Uncharacterized protein

Quick info Annotations Localization Abundance Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4IAR5_LEIIN

TriTrypDb:

LINF_350006500

Length:

119

Annotations

Annotations by Jardim et al.

Uncharacterized Protein, Uncharacterized

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	yes	yes: 18

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	9
GO:0110165	cellular anatomical entity	1	9

Abundance

Amastigote (protein)


Source	Evidence on protein	Close homologs
Pescher et al. (upgregulation)	no	yes: 0

Promastigote and amastigote


Source	Evidence on protein	Close homologs
Lahav et al. - mRNA - Protein

Expansion

Sequence features

A4IAR5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4IAR5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	113	115	PF00675	0.591
CLV_NRD_NRD_1	32	34	PF00675	0.367
CLV_PCSK_KEX2_1	31	33	PF00082	0.365
CLV_PCSK_KEX2_1	45	47	PF00082	0.345
CLV_PCSK_PC1ET2_1	31	33	PF00082	0.365
CLV_PCSK_PC1ET2_1	45	47	PF00082	0.345
CLV_PCSK_PC7_1	27	33	PF00082	0.369
DEG_Nend_Nbox_1	1	3	PF02207	0.636
DOC_USP7_MATH_1	38	42	PF00917	0.663
LIG_14-3-3_CanoR_1	3	7	PF00244	0.651
LIG_14-3-3_CanoR_1	60	67	PF00244	0.508
LIG_EH1_1	86	94	PF00400	0.329
LIG_LIR_Gen_1	58	67	PF02991	0.517
LIG_LIR_Gen_1	79	90	PF02991	0.313
LIG_LIR_Nem_3	58	64	PF02991	0.509
LIG_LIR_Nem_3	69	73	PF02991	0.497
LIG_LIR_Nem_3	79	85	PF02991	0.291
LIG_Pex14_2	48	52	PF04695	0.539
LIG_SH2_CRK	82	86	PF00017	0.314
LIG_SH2_NCK_1	82	86	PF00017	0.441
LIG_SH2_SRC	109	112	PF00017	0.405
LIG_SH2_STAP1	109	113	PF00017	0.302
LIG_SH2_STAP1	61	65	PF00017	0.506
LIG_SH2_STAT5	70	73	PF00017	0.525
LIG_SH2_STAT5	88	91	PF00017	0.296
LIG_SH3_3	12	18	PF00018	0.608
LIG_UBA3_1	95	104	PF00899	0.395
MOD_CK1_1	72	78	PF00069	0.504
MOD_CMANNOS	77	80	PF00535	0.306
MOD_GSK3_1	72	79	PF00069	0.508
MOD_N-GLC_1	48	53	PF02516	0.416
MOD_NEK2_1	2	7	PF00069	0.615
MOD_NEK2_2	109	114	PF00069	0.408
MOD_PKA_2	2	8	PF00069	0.616
MOD_PKA_2	59	65	PF00069	0.514
MOD_Plk_1	109	115	PF00069	0.409
MOD_Plk_1	48	54	PF00069	0.614
MOD_Plk_4	18	24	PF00069	0.678
MOD_Plk_4	2	8	PF00069	0.705
MOD_Plk_4	76	82	PF00069	0.443
MOD_Plk_4	88	94	PF00069	0.350
TRG_ENDOCYTIC_2	61	64	PF00928	0.511
TRG_ENDOCYTIC_2	70	73	PF00928	0.511
TRG_ENDOCYTIC_2	82	85	PF00928	0.310
TRG_ER_diArg_1	32	34	PF00400	0.567
TRG_Pf-PMV_PEXEL_1	32	37	PF00026	0.369

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P5M2	Leptomonas seymouri	88%	100%
A0A1X0NJM2	Trypanosomatidae	79%	100%
A0A3S7X8W1	Leishmania donovani	100%	100%
A0A422N7I5	Trypanosoma rangeli	78%	99%
A4HM53	Leishmania braziliensis	96%	100%
D0A2E7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	77%	99%
E9AEJ1	Leishmania major	98%	100%
E9B5Q2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	97%	100%
V5BNC2	Trypanosoma cruzi	73%	99%