LeishMANIAdb
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DUF1014-domain-containing protein

Quick info Annotations Function or PPIs Localization Phosphorylation Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
DUF1014-domain-containing protein
Gene product:
hypothetical protein - conserved
Species:
Leishmania infantum
UniProt:
A4IAT1_LEIIN
TriTrypDb:
LINF_350008100
Length:
332

Annotations

Annotations by Jardim et al.

Uncharacterized Protein, Uncharacterized

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 11
NetGPI no yes: 0, no: 11
Cellular components
Term Name Level Count
GO:0005634 nucleus 5 1
GO:0043226 organelle 2 1
GO:0043227 membrane-bounded organelle 3 1
GO:0043229 intracellular organelle 3 1
GO:0043231 intracellular membrane-bounded organelle 4 1
GO:0110165 cellular anatomical entity 1 1

Phosphorylation

Promastigote: 66

Expansion

Sequence features

A4IAT1
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4IAT1

Function

Biological processes
Term Name Level Count
GO:0006139 nucleobase-containing compound metabolic process 3 1
GO:0006259 DNA metabolic process 4 1
GO:0006260 DNA replication 5 1
GO:0006725 cellular aromatic compound metabolic process 3 1
GO:0006807 nitrogen compound metabolic process 2 1
GO:0008152 metabolic process 1 1
GO:0009987 cellular process 1 1
GO:0034641 cellular nitrogen compound metabolic process 3 1
GO:0043170 macromolecule metabolic process 3 1
GO:0044237 cellular metabolic process 2 1
GO:0044238 primary metabolic process 2 1
GO:0044260 obsolete cellular macromolecule metabolic process 3 1
GO:0046483 heterocycle metabolic process 3 1
GO:0071704 organic substance metabolic process 2 1
GO:0090304 nucleic acid metabolic process 4 1
GO:1901360 organic cyclic compound metabolic process 3 1
Could not find GO molecular_function term for this entry.

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 125 129 PF00656 0.531
CLV_C14_Caspase3-7 40 44 PF00656 0.528
CLV_NRD_NRD_1 283 285 PF00675 0.614
CLV_NRD_NRD_1 328 330 PF00675 0.530
CLV_NRD_NRD_1 52 54 PF00675 0.614
CLV_PCSK_KEX2_1 258 260 PF00082 0.541
CLV_PCSK_KEX2_1 282 284 PF00082 0.467
CLV_PCSK_KEX2_1 328 330 PF00082 0.530
CLV_PCSK_KEX2_1 54 56 PF00082 0.620
CLV_PCSK_PC1ET2_1 258 260 PF00082 0.541
CLV_PCSK_PC1ET2_1 282 284 PF00082 0.467
CLV_PCSK_PC1ET2_1 54 56 PF00082 0.626
CLV_PCSK_SKI1_1 109 113 PF00082 0.473
CLV_PCSK_SKI1_1 127 131 PF00082 0.418
CLV_PCSK_SKI1_1 283 287 PF00082 0.463
CLV_Separin_Metazoa 325 329 PF03568 0.449
DOC_MAPK_gen_1 151 160 PF00069 0.553
DOC_MAPK_gen_1 258 265 PF00069 0.610
DOC_USP7_MATH_1 171 175 PF00917 0.797
DOC_USP7_MATH_1 190 194 PF00917 0.697
DOC_USP7_MATH_1 239 243 PF00917 0.713
DOC_USP7_MATH_1 38 42 PF00917 0.576
DOC_USP7_MATH_1 88 92 PF00917 0.603
DOC_USP7_UBL2_3 109 113 PF12436 0.469
DOC_USP7_UBL2_3 282 286 PF12436 0.456
DOC_WW_Pin1_4 160 165 PF00397 0.605
DOC_WW_Pin1_4 63 68 PF00397 0.544
LIG_14-3-3_CanoR_1 238 247 PF00244 0.694
LIG_14-3-3_CanoR_1 309 319 PF00244 0.542
LIG_BIR_III_4 128 132 PF00653 0.600
LIG_BRCT_BRCA1_1 107 111 PF00533 0.574
LIG_BRCT_BRCA1_1 30 34 PF00533 0.610
LIG_BRCT_BRCA1_1 65 69 PF00533 0.580
LIG_BRCT_BRCA1_2 107 113 PF00533 0.577
LIG_CaM_IQ_9 45 60 PF13499 0.515
LIG_FHA_1 2 8 PF00498 0.686
LIG_FHA_1 221 227 PF00498 0.679
LIG_FHA_1 25 31 PF00498 0.490
LIG_FHA_1 265 271 PF00498 0.595
LIG_FHA_2 123 129 PF00498 0.563
LIG_FHA_2 27 33 PF00498 0.582
LIG_LIR_Nem_3 145 150 PF02991 0.503
LIG_LIR_Nem_3 293 299 PF02991 0.559
LIG_LIR_Nem_3 31 37 PF02991 0.615
LIG_LIR_Nem_3 313 319 PF02991 0.264
LIG_MAD2 156 164 PF02301 0.602
LIG_Pex14_2 292 296 PF04695 0.423
LIG_SH2_CRK 299 303 PF00017 0.603
LIG_SH2_STAT3 136 139 PF00017 0.628
LIG_SH3_3 4 10 PF00018 0.577
LIG_SH3_3 91 97 PF00018 0.605
MOD_CK1_1 101 107 PF00069 0.616
MOD_CK1_1 142 148 PF00069 0.523
MOD_CK1_1 163 169 PF00069 0.704
MOD_CK1_1 205 211 PF00069 0.763
MOD_CK1_1 41 47 PF00069 0.490
MOD_CK2_1 142 148 PF00069 0.523
MOD_CK2_1 291 297 PF00069 0.452
MOD_DYRK1A_RPxSP_1 63 67 PF00069 0.605
MOD_GlcNHglycan 172 176 PF01048 0.668
MOD_GlcNHglycan 193 196 PF01048 0.698
MOD_GlcNHglycan 197 200 PF01048 0.497
MOD_GlcNHglycan 212 215 PF01048 0.691
MOD_GlcNHglycan 228 231 PF01048 0.642
MOD_GlcNHglycan 241 244 PF01048 0.630
MOD_GlcNHglycan 251 254 PF01048 0.596
MOD_GlcNHglycan 90 93 PF01048 0.614
MOD_GSK3_1 101 108 PF00069 0.581
MOD_GSK3_1 163 170 PF00069 0.709
MOD_GSK3_1 171 178 PF00069 0.667
MOD_GSK3_1 191 198 PF00069 0.739
MOD_GSK3_1 20 27 PF00069 0.446
MOD_GSK3_1 204 211 PF00069 0.689
MOD_GSK3_1 216 223 PF00069 0.656
MOD_GSK3_1 264 271 PF00069 0.605
MOD_GSK3_1 37 44 PF00069 0.476
MOD_GSK3_1 9 16 PF00069 0.531
MOD_NEK2_1 210 215 PF00069 0.770
MOD_NEK2_1 24 29 PF00069 0.521
MOD_NEK2_1 249 254 PF00069 0.544
MOD_NEK2_1 327 332 PF00069 0.500
MOD_NEK2_1 69 74 PF00069 0.469
MOD_NEK2_2 122 127 PF00069 0.541
MOD_PIKK_1 179 185 PF00454 0.680
MOD_PIKK_1 22 28 PF00454 0.438
MOD_PIKK_1 69 75 PF00454 0.552
MOD_PIKK_1 9 15 PF00454 0.550
MOD_PKA_2 101 107 PF00069 0.634
MOD_PKA_2 150 156 PF00069 0.481
MOD_PKA_2 208 214 PF00069 0.753
MOD_Plk_1 122 128 PF00069 0.551
MOD_Plk_1 20 26 PF00069 0.591
MOD_Plk_1 205 211 PF00069 0.775
MOD_Plk_1 56 62 PF00069 0.603
MOD_Plk_4 2 8 PF00069 0.736
MOD_ProDKin_1 160 166 PF00069 0.614
MOD_ProDKin_1 63 69 PF00069 0.541
MOD_SUMO_for_1 322 325 PF00179 0.452
MOD_SUMO_rev_2 134 142 PF00179 0.575
TRG_ENDOCYTIC_2 299 302 PF00928 0.604
TRG_ENDOCYTIC_2 319 322 PF00928 0.243
TRG_ER_diArg_1 283 285 PF00400 0.523
TRG_ER_diArg_1 327 329 PF00400 0.465
TRG_ER_diArg_1 53 56 PF00400 0.508
TRG_NES_CRM1_1 255 269 PF08389 0.617
TRG_Pf-PMV_PEXEL_1 144 148 PF00026 0.501
TRG_Pf-PMV_PEXEL_1 283 287 PF00026 0.554

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1I316 Leptomonas seymouri 73% 100%
A0A0S4JRP8 Bodo saltans 35% 91%
A0A1X0NJS6 Trypanosomatidae 37% 82%
A0A3Q8IFZ2 Leishmania donovani 100% 100%
A0A3R7MJB6 Trypanosoma rangeli 37% 94%
A4HM69 Leishmania braziliensis 81% 92%
D0A2C8 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 38% 100%
E9AEK7 Leishmania major 95% 100%
E9B5R8 Leishmania mexicana (strain MHOM/GT/2001/U1103) 93% 100%
V5BSV2 Trypanosoma cruzi 38% 95%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS