Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4IAS6_LEIIN

TriTrypDb:

LINF_350007600

Length:

685

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005654	nucleoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4IAS6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4IAS6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	434	438	PF00656	0.624
CLV_NRD_NRD_1	333	335	PF00675	0.698
CLV_NRD_NRD_1	386	388	PF00675	0.827
CLV_NRD_NRD_1	6	8	PF00675	0.516
CLV_NRD_NRD_1	673	675	PF00675	0.614
CLV_PCSK_KEX2_1	333	335	PF00082	0.698
CLV_PCSK_KEX2_1	386	388	PF00082	0.725
CLV_PCSK_KEX2_1	431	433	PF00082	0.622
CLV_PCSK_KEX2_1	6	8	PF00082	0.516
CLV_PCSK_KEX2_1	683	685	PF00082	0.674
CLV_PCSK_PC1ET2_1	431	433	PF00082	0.583
CLV_PCSK_PC1ET2_1	683	685	PF00082	0.674
CLV_PCSK_SKI1_1	140	144	PF00082	0.558
CLV_PCSK_SKI1_1	239	243	PF00082	0.511
CLV_PCSK_SKI1_1	334	338	PF00082	0.736
CLV_Separin_Metazoa	95	99	PF03568	0.528
DEG_APCC_DBOX_1	69	77	PF00400	0.612
DEG_SPOP_SBC_1	497	501	PF00917	0.735
DOC_CDC14_PxL_1	598	606	PF14671	0.629
DOC_CYCLIN_yClb3_PxF_3	132	140	PF00134	0.556
DOC_CYCLIN_yClb5_NLxxxL_5	349	358	PF00134	0.687
DOC_CYCLIN_yCln2_LP_2	604	610	PF00134	0.634
DOC_MAPK_MEF2A_6	611	619	PF00069	0.570
DOC_PP2B_LxvP_1	583	586	PF13499	0.647
DOC_PP2B_LxvP_1	604	607	PF13499	0.665
DOC_PP2B_LxvP_1	615	618	PF13499	0.525
DOC_PP4_FxxP_1	193	196	PF00568	0.585
DOC_USP7_MATH_1	155	159	PF00917	0.687
DOC_USP7_MATH_1	258	262	PF00917	0.523
DOC_USP7_MATH_1	406	410	PF00917	0.793
DOC_USP7_MATH_1	419	423	PF00917	0.554
DOC_USP7_MATH_1	497	501	PF00917	0.735
DOC_WW_Pin1_4	128	133	PF00397	0.679
DOC_WW_Pin1_4	151	156	PF00397	0.755
DOC_WW_Pin1_4	192	197	PF00397	0.496
DOC_WW_Pin1_4	361	366	PF00397	0.773
DOC_WW_Pin1_4	552	557	PF00397	0.758
DOC_WW_Pin1_4	589	594	PF00397	0.709
LIG_14-3-3_CanoR_1	101	109	PF00244	0.557
LIG_14-3-3_CanoR_1	147	155	PF00244	0.750
LIG_14-3-3_CanoR_1	180	187	PF00244	0.493
LIG_14-3-3_CanoR_1	323	330	PF00244	0.624
LIG_14-3-3_CanoR_1	333	337	PF00244	0.645
LIG_14-3-3_CanoR_1	377	385	PF00244	0.748
LIG_14-3-3_CanoR_1	6	11	PF00244	0.512
LIG_14-3-3_CanoR_1	611	615	PF00244	0.676
LIG_14-3-3_CanoR_1	674	682	PF00244	0.662
LIG_Actin_WH2_2	529	547	PF00022	0.564
LIG_Actin_WH2_2	82	100	PF00022	0.593
LIG_BIR_II_1	1	5	PF00653	0.734
LIG_BRCT_BRCA1_1	421	425	PF00533	0.643
LIG_BRCT_BRCA1_1	591	595	PF00533	0.648
LIG_Clathr_ClatBox_1	460	464	PF01394	0.494
LIG_eIF4E_1	594	600	PF01652	0.712
LIG_FHA_1	101	107	PF00498	0.420
LIG_FHA_1	110	116	PF00498	0.625
LIG_FHA_1	129	135	PF00498	0.529
LIG_FHA_1	261	267	PF00498	0.497
LIG_FHA_1	279	285	PF00498	0.532
LIG_FHA_1	286	292	PF00498	0.493
LIG_FHA_1	3	9	PF00498	0.545
LIG_FHA_1	349	355	PF00498	0.703
LIG_FHA_1	45	51	PF00498	0.535
LIG_FHA_1	506	512	PF00498	0.648
LIG_FHA_1	611	617	PF00498	0.573
LIG_FHA_1	674	680	PF00498	0.626
LIG_FHA_1	85	91	PF00498	0.462
LIG_FHA_2	134	140	PF00498	0.496
LIG_FHA_2	308	314	PF00498	0.623
LIG_FHA_2	553	559	PF00498	0.701
LIG_LIR_Gen_1	261	272	PF02991	0.489
LIG_LIR_Gen_1	288	295	PF02991	0.532
LIG_LIR_Gen_1	508	516	PF02991	0.522
LIG_LIR_Nem_3	261	267	PF02991	0.497
LIG_LIR_Nem_3	288	293	PF02991	0.536
LIG_LIR_Nem_3	35	39	PF02991	0.459
LIG_LIR_Nem_3	422	428	PF02991	0.646
LIG_LIR_Nem_3	508	512	PF02991	0.559
LIG_LIR_Nem_3	592	598	PF02991	0.632
LIG_LYPXL_S_1	600	604	PF13949	0.632
LIG_LYPXL_yS_3	601	604	PF13949	0.640
LIG_MLH1_MIPbox_1	591	595	PF16413	0.750
LIG_NRP_CendR_1	683	685	PF00754	0.440
LIG_SH2_CRK	187	191	PF00017	0.395
LIG_SH2_CRK	456	460	PF00017	0.528
LIG_SH2_CRK	484	488	PF00017	0.498
LIG_SH2_CRK	651	655	PF00017	0.543
LIG_SH2_SRC	217	220	PF00017	0.446
LIG_SH2_STAP1	217	221	PF00017	0.446
LIG_SH2_STAP1	456	460	PF00017	0.528
LIG_SH2_STAP1	651	655	PF00017	0.543
LIG_SH2_STAT5	187	190	PF00017	0.400
LIG_SH2_STAT5	255	258	PF00017	0.494
LIG_SH2_STAT5	264	267	PF00017	0.474
LIG_SH2_STAT5	594	597	PF00017	0.646
LIG_SH3_1	129	135	PF00018	0.513
LIG_SH3_3	129	135	PF00018	0.656
LIG_SH3_3	228	234	PF00018	0.492
LIG_SH3_3	362	368	PF00018	0.743
LIG_SH3_3	485	491	PF00018	0.496
LIG_SH3_3	590	596	PF00018	0.738
LIG_SH3_3	650	656	PF00018	0.550
LIG_SUMO_SIM_anti_2	613	618	PF11976	0.667
LIG_TRAF2_1	136	139	PF00917	0.496
LIG_TRAF2_1	162	165	PF00917	0.612
LIG_TRAF2_1	669	672	PF00917	0.495
LIG_TRFH_1	598	602	PF08558	0.693
LIG_TYR_ITIM	599	604	PF00017	0.625
LIG_UBA3_1	424	431	PF00899	0.620
LIG_WRC_WIRS_1	134	139	PF05994	0.483
MOD_CDK_SPK_2	192	197	PF00069	0.376
MOD_CK1_1	120	126	PF00069	0.744
MOD_CK1_1	133	139	PF00069	0.470
MOD_CK1_1	148	154	PF00069	0.707
MOD_CK1_1	158	164	PF00069	0.591
MOD_CK1_1	2	8	PF00069	0.603
MOD_CK1_1	279	285	PF00069	0.556
MOD_CK1_1	328	334	PF00069	0.642
MOD_CK1_1	529	535	PF00069	0.555
MOD_CK1_1	9	15	PF00069	0.495
MOD_CK2_1	133	139	PF00069	0.577
MOD_CK2_1	167	173	PF00069	0.555
MOD_CK2_1	307	313	PF00069	0.627
MOD_CK2_1	535	541	PF00069	0.536
MOD_CK2_1	89	95	PF00069	0.496
MOD_GlcNHglycan	169	172	PF01048	0.569
MOD_GlcNHglycan	25	28	PF01048	0.461
MOD_GlcNHglycan	273	276	PF01048	0.574
MOD_GlcNHglycan	303	306	PF01048	0.668
MOD_GlcNHglycan	325	328	PF01048	0.665
MOD_GlcNHglycan	373	376	PF01048	0.842
MOD_GlcNHglycan	433	436	PF01048	0.684
MOD_GlcNHglycan	441	444	PF01048	0.652
MOD_GlcNHglycan	528	531	PF01048	0.591
MOD_GlcNHglycan	578	581	PF01048	0.561
MOD_GlcNHglycan	58	61	PF01048	0.517
MOD_GlcNHglycan	91	94	PF01048	0.530
MOD_GSK3_1	115	122	PF00069	0.636
MOD_GSK3_1	124	131	PF00069	0.668
MOD_GSK3_1	146	153	PF00069	0.790
MOD_GSK3_1	154	161	PF00069	0.653
MOD_GSK3_1	2	9	PF00069	0.562
MOD_GSK3_1	279	286	PF00069	0.525
MOD_GSK3_1	303	310	PF00069	0.703
MOD_GSK3_1	325	332	PF00069	0.553
MOD_GSK3_1	341	348	PF00069	0.714
MOD_GSK3_1	431	438	PF00069	0.694
MOD_GSK3_1	562	569	PF00069	0.646
MOD_GSK3_1	606	613	PF00069	0.705
MOD_GSK3_1	617	624	PF00069	0.632
MOD_GSK3_1	629	636	PF00069	0.537
MOD_N-GLC_1	120	125	PF02516	0.711
MOD_N-GLC_1	394	399	PF02516	0.797
MOD_N-GLC_1	45	50	PF02516	0.542
MOD_NEK2_1	1	6	PF00069	0.618
MOD_NEK2_1	109	114	PF00069	0.606
MOD_NEK2_1	259	264	PF00069	0.507
MOD_NEK2_1	283	288	PF00069	0.491
MOD_NEK2_1	291	296	PF00069	0.529
MOD_NEK2_1	303	308	PF00069	0.372
MOD_NEK2_1	322	327	PF00069	0.459
MOD_NEK2_1	349	354	PF00069	0.703
MOD_NEK2_1	424	429	PF00069	0.670
MOD_NEK2_1	571	576	PF00069	0.512
MOD_NEK2_1	610	615	PF00069	0.655
MOD_NEK2_2	345	350	PF00069	0.693
MOD_PK_1	6	12	PF00069	0.514
MOD_PKA_1	386	392	PF00069	0.827
MOD_PKA_1	431	437	PF00069	0.682
MOD_PKA_1	6	12	PF00069	0.514
MOD_PKA_2	100	106	PF00069	0.550
MOD_PKA_2	146	152	PF00069	0.688
MOD_PKA_2	179	185	PF00069	0.479
MOD_PKA_2	322	328	PF00069	0.603
MOD_PKA_2	332	338	PF00069	0.645
MOD_PKA_2	349	355	PF00069	0.703
MOD_PKA_2	376	382	PF00069	0.792
MOD_PKA_2	386	392	PF00069	0.749
MOD_PKA_2	431	437	PF00069	0.721
MOD_PKA_2	6	12	PF00069	0.514
MOD_PKA_2	610	616	PF00069	0.675
MOD_PKA_2	673	679	PF00069	0.662
MOD_Plk_1	138	144	PF00069	0.544
MOD_Plk_1	394	400	PF00069	0.753
MOD_Plk_1	45	51	PF00069	0.535
MOD_Plk_2-3	621	627	PF00069	0.737
MOD_Plk_4	138	144	PF00069	0.544
MOD_Plk_4	212	218	PF00069	0.587
MOD_Plk_4	279	285	PF00069	0.532
MOD_Plk_4	566	572	PF00069	0.450
MOD_Plk_4	610	616	PF00069	0.675
MOD_Plk_4	633	639	PF00069	0.570
MOD_ProDKin_1	128	134	PF00069	0.661
MOD_ProDKin_1	151	157	PF00069	0.753
MOD_ProDKin_1	192	198	PF00069	0.497
MOD_ProDKin_1	361	367	PF00069	0.774
MOD_ProDKin_1	552	558	PF00069	0.763
MOD_ProDKin_1	589	595	PF00069	0.706
MOD_SUMO_rev_2	133	142	PF00179	0.523
TRG_DiLeu_BaEn_1	139	144	PF01217	0.550
TRG_DiLeu_BaEn_2	137	143	PF01217	0.521
TRG_DiLeu_BaLyEn_6	455	460	PF01217	0.537
TRG_ENDOCYTIC_2	187	190	PF00928	0.400
TRG_ENDOCYTIC_2	264	267	PF00928	0.474
TRG_ENDOCYTIC_2	31	34	PF00928	0.464
TRG_ENDOCYTIC_2	456	459	PF00928	0.537
TRG_ENDOCYTIC_2	601	604	PF00928	0.640
TRG_ENDOCYTIC_2	651	654	PF00928	0.549
TRG_ER_diArg_1	385	387	PF00400	0.755
TRG_ER_diArg_1	6	8	PF00400	0.516
TRG_ER_diArg_1	70	73	PF00400	0.723
TRG_Pf-PMV_PEXEL_1	426	430	PF00026	0.637

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P5L9	Leptomonas seymouri	65%	93%
A0A3Q8IJ18	Leishmania donovani	100%	96%
A4HM64	Leishmania braziliensis	82%	100%
E9AEK2	Leishmania major	94%	100%
E9B5R3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	100%