C3H1-type domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4IAS4_LEIIN

TriTrypDb:

LINF_350007400

Length:

368

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4IAS4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4IAS4

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	10
GO:0043167	ion binding	2	10
GO:0043169	cation binding	3	10
GO:0046872	metal ion binding	4	10
GO:0003676	nucleic acid binding	3	1
GO:0003723	RNA binding	4	1
GO:0097159	organic cyclic compound binding	2	1
GO:1901363	heterocyclic compound binding	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	191	195	PF00656	0.691
CLV_NRD_NRD_1	128	130	PF00675	0.661
CLV_PCSK_KEX2_1	127	129	PF00082	0.688
CLV_PCSK_KEX2_1	245	247	PF00082	0.480
CLV_PCSK_PC1ET2_1	245	247	PF00082	0.501
CLV_PCSK_SKI1_1	103	107	PF00082	0.515
CLV_PCSK_SKI1_1	266	270	PF00082	0.441
DEG_SPOP_SBC_1	12	16	PF00917	0.644
DOC_ANK_TNKS_1	126	133	PF00023	0.773
DOC_MAPK_MEF2A_6	34	41	PF00069	0.410
DOC_PP2B_LxvP_1	137	140	PF13499	0.559
DOC_PP2B_LxvP_1	221	224	PF13499	0.473
DOC_USP7_MATH_1	209	213	PF00917	0.509
DOC_USP7_MATH_1	30	34	PF00917	0.573
DOC_USP7_MATH_1	48	52	PF00917	0.497
DOC_USP7_MATH_1	75	79	PF00917	0.441
DOC_USP7_MATH_1	86	90	PF00917	0.461
DOC_USP7_UBL2_3	170	174	PF12436	0.534
DOC_USP7_UBL2_3	241	245	PF12436	0.545
DOC_WW_Pin1_4	110	115	PF00397	0.659
DOC_WW_Pin1_4	143	148	PF00397	0.667
DOC_WW_Pin1_4	16	21	PF00397	0.665
DOC_WW_Pin1_4	175	180	PF00397	0.572
DOC_WW_Pin1_4	304	309	PF00397	0.698
LIG_14-3-3_CanoR_1	103	112	PF00244	0.539
LIG_14-3-3_CanoR_1	122	131	PF00244	0.702
LIG_14-3-3_CanoR_1	157	167	PF00244	0.710
LIG_14-3-3_CanoR_1	341	347	PF00244	0.668
LIG_DCNL_PONY_1	1	4	PF03556	0.641
LIG_FHA_1	321	327	PF00498	0.767
LIG_FHA_2	189	195	PF00498	0.615
LIG_FHA_2	214	220	PF00498	0.430
LIG_LIR_Apic_2	350	354	PF02991	0.501
LIG_LIR_Gen_1	216	224	PF02991	0.425
LIG_LIR_LC3C_4	134	139	PF02991	0.729
LIG_LIR_Nem_3	106	112	PF02991	0.681
LIG_LIR_Nem_3	216	221	PF02991	0.408
LIG_LIR_Nem_3	345	351	PF02991	0.535
LIG_PAM2_1	2	14	PF00658	0.646
LIG_PTAP_UEV_1	282	287	PF05743	0.558
LIG_SH2_CRK	218	222	PF00017	0.431
LIG_SH2_CRK	351	355	PF00017	0.496
LIG_SH2_GRB2like	42	45	PF00017	0.516
LIG_SH2_SRC	42	45	PF00017	0.516
LIG_SH2_STAP1	218	222	PF00017	0.530
LIG_SH2_STAP1	278	282	PF00017	0.454
LIG_SH2_STAP1	348	352	PF00017	0.665
LIG_SH2_STAT3	278	281	PF00017	0.560
LIG_SH3_2	283	288	PF14604	0.689
LIG_SH3_3	141	147	PF00018	0.746
LIG_SH3_3	280	286	PF00018	0.642
LIG_SUMO_SIM_par_1	354	360	PF11976	0.614
MOD_CDK_SPxK_1	304	310	PF00069	0.723
MOD_CDK_SPxxK_3	110	117	PF00069	0.519
MOD_CK1_1	14	20	PF00069	0.709
MOD_CK1_1	153	159	PF00069	0.639
MOD_CK1_1	161	167	PF00069	0.636
MOD_CK1_1	173	179	PF00069	0.536
MOD_CK1_1	293	299	PF00069	0.616
MOD_CK1_1	303	309	PF00069	0.692
MOD_CK1_1	317	323	PF00069	0.560
MOD_CK1_1	342	348	PF00069	0.726
MOD_CK2_1	157	163	PF00069	0.682
MOD_CK2_1	319	325	PF00069	0.707
MOD_CK2_1	48	54	PF00069	0.557
MOD_CK2_1	86	92	PF00069	0.569
MOD_GlcNHglycan	160	163	PF01048	0.764
MOD_GlcNHglycan	20	23	PF01048	0.687
MOD_GlcNHglycan	283	286	PF01048	0.604
MOD_GlcNHglycan	292	295	PF01048	0.635
MOD_GSK3_1	152	159	PF00069	0.625
MOD_GSK3_1	170	177	PF00069	0.699
MOD_GSK3_1	209	216	PF00069	0.505
MOD_GSK3_1	299	306	PF00069	0.659
MOD_GSK3_1	310	317	PF00069	0.608
MOD_GSK3_1	337	344	PF00069	0.608
MOD_GSK3_1	57	64	PF00069	0.532
MOD_GSK3_1	7	14	PF00069	0.586
MOD_LATS_1	339	345	PF00433	0.671
MOD_N-GLC_1	342	347	PF02516	0.728
MOD_NEK2_1	301	306	PF00069	0.740
MOD_NEK2_1	330	335	PF00069	0.679
MOD_NEK2_1	337	342	PF00069	0.689
MOD_NEK2_1	70	75	PF00069	0.506
MOD_NEK2_1	84	89	PF00069	0.454
MOD_PIKK_1	225	231	PF00454	0.503
MOD_PIKK_1	310	316	PF00454	0.730
MOD_PIKK_1	63	69	PF00454	0.450
MOD_PKA_2	156	162	PF00069	0.638
MOD_PKA_2	57	63	PF00069	0.516
MOD_Plk_1	120	126	PF00069	0.719
MOD_Plk_1	24	30	PF00069	0.527
MOD_Plk_1	342	348	PF00069	0.729
MOD_Plk_4	213	219	PF00069	0.416
MOD_Plk_4	342	348	PF00069	0.677
MOD_ProDKin_1	110	116	PF00069	0.660
MOD_ProDKin_1	143	149	PF00069	0.668
MOD_ProDKin_1	16	22	PF00069	0.669
MOD_ProDKin_1	175	181	PF00069	0.573
MOD_ProDKin_1	304	310	PF00069	0.700
TRG_DiLeu_BaEn_1	332	337	PF01217	0.554
TRG_ENDOCYTIC_2	109	112	PF00928	0.705
TRG_ENDOCYTIC_2	217	220	PF00928	0.403
TRG_ER_diArg_1	127	129	PF00400	0.743
TRG_ER_diArg_1	204	207	PF00400	0.504
TRG_NES_CRM1_1	67	77	PF08389	0.532
TRG_Pf-PMV_PEXEL_1	103	108	PF00026	0.621
TRG_Pf-PMV_PEXEL_1	260	264	PF00026	0.523

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I3P9	Leptomonas seymouri	59%	99%
A0A1X0NKL5	Trypanosomatidae	43%	98%
A0A3Q8IV00	Leishmania donovani	100%	100%
A0A422NNF8	Trypanosoma rangeli	41%	99%
A4HM62	Leishmania braziliensis	74%	99%
E9AEK0	Leishmania major	92%	100%
E9B5R1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	100%
V5BNB0	Trypanosoma cruzi	41%	100%