Phospholipid biosynthesis, Ketosphinganine reductase short chain dehydrogenase E=3 SV=1 - [A4IAT4_LEIIN]
| Source | Evidence on protein | Close homologs |
|---|---|---|
| Cuervo et al. | no | yes: 0 |
| Hassani et al. | no | yes: 0 |
| Forrest at al. (metacyclic) | no | yes: 0 |
| Forrest at al. (procyclic) | no | yes: 0 |
| Silverman et al. | no | yes: 0 |
| Pissara et al. | no | yes: 0 |
| Source | Evidence on protein | Close homologs |
|---|---|---|
| Pires et al. | no | yes: 0 |
| Source | Evidence on protein | Close homologs |
|---|---|---|
| Silverman et al. | no | yes: 0 |
| Source | Evidence on protein | Close homologs |
|---|---|---|
| Jamdhade et al. | yes | yes: 18 |
| Source | Evidence on protein | Close homologs |
|---|---|---|
| DeepLoc | ||
| SignalP6 | no | yes: 0, no: 11 |
| NetGPI | no | yes: 0, no: 11 |
| Term | Name | Level | Count |
|---|---|---|---|
| GO:0005789 | endoplasmic reticulum membrane | 4 | 1 |
| GO:0016020 | membrane | 2 | 3 |
| GO:0031090 | organelle membrane | 3 | 1 |
| GO:0110165 | cellular anatomical entity | 1 | 3 |
Related structures:
AlphaFold database: A4IAT4
| Term | Name | Level | Count |
|---|---|---|---|
| GO:0006629 | lipid metabolic process | 3 | 10 |
| GO:0006643 | membrane lipid metabolic process | 4 | 10 |
| GO:0006665 | sphingolipid metabolic process | 4 | 10 |
| GO:0006666 | 3-keto-sphinganine metabolic process | 4 | 10 |
| GO:0006807 | nitrogen compound metabolic process | 2 | 10 |
| GO:0008152 | metabolic process | 1 | 10 |
| GO:0008610 | lipid biosynthetic process | 4 | 10 |
| GO:0009058 | biosynthetic process | 2 | 10 |
| GO:0009987 | cellular process | 1 | 10 |
| GO:0030148 | sphingolipid biosynthetic process | 5 | 10 |
| GO:0042180 | cellular ketone metabolic process | 3 | 10 |
| GO:0044237 | cellular metabolic process | 2 | 10 |
| GO:0044238 | primary metabolic process | 2 | 10 |
| GO:0044249 | cellular biosynthetic process | 3 | 10 |
| GO:0044255 | cellular lipid metabolic process | 3 | 10 |
| GO:0044281 | small molecule metabolic process | 2 | 10 |
| GO:0046467 | membrane lipid biosynthetic process | 4 | 10 |
| GO:0046519 | sphingoid metabolic process | 5 | 10 |
| GO:0071704 | organic substance metabolic process | 2 | 10 |
| GO:1901564 | organonitrogen compound metabolic process | 3 | 10 |
| GO:1901566 | organonitrogen compound biosynthetic process | 4 | 10 |
| GO:1901576 | organic substance biosynthetic process | 3 | 10 |
| GO:0006082 | organic acid metabolic process | 3 | 1 |
| GO:0006631 | fatty acid metabolic process | 4 | 1 |
| GO:0006633 | fatty acid biosynthetic process | 5 | 1 |
| GO:0016053 | organic acid biosynthetic process | 4 | 1 |
| GO:0019752 | carboxylic acid metabolic process | 5 | 1 |
| GO:0032787 | monocarboxylic acid metabolic process | 6 | 1 |
| GO:0043436 | oxoacid metabolic process | 4 | 1 |
| GO:0044283 | small molecule biosynthetic process | 3 | 1 |
| GO:0046394 | carboxylic acid biosynthetic process | 5 | 1 |
| GO:0072330 | monocarboxylic acid biosynthetic process | 6 | 1 |
| Term | Name | Level | Count |
|---|---|---|---|
| GO:0003824 | catalytic activity | 1 | 10 |
| GO:0016491 | oxidoreductase activity | 2 | 10 |
| GO:0016614 | oxidoreductase activity, acting on CH-OH group of donors | 3 | 10 |
| GO:0016616 | oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor | 4 | 10 |
| GO:0047560 | 3-dehydrosphinganine reductase activity | 5 | 10 |
| Leishmania | From | To | Domain/Motif | Score |
|---|---|---|---|---|
| CLV_NRD_NRD_1 | 55 | 57 | PF00675 | 0.290 |
| CLV_NRD_NRD_1 | 67 | 69 | PF00675 | 0.224 |
| CLV_PCSK_KEX2_1 | 67 | 69 | PF00082 | 0.264 |
| CLV_PCSK_SKI1_1 | 173 | 177 | PF00082 | 0.332 |
| CLV_PCSK_SKI1_1 | 251 | 255 | PF00082 | 0.404 |
| DEG_Nend_Nbox_1 | 1 | 3 | PF02207 | 0.310 |
| DEG_SPOP_SBC_1 | 175 | 179 | PF00917 | 0.527 |
| DOC_CKS1_1 | 225 | 230 | PF01111 | 0.453 |
| DOC_MAPK_DCC_7 | 56 | 64 | PF00069 | 0.535 |
| DOC_MAPK_gen_1 | 142 | 150 | PF00069 | 0.421 |
| DOC_MAPK_gen_1 | 56 | 64 | PF00069 | 0.513 |
| DOC_MAPK_JIP1_4 | 119 | 125 | PF00069 | 0.539 |
| DOC_MAPK_MEF2A_6 | 56 | 64 | PF00069 | 0.522 |
| DOC_MAPK_RevD_3 | 44 | 58 | PF00069 | 0.502 |
| DOC_PP4_FxxP_1 | 130 | 133 | PF00568 | 0.453 |
| DOC_USP7_MATH_1 | 243 | 247 | PF00917 | 0.546 |
| DOC_USP7_MATH_1 | 291 | 295 | PF00917 | 0.523 |
| DOC_WW_Pin1_4 | 218 | 223 | PF00397 | 0.469 |
| DOC_WW_Pin1_4 | 224 | 229 | PF00397 | 0.447 |
| DOC_WW_Pin1_4 | 235 | 240 | PF00397 | 0.468 |
| DOC_WW_Pin1_4 | 333 | 338 | PF00397 | 0.656 |
| LIG_14-3-3_CanoR_1 | 280 | 285 | PF00244 | 0.562 |
| LIG_14-3-3_CanoR_1 | 327 | 335 | PF00244 | 0.599 |
| LIG_14-3-3_CanoR_1 | 91 | 95 | PF00244 | 0.546 |
| LIG_Actin_WH2_2 | 296 | 311 | PF00022 | 0.519 |
| LIG_Actin_WH2_2 | 57 | 75 | PF00022 | 0.493 |
| LIG_DCNL_PONY_1 | 1 | 4 | PF03556 | 0.310 |
| LIG_FHA_1 | 12 | 18 | PF00498 | 0.407 |
| LIG_FHA_1 | 34 | 40 | PF00498 | 0.539 |
| LIG_GBD_Chelix_1 | 295 | 303 | PF00786 | 0.254 |
| LIG_GBD_Chelix_1 | 8 | 16 | PF00786 | 0.427 |
| LIG_LIR_Gen_1 | 93 | 100 | PF02991 | 0.513 |
| LIG_PCNA_yPIPBox_3 | 301 | 309 | PF02747 | 0.567 |
| LIG_PTB_Apo_2 | 124 | 131 | PF02174 | 0.464 |
| LIG_SH2_CRK | 320 | 324 | PF00017 | 0.519 |
| LIG_SH2_STAP1 | 269 | 273 | PF00017 | 0.545 |
| LIG_SH2_STAT5 | 152 | 155 | PF00017 | 0.493 |
| LIG_SH2_STAT5 | 94 | 97 | PF00017 | 0.463 |
| LIG_SH3_3 | 216 | 222 | PF00018 | 0.453 |
| LIG_SH3_3 | 233 | 239 | PF00018 | 0.518 |
| LIG_SUMO_SIM_anti_2 | 14 | 20 | PF11976 | 0.374 |
| LIG_SUMO_SIM_anti_2 | 155 | 160 | PF11976 | 0.460 |
| LIG_SUMO_SIM_par_1 | 17 | 23 | PF11976 | 0.456 |
| LIG_SUMO_SIM_par_1 | 33 | 40 | PF11976 | 0.530 |
| LIG_TYR_ITIM | 318 | 323 | PF00017 | 0.503 |
| LIG_Vh1_VBS_1 | 5 | 23 | PF01044 | 0.374 |
| LIG_WRC_WIRS_1 | 244 | 249 | PF05994 | 0.553 |
| MOD_CDK_SPK_2 | 333 | 338 | PF00069 | 0.652 |
| MOD_CK1_1 | 104 | 110 | PF00069 | 0.535 |
| MOD_CK1_1 | 283 | 289 | PF00069 | 0.545 |
| MOD_CK1_1 | 329 | 335 | PF00069 | 0.643 |
| MOD_GlcNHglycan | 138 | 141 | PF01048 | 0.330 |
| MOD_GlcNHglycan | 192 | 195 | PF01048 | 0.339 |
| MOD_GlcNHglycan | 285 | 288 | PF01048 | 0.330 |
| MOD_GlcNHglycan | 332 | 335 | PF01048 | 0.462 |
| MOD_GSK3_1 | 267 | 274 | PF00069 | 0.564 |
| MOD_GSK3_1 | 326 | 333 | PF00069 | 0.607 |
| MOD_GSK3_1 | 33 | 40 | PF00069 | 0.487 |
| MOD_N-GLC_2 | 210 | 212 | PF02516 | 0.261 |
| MOD_NEK2_1 | 12 | 17 | PF00069 | 0.412 |
| MOD_NEK2_1 | 136 | 141 | PF00069 | 0.474 |
| MOD_NEK2_1 | 176 | 181 | PF00069 | 0.458 |
| MOD_NEK2_1 | 208 | 213 | PF00069 | 0.477 |
| MOD_NEK2_1 | 271 | 276 | PF00069 | 0.508 |
| MOD_NEK2_1 | 299 | 304 | PF00069 | 0.592 |
| MOD_PK_1 | 67 | 73 | PF00069 | 0.502 |
| MOD_PKA_1 | 67 | 73 | PF00069 | 0.488 |
| MOD_PKA_2 | 326 | 332 | PF00069 | 0.579 |
| MOD_PKA_2 | 67 | 73 | PF00069 | 0.527 |
| MOD_PKA_2 | 90 | 96 | PF00069 | 0.539 |
| MOD_Plk_1 | 101 | 107 | PF00069 | 0.477 |
| MOD_Plk_1 | 208 | 214 | PF00069 | 0.493 |
| MOD_Plk_1 | 267 | 273 | PF00069 | 0.509 |
| MOD_Plk_1 | 32 | 38 | PF00069 | 0.587 |
| MOD_Plk_4 | 12 | 18 | PF00069 | 0.392 |
| MOD_Plk_4 | 299 | 305 | PF00069 | 0.531 |
| MOD_Plk_4 | 318 | 324 | PF00069 | 0.582 |
| MOD_Plk_4 | 33 | 39 | PF00069 | 0.539 |
| MOD_Plk_4 | 67 | 73 | PF00069 | 0.545 |
| MOD_Plk_4 | 90 | 96 | PF00069 | 0.518 |
| MOD_ProDKin_1 | 218 | 224 | PF00069 | 0.469 |
| MOD_ProDKin_1 | 235 | 241 | PF00069 | 0.464 |
| MOD_SUMO_rev_2 | 233 | 239 | PF00179 | 0.555 |
| TRG_DiLeu_BaLyEn_6 | 277 | 282 | PF01217 | 0.561 |
| TRG_ENDOCYTIC_2 | 320 | 323 | PF00928 | 0.504 |
| TRG_ENDOCYTIC_2 | 94 | 97 | PF00928 | 0.464 |
| TRG_NLS_MonoExtC_3 | 55 | 60 | PF00514 | 0.474 |
| Protein | Taxonomy | Sequence identity | Coverage |
|---|---|---|---|
| A0A0N1HTS4 | Leptomonas seymouri | 29% | 100% |
| A0A0N1I1P8 | Leptomonas seymouri | 79% | 99% |
| A0A0N1I6F8 | Leptomonas seymouri | 27% | 100% |
| A0A0N1I7L3 | Leptomonas seymouri | 29% | 100% |
| A0A0S4JMY7 | Bodo saltans | 50% | 99% |
| A0A1X0NFB1 | Trypanosomatidae | 28% | 100% |
| A0A1X0NKR7 | Trypanosomatidae | 45% | 91% |
| A0A1X0NWL8 | Trypanosomatidae | 27% | 100% |
| A0A3Q8GLE8 | Nepeta racemosa | 26% | 100% |
| A0A3Q8IHN8 | Leishmania donovani | 100% | 100% |
| A0A3Q8IIU6 | Leishmania donovani | 30% | 100% |
| A0A3S7X6T1 | Leishmania donovani | 28% | 100% |
| A0A3S7XB64 | Leishmania donovani | 30% | 100% |
| A0A422N9W5 | Trypanosoma rangeli | 27% | 100% |
| A0A422NG64 | Trypanosoma rangeli | 29% | 100% |
| A0A422NNE9 | Trypanosoma rangeli | 54% | 100% |
| A4HLM0 | Leishmania braziliensis | 27% | 100% |
| A4HM71 | Leishmania braziliensis | 89% | 100% |
| A4HME4 | Leishmania braziliensis | 26% | 100% |
| A4HPK8 | Leishmania braziliensis | 31% | 100% |
| A4I931 | Leishmania infantum | 28% | 100% |
| A4IB16 | Leishmania infantum | 30% | 100% |
| A4ID56 | Leishmania infantum | 30% | 100% |
| A5PJF6 | Bos taurus | 28% | 100% |
| D0A2C4 | Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) | 50% | 97% |
| D0A534 | Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) | 30% | 100% |
| D3U1D9 | Klebsiella oxytoca | 30% | 100% |
| E9AEL0 | Leishmania major | 96% | 100% |
| E9AEU5 | Leishmania major | 29% | 100% |
| E9AX49 | Leishmania mexicana (strain MHOM/GT/2001/U1103) | 25% | 100% |
| E9B3Z6 | Leishmania mexicana (strain MHOM/GT/2001/U1103) | 26% | 100% |
| E9B4G7 | Leishmania mexicana (strain MHOM/GT/2001/U1103) | 25% | 100% |
| E9B5S1 | Leishmania mexicana (strain MHOM/GT/2001/U1103) | 96% | 100% |
| E9B601 | Leishmania mexicana (strain MHOM/GT/2001/U1103) | 30% | 100% |
| E9B602 | Leishmania mexicana (strain MHOM/GT/2001/U1103) | 28% | 100% |
| F4JZN6 | Arabidopsis thaliana | 33% | 100% |
| O05730 | Helicobacter pylori (strain ATCC 700392 / 26695) | 25% | 100% |
| O75452 | Homo sapiens | 29% | 100% |
| O88451 | Mus musculus | 28% | 100% |
| P0AFP4 | Escherichia coli (strain K12) | 28% | 100% |
| P0AFP5 | Escherichia coli O6:H1 (strain CFT073 / ATCC 700928 / UPEC) | 28% | 100% |
| P0CR36 | Cryptococcus neoformans var. neoformans serotype D (strain JEC21 / ATCC MYA-565) | 24% | 100% |
| P0CR37 | Cryptococcus neoformans var. neoformans serotype D (strain B-3501A) | 24% | 100% |
| P10528 | Priestia megaterium | 23% | 100% |
| P25970 | Myxococcus xanthus (strain DK1622) | 31% | 100% |
| P28845 | Homo sapiens | 28% | 100% |
| P37694 | Nostoc sp. (strain PCC 7120 / SAG 25.82 / UTEX 2576) | 26% | 100% |
| P39482 | Priestia megaterium | 25% | 100% |
| P39483 | Priestia megaterium | 24% | 100% |
| P39484 | Priestia megaterium | 23% | 100% |
| P39485 | Priestia megaterium | 23% | 100% |
| P39577 | Bacillus subtilis (strain 168) | 28% | 100% |
| P39831 | Escherichia coli (strain K12) | 26% | 100% |
| P40288 | Priestia megaterium | 24% | 100% |
| P69935 | Salmonella typhi | 27% | 100% |
| P69936 | Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720) | 27% | 100% |
| P80869 | Bacillus subtilis (strain 168) | 24% | 100% |
| P9WGR4 | Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh) | 30% | 100% |
| P9WGR5 | Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) | 30% | 100% |
| Q02337 | Bos taurus | 27% | 98% |
| Q06136 | Homo sapiens | 32% | 100% |
| Q0VFE7 | Xenopus tropicalis | 27% | 100% |
| Q0WRJ2 | Arabidopsis thaliana | 30% | 100% |
| Q13268 | Homo sapiens | 27% | 100% |
| Q2KIJ5 | Bos taurus | 34% | 100% |
| Q3T0R4 | Bos taurus | 29% | 100% |
| Q3U0B3 | Mus musculus | 25% | 100% |
| Q3ZBV9 | Bos taurus | 26% | 100% |
| Q4L8Y1 | Staphylococcus haemolyticus (strain JCSC1435) | 27% | 100% |
| Q4Q428 | Leishmania major | 26% | 100% |
| Q4QAC7 | Leishmania major | 27% | 100% |
| Q556J2 | Dictyostelium discoideum | 29% | 100% |
| Q566S6 | Danio rerio | 26% | 100% |
| Q59RQ2 | Candida albicans (strain SC5314 / ATCC MYA-2876) | 28% | 100% |
| Q5B0R9 | Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) | 25% | 98% |
| Q5BE65 | Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) | 26% | 92% |
| Q5FPE5 | Gluconobacter oxydans (strain 621H) | 30% | 100% |
| Q5HLD8 | Staphylococcus epidermidis (strain ATCC 35984 / RP62A) | 30% | 100% |
| Q5R6U1 | Pongo abelii | 25% | 100% |
| Q5RJY4 | Rattus norvegicus | 29% | 100% |
| Q5ZJG8 | Gallus gallus | 27% | 100% |
| Q6CLN0 | Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37) | 25% | 100% |
| Q6CVS4 | Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37) | 25% | 98% |
| Q6F7B8 | Acinetobacter baylyi (strain ATCC 33305 / BD413 / ADP1) | 29% | 100% |
| Q6FQ42 | Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65) | 26% | 93% |
| Q6GV12 | Mus musculus | 33% | 100% |
| Q6IAN0 | Homo sapiens | 25% | 100% |
| Q6UWP2 | Homo sapiens | 25% | 100% |
| Q71R50 | Gallus gallus | 27% | 100% |
| Q758B6 | Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056) | 31% | 100% |
| Q7Q732 | Anopheles gambiae | 32% | 100% |
| Q7RZR2 | Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987) | 30% | 93% |
| Q7T2D1 | Danio rerio | 26% | 100% |
| Q7TQA3 | Mus musculus | 26% | 100% |
| Q83RE8 | Shigella flexneri | 25% | 100% |
| Q8CN40 | Staphylococcus epidermidis (strain ATCC 12228 / FDA PCI 1200) | 30% | 100% |
| Q8FHD2 | Escherichia coli O6:H1 (strain CFT073 / ATCC 700928 / UPEC) | 25% | 100% |
| Q8K9J5 | Buchnera aphidicola subsp. Schizaphis graminum (strain Sg) | 25% | 100% |
| Q8N3Y7 | Homo sapiens | 26% | 100% |
| Q8U8I2 | Agrobacterium fabrum (strain C58 / ATCC 33970) | 30% | 100% |
| Q8X505 | Escherichia coli O157:H7 | 26% | 100% |
| Q94K41 | Arabidopsis thaliana | 27% | 100% |
| Q99J47 | Mus musculus | 29% | 100% |
| Q9FYL6 | Arabidopsis thaliana | 25% | 100% |
| Q9KWN1 | Rhizobium radiobacter | 30% | 100% |
| Q9N126 | Bos taurus | 28% | 100% |
| Q9NYR8 | Homo sapiens | 27% | 100% |
| Q9P7B4 | Schizosaccharomyces pombe (strain 972 / ATCC 24843) | 29% | 100% |
| Q9X248 | Thermotoga maritima (strain ATCC 43589 / DSM 3109 / JCM 10099 / NBRC 100826 / MSB8) | 28% | 100% |
| Q9Y140 | Drosophila melanogaster | 30% | 100% |
| Q9Y7P2 | Schizosaccharomyces pombe (strain 972 / ATCC 24843) | 26% | 68% |
| Q9ZKW1 | Helicobacter pylori (strain J99 / ATCC 700824) | 27% | 100% |
| V5B376 | Trypanosoma cruzi | 51% | 100% |
| V5BCN8 | Trypanosoma cruzi | 27% | 100% |
| V5BS47 | Trypanosoma cruzi | 27% | 100% |