Putative GTP-ase activating protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

GTP-ase activating protein - putative

Species:

Leishmania infantum

UniProt:

A4IAS7_LEIIN

TriTrypDb:

LINF_350007700

Length:

578

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4IAS7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4IAS7

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	5
GO:0003924	GTPase activity	7	5
GO:0003925	G protein activity	2	5
GO:0005096	GTPase activator activity	4	10
GO:0005488	binding	1	10
GO:0005543	phospholipid binding	3	10
GO:0008047	enzyme activator activity	3	10
GO:0008289	lipid binding	2	10
GO:0016462	pyrophosphatase activity	5	5
GO:0016787	hydrolase activity	2	5
GO:0016817	hydrolase activity, acting on acid anhydrides	3	5
GO:0016818	hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	4	5
GO:0017111	ribonucleoside triphosphate phosphatase activity	6	5
GO:0030234	enzyme regulator activity	2	10
GO:0030695	GTPase regulator activity	4	10
GO:0060589	nucleoside-triphosphatase regulator activity	3	10
GO:0098772	molecular function regulator activity	1	10
GO:0140677	molecular function activator activity	2	10

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	125	129	PF00656	0.718
CLV_NRD_NRD_1	197	199	PF00675	0.674
CLV_NRD_NRD_1	217	219	PF00675	0.763
CLV_NRD_NRD_1	302	304	PF00675	0.439
CLV_NRD_NRD_1	387	389	PF00675	0.621
CLV_PCSK_KEX2_1	196	198	PF00082	0.650
CLV_PCSK_KEX2_1	386	388	PF00082	0.485
CLV_PCSK_PC1ET2_1	196	198	PF00082	0.650
CLV_PCSK_SKI1_1	263	267	PF00082	0.272
CLV_PCSK_SKI1_1	28	32	PF00082	0.594
CLV_PCSK_SKI1_1	360	364	PF00082	0.408
CLV_PCSK_SKI1_1	409	413	PF00082	0.604
CLV_PCSK_SKI1_1	485	489	PF00082	0.620
CLV_PCSK_SKI1_1	90	94	PF00082	0.497
DEG_SPOP_SBC_1	202	206	PF00917	0.565
DOC_ANK_TNKS_1	123	130	PF00023	0.629
DOC_CKS1_1	559	564	PF01111	0.665
DOC_CYCLIN_yCln2_LP_2	399	405	PF00134	0.418
DOC_MAPK_gen_1	102	110	PF00069	0.616
DOC_MAPK_gen_1	3	11	PF00069	0.580
DOC_MAPK_gen_1	376	384	PF00069	0.485
DOC_MAPK_MEF2A_6	447	456	PF00069	0.502
DOC_PP1_RVXF_1	26	33	PF00149	0.572
DOC_PP1_RVXF_1	545	551	PF00149	0.588
DOC_PP1_RVXF_1	88	95	PF00149	0.516
DOC_USP7_MATH_1	149	153	PF00917	0.771
DOC_USP7_MATH_1	156	160	PF00917	0.753
DOC_USP7_MATH_1	162	166	PF00917	0.715
DOC_USP7_MATH_1	280	284	PF00917	0.444
DOC_USP7_MATH_1	343	347	PF00917	0.396
DOC_USP7_MATH_1	538	542	PF00917	0.551
DOC_USP7_MATH_1	562	566	PF00917	0.530
DOC_USP7_MATH_1	71	75	PF00917	0.713
DOC_USP7_UBL2_3	268	272	PF12436	0.272
DOC_WW_Pin1_4	203	208	PF00397	0.609
DOC_WW_Pin1_4	255	260	PF00397	0.462
DOC_WW_Pin1_4	558	563	PF00397	0.674
LIG_14-3-3_CanoR_1	218	227	PF00244	0.606
LIG_14-3-3_CanoR_1	491	500	PF00244	0.551
LIG_14-3-3_CanoR_1	70	74	PF00244	0.664
LIG_APCC_ABBA_1	108	113	PF00400	0.587
LIG_APCC_ABBAyCdc20_2	6	12	PF00400	0.663
LIG_BIR_II_1	1	5	PF00653	0.414
LIG_BRCT_BRCA1_1	347	351	PF00533	0.484
LIG_BRCT_BRCA1_1	540	544	PF00533	0.517
LIG_deltaCOP1_diTrp_1	316	325	PF00928	0.344
LIG_deltaCOP1_diTrp_1	528	536	PF00928	0.546
LIG_deltaCOP1_diTrp_1	564	570	PF00928	0.540
LIG_EH_1	147	151	PF12763	0.577
LIG_EVH1_1	396	400	PF00568	0.574
LIG_FHA_1	391	397	PF00498	0.606
LIG_FHA_2	123	129	PF00498	0.624
LIG_FHA_2	219	225	PF00498	0.706
LIG_FHA_2	241	247	PF00498	0.632
LIG_FHA_2	492	498	PF00498	0.436
LIG_FHA_2	559	565	PF00498	0.695
LIG_IBAR_NPY_1	161	163	PF08397	0.674
LIG_KLC1_Yacidic_2	7	12	PF13176	0.663
LIG_LIR_Gen_1	104	112	PF02991	0.573
LIG_LIR_Gen_1	188	194	PF02991	0.685
LIG_LIR_Gen_1	283	292	PF02991	0.344
LIG_LIR_Gen_1	339	349	PF02991	0.444
LIG_LIR_Gen_1	473	483	PF02991	0.488
LIG_LIR_Gen_1	572	578	PF02991	0.546
LIG_LIR_Nem_3	104	110	PF02991	0.580
LIG_LIR_Nem_3	188	192	PF02991	0.617
LIG_LIR_Nem_3	283	287	PF02991	0.328
LIG_LIR_Nem_3	339	344	PF02991	0.333
LIG_LIR_Nem_3	473	479	PF02991	0.492
LIG_LIR_Nem_3	572	577	PF02991	0.436
LIG_LYPXL_SIV_4	21	29	PF13949	0.637
LIG_Pex14_1	566	570	PF04695	0.510
LIG_PTB_Apo_2	32	39	PF02174	0.631
LIG_PTB_Apo_2	75	82	PF02174	0.644
LIG_PTB_Phospho_1	32	38	PF10480	0.624
LIG_PTB_Phospho_1	75	81	PF10480	0.649
LIG_REV1ctd_RIR_1	381	389	PF16727	0.408
LIG_SH2_CRK	448	452	PF00017	0.522
LIG_SH2_CRK	513	517	PF00017	0.529
LIG_SH2_CRK	574	578	PF00017	0.564
LIG_SH2_NCK_1	22	26	PF00017	0.688
LIG_SH2_PTP2	341	344	PF00017	0.408
LIG_SH2_SRC	10	13	PF00017	0.657
LIG_SH2_STAP1	261	265	PF00017	0.523
LIG_SH2_STAP1	379	383	PF00017	0.444
LIG_SH2_STAP1	38	42	PF00017	0.659
LIG_SH2_STAP1	422	426	PF00017	0.711
LIG_SH2_STAT3	81	84	PF00017	0.640
LIG_SH2_STAT5	10	13	PF00017	0.614
LIG_SH2_STAT5	107	110	PF00017	0.670
LIG_SH2_STAT5	341	344	PF00017	0.373
LIG_SH2_STAT5	51	54	PF00017	0.690
LIG_SH2_STAT5	513	516	PF00017	0.429
LIG_SH3_1	394	400	PF00018	0.582
LIG_SH3_3	135	141	PF00018	0.751
LIG_SH3_3	143	149	PF00018	0.767
LIG_SH3_3	204	210	PF00018	0.712
LIG_SH3_3	339	345	PF00018	0.416
LIG_SH3_3	355	361	PF00018	0.225
LIG_SH3_3	392	398	PF00018	0.548
LIG_SH3_3	532	538	PF00018	0.488
LIG_SH3_4	268	275	PF00018	0.444
LIG_SUMO_SIM_anti_2	167	176	PF11976	0.708
LIG_SUMO_SIM_anti_2	39	46	PF11976	0.642
LIG_TRAF2_1	191	194	PF00917	0.677
LIG_UBA3_1	451	457	PF00899	0.546
LIG_UBA3_1	543	547	PF00899	0.462
LIG_UBA3_1	96	105	PF00899	0.636
LIG_WRC_WIRS_1	362	367	PF05994	0.444
LIG_WW_1	445	448	PF00397	0.503
LIG_WW_2	397	400	PF00397	0.434
LIG_WW_3	444	448	PF00397	0.512
MOD_CK1_1	169	175	PF00069	0.669
MOD_CK1_1	364	370	PF00069	0.444
MOD_CK1_1	424	430	PF00069	0.717
MOD_CK1_1	558	564	PF00069	0.693
MOD_CK1_1	72	78	PF00069	0.640
MOD_CK2_1	162	168	PF00069	0.779
MOD_CK2_1	172	178	PF00069	0.624
MOD_CK2_1	240	246	PF00069	0.563
MOD_CK2_1	318	324	PF00069	0.477
MOD_CK2_1	363	369	PF00069	0.401
MOD_CK2_1	414	420	PF00069	0.644
MOD_CK2_1	558	564	PF00069	0.707
MOD_GlcNHglycan	120	123	PF01048	0.531
MOD_GlcNHglycan	143	146	PF01048	0.687
MOD_GlcNHglycan	158	161	PF01048	0.747
MOD_GlcNHglycan	168	171	PF01048	0.698
MOD_GlcNHglycan	311	314	PF01048	0.441
MOD_GlcNHglycan	366	369	PF01048	0.436
MOD_GlcNHglycan	423	426	PF01048	0.635
MOD_GSK3_1	118	125	PF00069	0.645
MOD_GSK3_1	162	169	PF00069	0.721
MOD_GSK3_1	242	249	PF00069	0.613
MOD_GSK3_1	405	412	PF00069	0.622
MOD_GSK3_1	558	565	PF00069	0.657
MOD_GSK3_1	566	573	PF00069	0.483
MOD_GSK3_1	65	72	PF00069	0.659
MOD_LATS_1	164	170	PF00433	0.746
MOD_LATS_1	302	308	PF00433	0.441
MOD_LATS_1	489	495	PF00433	0.580
MOD_N-GLC_2	308	310	PF02516	0.444
MOD_NEK2_1	118	123	PF00069	0.569
MOD_NEK2_1	192	197	PF00069	0.549
MOD_NEK2_1	240	245	PF00069	0.648
MOD_NEK2_1	363	368	PF00069	0.500
MOD_NEK2_1	382	387	PF00069	0.245
MOD_NEK2_1	405	410	PF00069	0.567
MOD_NEK2_1	490	495	PF00069	0.567
MOD_NEK2_1	512	517	PF00069	0.570
MOD_NEK2_1	548	553	PF00069	0.521
MOD_NEK2_1	570	575	PF00069	0.412
MOD_NEK2_2	475	480	PF00069	0.608
MOD_PIKK_1	478	484	PF00454	0.575
MOD_PIKK_1	548	554	PF00454	0.560
MOD_PIKK_1	555	561	PF00454	0.689
MOD_PIKK_1	65	71	PF00454	0.609
MOD_PKA_1	218	224	PF00069	0.618
MOD_PKA_1	555	561	PF00069	0.657
MOD_PKA_2	101	107	PF00069	0.657
MOD_PKA_2	134	140	PF00069	0.788
MOD_PKA_2	156	162	PF00069	0.589
MOD_PKA_2	217	223	PF00069	0.780
MOD_PKA_2	370	376	PF00069	0.444
MOD_PKA_2	490	496	PF00069	0.559
MOD_PKA_2	69	75	PF00069	0.631
MOD_PKB_1	386	394	PF00069	0.644
MOD_PKB_1	407	415	PF00069	0.639
MOD_Plk_1	405	411	PF00069	0.611
MOD_Plk_4	370	376	PF00069	0.444
MOD_Plk_4	512	518	PF00069	0.533
MOD_ProDKin_1	203	209	PF00069	0.611
MOD_ProDKin_1	255	261	PF00069	0.459
MOD_ProDKin_1	558	564	PF00069	0.668
MOD_SUMO_for_1	210	213	PF00179	0.753
TRG_DiLeu_BaEn_1	40	45	PF01217	0.642
TRG_DiLeu_BaEn_1	483	488	PF01217	0.636
TRG_DiLeu_BaLyEn_6	25	30	PF01217	0.666
TRG_DiLeu_BaLyEn_6	92	97	PF01217	0.583
TRG_ENDOCYTIC_2	107	110	PF00928	0.620
TRG_ENDOCYTIC_2	189	192	PF00928	0.605
TRG_ENDOCYTIC_2	341	344	PF00928	0.369
TRG_ENDOCYTIC_2	379	382	PF00928	0.485
TRG_ENDOCYTIC_2	448	451	PF00928	0.429
TRG_ENDOCYTIC_2	513	516	PF00928	0.449
TRG_ENDOCYTIC_2	574	577	PF00928	0.484
TRG_ER_diArg_1	197	199	PF00400	0.615
TRG_ER_diArg_1	386	388	PF00400	0.485
TRG_ER_diArg_1	407	410	PF00400	0.656
TRG_ER_diArg_1	517	520	PF00400	0.633

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HYE2	Leptomonas seymouri	58%	92%
A0A1X0NIZ1	Trypanosomatidae	33%	98%
A0A3S5IRI6	Trypanosoma rangeli	32%	100%
A0A3S7X8N7	Leishmania donovani	100%	92%
A4HM65	Leishmania braziliensis	79%	100%
E9AEK3	Leishmania major	91%	100%
E9B5R4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	100%
V5B380	Trypanosoma cruzi	33%	100%