Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Thioredoxin - putative

Species:

Leishmania infantum

UniProt:

A4IAT8_LEIIN

TriTrypDb:

LINF_350008900

Length:

615

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Cellular components
Term	Name	Level	Count
GO:0005654	nucleoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4IAT8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4IAT8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	246	250	PF00656	0.703
CLV_NRD_NRD_1	255	257	PF00675	0.725
CLV_NRD_NRD_1	554	556	PF00675	0.385
CLV_PCSK_FUR_1	253	257	PF00082	0.723
CLV_PCSK_KEX2_1	16	18	PF00082	0.686
CLV_PCSK_KEX2_1	237	239	PF00082	0.700
CLV_PCSK_KEX2_1	255	257	PF00082	0.725
CLV_PCSK_KEX2_1	554	556	PF00082	0.385
CLV_PCSK_PC1ET2_1	16	18	PF00082	0.686
CLV_PCSK_PC1ET2_1	237	239	PF00082	0.674
CLV_PCSK_SKI1_1	13	17	PF00082	0.739
CLV_PCSK_SKI1_1	217	221	PF00082	0.495
CLV_PCSK_SKI1_1	435	439	PF00082	0.476
CLV_PCSK_SKI1_1	450	454	PF00082	0.340
CLV_PCSK_SKI1_1	480	484	PF00082	0.417
DEG_Nend_Nbox_1	1	3	PF02207	0.670
DEG_SCF_FBW7_1	122	129	PF00400	0.775
DEG_SPOP_SBC_1	298	302	PF00917	0.720
DOC_CKS1_1	414	419	PF01111	0.636
DOC_CKS1_1	54	59	PF01111	0.711
DOC_CYCLIN_yCln2_LP_2	283	289	PF00134	0.719
DOC_CYCLIN_yCln2_LP_2	383	389	PF00134	0.444
DOC_MAPK_gen_1	176	185	PF00069	0.561
DOC_MAPK_gen_1	379	385	PF00069	0.501
DOC_MAPK_gen_1	478	485	PF00069	0.430
DOC_MAPK_HePTP_8	183	195	PF00069	0.516
DOC_MAPK_MEF2A_6	176	185	PF00069	0.579
DOC_MAPK_MEF2A_6	186	195	PF00069	0.253
DOC_USP7_MATH_1	126	130	PF00917	0.781
DOC_USP7_MATH_1	23	27	PF00917	0.710
DOC_USP7_MATH_1	248	252	PF00917	0.749
DOC_USP7_MATH_1	298	302	PF00917	0.717
DOC_USP7_MATH_1	310	314	PF00917	0.686
DOC_USP7_MATH_1	326	330	PF00917	0.675
DOC_USP7_MATH_1	358	362	PF00917	0.709
DOC_USP7_MATH_1	49	53	PF00917	0.804
DOC_USP7_MATH_1	561	565	PF00917	0.654
DOC_USP7_MATH_1	569	573	PF00917	0.512
DOC_USP7_MATH_1	80	84	PF00917	0.667
DOC_USP7_MATH_2	417	423	PF00917	0.581
DOC_WW_Pin1_4	106	111	PF00397	0.647
DOC_WW_Pin1_4	122	127	PF00397	0.774
DOC_WW_Pin1_4	19	24	PF00397	0.677
DOC_WW_Pin1_4	244	249	PF00397	0.706
DOC_WW_Pin1_4	259	264	PF00397	0.654
DOC_WW_Pin1_4	413	418	PF00397	0.537
DOC_WW_Pin1_4	53	58	PF00397	0.708
DOC_WW_Pin1_4	62	67	PF00397	0.661
DOC_WW_Pin1_4	72	77	PF00397	0.608
LIG_14-3-3_CanoR_1	217	222	PF00244	0.495
LIG_14-3-3_CanoR_1	311	320	PF00244	0.692
LIG_14-3-3_CanoR_1	424	432	PF00244	0.500
LIG_14-3-3_CanoR_1	450	456	PF00244	0.464
LIG_APCC_ABBA_1	193	198	PF00400	0.500
LIG_CAP-Gly_1	612	615	PF01302	0.597
LIG_Clathr_ClatBox_1	194	198	PF01394	0.502
LIG_EVH1_1	401	405	PF00568	0.560
LIG_FHA_1	117	123	PF00498	0.746
LIG_FHA_1	132	138	PF00498	0.732
LIG_FHA_1	188	194	PF00498	0.497
LIG_FHA_1	208	214	PF00498	0.464
LIG_FHA_1	218	224	PF00498	0.502
LIG_FHA_1	298	304	PF00498	0.781
LIG_FHA_1	535	541	PF00498	0.430
LIG_FHA_1	54	60	PF00498	0.697
LIG_FHA_1	66	72	PF00498	0.724
LIG_FHA_2	269	275	PF00498	0.735
LIG_FHA_2	300	306	PF00498	0.790
LIG_FHA_2	414	420	PF00498	0.626
LIG_FHA_2	436	442	PF00498	0.462
LIG_FHA_2	5	11	PF00498	0.771
LIG_GBD_Chelix_1	512	520	PF00786	0.501
LIG_LIR_Apic_2	488	492	PF02991	0.376
LIG_LIR_Gen_1	537	546	PF02991	0.408
LIG_LIR_Nem_3	447	452	PF02991	0.412
LIG_LIR_Nem_3	456	462	PF02991	0.409
LIG_LIR_Nem_3	528	532	PF02991	0.385
LIG_LIR_Nem_3	537	541	PF02991	0.392
LIG_MYND_1	382	386	PF01753	0.529
LIG_PDZ_Class_3	610	615	PF00595	0.583
LIG_Pex14_2	449	453	PF04695	0.535
LIG_Pex14_2	611	615	PF04695	0.555
LIG_SH2_NCK_1	231	235	PF00017	0.574
LIG_SH2_STAP1	574	578	PF00017	0.581
LIG_SH2_STAP1	98	102	PF00017	0.492
LIG_SH2_STAT3	409	412	PF00017	0.672
LIG_SH2_STAT5	484	487	PF00017	0.376
LIG_SH2_STAT5	529	532	PF00017	0.430
LIG_SH3_3	140	146	PF00018	0.629
LIG_SH3_3	17	23	PF00018	0.701
LIG_SH3_3	399	405	PF00018	0.567
LIG_SH3_3	411	417	PF00018	0.669
LIG_SH3_5	227	231	PF00018	0.558
LIG_SH3_5	525	529	PF00018	0.430
LIG_SUMO_SIM_anti_2	189	195	PF11976	0.440
LIG_SUMO_SIM_par_1	348	354	PF11976	0.556
LIG_SUMO_SIM_par_1	430	436	PF11976	0.513
LIG_TRAF2_1	397	400	PF00917	0.619
LIG_TRAF2_1	577	580	PF00917	0.581
LIG_TRAF2_1	9	12	PF00917	0.773
LIG_WRC_WIRS_1	535	540	PF05994	0.376
LIG_WRC_WIRS_1	598	603	PF05994	0.513
MOD_CDK_SPxxK_3	106	113	PF00069	0.741
MOD_CK1_1	169	175	PF00069	0.667
MOD_CK1_1	201	207	PF00069	0.606
MOD_CK1_1	259	265	PF00069	0.788
MOD_CK1_1	313	319	PF00069	0.716
MOD_CK1_1	329	335	PF00069	0.528
MOD_CK1_1	36	42	PF00069	0.721
MOD_CK1_1	603	609	PF00069	0.554
MOD_CK1_1	83	89	PF00069	0.732
MOD_CK2_1	272	278	PF00069	0.734
MOD_CK2_1	299	305	PF00069	0.707
MOD_CK2_1	4	10	PF00069	0.773
MOD_CK2_1	413	419	PF00069	0.584
MOD_CK2_1	580	586	PF00069	0.483
MOD_CK2_1	607	613	PF00069	0.587
MOD_Cter_Amidation	377	380	PF01082	0.607
MOD_GlcNHglycan	128	131	PF01048	0.677
MOD_GlcNHglycan	173	176	PF01048	0.619
MOD_GlcNHglycan	23	26	PF01048	0.771
MOD_GlcNHglycan	239	242	PF01048	0.705
MOD_GlcNHglycan	331	334	PF01048	0.546
MOD_GlcNHglycan	368	371	PF01048	0.695
MOD_GlcNHglycan	425	428	PF01048	0.522
MOD_GlcNHglycan	51	54	PF01048	0.696
MOD_GlcNHglycan	558	561	PF01048	0.620
MOD_GlcNHglycan	563	566	PF01048	0.700
MOD_GSK3_1	116	123	PF00069	0.781
MOD_GSK3_1	131	138	PF00069	0.702
MOD_GSK3_1	152	159	PF00069	0.519
MOD_GSK3_1	162	169	PF00069	0.488
MOD_GSK3_1	19	26	PF00069	0.660
MOD_GSK3_1	197	204	PF00069	0.529
MOD_GSK3_1	2	9	PF00069	0.781
MOD_GSK3_1	207	214	PF00069	0.426
MOD_GSK3_1	244	251	PF00069	0.700
MOD_GSK3_1	268	275	PF00069	0.789
MOD_GSK3_1	336	343	PF00069	0.529
MOD_GSK3_1	408	415	PF00069	0.580
MOD_GSK3_1	419	426	PF00069	0.581
MOD_GSK3_1	458	465	PF00069	0.449
MOD_GSK3_1	472	479	PF00069	0.505
MOD_GSK3_1	49	56	PF00069	0.722
MOD_GSK3_1	508	515	PF00069	0.430
MOD_GSK3_1	596	603	PF00069	0.526
MOD_GSK3_1	72	79	PF00069	0.726
MOD_GSK3_1	83	90	PF00069	0.699
MOD_N-GLC_1	170	175	PF02516	0.616
MOD_N-GLC_1	81	86	PF02516	0.739
MOD_N-GLC_2	35	37	PF02516	0.696
MOD_NEK2_1	166	171	PF00069	0.576
MOD_NEK2_1	197	202	PF00069	0.521
MOD_NEK2_1	2	7	PF00069	0.786
MOD_NEK2_1	458	463	PF00069	0.403
MOD_NEK2_1	485	490	PF00069	0.423
MOD_NEK2_1	590	595	PF00069	0.538
MOD_NEK2_1	597	602	PF00069	0.521
MOD_NEK2_2	153	158	PF00069	0.459
MOD_NEK2_2	549	554	PF00069	0.385
MOD_PIKK_1	211	217	PF00454	0.460
MOD_PIKK_1	265	271	PF00454	0.714
MOD_PIKK_1	358	364	PF00454	0.671
MOD_PIKK_1	408	414	PF00454	0.672
MOD_PIKK_1	567	573	PF00454	0.585
MOD_PIKK_1	603	609	PF00454	0.524
MOD_PKA_1	237	243	PF00069	0.644
MOD_PKA_2	120	126	PF00069	0.700
MOD_PKA_2	237	243	PF00069	0.644
MOD_PKA_2	310	316	PF00069	0.678
MOD_PKA_2	423	429	PF00069	0.513
MOD_PKA_2	472	478	PF00069	0.642
MOD_PKA_2	86	92	PF00069	0.696
MOD_PKB_1	85	93	PF00069	0.788
MOD_Plk_1	11	17	PF00069	0.759
MOD_Plk_1	197	203	PF00069	0.537
MOD_Plk_1	211	217	PF00069	0.484
MOD_Plk_1	265	271	PF00069	0.756
MOD_Plk_4	162	168	PF00069	0.487
MOD_Plk_4	187	193	PF00069	0.455
MOD_Plk_4	351	357	PF00069	0.571
MOD_Plk_4	444	450	PF00069	0.387
MOD_Plk_4	508	514	PF00069	0.430
MOD_Plk_4	534	540	PF00069	0.376
MOD_Plk_4	597	603	PF00069	0.520
MOD_ProDKin_1	106	112	PF00069	0.648
MOD_ProDKin_1	122	128	PF00069	0.776
MOD_ProDKin_1	19	25	PF00069	0.678
MOD_ProDKin_1	244	250	PF00069	0.706
MOD_ProDKin_1	259	265	PF00069	0.653
MOD_ProDKin_1	413	419	PF00069	0.535
MOD_ProDKin_1	53	59	PF00069	0.709
MOD_ProDKin_1	62	68	PF00069	0.661
MOD_ProDKin_1	72	78	PF00069	0.606
MOD_SUMO_for_1	530	533	PF00179	0.430
TRG_DiLeu_BaEn_1	189	194	PF01217	0.495
TRG_DiLeu_BaEn_1	499	504	PF01217	0.473
TRG_DiLeu_BaLyEn_6	379	384	PF01217	0.580
TRG_ENDOCYTIC_2	527	530	PF00928	0.430
TRG_ENDOCYTIC_2	550	553	PF00928	0.430
TRG_ER_diArg_1	253	256	PF00400	0.664
TRG_ER_diArg_1	553	555	PF00400	0.385
TRG_NES_CRM1_1	340	353	PF08389	0.615
TRG_NES_CRM1_1	521	533	PF08389	0.376
TRG_NLS_MonoExtC_3	15	21	PF00514	0.672
TRG_NLS_MonoExtN_4	13	20	PF00514	0.727
TRG_Pf-PMV_PEXEL_1	158	162	PF00026	0.464
TRG_Pf-PMV_PEXEL_1	576	580	PF00026	0.516

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PA84	Leptomonas seymouri	59%	98%
A0A1X0NIY2	Trypanosomatidae	35%	100%
A0A3S7X8S7	Leishmania donovani	99%	100%
A4HM75	Leishmania braziliensis	79%	100%
E9AEL5	Leishmania major	93%	100%
E9B5S6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	93%	99%