Coiled-coil domain-containing protein 63

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4IAR8_LEIIN

TriTrypDb:

LINF_350006800

Length:

341

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4IAR8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4IAR8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	22	24	PF00675	0.414
CLV_NRD_NRD_1	262	264	PF00675	0.438
CLV_NRD_NRD_1	279	281	PF00675	0.416
CLV_NRD_NRD_1	288	290	PF00675	0.418
CLV_NRD_NRD_1	45	47	PF00675	0.437
CLV_NRD_NRD_1	72	74	PF00675	0.534
CLV_PCSK_FUR_1	23	27	PF00082	0.397
CLV_PCSK_KEX2_1	18	20	PF00082	0.549
CLV_PCSK_KEX2_1	25	27	PF00082	0.471
CLV_PCSK_KEX2_1	288	290	PF00082	0.418
CLV_PCSK_KEX2_1	74	76	PF00082	0.489
CLV_PCSK_PC1ET2_1	18	20	PF00082	0.549
CLV_PCSK_PC1ET2_1	25	27	PF00082	0.471
CLV_PCSK_PC1ET2_1	74	76	PF00082	0.489
CLV_PCSK_SKI1_1	134	138	PF00082	0.547
CLV_PCSK_SKI1_1	280	284	PF00082	0.603
CLV_PCSK_SKI1_1	75	79	PF00082	0.468
DEG_Nend_UBRbox_3	1	3	PF02207	0.559
DOC_CYCLIN_RxL_1	128	138	PF00134	0.541
DOC_MAPK_gen_1	186	195	PF00069	0.479
DOC_MAPK_gen_1	261	268	PF00069	0.508
DOC_PP1_RVXF_1	45	52	PF00149	0.523
DOC_PP1_SILK_1	318	323	PF00149	0.492
DOC_PP2B_LxvP_1	321	324	PF13499	0.617
DOC_USP7_UBL2_3	25	29	PF12436	0.461
DOC_USP7_UBL2_3	74	78	PF12436	0.450
LIG_14-3-3_CanoR_1	156	162	PF00244	0.541
LIG_14-3-3_CanoR_1	224	234	PF00244	0.460
LIG_14-3-3_CanoR_1	26	32	PF00244	0.473
LIG_14-3-3_CanoR_1	289	295	PF00244	0.476
LIG_14-3-3_CanoR_1	322	332	PF00244	0.511
LIG_14-3-3_CanoR_1	46	52	PF00244	0.272
LIG_14-3-3_CanoR_1	86	92	PF00244	0.486
LIG_FHA_1	161	167	PF00498	0.633
LIG_FHA_1	170	176	PF00498	0.515
LIG_FHA_1	225	231	PF00498	0.443
LIG_FHA_1	26	32	PF00498	0.451
LIG_FHA_2	112	118	PF00498	0.567
LIG_FHA_2	6	12	PF00498	0.451
LIG_GBD_Chelix_1	91	99	PF00786	0.487
LIG_NRBOX	12	18	PF00104	0.479
LIG_NRBOX	229	235	PF00104	0.431
LIG_PCNA_yPIPBox_3	36	49	PF02747	0.536
LIG_REV1ctd_RIR_1	220	228	PF16727	0.440
LIG_SH2_NCK_1	273	277	PF00017	0.463
LIG_SH2_SRC	273	276	PF00017	0.468
LIG_SH2_STAT5	157	160	PF00017	0.509
LIG_SH2_STAT5	165	168	PF00017	0.485
LIG_SH2_STAT5	20	23	PF00017	0.528
LIG_SH2_STAT5	48	51	PF00017	0.528
LIG_SUMO_SIM_anti_2	191	197	PF11976	0.381
LIG_SUMO_SIM_par_1	309	315	PF11976	0.530
LIG_TRAF2_1	115	118	PF00917	0.503
LIG_TRAF2_1	30	33	PF00917	0.513
LIG_WRC_WIRS_1	127	132	PF05994	0.487
LIG_WRC_WIRS_1	219	224	PF05994	0.537
LIG_WRC_WIRS_1	48	53	PF05994	0.366
MOD_CK1_1	144	150	PF00069	0.581
MOD_CK1_1	155	161	PF00069	0.453
MOD_CK1_1	326	332	PF00069	0.623
MOD_CK2_1	111	117	PF00069	0.568
MOD_CK2_1	158	164	PF00069	0.615
MOD_CK2_1	27	33	PF00069	0.464
MOD_CK2_1	47	53	PF00069	0.412
MOD_GlcNHglycan	301	304	PF01048	0.416
MOD_GlcNHglycan	38	42	PF01048	0.429
MOD_GSK3_1	126	133	PF00069	0.458
MOD_GSK3_1	214	221	PF00069	0.538
MOD_GSK3_1	322	329	PF00069	0.593
MOD_NEK2_1	130	135	PF00069	0.470
MOD_NEK2_1	141	146	PF00069	0.586
MOD_NEK2_1	152	157	PF00069	0.476
MOD_NEK2_1	218	223	PF00069	0.541
MOD_PKA_1	25	31	PF00069	0.386
MOD_PKA_2	155	161	PF00069	0.529
MOD_PKA_2	214	220	PF00069	0.484
MOD_PKA_2	223	229	PF00069	0.403
MOD_PKA_2	25	31	PF00069	0.406
MOD_Plk_1	158	164	PF00069	0.538
MOD_Plk_4	214	220	PF00069	0.424
MOD_SUMO_for_1	35	38	PF00179	0.510
MOD_SUMO_rev_2	50	56	PF00179	0.431
TRG_DiLeu_BaEn_1	12	17	PF01217	0.541
TRG_DiLeu_BaEn_1	191	196	PF01217	0.381
TRG_DiLeu_BaEn_1	214	219	PF01217	0.532
TRG_DiLeu_BaLyEn_6	229	234	PF01217	0.433
TRG_ENDOCYTIC_2	48	51	PF00928	0.528
TRG_ER_diArg_1	288	290	PF00400	0.418
TRG_NES_CRM1_1	257	271	PF08389	0.565
TRG_NES_CRM1_1	312	327	PF08389	0.522
TRG_NLS_MonoExtN_4	23	28	PF00514	0.383
TRG_Pf-PMV_PEXEL_1	134	138	PF00026	0.547
TRG_Pf-PMV_PEXEL_1	232	236	PF00026	0.442
TRG_Pf-PMV_PEXEL_1	29	33	PF00026	0.577
TRG_Pf-PMV_PEXEL_1	68	72	PF00026	0.524

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P5M0	Leptomonas seymouri	38%	100%
A0A3Q8INY6	Leishmania donovani	99%	100%
A4HM56	Leishmania braziliensis	60%	100%
E9AEJ4	Leishmania major	87%	100%
E9B5Q5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	84%	100%