LeishMANIAdb
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C3H1-type domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
C3H1-type domain-containing protein
Gene product:
hypothetical protein - conserved
Species:
Leishmania infantum
UniProt:
A4IAS4_LEIIN
TriTrypDb:
LINF_350007400
Length:
368

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 9
NetGPI no yes: 0, no: 9
Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4IAS4
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4IAS4

Function

Could not find GO biological_process term for this entry.
Molecular functions
TermNameLevelCount
GO:0003676 nucleic acid binding 3 1
GO:0003723 RNA binding 4 1
GO:0005488 binding 1 10
GO:0043167 ion binding 2 10
GO:0043169 cation binding 3 10
GO:0046872 metal ion binding 4 10
GO:0097159 organic cyclic compound binding 2 1
GO:1901363 heterocyclic compound binding 2 1
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Putative motif mimicry

LeishmaniaFromToDomain/MotifScore
CLV_C14_Caspase3-7 191 195 PF00656 0.691
CLV_NRD_NRD_1 128 130 PF00675 0.661
CLV_PCSK_KEX2_1 127 129 PF00082 0.688
CLV_PCSK_KEX2_1 245 247 PF00082 0.480
CLV_PCSK_PC1ET2_1 245 247 PF00082 0.501
CLV_PCSK_SKI1_1 103 107 PF00082 0.515
CLV_PCSK_SKI1_1 266 270 PF00082 0.441
DEG_SPOP_SBC_1 12 16 PF00917 0.644
DOC_ANK_TNKS_1 126 133 PF00023 0.773
DOC_MAPK_MEF2A_6 34 41 PF00069 0.410
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Homologs

ProteinTaxonomySequence identityCoverage
A0A0N1I3P9 Leptomonas seymouri 59% 99%
A0A1X0NKL5 Trypanosomatidae 43% 98%
A0A3Q8IV00 Leishmania donovani 100% 100%
A0A422NNF8 Trypanosoma rangeli 41% 99%
A4HM62 Leishmania braziliensis 74% 99%
E9AEK0 Leishmania major 92% 100%
E9B5R1 Leishmania mexicana (strain MHOM/GT/2001/U1103) 92% 100%
V5BNB0 Trypanosoma cruzi 41% 100%
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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS