Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Arrestin (or S-antigen) - N-terminal domain containing protein - putative

Species:

Leishmania infantum

UniProt:

A4IAU3_LEIIN

TriTrypDb:

LINF_350009500

Length:

637

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

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Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

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Expansion

Sequence features

A4IAU3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4IAU3

Function

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Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	1
GO:0008104	protein localization	4	1
GO:0009987	cellular process	1	1
GO:0015031	protein transport	4	1
GO:0033036	macromolecule localization	2	1
GO:0045184	establishment of protein localization	3	1
GO:0051179	localization	1	1
GO:0051234	establishment of localization	2	1
GO:0051641	cellular localization	2	1
GO:0070727	cellular macromolecule localization	3	1

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Could not find GO molecular_function term for this entry.

Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	279	281	PF00675	0.651
CLV_NRD_NRD_1	306	308	PF00675	0.626
CLV_NRD_NRD_1	333	335	PF00675	0.574
CLV_NRD_NRD_1	377	379	PF00675	0.622
CLV_NRD_NRD_1	570	572	PF00675	0.562
CLV_PCSK_FUR_1	568	572	PF00082	0.545
CLV_PCSK_KEX2_1	277	279	PF00082	0.653
CLV_PCSK_KEX2_1	281	283	PF00082	0.646
CLV_PCSK_KEX2_1	306	308	PF00082	0.615
CLV_PCSK_KEX2_1	333	335	PF00082	0.574

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HSS5	Leptomonas seymouri	62%	96%
A0A3S5H7Y4	Leishmania donovani	100%	100%
A4HM80	Leishmania braziliensis	79%	99%
E9AEM1	Leishmania major	94%	100%
E9B5T0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	100%

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