Uncharacterized protein

Quick info Annotations Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4IAR6_LEIIN

TriTrypDb:

LINF_350006600

Length:

290

Annotations

LeishMANIAdb annotations

A conserved mitochondrial transporter, might be an ADP/ATP translocase

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	10
GO:0110165	cellular anatomical entity	1	10

Expansion

Sequence features

A4IAR6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4IAR6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	288	290	PF00675	0.492
CLV_PCSK_KEX2_1	288	290	PF00082	0.492
CLV_PCSK_KEX2_1	48	50	PF00082	0.654
CLV_PCSK_PC1ET2_1	48	50	PF00082	0.662
CLV_PCSK_PC7_1	284	290	PF00082	0.563
CLV_PCSK_SKI1_1	238	242	PF00082	0.605
CLV_PCSK_SKI1_1	51	55	PF00082	0.637
DEG_APCC_DBOX_1	50	58	PF00400	0.409
DOC_CYCLIN_yCln2_LP_2	57	63	PF00134	0.395
DOC_MAPK_MEF2A_6	222	231	PF00069	0.394
DOC_PP2B_LxvP_1	186	189	PF13499	0.436
DOC_PP2B_LxvP_1	63	66	PF13499	0.390
DOC_USP7_MATH_1	10	14	PF00917	0.449
LIG_14-3-3_CanoR_1	191	195	PF00244	0.375
LIG_14-3-3_CanoR_1	246	250	PF00244	0.368
LIG_APCC_ABBA_1	21	26	PF00400	0.408
LIG_BIR_II_1	1	5	PF00653	0.591
LIG_BRCT_BRCA1_1	12	16	PF00533	0.485
LIG_BRCT_BRCA1_1	165	169	PF00533	0.437
LIG_BRCT_BRCA1_1	251	255	PF00533	0.321
LIG_BRCT_BRCA1_1	286	290	PF00533	0.705
LIG_deltaCOP1_diTrp_1	171	177	PF00928	0.348
LIG_EH1_1	176	184	PF00400	0.390
LIG_FHA_1	185	191	PF00498	0.339
LIG_FHA_1	256	262	PF00498	0.348
LIG_FHA_1	4	10	PF00498	0.365
LIG_LIR_Apic_2	110	115	PF02991	0.582
LIG_LIR_Gen_1	13	24	PF02991	0.471
LIG_LIR_Gen_1	171	182	PF02991	0.346
LIG_LIR_Gen_1	258	265	PF02991	0.344
LIG_LIR_Nem_3	13	19	PF02991	0.420
LIG_LIR_Nem_3	171	177	PF02991	0.348
LIG_LIR_Nem_3	258	262	PF02991	0.344
LIG_NRBOX	85	91	PF00104	0.408
LIG_Pex14_2	286	290	PF04695	0.705
LIG_Pex14_2	72	76	PF04695	0.485
LIG_SH2_CRK	112	116	PF00017	0.631
LIG_SH2_CRK	120	124	PF00017	0.565
LIG_SH2_CRK	134	138	PF00017	0.462
LIG_SH2_STAP1	165	169	PF00017	0.457
LIG_SH2_STAP1	93	97	PF00017	0.641
LIG_SH2_STAT5	213	216	PF00017	0.451
LIG_SH2_STAT5	45	48	PF00017	0.461
LIG_SH2_STAT5	71	74	PF00017	0.401
LIG_SH2_STAT5	93	96	PF00017	0.641
LIG_SUMO_SIM_anti_2	157	162	PF11976	0.361
LIG_TRAF2_1	232	235	PF00917	0.394
LIG_WRC_WIRS_1	136	141	PF05994	0.401
LIG_WRC_WIRS_1	182	187	PF05994	0.352
MOD_CK1_1	110	116	PF00069	0.594
MOD_CK1_1	14	20	PF00069	0.230
MOD_CK1_1	201	207	PF00069	0.450
MOD_CK1_1	3	9	PF00069	0.401
MOD_CK2_1	165	171	PF00069	0.463
MOD_GlcNHglycan	120	123	PF01048	0.466
MOD_GlcNHglycan	129	132	PF01048	0.344
MOD_GlcNHglycan	202	206	PF01048	0.630
MOD_GlcNHglycan	29	32	PF01048	0.622
MOD_GSK3_1	10	17	PF00069	0.414
MOD_GSK3_1	161	168	PF00069	0.455
MOD_GSK3_1	190	197	PF00069	0.402
MOD_GSK3_1	241	248	PF00069	0.364
MOD_N-GLC_1	241	246	PF02516	0.605
MOD_NEK2_1	144	149	PF00069	0.412
MOD_NEK2_1	161	166	PF00069	0.249
MOD_NEK2_1	194	199	PF00069	0.432
MOD_NEK2_1	241	246	PF00069	0.382
MOD_NEK2_1	249	254	PF00069	0.352
MOD_NEK2_1	255	260	PF00069	0.324
MOD_NEK2_1	53	58	PF00069	0.434
MOD_NEK2_1	91	96	PF00069	0.525
MOD_NEK2_2	11	16	PF00069	0.452
MOD_NEK2_2	135	140	PF00069	0.369
MOD_PIKK_1	55	61	PF00454	0.376
MOD_PKA_2	110	116	PF00069	0.685
MOD_PKA_2	190	196	PF00069	0.376
MOD_PKA_2	245	251	PF00069	0.370
MOD_Plk_4	11	17	PF00069	0.364
MOD_Plk_4	135	141	PF00069	0.392
MOD_Plk_4	144	150	PF00069	0.328
MOD_Plk_4	181	187	PF00069	0.383
MOD_Plk_4	194	200	PF00069	0.436
MOD_Plk_4	93	99	PF00069	0.632
TRG_ENDOCYTIC_2	120	123	PF00928	0.567
TRG_ENDOCYTIC_2	134	137	PF00928	0.476
TRG_ENDOCYTIC_2	24	27	PF00928	0.358
TRG_ENDOCYTIC_2	259	262	PF00928	0.444
TRG_ENDOCYTIC_2	50	53	PF00928	0.362
TRG_ER_diArg_1	288	290	PF00400	0.670

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0S4JQQ1	Bodo saltans	37%	98%
A0A1X0NJA4	Trypanosomatidae	46%	100%
A0A3S7X8R5	Leishmania donovani	100%	100%
A4HM54	Leishmania braziliensis	86%	100%
D0A2E6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	47%	100%
E9AEJ2	Leishmania major	95%	100%
E9B5Q3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	96%	100%
V5BNB5	Trypanosoma cruzi	47%	100%