Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4IAS3_LEIIN

TriTrypDb:

LINF_350007300

Length:

263

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005743	mitochondrial inner membrane	5	10
GO:0016020	membrane	2	10
GO:0019866	organelle inner membrane	4	10
GO:0031090	organelle membrane	3	10
GO:0031966	mitochondrial membrane	4	10
GO:0110165	cellular anatomical entity	1	10
GO:0005747	mitochondrial respiratory chain complex I	4	1
GO:0030964	NADH dehydrogenase complex	3	1
GO:0032991	protein-containing complex	1	1
GO:0045271	respiratory chain complex I	4	1
GO:0098796	membrane protein complex	2	1
GO:0098798	mitochondrial protein-containing complex	2	1
GO:0098800	inner mitochondrial membrane protein complex	3	1
GO:0098803	respiratory chain complex	3	1
GO:1902494	catalytic complex	2	1
GO:1902495	transmembrane transporter complex	3	1
GO:1990204	oxidoreductase complex	3	1
GO:1990351	transporter complex	2	1

Expansion

Sequence features

A4IAS3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4IAS3

Function

Biological processes
Term	Name	Level	Count
GO:0006091	generation of precursor metabolites and energy	3	11
GO:0008152	metabolic process	1	11
GO:0009987	cellular process	1	11
GO:0022900	electron transport chain	4	11
GO:0022904	respiratory electron transport chain	5	11
GO:0044237	cellular metabolic process	2	11

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	168	170	PF00675	0.543
CLV_NRD_NRD_1	198	200	PF00675	0.489
CLV_PCSK_KEX2_1	138	140	PF00082	0.611
CLV_PCSK_KEX2_1	168	170	PF00082	0.542
CLV_PCSK_KEX2_1	182	184	PF00082	0.474
CLV_PCSK_KEX2_1	221	223	PF00082	0.492
CLV_PCSK_KEX2_1	81	83	PF00082	0.398
CLV_PCSK_PC1ET2_1	138	140	PF00082	0.611
CLV_PCSK_PC1ET2_1	168	170	PF00082	0.561
CLV_PCSK_PC1ET2_1	182	184	PF00082	0.487
CLV_PCSK_PC1ET2_1	221	223	PF00082	0.492
CLV_PCSK_PC1ET2_1	81	83	PF00082	0.417
CLV_PCSK_SKI1_1	16	20	PF00082	0.588
CLV_PCSK_SKI1_1	170	174	PF00082	0.531
CLV_PCSK_SKI1_1	216	220	PF00082	0.484
CLV_PCSK_SKI1_1	5	9	PF00082	0.596
CLV_PCSK_SKI1_1	99	103	PF00082	0.528
DEG_Nend_Nbox_1	1	3	PF02207	0.636
DEG_SPOP_SBC_1	31	35	PF00917	0.469
DOC_CKS1_1	154	159	PF01111	0.611
DOC_USP7_MATH_1	10	14	PF00917	0.673
DOC_USP7_MATH_1	234	238	PF00917	0.662
DOC_USP7_MATH_1	30	34	PF00917	0.281
DOC_USP7_MATH_1	52	56	PF00917	0.450
DOC_USP7_UBL2_3	217	221	PF12436	0.485
DOC_WW_Pin1_4	153	158	PF00397	0.543
DOC_WW_Pin1_4	254	259	PF00397	0.673
LIG_14-3-3_CanoR_1	251	255	PF00244	0.692
LIG_deltaCOP1_diTrp_1	126	130	PF00928	0.455
LIG_deltaCOP1_diTrp_1	92	101	PF00928	0.512
LIG_FHA_1	12	18	PF00498	0.553
LIG_FHA_1	32	38	PF00498	0.262
LIG_FHA_1	61	67	PF00498	0.458
LIG_FHA_1	74	80	PF00498	0.442
LIG_FHA_2	112	118	PF00498	0.398
LIG_FHA_2	154	160	PF00498	0.599
LIG_FHA_2	17	23	PF00498	0.556
LIG_FHA_2	172	178	PF00498	0.395
LIG_LIR_Gen_1	156	166	PF02991	0.532
LIG_LIR_Gen_1	92	102	PF02991	0.382
LIG_LIR_Nem_3	114	118	PF02991	0.406
LIG_LIR_Nem_3	126	132	PF02991	0.438
LIG_LIR_Nem_3	156	161	PF02991	0.533
LIG_LIR_Nem_3	69	75	PF02991	0.429
LIG_LIR_Nem_3	92	97	PF02991	0.381
LIG_Pex14_1	105	109	PF04695	0.378
LIG_Pex14_2	101	105	PF04695	0.522
LIG_PTB_Apo_2	217	224	PF02174	0.486
LIG_PTB_Phospho_1	217	223	PF10480	0.599
LIG_SH2_GRB2like	72	75	PF00017	0.414
LIG_SH2_STAT3	109	112	PF00017	0.384
LIG_SH2_STAT5	109	112	PF00017	0.417
LIG_SH2_STAT5	24	27	PF00017	0.526
LIG_SUMO_SIM_par_1	13	23	PF11976	0.658
LIG_TRAF2_1	174	177	PF00917	0.534
LIG_UBA3_1	229	236	PF00899	0.704
LIG_UBA3_1	246	255	PF00899	0.365
MOD_CK1_1	239	245	PF00069	0.530
MOD_CK2_1	111	117	PF00069	0.395
MOD_CK2_1	153	159	PF00069	0.541
MOD_CK2_1	171	177	PF00069	0.508
MOD_CMANNOS	124	127	PF00535	0.438
MOD_GlcNHglycan	238	241	PF01048	0.554
MOD_GSK3_1	12	19	PF00069	0.666
MOD_GSK3_1	250	257	PF00069	0.672
MOD_N-GLC_1	73	78	PF02516	0.518
MOD_NEK2_1	1	6	PF00069	0.542
MOD_NEK2_1	11	16	PF00069	0.571
MOD_NEK2_1	111	116	PF00069	0.398
MOD_NEK2_1	250	255	PF00069	0.616
MOD_PIKK_1	171	177	PF00454	0.537
MOD_PKA_2	190	196	PF00069	0.487
MOD_PKA_2	250	256	PF00069	0.659
MOD_Plk_1	68	74	PF00069	0.429
MOD_Plk_2-3	93	99	PF00069	0.378
MOD_Plk_4	68	74	PF00069	0.429
MOD_Plk_4	75	81	PF00069	0.399
MOD_ProDKin_1	153	159	PF00069	0.541
MOD_ProDKin_1	254	260	PF00069	0.677
MOD_SUMO_rev_2	176	184	PF00179	0.518
MOD_SUMO_rev_2	92	102	PF00179	0.470
TRG_DiLeu_BaEn_2	55	61	PF01217	0.398
TRG_DiLeu_BaEn_4	176	182	PF01217	0.519
TRG_DiLeu_BaLyEn_6	13	18	PF01217	0.652
TRG_ENDOCYTIC_2	72	75	PF00928	0.414
TRG_NLS_MonoExtN_4	168	173	PF00514	0.542

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PE52	Leptomonas seymouri	92%	100%
A0A0S4JMX5	Bodo saltans	81%	100%
A0A1X0NKS0	Trypanosomatidae	85%	99%
A0A3S7X8P0	Leishmania donovani	100%	100%
A4HM61	Leishmania braziliensis	96%	100%
D0A2D5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	86%	99%
E9AEJ9	Leishmania major	98%	100%
E9B5R0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	99%	100%
V5BSV6	Trypanosoma cruzi	86%	99%