00498	0.493
LIG_IRF3_LxIS_1	7	12	PF10401	0.393
LIG_LIR_Apic_2	544	550	PF02991	0.418
LIG_LIR_Gen_1	112	122	PF02991	0.572
LIG_LIR_Gen_1	217	225	PF02991	0.286
LIG_LIR_Gen_1	409	420	PF02991	0.490
LIG_LIR_Gen_1	541	550	PF02991	0.424
LIG_LIR_Gen_1	592	603	PF02991	0.427
LIG_LIR_Gen_1	63	71	PF02991	0.506
LIG_LIR_LC3C_4	435	439	PF02991	0.509
LIG_LIR_Nem_3	112	117	PF02991	0.574
LIG_LIR_Nem_3	125	130	PF02991	0.539
LIG_LIR_Nem_3	191	197	PF02991	0.493
LIG_LIR_Nem_3	201	207	PF02991	0.205
LIG_LIR_Nem_3	217	223	PF02991	0.239
LIG_LIR_Nem_3	246	251	PF02991	0.592
LIG_LIR_Nem_3	339	343	PF02991	0.688
LIG_LIR_Nem_3	409	415	PF02991	0.493
LIG_LIR_Nem_3	448	453	PF02991	0.483
LIG_LIR_Nem_3	526	531	PF02991	0.492
LIG_LIR_Nem_3	536	540	PF02991	0.490
LIG_LIR_Nem_3	541	545	PF02991	0.433
LIG_LIR_Nem_3	592	598	PF02991	0.428
LIG_LIR_Nem_3	63	67	PF02991	0.485
LIG_MYND_1	195	199	PF01753	0.307
LIG_MYND_1	212	216	PF01753	0.307
LIG_Pex14_2	204	208	PF04695	0.307
LIG_Pex14_2	218	222	PF04695	0.307
LIG_Pex14_2	415	419	PF04695	0.518
LIG_SH2_CRK	114	118	PF00017	0.578
LIG_SH2_CRK	220	224	PF00017	0.438
LIG_SH2_CRK	547	551	PF00017	0.403
LIG_SH2_NCK_1	114	118	PF00017	0.578
LIG_SH2_STAP1	114	118	PF00017	0.566
LIG_SH2_STAP1	231	235	PF00017	0.307
LIG_SH2_STAT5	130	133	PF00017	0.544
LIG_SH2_STAT5	508	511	PF00017	0.450
LIG_SH2_STAT5	547	550	PF00017	0.415
LIG_SH2_STAT5	604	607	PF00017	0.496
LIG_SH2_STAT5	71	74	PF00017	0.552
LIG_SH2_STAT5	77	80	PF00017	0.468
LIG_SH3_1	209	215	PF00018	0.307
LIG_SH3_1	547	553	PF00018	0.404
LIG_SH3_2	119	124	PF14604	0.599
LIG_SH3_3	116	122	PF00018	0.640
LIG_SH3_3	189	195	PF00018	0.555
LIG_SH3_3	209	215	PF00018	0.325
LIG_SH3_3	310	316	PF00018	0.590
LIG_SH3_3	455	461	PF00018	0.618
LIG_SH3_3	477	483	PF00018	0.612
LIG_SH3_3	484	490	PF00018	0.615
LIG_SH3_3	547	553	PF00018	0.423
LIG_SH3_3	595	601	PF00018	0.409
LIG_SUMO_SIM_anti_2	317	324	PF11976	0.451
LIG_SUMO_SIM_anti_2	326	332	PF11976	0.471
LIG_SUMO_SIM_anti_2	435	440	PF11976	0.458
LIG_SUMO_SIM_par_1	290	299	PF11976	0.647
LIG_SUMO_SIM_par_1	442	449	PF11976	0.558
LIG_SUMO_SIM_par_1	621	628	PF11976	0.539
LIG_TRAF2_1	131	134	PF00917	0.501
LIG_TRFH_1	208	212	PF08558	0.307
LIG_TYR_ITIM	40	45	PF00017	0.383
LIG_TYR_ITSM	110	117	PF00017	0.570
LIG_UBA3_1	527	532	PF00899	0.601
LIG_WRC_WIRS_1	219	224	PF05994	0.307
LIG_WRC_WIRS_1	412	417	PF05994	0.465
LIG_WRC_WIRS_1	542	547	PF05994	0.416
MOD_CK1_1	168	174	PF00069	0.573
MOD_CK1_1	256	262	PF00069	0.585
MOD_CK1_1	391	397	PF00069	0.640
MOD_CK1_1	530	536	PF00069	0.568
MOD_CK1_1	541	547	PF00069	0.455
MOD_CK2_1	128	134	PF00069	0.520
MOD_CK2_1	187	193	PF00069	0.594
MOD_CK2_1	571	577	PF00069	0.569
MOD_CK2_1	602	608	PF00069	0.480
MOD_CK2_1	86	92	PF00069	0.480
MOD_CK2_1	9	15	PF00069	0.401
MOD_GlcNHglycan	179	182	PF01048	0.803
MOD_GlcNHglycan	231	234	PF01048	0.317
MOD_GlcNHglycan	254	258	PF01048	0.721
MOD_GlcNHglycan	274	277	PF01048	0.675
MOD_GlcNHglycan	287	290	PF01048	0.647
MOD_GlcNHglycan	390	393	PF01048	0.634
MOD_GlcNHglycan	408	411	PF01048	0.450
MOD_GSK3_1	142	149	PF00069	0.570
MOD_GSK3_1	16	23	PF00069	0.508
MOD_GSK3_1	214	221	PF00069	0.431
MOD_GSK3_1	229	236	PF00069	0.352
MOD_GSK3_1	252	259	PF00069	0.536
MOD_GSK3_1	314	321	PF00069	0.645
MOD_GSK3_1	388	395	PF00069	0.597
MOD_GSK3_1	541	548	PF00069	0.425
MOD_GSK3_1	571	578	PF00069	0.570
MOD_GSK3_1	584	591	PF00069	0.516
MOD_GSK3_1	82	89	PF00069	0.488
MOD_N-GLC_1	363	368	PF02516	0.582
MOD_N-GLC_1	588	593	PF02516	0.468
MOD_N-GLC_2	163	165	PF02516	0.644
MOD_N-GLC_2	422	424	PF02516	0.566
MOD_N-GLC_2	507	509	PF02516	0.388
MOD_NEK2_1	142	147	PF00069	0.594
MOD_NEK2_1	218	223	PF00069	0.307
MOD_NEK2_1	229	234	PF00069	0.307
MOD_NEK2_1	406	411	PF00069	0.536
MOD_NEK2_1	545	550	PF00069	0.415
MOD_NEK2_1	596	601	PF00069	0.473
MOD_NEK2_1	9	14	PF00069	0.404
MOD_NEK2_2	20	25	PF00069	0.385
MOD_NEK2_2	497	502	PF00069	0.507
MOD_PIKK_1	165	171	PF00454	0.724
MOD_PIKK_1	86	92	PF00454	0.537
MOD_PKA_1	306	312	PF00069	0.617
MOD_PKA_2	259	265	PF00069	0.582
MOD_PKA_2	306	312	PF00069	0.617
MOD_PKA_2	350	356	PF00069	0.810
MOD_Plk_1	262	268	PF00069	0.582
MOD_Plk_1	401	407	PF00069	0.648
MOD_Plk_1	52	58	PF00069	0.449
MOD_Plk_1	545	551	PF00069	0.474
MOD_Plk_4	214	220	PF00069	0.307
MOD_Plk_4	233	239	PF00069	0.307
MOD_Plk_4	243	249	PF00069	0.544
MOD_Plk_4	326	332	PF00069	0.495
MOD_Plk_4	575	581	PF00069	0.538
MOD_Plk_4	591	597	PF00069	0.602
MOD_Plk_4	602	608	PF00069	0.480
MOD_ProDKin_1	109	115	PF00069	0.563
MOD_ProDKin_1	16	22	PF00069	0.390
MOD_ProDKin_1	479	485	PF00069	0.665
MOD_ProDKin_1	489	495	PF00069	0.497
MOD_ProDKin_1	530	536	PF00069	0.529
MOD_SUMO_for_1	276	279	PF00179	0.566
MOD_SUMO_rev_2	27	32	PF00179	0.343
MOD_SUMO_rev_2	275	283	PF00179	0.592
MOD_SUMO_rev_2	382	391	PF00179	0.612
MOD_SUMO_rev_2	515	524	PF00179	0.411
MOD_SUMO_rev_2	608	616	PF00179	0.518
TRG_DiLeu_BaEn_1	193	198	PF01217	0.545
TRG_DiLeu_BaEn_1	43	48	PF01217	0.371
TRG_DiLeu_BaEn_1	433	438	PF01217	0.429
TRG_DiLeu_BaEn_1	63	68	PF01217	0.365
TRG_DiLeu_BaEn_2	101	107	PF01217	0.579
TRG_DiLeu_BaEn_4	102	108	PF01217	0.578
TRG_ENDOCYTIC_2	114	117	PF00928	0.576
TRG_ENDOCYTIC_2	219	222	PF00928	0.307
TRG_ENDOCYTIC_2	340	343	PF00928	0.561
TRG_ENDOCYTIC_2	412	415	PF00928	0.465
TRG_ENDOCYTIC_2	42	45	PF00928	0.402
TRG_ENDOCYTIC_2	542	545	PF00928	0.442
TRG_ENDOCYTIC_2	604	607	PF00928	0.487
TRG_ER_diArg_1	280	283	PF00400	0.669
TRG_ER_diArg_1	306	308	PF00400	0.625
TRG_ER_diArg_1	332	334	PF00400	0.581
TRG_ER_diArg_1	375	378	PF00400	0.634
TRG_ER_diArg_1	501	504	PF00400	0.433
TRG_ER_diArg_1	569	571	PF00400	0.544
TRG_NLS_MonoExtC_3	372	377	PF00514	0.560
TRG_Pf-PMV_PEXEL_1	334	339	PF00026	0.541

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HSS5	Leptomonas seymouri	62%	96%
A0A3S5H7Y4	Leishmania donovani	100%	100%
A4HM80	Leishmania braziliensis	79%	99%
E9AEM1	Leishmania major	94%	100%
E9B5T0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	100%