LeishMANIAdb
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ANK_REP_REGION domain-containing protein

Quick info Annotations Function or PPIs Localization Abundance Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
ANK_REP_REGION domain-containing protein
Gene product:
Ankyrin repeats (3 copies)/Ankyrin repeat - putative
Species:
Leishmania infantum
UniProt:
A4IAT2_LEIIN
TriTrypDb:
LINF_350008200
Length:
427

Annotations

Annotations by Jardim et al.

Uncharacterized Protein, Uncharacterized

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 11
NetGPI no yes: 0, no: 11
Cellular components
Term Name Level Count
GO:0005634 nucleus 5 1
GO:0005737 cytoplasm 2 1
GO:0031974 membrane-enclosed lumen 2 1
GO:0031981 nuclear lumen 5 1
GO:0032838 plasma membrane bounded cell projection cytoplasm 4 1
GO:0043226 organelle 2 1
GO:0043227 membrane-bounded organelle 3 1
GO:0043229 intracellular organelle 3 1
GO:0043231 intracellular membrane-bounded organelle 4 1
GO:0043233 organelle lumen 3 1
GO:0070013 intracellular organelle lumen 4 1
GO:0097014 ciliary plasm 5 1
GO:0099568 cytoplasmic region 3 1
GO:0110165 cellular anatomical entity 1 1

Abundance

Amastigote (protein)
Source Evidence on protein Close homologs
Pescher et al. (upgregulation) no yes: 0
Promastigote and amastigote
Source Evidence on protein Close homologs
Lahav et al.
- mRNA
- Protein

Expansion

Sequence features

A4IAT2
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4IAT2

Function

Biological processes
Term Name Level Count
GO:0006355 regulation of DNA-templated transcription 6 1
GO:0009889 regulation of biosynthetic process 4 1
GO:0010468 regulation of gene expression 5 1
GO:0010556 regulation of macromolecule biosynthetic process 5 1
GO:0010941 regulation of cell death 4 1
GO:0019219 regulation of nucleobase-containing compound metabolic process 5 1
GO:0019222 regulation of metabolic process 3 1
GO:0031323 regulation of cellular metabolic process 4 1
GO:0031326 regulation of cellular biosynthetic process 5 1
GO:0042981 regulation of apoptotic process 6 1
GO:0043067 regulation of programmed cell death 5 1
GO:0044093 positive regulation of molecular function 3 1
GO:0050789 regulation of biological process 2 1
GO:0050794 regulation of cellular process 3 1
GO:0051090 regulation of DNA-binding transcription factor activity 3 1
GO:0051091 positive regulation of DNA-binding transcription factor activity 4 1
GO:0051171 regulation of nitrogen compound metabolic process 4 1
GO:0051252 regulation of RNA metabolic process 5 1
GO:0060255 regulation of macromolecule metabolic process 4 1
GO:0065007 biological regulation 1 1
GO:0065009 regulation of molecular function 2 1
GO:0080090 regulation of primary metabolic process 4 1
GO:1903506 regulation of nucleic acid-templated transcription 7 1
GO:2001141 regulation of RNA biosynthetic process 6 1
Could not find GO molecular_function term for this entry.

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_NRD_NRD_1 2 4 PF00675 0.637
CLV_NRD_NRD_1 411 413 PF00675 0.567
CLV_NRD_NRD_1 78 80 PF00675 0.618
CLV_NRD_NRD_1 99 101 PF00675 0.457
CLV_PCSK_KEX2_1 413 415 PF00082 0.551
CLV_PCSK_KEX2_1 58 60 PF00082 0.604
CLV_PCSK_KEX2_1 78 80 PF00082 0.618
CLV_PCSK_KEX2_1 99 101 PF00082 0.498
CLV_PCSK_PC1ET2_1 413 415 PF00082 0.573
CLV_PCSK_PC1ET2_1 58 60 PF00082 0.604
CLV_PCSK_SKI1_1 190 194 PF00082 0.379
CLV_PCSK_SKI1_1 423 427 PF00082 0.624
DEG_Nend_UBRbox_3 1 3 PF02207 0.657
DEG_SPOP_SBC_1 343 347 PF00917 0.754
DOC_AGCK_PIF_2 70 75 PF00069 0.622
DOC_MAPK_gen_1 138 147 PF00069 0.522
DOC_MAPK_gen_1 363 372 PF00069 0.483
DOC_MAPK_gen_1 58 67 PF00069 0.615
DOC_MAPK_gen_1 78 88 PF00069 0.558
DOC_MAPK_gen_1 99 107 PF00069 0.468
DOC_MAPK_MEF2A_6 138 147 PF00069 0.488
DOC_MAPK_MEF2A_6 82 90 PF00069 0.517
DOC_PP1_RVXF_1 366 373 PF00149 0.542
DOC_PP2B_LxvP_1 276 279 PF13499 0.464
DOC_USP7_MATH_1 148 152 PF00917 0.377
DOC_USP7_MATH_1 259 263 PF00917 0.365
DOC_USP7_MATH_1 286 290 PF00917 0.496
DOC_USP7_MATH_1 320 324 PF00917 0.623
DOC_USP7_MATH_1 344 348 PF00917 0.748
DOC_USP7_MATH_1 69 73 PF00917 0.595
DOC_USP7_UBL2_3 117 121 PF12436 0.479
DOC_USP7_UBL2_3 58 62 PF12436 0.591
DOC_WW_Pin1_4 131 136 PF00397 0.655
DOC_WW_Pin1_4 205 210 PF00397 0.345
DOC_WW_Pin1_4 216 221 PF00397 0.213
DOC_WW_Pin1_4 249 254 PF00397 0.280
DOC_WW_Pin1_4 390 395 PF00397 0.609
DOC_WW_Pin1_4 46 51 PF00397 0.614
LIG_14-3-3_CanoR_1 387 396 PF00244 0.506
LIG_14-3-3_CanoR_1 412 418 PF00244 0.532
LIG_14-3-3_CanoR_1 82 87 PF00244 0.428
LIG_14-3-3_CterR_2 423 427 PF00244 0.678
LIG_AP2alpha_2 68 70 PF02296 0.624
LIG_BRCT_BRCA1_1 150 154 PF00533 0.453
LIG_BRCT_BRCA1_1 218 222 PF00533 0.328
LIG_deltaCOP1_diTrp_1 391 398 PF00928 0.604
LIG_EVH1_2 313 317 PF00568 0.588
LIG_FHA_1 172 178 PF00498 0.327
LIG_FHA_1 187 193 PF00498 0.260
LIG_FHA_1 261 267 PF00498 0.337
LIG_FHA_1 41 47 PF00498 0.589
LIG_FHA_1 55 61 PF00498 0.384
LIG_LIR_Apic_2 297 301 PF02991 0.529
LIG_LIR_Apic_2 323 327 PF02991 0.650
LIG_LIR_Gen_1 118 123 PF02991 0.520
LIG_LIR_Gen_1 174 181 PF02991 0.329
LIG_LIR_Gen_1 219 230 PF02991 0.309
LIG_LIR_Nem_3 118 122 PF02991 0.511
LIG_LIR_Nem_3 174 178 PF02991 0.333
LIG_LIR_Nem_3 213 218 PF02991 0.321
LIG_LIR_Nem_3 219 225 PF02991 0.284
LIG_LIR_Nem_3 280 285 PF02991 0.477
LIG_LIR_Nem_3 293 298 PF02991 0.441
LIG_LIR_Nem_3 68 73 PF02991 0.616
LIG_LIR_Nem_3 93 98 PF02991 0.362
LIG_MLH1_MIPbox_1 150 154 PF16413 0.453
LIG_Pex14_2 149 153 PF04695 0.429
LIG_REV1ctd_RIR_1 151 158 PF16727 0.466
LIG_RPA_C_Fungi 165 177 PF08784 0.507
LIG_SH2_CRK 14 18 PF00017 0.544
LIG_SH2_CRK 218 222 PF00017 0.401
LIG_SH2_CRK 298 302 PF00017 0.537
LIG_SH2_GRB2like 5 8 PF00017 0.587
LIG_SH2_NCK_1 218 222 PF00017 0.401
LIG_SH2_NCK_1 5 9 PF00017 0.582
LIG_SH2_SRC 73 76 PF00017 0.555
LIG_SH2_STAT3 35 38 PF00017 0.597
LIG_SH2_STAT5 175 178 PF00017 0.401
LIG_SH2_STAT5 277 280 PF00017 0.503
LIG_SH2_STAT5 316 319 PF00017 0.528
LIG_SH2_STAT5 35 38 PF00017 0.570
LIG_SH2_STAT5 5 8 PF00017 0.587
LIG_SH3_3 142 148 PF00018 0.496
LIG_SH3_3 306 312 PF00018 0.521
LIG_SH3_3 63 69 PF00018 0.596
LIG_SUMO_SIM_anti_2 228 234 PF11976 0.341
LIG_SUMO_SIM_par_1 176 182 PF11976 0.345
LIG_SUMO_SIM_par_1 301 307 PF11976 0.583
LIG_TRAF2_1 109 112 PF00917 0.475
LIG_TRAF2_1 304 307 PF00917 0.626
LIG_TRAF2_1 407 410 PF00917 0.582
LIG_UBA3_1 177 185 PF00899 0.400
LIG_UBA3_1 302 310 PF00899 0.609
LIG_UBA3_1 52 58 PF00899 0.548
LIG_WRC_WIRS_1 116 121 PF05994 0.510
LIG_WW_1 313 316 PF00397 0.598
MOD_CDK_SPxxK_3 131 138 PF00069 0.644
MOD_CK1_1 131 137 PF00069 0.548
MOD_CK1_1 164 170 PF00069 0.593
MOD_CK1_1 179 185 PF00069 0.228
MOD_CK1_1 262 268 PF00069 0.401
MOD_CK1_1 331 337 PF00069 0.742
MOD_CK1_1 348 354 PF00069 0.680
MOD_CK2_1 21 27 PF00069 0.525
MOD_CK2_1 348 354 PF00069 0.722
MOD_GlcNHglycan 130 133 PF01048 0.554
MOD_GlcNHglycan 150 153 PF01048 0.440
MOD_GlcNHglycan 19 22 PF01048 0.601
MOD_GlcNHglycan 23 26 PF01048 0.599
MOD_GlcNHglycan 347 350 PF01048 0.667
MOD_GlcNHglycan 365 368 PF01048 0.466
MOD_GlcNHglycan 398 401 PF01048 0.477
MOD_GlcNHglycan 417 420 PF01048 0.636
MOD_GlcNHglycan 92 95 PF01048 0.397
MOD_GSK3_1 17 24 PF00069 0.497
MOD_GSK3_1 235 242 PF00069 0.365
MOD_GSK3_1 286 293 PF00069 0.509
MOD_GSK3_1 344 351 PF00069 0.678
MOD_LATS_1 80 86 PF00433 0.540
MOD_N-GLC_1 199 204 PF02516 0.318
MOD_N-GLC_1 396 401 PF02516 0.593
MOD_N-GLC_1 46 51 PF02516 0.597
MOD_N-GLC_1 82 87 PF02516 0.487
MOD_NEK2_1 161 166 PF00069 0.561
MOD_NEK2_1 17 22 PF00069 0.559
MOD_NEK2_1 176 181 PF00069 0.249
MOD_NEK2_1 235 240 PF00069 0.317
MOD_NEK2_1 34 39 PF00069 0.401
MOD_NEK2_1 84 89 PF00069 0.418
MOD_NEK2_2 239 244 PF00069 0.389
MOD_PIKK_1 290 296 PF00454 0.522
MOD_PIKK_1 34 40 PF00454 0.616
MOD_PK_1 141 147 PF00069 0.508
MOD_PKA_1 3 9 PF00069 0.601
MOD_PKA_1 412 418 PF00069 0.624
MOD_PKA_2 328 334 PF00069 0.731
MOD_PKA_2 413 419 PF00069 0.598
MOD_PKA_2 54 60 PF00069 0.543
MOD_PKA_2 98 104 PF00069 0.486
MOD_PKB_1 385 393 PF00069 0.606
MOD_Plk_1 141 147 PF00069 0.508
MOD_Plk_1 199 205 PF00069 0.315
MOD_Plk_1 260 266 PF00069 0.213
MOD_Plk_1 296 302 PF00069 0.500
MOD_Plk_1 396 402 PF00069 0.486
MOD_Plk_1 82 88 PF00069 0.523
MOD_Plk_4 161 167 PF00069 0.522
MOD_Plk_4 171 177 PF00069 0.296
MOD_Plk_4 199 205 PF00069 0.296
MOD_Plk_4 312 318 PF00069 0.542
MOD_ProDKin_1 131 137 PF00069 0.651
MOD_ProDKin_1 205 211 PF00069 0.345
MOD_ProDKin_1 216 222 PF00069 0.213
MOD_ProDKin_1 249 255 PF00069 0.280
MOD_ProDKin_1 390 396 PF00069 0.606
MOD_ProDKin_1 46 52 PF00069 0.607
MOD_SUMO_for_1 357 360 PF00179 0.536
MOD_SUMO_rev_2 126 131 PF00179 0.625
MOD_SUMO_rev_2 328 334 PF00179 0.692
MOD_SUMO_rev_2 351 359 PF00179 0.637
MOD_SUMO_rev_2 409 415 PF00179 0.598
TRG_DiLeu_BaEn_1 231 236 PF01217 0.316
TRG_ENDOCYTIC_2 14 17 PF00928 0.539
TRG_ENDOCYTIC_2 175 178 PF00928 0.401
TRG_ENDOCYTIC_2 218 221 PF00928 0.280
TRG_ER_diArg_1 98 100 PF00400 0.471

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N0P3M0 Leptomonas seymouri 77% 95%
A0A0S4JN35 Bodo saltans 41% 100%
A0A1X0NIX5 Trypanosomatidae 38% 100%
A0A3S5H7Y3 Leishmania donovani 100% 100%
A0A422NN82 Trypanosoma rangeli 36% 100%
A4HM70 Leishmania braziliensis 91% 100%
D0A2C7 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 33% 100%
E9AEK8 Leishmania major 96% 100%
E9B5R9 Leishmania mexicana (strain MHOM/GT/2001/U1103) 96% 100%
V5BNA7 Trypanosoma cruzi 36% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS