Complex I-B22

Quick info Annotations Localization Abundance Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Complex I-B22

Gene product:

Ubiquinol-cytochrome C reductase complex 14kD subunit - putative

Species:

Leishmania infantum

UniProt:

A4IAR1_LEIIN

TriTrypDb:

LINF_350006100

Length:

202

Annotations

Annotations by Jardim et al.

Electron Transport Chain (see tricarboxylic acid section for Complex II), Cytochrome b-c1 subunit 7 Uncharacterized

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 18

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005750	mitochondrial respiratory chain complex III	4	12
GO:0032991	protein-containing complex	1	12
GO:0045275	respiratory chain complex III	4	12
GO:0070069	cytochrome complex	3	12
GO:0098796	membrane protein complex	2	12
GO:0098798	mitochondrial protein-containing complex	2	12
GO:0098800	inner mitochondrial membrane protein complex	3	12
GO:0098803	respiratory chain complex	3	12
GO:1902494	catalytic complex	2	12
GO:1902495	transmembrane transporter complex	3	12
GO:1990204	oxidoreductase complex	3	12
GO:1990351	transporter complex	2	12

Abundance

Amastigote (protein)


Source	Evidence on protein	Close homologs
Pescher et al. (upgregulation)	no	yes: 0

Promastigote and amastigote


Source	Evidence on protein	Close homologs
Lahav et al. - mRNA - Protein

Expansion

Sequence features

A4IAR1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4IAR1

Function

Biological processes
Term	Name	Level	Count
GO:0006091	generation of precursor metabolites and energy	3	12
GO:0006122	mitochondrial electron transport, ubiquinol to cytochrome c	7	12
GO:0008152	metabolic process	1	12
GO:0009060	aerobic respiration	6	12
GO:0009987	cellular process	1	12
GO:0015980	energy derivation by oxidation of organic compounds	4	12
GO:0019646	aerobic electron transport chain	6	12
GO:0022900	electron transport chain	4	12
GO:0022904	respiratory electron transport chain	5	12
GO:0044237	cellular metabolic process	2	12
GO:0045333	cellular respiration	5	12

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	147	149	PF00675	0.263
CLV_PCSK_KEX2_1	147	149	PF00082	0.277
CLV_PCSK_SKI1_1	153	157	PF00082	0.366
CLV_PCSK_SKI1_1	32	36	PF00082	0.399
CLV_PCSK_SKI1_1	51	55	PF00082	0.462
CLV_PCSK_SKI1_1	61	65	PF00082	0.365
DOC_MAPK_FxFP_2	25	28	PF00069	0.431
DOC_MAPK_MEF2A_6	61	68	PF00069	0.379
DOC_MAPK_NFAT4_5	61	69	PF00069	0.381
DOC_PP2B_LxvP_1	64	67	PF13499	0.384
DOC_PP4_FxxP_1	25	28	PF00568	0.431
DOC_WW_Pin1_4	3	8	PF00397	0.624
LIG_BRCT_BRCA1_1	5	9	PF00533	0.617
LIG_deltaCOP1_diTrp_1	186	195	PF00928	0.263
LIG_HP1_1	179	183	PF01393	0.279
LIG_LIR_Apic_2	165	170	PF02991	0.291
LIG_LIR_Gen_1	33	40	PF02991	0.381
LIG_LIR_Gen_1	78	89	PF02991	0.393
LIG_LIR_Nem_3	189	195	PF02991	0.433
LIG_LIR_Nem_3	33	37	PF02991	0.378
LIG_LIR_Nem_3	59	63	PF02991	0.390
LIG_LIR_Nem_3	78	84	PF02991	0.390
LIG_LYPXL_S_1	26	30	PF13949	0.423
LIG_LYPXL_yS_3	27	30	PF13949	0.419
LIG_PTB_Apo_2	170	177	PF02174	0.279
LIG_PTB_Phospho_1	170	176	PF10480	0.279
LIG_SH2_CRK	60	64	PF00017	0.402
LIG_SH2_STAP1	99	103	PF00017	0.263
LIG_SH2_STAT5	159	162	PF00017	0.263
LIG_SH2_STAT5	176	179	PF00017	0.263
LIG_SH2_STAT5	180	183	PF00017	0.263
LIG_SH2_STAT5	21	24	PF00017	0.405
LIG_SH3_3	1	7	PF00018	0.513
LIG_TRAF2_1	196	199	PF00917	0.490
LIG_TYR_ITIM	58	63	PF00017	0.409
MOD_ProDKin_1	3	9	PF00069	0.625
TRG_ENDOCYTIC_2	107	110	PF00928	0.263
TRG_ENDOCYTIC_2	180	183	PF00928	0.279
TRG_ENDOCYTIC_2	27	30	PF00928	0.419
TRG_ENDOCYTIC_2	31	34	PF00928	0.391
TRG_ENDOCYTIC_2	60	63	PF00928	0.404
TRG_ER_diArg_1	147	149	PF00400	0.263
TRG_ER_diArg_1	150	153	PF00400	0.263
TRG_Pf-PMV_PEXEL_1	153	157	PF00026	0.263
TRG_Pf-PMV_PEXEL_1	45	50	PF00026	0.408

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PB98	Leptomonas seymouri	97%	100%
A0A0S4JMJ5	Bodo saltans	84%	100%
A0A1X0NIZ5	Trypanosomatidae	90%	100%
A0A3R7N7A2	Trypanosoma rangeli	89%	100%
A0A3S7X8N8	Leishmania donovani	100%	100%
A4HM49	Leishmania braziliensis	98%	100%
D0A2F1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	86%	100%
E9AEI7	Leishmania major	100%	100%
E9B5P8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	99%	100%
V5B398	Trypanosoma cruzi	90%	100%