Uncharacterized protein

Quick info Annotations Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4IAT9_LEIIN

TriTrypDb:

LINF_350009100

Length:

548

Annotations

Annotations by Jardim et al.

Uncharacterized Protein, Uncharacterized

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4IAT9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4IAT9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	100	104	PF00656	0.608
CLV_C14_Caspase3-7	161	165	PF00656	0.628
CLV_C14_Caspase3-7	186	190	PF00656	0.678
CLV_C14_Caspase3-7	485	489	PF00656	0.695
CLV_NRD_NRD_1	118	120	PF00675	0.504
CLV_NRD_NRD_1	174	176	PF00675	0.762
CLV_NRD_NRD_1	212	214	PF00675	0.510
CLV_NRD_NRD_1	406	408	PF00675	0.450
CLV_NRD_NRD_1	481	483	PF00675	0.755
CLV_PCSK_KEX2_1	118	120	PF00082	0.474
CLV_PCSK_KEX2_1	172	174	PF00082	0.634
CLV_PCSK_KEX2_1	212	214	PF00082	0.510
CLV_PCSK_PC1ET2_1	172	174	PF00082	0.634
CLV_PCSK_PC7_1	208	214	PF00082	0.516
CLV_PCSK_SKI1_1	325	329	PF00082	0.665
CLV_PCSK_SKI1_1	411	415	PF00082	0.509
CLV_PCSK_SKI1_1	458	462	PF00082	0.683
CLV_PCSK_SKI1_1	466	470	PF00082	0.614
DEG_SPOP_SBC_1	126	130	PF00917	0.708
DOC_ANK_TNKS_1	44	51	PF00023	0.695
DOC_CDC14_PxL_1	363	371	PF14671	0.593
DOC_CKS1_1	191	196	PF01111	0.591
DOC_MAPK_gen_1	118	125	PF00069	0.512
DOC_MAPK_MEF2A_6	118	125	PF00069	0.583
DOC_PP2B_LxvP_1	123	126	PF13499	0.535
DOC_USP7_MATH_1	108	112	PF00917	0.525
DOC_USP7_MATH_1	113	117	PF00917	0.460
DOC_USP7_MATH_1	215	219	PF00917	0.648
DOC_USP7_MATH_1	22	26	PF00917	0.454
DOC_USP7_MATH_1	310	314	PF00917	0.616
DOC_USP7_MATH_1	33	37	PF00917	0.406
DOC_USP7_MATH_1	71	75	PF00917	0.751
DOC_WW_Pin1_4	101	106	PF00397	0.677
DOC_WW_Pin1_4	190	195	PF00397	0.596
DOC_WW_Pin1_4	350	355	PF00397	0.767
LIG_14-3-3_CanoR_1	182	191	PF00244	0.666
LIG_14-3-3_CanoR_1	197	203	PF00244	0.676
LIG_14-3-3_CanoR_1	212	220	PF00244	0.485
LIG_14-3-3_CanoR_1	269	277	PF00244	0.591
LIG_14-3-3_CanoR_1	373	379	PF00244	0.488
LIG_14-3-3_CanoR_1	411	421	PF00244	0.426
LIG_14-3-3_CanoR_1	509	515	PF00244	0.577
LIG_14-3-3_CanoR_1	95	99	PF00244	0.463
LIG_Actin_WH2_2	405	422	PF00022	0.533
LIG_APCC_ABBA_1	96	101	PF00400	0.556
LIG_APCC_ABBAyCdc20_2	95	101	PF00400	0.526
LIG_BIR_II_1	1	5	PF00653	0.626
LIG_BRCT_BRCA1_1	1	5	PF00533	0.545
LIG_BRCT_BRCA1_1	216	220	PF00533	0.728
LIG_CSL_BTD_1	123	126	PF09270	0.591
LIG_CSL_BTD_1	191	194	PF09270	0.606
LIG_EH_1	388	392	PF12763	0.528
LIG_eIF4E_1	254	260	PF01652	0.565
LIG_FHA_1	150	156	PF00498	0.525
LIG_FHA_1	373	379	PF00498	0.505
LIG_FHA_2	128	134	PF00498	0.734
LIG_FHA_2	174	180	PF00498	0.670
LIG_FHA_2	299	305	PF00498	0.454
LIG_FHA_2	61	67	PF00498	0.753
LIG_Integrin_RGD_1	47	49	PF01839	0.652
LIG_LIR_Apic_2	97	102	PF02991	0.630
LIG_LIR_Gen_1	2	13	PF02991	0.509
LIG_LIR_Gen_1	252	262	PF02991	0.539
LIG_LIR_Nem_3	189	195	PF02991	0.504
LIG_LIR_Nem_3	2	8	PF02991	0.498
LIG_LIR_Nem_3	252	257	PF02991	0.489
LIG_MAD2	119	127	PF02301	0.591
LIG_MYND_1	367	371	PF01753	0.614
LIG_NRBOX	81	87	PF00104	0.537
LIG_PCNA_PIPBox_1	117	126	PF02747	0.582
LIG_Pex14_2	156	160	PF04695	0.533
LIG_Pex14_2	409	413	PF04695	0.546
LIG_Rb_pABgroove_1	297	305	PF01858	0.464
LIG_SH2_NCK_1	99	103	PF00017	0.640
LIG_SH2_SRC	421	424	PF00017	0.402
LIG_SH2_STAT5	20	23	PF00017	0.505
LIG_SH2_STAT5	421	424	PF00017	0.492
LIG_SH3_1	99	105	PF00018	0.657
LIG_SH3_2	368	373	PF14604	0.608
LIG_SH3_3	188	194	PF00018	0.616
LIG_SH3_3	277	283	PF00018	0.538
LIG_SH3_3	302	308	PF00018	0.522
LIG_SH3_3	362	368	PF00018	0.673
LIG_SH3_3	99	105	PF00018	0.628
LIG_SH3_4	483	490	PF00018	0.665
LIG_SUMO_SIM_par_1	309	316	PF11976	0.612
LIG_UBA3_1	446	452	PF00899	0.608
LIG_Vh1_VBS_1	412	430	PF01044	0.508
LIG_Vh1_VBS_1	449	467	PF01044	0.696
MOD_CDK_SPxxK_3	190	197	PF00069	0.523
MOD_CK1_1	149	155	PF00069	0.535
MOD_CK1_1	200	206	PF00069	0.698
MOD_CK1_1	211	217	PF00069	0.598
MOD_CK1_1	4	10	PF00069	0.481
MOD_CK1_1	425	431	PF00069	0.495
MOD_CK1_1	515	521	PF00069	0.527
MOD_CK1_1	74	80	PF00069	0.628
MOD_CK2_1	127	133	PF00069	0.509
MOD_CK2_1	246	252	PF00069	0.498
MOD_CK2_1	310	316	PF00069	0.626
MOD_CK2_1	317	323	PF00069	0.591
MOD_CK2_1	338	344	PF00069	0.693
MOD_CK2_1	60	66	PF00069	0.763
MOD_CK2_1	73	79	PF00069	0.676
MOD_GlcNHglycan	110	113	PF01048	0.533
MOD_GlcNHglycan	130	133	PF01048	0.410
MOD_GlcNHglycan	160	163	PF01048	0.627
MOD_GlcNHglycan	213	216	PF01048	0.643
MOD_GlcNHglycan	241	244	PF01048	0.651
MOD_GlcNHglycan	248	251	PF01048	0.414
MOD_GlcNHglycan	308	311	PF01048	0.584
MOD_GlcNHglycan	31	34	PF01048	0.580
MOD_GlcNHglycan	357	360	PF01048	0.699
MOD_GlcNHglycan	478	481	PF01048	0.702
MOD_GlcNHglycan	73	76	PF01048	0.669
MOD_GlcNHglycan	91	94	PF01048	0.566
MOD_GSK3_1	173	180	PF00069	0.693
MOD_GSK3_1	197	204	PF00069	0.592
MOD_GSK3_1	211	218	PF00069	0.597
MOD_GSK3_1	235	242	PF00069	0.635
MOD_GSK3_1	267	274	PF00069	0.476
MOD_GSK3_1	29	36	PF00069	0.546
MOD_GSK3_1	306	313	PF00069	0.612
MOD_GSK3_1	450	457	PF00069	0.651
MOD_GSK3_1	505	512	PF00069	0.598
MOD_GSK3_1	70	77	PF00069	0.750
MOD_GSK3_1	85	92	PF00069	0.483
MOD_GSK3_1	97	104	PF00069	0.491
MOD_LATS_1	450	456	PF00433	0.629
MOD_N-GLC_2	139	141	PF02516	0.574
MOD_NEK2_1	1	6	PF00069	0.520
MOD_NEK2_1	220	225	PF00069	0.650
MOD_NEK2_1	235	240	PF00069	0.606
MOD_NEK2_1	29	34	PF00069	0.515
MOD_NEK2_1	374	379	PF00069	0.527
MOD_NEK2_1	412	417	PF00069	0.475
MOD_NEK2_1	486	491	PF00069	0.660
MOD_NEK2_1	510	515	PF00069	0.593
MOD_NEK2_2	215	220	PF00069	0.670
MOD_NEK2_2	298	303	PF00069	0.406
MOD_NEK2_2	502	507	PF00069	0.676
MOD_PIKK_1	113	119	PF00454	0.516
MOD_PIKK_1	13	19	PF00454	0.482
MOD_PIKK_1	317	323	PF00454	0.591
MOD_PIKK_1	39	45	PF00454	0.686
MOD_PIKK_1	466	472	PF00454	0.708
MOD_PKA_1	173	179	PF00069	0.708
MOD_PKA_2	173	179	PF00069	0.783
MOD_PKA_2	211	217	PF00069	0.534
MOD_PKA_2	22	28	PF00069	0.521
MOD_PKA_2	372	378	PF00069	0.494
MOD_PKA_2	508	514	PF00069	0.589
MOD_PKA_2	57	63	PF00069	0.750
MOD_PKA_2	94	100	PF00069	0.496
MOD_PKB_1	507	515	PF00069	0.549
MOD_Plk_4	215	221	PF00069	0.692
MOD_Plk_4	289	295	PF00069	0.413
MOD_Plk_4	298	304	PF00069	0.365
MOD_Plk_4	414	420	PF00069	0.469
MOD_Plk_4	94	100	PF00069	0.556
MOD_ProDKin_1	101	107	PF00069	0.679
MOD_ProDKin_1	190	196	PF00069	0.592
MOD_ProDKin_1	350	356	PF00069	0.767
MOD_SUMO_rev_2	485	492	PF00179	0.699
TRG_DiLeu_BaLyEn_6	255	260	PF01217	0.490
TRG_DiLeu_BaLyEn_6	365	370	PF01217	0.662
TRG_DiLeu_BaLyEn_6	442	447	PF01217	0.543
TRG_ENDOCYTIC_2	254	257	PF00928	0.549
TRG_ER_diArg_1	118	120	PF00400	0.504
TRG_ER_diArg_1	173	175	PF00400	0.754
TRG_ER_diArg_1	506	509	PF00400	0.591
TRG_NLS_MonoExtC_3	473	478	PF00514	0.720
TRG_NLS_MonoExtN_4	474	479	PF00514	0.708
TRG_Pf-PMV_PEXEL_1	182	186	PF00026	0.691

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1II05	Leptomonas seymouri	55%	96%
A0A0S4JU63	Bodo saltans	25%	100%
A0A1X0NIV1	Trypanosomatidae	30%	100%
A0A3S7X8R0	Leishmania donovani	99%	100%
A4HM76	Leishmania braziliensis	77%	100%
D0A2B2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	31%	100%
E9AEL6	Leishmania major	93%	100%
E9B5S7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	100%
V5BNA1	Trypanosoma cruzi	30%	100%