Coatomer subunit zeta

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

coatomer subunit zeta - putative

Species:

Leishmania infantum

UniProt:

A4IAR2_LEIIN

TriTrypDb:

LINF_350006200

Length:

184

Annotations

Annotations by Jardim et al.

Intracellular protein trafficking, coatomer zeta subunit

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 10

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0000139	Golgi membrane	5	11
GO:0016020	membrane	2	11
GO:0030117	membrane coat	3	11
GO:0030120	vesicle coat	4	11
GO:0030126	COPI vesicle coat	5	11
GO:0031090	organelle membrane	3	11
GO:0032991	protein-containing complex	1	11
GO:0098588	bounding membrane of organelle	4	11
GO:0098796	membrane protein complex	2	11
GO:0110165	cellular anatomical entity	1	11

Expansion

Sequence features

A4IAR2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4IAR2

Function

Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	11
GO:0006890	retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum	6	11
GO:0008104	protein localization	4	11
GO:0009987	cellular process	1	11
GO:0015031	protein transport	4	11
GO:0016192	vesicle-mediated transport	4	11
GO:0033036	macromolecule localization	2	11
GO:0045184	establishment of protein localization	3	11
GO:0048193	Golgi vesicle transport	5	11
GO:0051179	localization	1	11
GO:0051234	establishment of localization	2	11
GO:0051641	cellular localization	2	11
GO:0070727	cellular macromolecule localization	3	11
GO:0071702	organic substance transport	4	11
GO:0071705	nitrogen compound transport	4	11
GO:0006886	intracellular protein transport	4	1
GO:0006891	intra-Golgi vesicle-mediated transport	6	1
GO:0046907	intracellular transport	3	1
GO:0051649	establishment of localization in cell	3	1

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	58	60	PF00675	0.380
CLV_PCSK_KEX2_1	58	60	PF00082	0.298
CLV_PCSK_SKI1_1	123	127	PF00082	0.317
CLV_PCSK_SKI1_1	170	174	PF00082	0.463
DEG_APCC_DBOX_1	169	177	PF00400	0.454
DEG_SCF_FBW7_1	115	121	PF00400	0.408
DOC_CKS1_1	115	120	PF01111	0.413
DOC_CYCLIN_RxL_1	120	127	PF00134	0.424
DOC_USP7_MATH_1	31	35	PF00917	0.424
DOC_USP7_MATH_1	64	68	PF00917	0.314
DOC_WW_Pin1_4	114	119	PF00397	0.419
DOC_WW_Pin1_4	27	32	PF00397	0.390
LIG_BIR_II_1	1	5	PF00653	0.558
LIG_BRCT_BRCA1_1	17	21	PF00533	0.456
LIG_BRCT_BRCA1_2	17	23	PF00533	0.408
LIG_Clathr_ClatBox_1	133	137	PF01394	0.376
LIG_eIF4E_1	65	71	PF01652	0.408
LIG_FHA_1	115	121	PF00498	0.421
LIG_FHA_1	84	90	PF00498	0.345
LIG_FHA_2	133	139	PF00498	0.317
LIG_GBD_Chelix_1	107	115	PF00786	0.317
LIG_LIR_Gen_1	127	136	PF02991	0.317
LIG_LIR_LC3C_4	67	72	PF02991	0.404
LIG_LIR_Nem_3	127	132	PF02991	0.317
LIG_LIR_Nem_3	18	24	PF02991	0.408
LIG_PDZ_Class_3	179	184	PF00595	0.419
LIG_Pex14_2	21	25	PF04695	0.424
LIG_RPA_C_Fungi	1	13	PF08784	0.408
LIG_SH2_CRK	129	133	PF00017	0.298
LIG_SH2_STAP1	65	69	PF00017	0.424
LIG_SH2_STAT5	129	132	PF00017	0.465
LIG_SH2_STAT5	160	163	PF00017	0.580
LIG_SH2_STAT5	179	182	PF00017	0.413
LIG_SH2_STAT5	24	27	PF00017	0.324
LIG_SUMO_SIM_anti_2	66	73	PF11976	0.423
LIG_SUMO_SIM_anti_2	82	89	PF11976	0.432
LIG_SUMO_SIM_par_1	160	165	PF11976	0.605
LIG_SUMO_SIM_par_1	66	73	PF11976	0.401
MOD_CK1_1	165	171	PF00069	0.555
MOD_CK2_1	132	138	PF00069	0.317
MOD_CK2_1	91	97	PF00069	0.425
MOD_GlcNHglycan	149	152	PF01048	0.403
MOD_GSK3_1	114	121	PF00069	0.427
MOD_GSK3_1	145	152	PF00069	0.421
MOD_GSK3_1	27	34	PF00069	0.437
MOD_GSK3_1	79	86	PF00069	0.419
MOD_N-GLC_1	13	18	PF02516	0.368
MOD_N-GLC_1	165	170	PF02516	0.594
MOD_N-GLC_2	128	130	PF02516	0.408
MOD_NEK2_1	13	18	PF00069	0.431
MOD_Plk_1	83	89	PF00069	0.345
MOD_Plk_4	83	89	PF00069	0.325
MOD_ProDKin_1	114	120	PF00069	0.419
MOD_ProDKin_1	27	33	PF00069	0.390
TRG_DiLeu_BaEn_1	66	71	PF01217	0.408
TRG_DiLeu_BaLyEn_6	120	125	PF01217	0.376
TRG_ENDOCYTIC_2	129	132	PF00928	0.298
TRG_ER_diArg_1	57	59	PF00400	0.424
TRG_Pf-PMV_PEXEL_1	123	127	PF00026	0.403

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HYF6	Leptomonas seymouri	76%	100%
A0A1X0NJF5	Trypanosomatidae	48%	100%
A0A3S7X8M6	Leishmania donovani	100%	100%
A0A422N7K5	Trypanosoma rangeli	43%	100%
A4HM50	Leishmania braziliensis	94%	100%
D0A2F0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	40%	77%
E9AEI8	Leishmania major	98%	100%
E9B5P9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	96%	100%
O17901	Caenorhabditis elegans	27%	100%
O74891	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	31%	97%
P35604	Bos taurus	36%	100%
P53600	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	34%	97%
P61923	Homo sapiens	36%	100%
P61924	Mus musculus	36%	100%
Q54CA7	Dictyostelium discoideum	26%	100%
Q54HD4	Dictyostelium discoideum	27%	100%
Q5NA06	Oryza sativa subsp. japonica	27%	100%
Q5R5F2	Pongo abelii	36%	100%
Q6Z844	Oryza sativa subsp. japonica	31%	100%
Q84LG4	Arabidopsis thaliana	27%	100%
Q8H1F4	Arabidopsis thaliana	28%	100%
Q940S5	Arabidopsis thaliana	28%	100%
Q9JHH9	Mus musculus	32%	90%
Q9MAX5	Oryza sativa subsp. japonica	29%	100%
Q9P299	Homo sapiens	31%	88%
V5BSX4	Trypanosoma cruzi	47%	100%